sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.691 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.649 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.627 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.609 | |
| 3qly | 55V | Uncharacterized protein | / | 0.609 | |
| 3eek | 53S | Uncharacterized protein | / | 0.605 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.593 | |
| 3cse | N22 | Uncharacterized protein | / | 0.591 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.587 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.583 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.577 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.575 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.572 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.572 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.570 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.570 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.570 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.565 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.565 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.564 | |
| 3eej | 53R | Uncharacterized protein | / | 0.563 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.562 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.561 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.557 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.557 | |
| 3eel | 53T | Uncharacterized protein | / | 0.556 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.554 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.550 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.550 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.550 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.546 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.546 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.545 | |
| 3eem | 53V | Uncharacterized protein | / | 0.544 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.544 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.543 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.542 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.542 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.542 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.541 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.539 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.538 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.537 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.536 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.534 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.533 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.532 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.530 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.530 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.530 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.529 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.528 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.527 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.526 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.524 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.523 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.519 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.518 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.518 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.518 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.516 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.506 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.505 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.502 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.501 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.500 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.500 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.499 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.494 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.492 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.488 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.486 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.483 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.482 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.482 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.482 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.481 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.481 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.480 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.480 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.480 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.479 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.479 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.478 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.478 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.478 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.477 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.477 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.476 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.476 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.476 | |
| 4m7v | RAR | Dihydrofolate reductase | / | 0.476 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.475 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.474 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.474 | |
| 1yin | CM3 | Estrogen receptor | / | 0.474 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.474 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.474 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.473 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.473 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.473 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.473 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.473 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.472 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.471 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.470 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.470 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.470 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.470 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.468 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.468 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.468 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.468 | |
| 3sru | Q26 | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.468 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.467 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.466 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.466 | |
| 1tdu | DUR | Thymidylate synthase | / | 0.466 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.466 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.466 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.465 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.464 | |
| 2j2i | LY4 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.463 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.463 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3r33 | 6ME | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.462 | |
| 2x20 | PID | Peridinin-chlorophyll a-binding protein 1, chloroplastic | / | 0.462 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.462 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3v9v | 21L | Peroxisome proliferator-activated receptor gamma | / | 0.462 | |
| 4iv2 | 1GR | Estrogen receptor | / | 0.462 | |
| 1e1n | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.461 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.461 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.461 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 2itt | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.460 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.460 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.460 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 3dho | B2M | Streptogramin A acetyltransferase | 2.3.1 | 0.459 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.459 | |
| 3wsb | RWZ | Farnesyltransferase, putative | / | 0.459 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.459 | |
| 4f1s | F1S | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.459 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.458 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2w9g | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.458 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.458 | |
| 3rg9 | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.458 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.458 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.458 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 1rg7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.457 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.455 | |
| 1nq1 | 4HY | Thyroid hormone receptor beta | / | 0.455 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.455 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.455 | |
| 2i0e | PDS | Protein kinase C beta type | 2.7.11.13 | 0.455 | |
| 3mfs | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.455 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.455 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.455 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.455 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.455 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.454 | |
| 3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.454 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.454 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.454 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.454 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.453 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.453 | |
| 2wue | KEK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.453 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3iw4 | LW4 | Protein kinase C alpha type | 2.7.11.13 | 0.453 | |
| 3w9r | A8S | Abscisic acid receptor PYL9 | / | 0.453 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.453 | |
| 4hw2 | 19H | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.453 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.453 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.452 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.452 | |
| 1qxo | FMN | Chorismate synthase | / | 0.452 | |
| 2b9w | FAD | Putative aminooxidase | / | 0.452 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.452 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 3vsp | EK8 | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 4lmu | QUE | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.452 | |
| 1err | RAL | Estrogen receptor | / | 0.451 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.451 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1sej | F89 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.451 | |
| 1t13 | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | / | 0.451 | |
| 3bgr | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.451 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4bqp | VMY | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.451 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.451 | |
| 4k9o | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.451 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.451 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.450 | |
| 1e7a | PFL | Serum albumin | / | 0.450 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.450 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.450 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1yhs | STU | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 2fai | 459 | Estrogen receptor | / | 0.450 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.450 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.450 | |
| 4a7c | E46 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.450 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.450 | |
| 1tez | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.449 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 3cz0 | 9OD | Pheromone-binding protein ASP1 | / | 0.449 | |
| 3glu | LYS_VAL_MET | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.449 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.449 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.449 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.449 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.449 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.448 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1pp9 | SMA | Cytochrome b | / | 0.448 | |
| 1ywr | LI9 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 2b1z | 17M | Estrogen receptor | / | 0.448 | |
| 3b9l | AZZ | Serum albumin | / | 0.448 | |
| 3bgq | VX2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.448 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.447 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.447 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.447 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3cgb | COA | Coenzyme A disulfide reductase | / | 0.447 | |
| 4ckc | SAH | mRNA-capping enzyme catalytic subunit | 2.1.1.56 | 0.447 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.447 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.447 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.447 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.446 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.446 | |
| 1r6g | 442 | Thyroid hormone receptor beta | / | 0.446 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.446 | |
| 1rx2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.446 | |
| 3qyo | Q24 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.446 | |
| 4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.446 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.446 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.446 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.446 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.446 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.445 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2b37 | 8PS | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 3sgx | 0FW | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.445 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4em9 | TCE | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.445 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1f4g | TP4 | Thymidylate synthase | / | 0.444 | |
| 1kb9 | SMA | Cytochrome b | / | 0.444 | |
| 1zhw | HC2 | Oxysterol-binding protein homolog 4 | / | 0.444 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 3jw3 | TOP | Dihydrofolate reductase | / | 0.444 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.444 | |
| 3nta | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.444 | |
| 3sqy | Q11 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3tq8 | TOP | Dihydrofolate reductase | / | 0.444 | |
| 4b1f | KRH | Glutamate racemase | / | 0.444 | |
| 4dtk | 7LI | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.444 | |
| 4ixc | 1JD | Glucokinase | 2.7.1.2 | 0.444 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.443 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.443 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.443 | |
| 2bik | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 2p7z | OHT | Estrogen-related receptor gamma | / | 0.443 | |
| 3c4e | C4E | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.443 | |
| 3ics | ADP | Coenzyme A disulfide reductase | / | 0.443 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3r7c | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.443 | |
| 4acc | 7YG | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.443 | |
| 4bch | T7Z | Cyclin-dependent kinase 9 | 2.7.11.22 | 0.443 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.443 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.443 | |
| 4pxm | EST | Estrogen receptor | / | 0.443 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.443 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.443 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.442 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.442 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.442 | |
| 1s9q | OHT | Estrogen-related receptor gamma | / | 0.442 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 1zdw | FLV | Prenyltransferase | / | 0.442 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.442 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2bxq | IMN | Serum albumin | / | 0.442 | |
| 3l03 | 4OH | Estrogen receptor | / | 0.442 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.442 | |
| 3v49 | PK0 | Androgen receptor | / | 0.442 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.442 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.442 | |
| 4l98 | LRG | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.442 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.442 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.442 | |
| 4ea3 | 0NN | Nociceptin receptor | / | 0.442 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.441 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.441 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.441 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.441 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3fyv | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.441 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.441 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.441 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.441 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.441 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.441 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1owm | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.440 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.440 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.440 | |
| 1rp4 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.440 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.440 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.440 | |
| 2pnu | ENM | Androgen receptor | / | 0.440 | |
| 2puj | HPZ | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase | 3.7.1.8 | 0.440 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2xh9 | J01 | Uncharacterized protein | / | 0.440 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 3iqz | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.440 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3new | 3NE | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3njo | P2M | Abscisic acid receptor PYR1 | / | 0.440 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.440 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.440 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.440 | |
| 3wgw | T2B | Proliferating cell nuclear antigen | / | 0.440 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.440 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.440 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.440 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.440 |