sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4ajb | TAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4ajb | TAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 1.000 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.502 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.489 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.486 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.485 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.479 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.477 | |
| 4jb1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.473 | |
| 4l4x | NDP | AmphI | / | 0.473 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.471 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.471 | |
| 4pd6 | URI | Nucleoside permease | / | 0.471 | |
| 5bsf | NAD | Pyrroline-5-carboxylate reductase | / | 0.471 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.470 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.469 | |
| 2ep7 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.468 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.468 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.468 | |
| 4prv | ADP | DNA gyrase subunit B | / | 0.467 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.467 | |
| 1ybm | NAP | Uncharacterized protein At5g02240 | / | 0.466 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4mxe | ACO | N-acetyltransferase ESCO1 | 2.3.1 | 0.466 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.465 | |
| 1eio | GCH | Gastrotropin | / | 0.465 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.465 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.465 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.465 | |
| 4ntd | FAD | Thioredoxin reductase | / | 0.465 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.464 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.464 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.464 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.464 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.464 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.464 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.464 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.463 | |
| 3da2 | 4MD | Carbonic anhydrase 13 | 4.2.1.1 | 0.463 | |
| 3gob | HXX | DdmC | / | 0.463 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.463 | |
| 3oia | A31 | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 4g6h | NAI | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.463 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.463 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.462 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.462 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.462 | |
| 3q71 | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.462 | |
| 1fm6 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.461 | |
| 1mok | FAD | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.461 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.461 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.461 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.460 | |
| 3vfq | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.460 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.460 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.459 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.458 | |
| 2i5b | ADP | Pyridoxine kinase | / | 0.458 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.458 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.458 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.458 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.458 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.457 | |
| 2nua | COA | Succinate--CoA ligase [ADP-forming] subunit alpha | 6.2.1.5 | 0.457 | |
| 4xxv | NAD | 3-isopropylmalate dehydrogenase | / | 0.457 | |
| 2q46 | NAP | Uncharacterized protein At5g02240 | / | 0.456 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.456 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.456 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.456 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.456 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.456 | |
| 4uir | FAD | Oleate hydratase | 4.2.1.53 | 0.456 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.455 | |
| 2yph | QQY | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.455 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.455 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.455 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.455 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.455 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.455 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3v9v | 21L | Peroxisome proliferator-activated receptor gamma | / | 0.454 | |
| 4xiv | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.454 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.453 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.453 | |
| 2cvz | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.453 | |
| 2d1c | NAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.453 | |
| 2d4v | NAD | Isocitrate dehydrogenase [NADP] | / | 0.453 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.453 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.453 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.453 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.453 | |
| 3mvm | 39P | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.453 | |
| 3pxy | JWS | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3rwp | ABQ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.453 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.453 | |
| 1lik | ADN | Adenosine kinase | 2.7.1.20 | 0.452 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.452 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.452 | |
| 3bv2 | P38 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 3cvu | FAD | RE11660p | / | 0.452 | |
| 3gqo | APR | Non-structural polyprotein | / | 0.452 | |
| 3rdq | DTB | Streptavidin | / | 0.452 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4cvl | ACP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.452 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.452 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.452 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.451 | |
| 2hqp | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2ign | FAD | Pyranose 2-oxidase | / | 0.451 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.451 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.451 | |
| 3a8t | ATP | Adenylate isopentenyltransferase | / | 0.451 | |
| 3ac2 | KSE | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.451 | |
| 3tkh | 07S | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 4feh | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.451 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.451 | |
| 4kgm | ATP | Uncharacterized protein | / | 0.451 | |
| 1dc6 | NAD | Glyceraldehyde-3-phosphate dehydrogenase A | / | 0.450 | |
| 1qnf | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.450 | |
| 1rrm | APR | Lactaldehyde reductase | 1.1.1.77 | 0.450 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 1z1f | STL | Resveratrol synthase | / | 0.450 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.450 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.450 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.450 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.450 | |
| 4uya | AGS | Mitogen-activated protein kinase kinase kinase 21 | 2.7.11.25 | 0.450 | |
| 4y9q | C2E | Uncharacterized protein | / | 0.450 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.450 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.449 | |
| 1u8f | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.449 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.449 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.449 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.449 | |
| 2jlc | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.449 | |
| 2o0u | C0M | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.449 | |
| 3ieu | GDP | GTPase Era | / | 0.449 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3m8q | DJZ | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.449 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.449 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.449 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.449 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.449 | |
| 4hjo | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.449 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.449 | |
| 1a27 | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.448 | |
| 1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.448 | |
| 1osv | CHC | Bile acid receptor | / | 0.448 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.448 | |
| 2xgs | 44P | Uncharacterized protein | / | 0.448 | |
| 2ze2 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.448 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.448 | |
| 3v9y | 24L | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.448 | |
| 4wqm | FAD | Toluene-4-monooxygenase electron transfer component | 1.18.1.3 | 0.448 | |
| 1c1d | NAI | Phenylalanine dehydrogenase | / | 0.447 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.447 | |
| 1rc0 | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.447 | |
| 1zz2 | B11 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 2gr1 | FAD | Ferredoxin reductase | / | 0.447 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.447 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.447 | |
| 2qo6 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.447 | |
| 2qo7 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.447 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.447 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.447 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.447 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.447 | |
| 3wtk | TH4 | Acetylcholine-binding protein | / | 0.447 | |
| 4fdp | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.447 | |
| 4hxy | NDP | Plm1 | / | 0.447 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.447 | |
| 4pgh | SAM | Caffeic acid O-methyltransferase | / | 0.447 | |
| 4xx0 | COA | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial | 6.2.1.4 | 0.447 | |
| 1cbq | RE9 | Cellular retinoic acid-binding protein 2 | / | 0.446 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1ja0 | NAP | NADPH--cytochrome P450 reductase | / | 0.446 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1kt7 | RTL | Retinol-binding protein 4 | / | 0.446 | |
| 1njf | AGS | DNA polymerase III subunit tau | 2.7.7.7 | 0.446 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.446 | |
| 2bdj | HET | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.446 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.446 | |
| 2of2 | 547 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.446 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.446 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3e5r | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic | 1.2.1.12 | 0.446 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.446 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.446 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 4die | C5P | Cytidylate kinase | / | 0.446 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.446 | |
| 4ebf | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.446 | |
| 4lk3 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.446 | |
| 4zow | CLM | Multidrug transporter MdfA | / | 0.446 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.445 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 1kqw | RTL | Cellular retinol-binding protein type II | / | 0.445 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.445 | |
| 1py5 | PY1 | TGF-beta receptor type-1 | 2.7.11.30 | 0.445 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.445 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.445 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.445 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3b2e | ADP | ATPase GET3 | / | 0.445 | |
| 3bpz | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | / | 0.445 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.445 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.445 | |
| 3q70 | RIT | Candidapepsin-2 | 3.4.23.24 | 0.445 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.445 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.445 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.445 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.445 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.445 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.444 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.444 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.444 | |
| 1q0q | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.444 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.444 | |
| 2bhi | SFT | Cytotoxin 3 | / | 0.444 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.444 | |
| 2wbd | RO5 | Fructose-1,6-bisphosphatase 1 | 3.1.3.11 | 0.444 | |
| 2yit | YIT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.444 | |
| 3cbs | R12 | Cellular retinoic acid-binding protein 2 | / | 0.444 | |
| 3gon | ANP | Phosphomevalonate kinase | / | 0.444 | |
| 3nx2 | FER | Ferulic acid decarboxylase | / | 0.444 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.444 | |
| 4h2n | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.444 | |
| 4hjf | C2E | GGDEF family protein | / | 0.444 | |
| 4k5y | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.444 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.443 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.443 | |
| 1ikg | REX | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.443 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.443 | |
| 1npt | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.443 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.443 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.443 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.443 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.443 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.443 | |
| 2hbh | XE4 | Vitamin D3 receptor A | / | 0.443 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.443 | |
| 3au8 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.443 | |
| 3l9h | EMQ | Kinesin-like protein KIF11 | / | 0.443 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.443 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.443 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.443 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.443 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.443 | |
| 1cjv | FOK | Adenylate cyclase type 2 | / | 0.442 | |
| 1cjv | FOK | Adenylate cyclase type 5 | / | 0.442 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1ie4 | T44 | Transthyretin | / | 0.442 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1nht | PGS | Adenylosuccinate synthetase | / | 0.442 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1xdu | SFG | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.442 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2d3u | CCT | Polyprotein | / | 0.442 | |
| 2j5b | TYE | Tyrosine--tRNA ligase | 6.1.1.1 | 0.442 | |
| 2rm2 | W43 | Genome polyprotein | / | 0.442 | |
| 2uuv | FAD | Alkyldihydroxyacetonephosphate synthase | 2.5.1.26 | 0.442 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.442 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.442 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 3a14 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.442 | |
| 3ac3 | KSH | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.442 | |
| 3cs8 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 3dhb | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.442 | |
| 3n7u | NAD | Formate dehydrogenase, chloroplastic/mitochondrial | / | 0.442 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.442 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.442 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.442 | |
| 4gj3 | 0XP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.442 | |
| 4o0m | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.442 | |
| 4otw | DB8 | Receptor tyrosine-protein kinase erbB-3 | 2.7.10.1 | 0.442 | |
| 5br7 | FAD | UDP-galactopyranose mutase | / | 0.442 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 1a7k | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.441 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.441 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.441 | |
| 1ep1 | FMN | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit | 1.3.1.14 | 0.441 | |
| 1jgt | APC | Carboxyethyl-arginine beta-lactam-synthase | 6.3.3.4 | 0.441 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.441 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.441 | |
| 1mzs | 669 | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | / | 0.441 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1u0w | STL | Chalcone synthase 2 | 2.3.1.74 | 0.441 | |
| 2bju | IH4 | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 2bxm | IMN | Serum albumin | / | 0.441 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 2f2s | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.441 | |
| 2gcq | DOI | Adenylosuccinate synthetase | / | 0.441 | |
| 2nn7 | M29 | Carbonic anhydrase 1 | 4.2.1.1 | 0.441 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.441 | |
| 3cr3 | ADP | PTS-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL | 2.7 | 0.441 | |
| 3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.441 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.441 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.441 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.441 | |
| 3w0q | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.441 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 3zux | TCH | Transporter | / | 0.441 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.441 | |
| 4hmv | WUB | Phenazine biosynthesis protein PhzG | 1.4 | 0.441 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.440 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.440 | |
| 1me8 | RVP | Inosine-5'-monophosphate dehydrogenase | / | 0.440 | |
| 1u2d | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.440 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.440 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2q0k | NAP | Thioredoxin reductase | 1.8.1.9 | 0.440 | |
| 2qfx | NDP | Isocitrate dehydrogenase [NADP], mitochondrial | 1.1.1.42 | 0.440 | |
| 2w2x | GSP | Ras-related C3 botulinum toxin substrate 2 | / | 0.440 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.440 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.440 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.440 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.440 | |
| 3zon | IK1 | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.440 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4eu5 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.440 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.440 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.440 | |
| 4kqr | VPP | Peptidoglycan D,D-transpeptidase FtsI | / | 0.440 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.440 |