sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4c03 | SFG | Protein arginine N-methyltransferase 6 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4c03 | SFG | Protein arginine N-methyltransferase 6 | / | 1.000 | |
| 5dxj | SFG | Histone-arginine methyltransferase CARM1 | / | 0.604 | |
| 5dwq | SFG | Histone-arginine methyltransferase CARM1 | / | 0.600 | |
| 5dx1 | SFG | Histone-arginine methyltransferase CARM1 | / | 0.582 | |
| 2y1w | SFG | Histone-arginine methyltransferase CARM1 | / | 0.580 | |
| 1f3l | SAH | Protein arginine N-methyltransferase 3 | / | 0.578 | |
| 5dx8 | SFG | Histone-arginine methyltransferase CARM1 | / | 0.575 | |
| 2y1x | SAH | Histone-arginine methyltransferase CARM1 | / | 0.574 | |
| 5dxa | SFG | Histone-arginine methyltransferase CARM1 | / | 0.558 | |
| 3b3f | SAH | Histone-arginine methyltransferase CARM1 | / | 0.530 | |
| 5dst | SAH | Protein arginine N-methyltransferase 8 | 2.1.1 | 0.523 | |
| 3uj8 | SFG | Phosphoethanolamine N-methyltransferase | / | 0.513 | |
| 5egh | PC | Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 | / | 0.510 | |
| 4d03 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.505 | |
| 5icf | SAH | (S)-norcoclaurine 6-O-methyltransferase | / | 0.505 | |
| 3sso | SAH | Mycinamicin VI 2''-O-methyltransferase | / | 0.496 | |
| 3t7s | SAM | Uncharacterized protein | / | 0.493 | |
| 3reo | SAH | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.489 | |
| 4qpp | SAH | Protein arginine N-methyltransferase 6 | / | 0.489 | |
| 5il2 | SAH | N6-adenosine-methyltransferase 70 kDa subunit | / | 0.487 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.481 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.480 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.479 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.478 | |
| 4mwz | SAM | Phosphoethanolamine N-methyltransferase, putative | / | 0.478 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.475 | |
| 4de1 | 0J6 | Beta-lactamase | / | 0.475 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.474 | |
| 2zvj | KOM | Catechol O-methyltransferase | 2.1.1.6 | 0.474 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.473 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.473 | |
| 3vy2 | FMN | FMN-binding protein | / | 0.473 | |
| 1tkc | M6T | Transketolase 1 | 2.2.1.1 | 0.472 | |
| 5bw4 | SAM | Uncharacterized protein | / | 0.472 | |
| 3pvc | FAD | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | / | 0.471 | |
| 4kwc | SAH | Methyltransferase domain family | / | 0.471 | |
| 4r6x | SAH | Phosphoethanolamine N-methyltransferase | / | 0.471 | |
| 1sre | HAB | Streptavidin | / | 0.470 | |
| 2ylx | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.470 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.470 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.470 | |
| 3dlc | SAM | SAM (And some other nucleotide) binding motif:Generic methyltransferase | / | 0.469 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.469 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.469 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.468 | |
| 2bzg | SAH | Thiopurine S-methyltransferase | 2.1.1.67 | 0.468 | |
| 2pci | SAH | Diphthine synthase | / | 0.468 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.468 | |
| 3uj7 | SAM | Phosphoethanolamine N-methyltransferase | / | 0.468 | |
| 4brd | ANP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.468 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
| 4fgz | SAH | Phosphoethanolamine N-methyltransferase | / | 0.468 | |
| 4g67 | SAH | Uncharacterized ACR, COG1565 superfamily | / | 0.468 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.467 | |
| 3wtk | TH4 | Acetylcholine-binding protein | / | 0.467 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.466 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.466 | |
| 5epe | SAH | Uncharacterized protein | / | 0.466 | |
| 1pw1 | HEL | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.465 | |
| 4py2 | 43E | Methionine--tRNA ligase | / | 0.465 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.464 | |
| 3ou7 | SAM | SAM-dependent methyltransferase | / | 0.464 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.463 | |
| 1dlj | UGA | UDP-glucose 6-dehydrogenase | / | 0.463 | |
| 1jr4 | CL4 | Catechol O-methyltransferase | 2.1.1.6 | 0.463 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.463 | |
| 1svl | ADP | Large T antigen | 3.6.4 | 0.463 | |
| 2rm2 | W43 | Genome polyprotein | / | 0.463 | |
| 3grr | SAH | Probable ribosomal RNA small subunit methyltransferase A | / | 0.463 | |
| 3t7t | SAH | Uncharacterized protein | / | 0.463 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.463 | |
| 4wqm | FAD | Toluene-4-monooxygenase electron transfer component | 1.18.1.3 | 0.463 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.462 | |
| 1sri | DMB | Streptavidin | / | 0.462 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.462 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.462 | |
| 4id9 | NAD | Putative UDP-glucose 4-epimerase | / | 0.462 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.461 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.461 | |
| 3fzf | ATP | Heat shock cognate 71 kDa protein | / | 0.461 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.461 | |
| 4bmo | FMN | Protein NrdI | / | 0.461 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.460 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.460 | |
| 1yob | FMN | Flavodoxin 2 | / | 0.460 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.460 | |
| 1c4u | IH1 | Prothrombin | 3.4.21.5 | 0.459 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.459 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.459 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.459 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.459 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 4u8i | FDA | UDP-galactopyranose mutase | / | 0.459 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.458 | |
| 1ja0 | NAP | NADPH--cytochrome P450 reductase | / | 0.458 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.458 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.458 | |
| 4e32 | DWN | Methyltransferase | / | 0.458 | |
| 4emt | C2E | Stimulator of interferon genes protein | / | 0.458 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.458 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.458 | |
| 1njf | AGS | DNA polymerase III subunit tau | 2.7.7.7 | 0.457 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.457 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.457 | |
| 2zsc | BTN | Tamavidin2 | / | 0.457 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.457 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.457 | |
| 3mte | SAM | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.457 | |
| 3p17 | 99P | Prothrombin | 3.4.21.5 | 0.457 | |
| 4xzj | NAD | Putative NAD(+)--arginine ADP-ribosyltransferase Vis | 2.4.2.31 | 0.457 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.456 | |
| 2fhl | BNI | Avidin-related protein 4/5 | / | 0.456 | |
| 2ph6 | 712 | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 3ab1 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.456 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.456 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.456 | |
| 1g28 | FMN | PHY3 | / | 0.455 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.455 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.455 | |
| 3nd6 | ATP | Phosphopantetheine adenylyltransferase | / | 0.455 | |
| 3w8w | FAD | Putative FAD-dependent oxygenase EncM | / | 0.455 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.455 | |
| 4j7h | TRH | PCZA361.3 | / | 0.455 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE26 | / | 0.455 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE27 | / | 0.455 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.454 | |
| 1gpu | THD | Transketolase 1 | 2.2.1.1 | 0.454 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.454 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.454 | |
| 2abj | PLP | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.454 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3klb | FMN | Uncharacterized protein | / | 0.454 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.454 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.454 | |
| 3p2k | SAM | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.454 | |
| 3r94 | FLR | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 3ssm | SAH | Mycinamicin VI 2''-O-methyltransferase | / | 0.454 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.454 | |
| 2bif | ANP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 | 2.7.1.105 | 0.453 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.453 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.453 | |
| 2wca | NP6 | O-GlcNAcase BT_4395 | / | 0.453 | |
| 2zhe | 13U | Prothrombin | 3.4.21.5 | 0.453 | |
| 3c27 | DKK | Prothrombin | 3.4.21.5 | 0.453 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.453 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.453 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.453 | |
| 4m37 | SAH | Protein arginine N-methyltransferase 7 | 2.1.1 | 0.453 | |
| 4prx | ADP | DNA gyrase subunit B | / | 0.453 | |
| 1c1u | BAI | Prothrombin | 3.4.21.5 | 0.452 | |
| 1p4m | ADP | Riboflavin kinase | 2.7.1.26 | 0.452 | |
| 1wnb | NAI | Gamma-aminobutyraldehyde dehydrogenase | 1.2.1.19 | 0.452 | |
| 2cnd | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.452 | |
| 2dv7 | SAH | Diphthine synthase | / | 0.452 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 2yls | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.452 | |
| 3awh | FMN | FMN-binding protein | / | 0.452 | |
| 3kpj | SAH | Phenylethanolamine N-methyltransferase | 2.1.1.28 | 0.452 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.452 | |
| 4b1e | 6T6 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4bue | JQF | Tankyrase-2 | 2.4.2.30 | 0.452 | |
| 4x9n | FAD | Uncharacterized protein MG039 homolog | / | 0.452 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.451 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.451 | |
| 3ely | SAH | Methyltransferase | / | 0.451 | |
| 1sg9 | SAM | Release factor glutamine methyltransferase | 2.1.1.297 | 0.450 | |
| 1tkb | N1T | Transketolase 1 | 2.2.1.1 | 0.450 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.450 | |
| 2g97 | DGB | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.450 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.450 | |
| 2r8o | T5X | Transketolase 1 | / | 0.450 | |
| 3wqu | ATP | Cell division protein FtsA | / | 0.450 | |
| 4bam | MM9 | Prothrombin | 3.4.21.5 | 0.450 | |
| 1fw0 | KAI | Glutamate receptor 2 | / | 0.449 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.449 | |
| 1typ | FAD | Trypanothione reductase | 1.8.1.12 | 0.449 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.449 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 2xlt | NA0 | Putative flavin-containing monooxygenase | / | 0.449 | |
| 2zfu | SAH | Ribosomal RNA-processing protein 8 | / | 0.449 | |
| 3clu | FAD | Electron transfer flavoprotein subunit alpha | / | 0.449 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3ime | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.449 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.449 | |
| 4obw | SAM | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial | / | 0.449 | |
| 4qdk | SAH | Magnesium-protoporphyrin O-methyltransferase | 2.1.1.11 | 0.449 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.448 | |
| 1nc9 | IMI | Streptavidin | / | 0.448 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.448 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.448 | |
| 2p35 | SAH | Trans-aconitate 2-methyltransferase | / | 0.448 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 4xba | GMP | Aprataxin-like protein | 3 | 0.448 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.447 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.447 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.447 | |
| 2xrl | DXT | Tetracycline repressor protein class D | / | 0.447 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 2zg0 | 50U | Prothrombin | 3.4.21.5 | 0.447 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.447 | |
| 3qbw | ADP | Anhydro-N-acetylmuramic acid kinase | / | 0.447 | |
| 4o9c | COA | Acetyl-CoA acetyltransferase | 2.3.1.9 | 0.447 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.447 | |
| 1ao0 | 5GP | Amidophosphoribosyltransferase | / | 0.446 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2r8p | T6F | Transketolase 1 | / | 0.446 | |
| 2rc4 | ACO | Histone acetyltransferase KAT6A | / | 0.446 | |
| 2rtr | IMI | Streptavidin | / | 0.446 | |
| 2v3h | I25 | Prothrombin | 3.4.21.5 | 0.446 | |
| 2ym2 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.446 | |
| 2zbw | FAD | Ferredoxin--NADP reductase | / | 0.446 | |
| 3a26 | MTA | tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase | / | 0.446 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.446 | |
| 3tp0 | FO5 | HTH-type transcriptional regulator EthR | / | 0.446 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.446 | |
| 4kvz | SAH | PtnL protein | / | 0.446 | |
| 4lxl | PD2 | Lysine-specific demethylase 4B | 1.14.11 | 0.446 | |
| 5dib | NAD | Betaine-aldehyde dehydrogenase | / | 0.446 | |
| 5hq8 | SAH | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.446 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.446 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.445 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2ffq | GSP | Ras-related protein Rab-6B | / | 0.445 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.445 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3hat | GLY_VAL_ARG_RNG | Prothrombin | 3.4.21.5 | 0.445 | |
| 3oe1 | TDL | Pyruvate decarboxylase | 4.1.1.1 | 0.445 | |
| 3ou6 | SAM | SAM-dependent methyltransferase | / | 0.445 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.445 | |
| 4u07 | ATP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.445 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.445 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1fvp | FMA | Non-fluorescent flavoprotein | / | 0.444 | |
| 1n2h | PAJ | Pantothenate synthetase | 6.3.2.1 | 0.444 | |
| 1ywg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.444 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.444 | |
| 2v7q | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.444 | |
| 2v7q | ATP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.444 | |
| 2zwa | SAH | tRNA wybutosine-synthesizing protein 4 | 2.1.1.290 | 0.444 | |
| 3ld6 | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.444 | |
| 4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.444 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.444 | |
| 4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.444 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.443 | |
| 2ohj | FMN | Type A flavoprotein FprA | 1 | 0.443 | |
| 3bwc | SAM | Spermidine synthase, putative | / | 0.443 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.443 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.443 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.443 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.442 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.442 | |
| 2iid | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.442 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 2rc6 | FAD | Ferredoxin--NADP reductase | / | 0.442 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.442 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3pbz | F02 | Endothiapepsin | 3.4.23.22 | 0.442 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.442 | |
| 3utu | 1TS | Prothrombin | 3.4.21.5 | 0.442 | |
| 3uxv | GUN | NADPH-dependent 7-cyano-7-deazaguanine reductase | / | 0.442 | |
| 4bah | MEL | Prothrombin | 3.4.21.5 | 0.442 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.442 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4ggz | BTN | Bll1558 protein | / | 0.442 | |
| 4io8 | 3FD | Heat shock 70 kDa protein 1B | / | 0.442 | |
| 1b9i | PXG | 3-amino-5-hydroxybenzoate synthase | 4.2.1.144 | 0.441 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.441 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.441 | |
| 1j8u | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.441 | |
| 1ld7 | U66 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.441 | |
| 1rx6 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.441 | |
| 2cft | PLP | Pyridoxal phosphate phosphatase | / | 0.441 | |
| 2gr0 | ADP | Ferredoxin reductase | / | 0.441 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.441 | |
| 2ylw | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.441 | |
| 3kr8 | XAV | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.441 | |
| 3wth | IM4 | Acetylcholine-binding protein | / | 0.441 | |
| 4hfp | 15U | Prothrombin | 3.4.21.5 | 0.441 | |
| 4zu4 | 4TG | WxcM-like protein | / | 0.441 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.440 | |
| 1wze | NAD | Malate dehydrogenase | / | 0.440 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2avi | BTN | Avidin | / | 0.440 | |
| 2e07 | SAH | Diphthine synthase | / | 0.440 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.440 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.440 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.440 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.440 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.440 | |
| 4de0 | 0JB | Beta-lactamase | / | 0.440 | |
| 4ivr | N50 | Thymidine kinase | / | 0.440 | |
| 4ntd | FAD | Thioredoxin reductase | / | 0.440 | |
| 4qtu | SAM | 18S rRNA (guanine(1575)-N(7))-methyltransferase | / | 0.440 | |
| 4u7w | NDP | MxaA | / | 0.440 | |
| 5a8a | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.440 |