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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3s0o50ZCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3s0o50ZCyclin-dependent kinase 22.7.11.221.000
3sqq99ZCyclin-dependent kinase 22.7.11.220.703
3qzgX67Cyclin-dependent kinase 22.7.11.220.661
3r73X87Cyclin-dependent kinase 22.7.11.220.628
1h0w207Cyclin-dependent kinase 22.7.11.220.625
3qxoX65Cyclin-dependent kinase 22.7.11.220.620
3rk909ZCyclin-dependent kinase 22.7.11.220.614
3qqfX07Cyclin-dependent kinase 22.7.11.220.613
2w06FRVCyclin-dependent kinase 22.7.11.220.612
3unk0BYCyclin-dependent kinase 22.7.11.220.605
3qtzX42Cyclin-dependent kinase 22.7.11.220.602
3rjc06ZCyclin-dependent kinase 22.7.11.220.602
3r6xX84Cyclin-dependent kinase 22.7.11.220.601
3iggEFQCyclin-dependent kinase 22.7.11.220.600
3rk708ZCyclin-dependent kinase 22.7.11.220.598
1e1xNW1Cyclin-dependent kinase 22.7.11.220.597
3qu0X40Cyclin-dependent kinase 22.7.11.220.596
3rk507ZCyclin-dependent kinase 22.7.11.220.595
4ez30S0Cyclin-dependent kinase 22.7.11.220.593
3ral04ZCyclin-dependent kinase 22.7.11.220.592
3roy22ZCyclin-dependent kinase 22.7.11.220.592
3qruX19Cyclin-dependent kinase 22.7.11.220.589
3r9hZ67Cyclin-dependent kinase 22.7.11.220.587
1ke6LS2Cyclin-dependent kinase 22.7.11.220.585
1h1s4SPCyclin-dependent kinase 22.7.11.220.584
3ql8X01Cyclin-dependent kinase 22.7.11.220.584
4ek610KCyclin-dependent kinase 22.7.11.220.584
3rni21ZCyclin-dependent kinase 22.7.11.220.583
3rpo24ZCyclin-dependent kinase 22.7.11.220.582
2btsU32Cyclin-dependent kinase 22.7.11.220.580
3unj0BXCyclin-dependent kinase 22.7.11.220.579
3qqkX02Cyclin-dependent kinase 22.7.11.220.577
1v1k3FPCyclin-dependent kinase 22.7.11.220.576
3rm719ZCyclin-dependent kinase 22.7.11.220.576
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.575
3rmf20ZCyclin-dependent kinase 22.7.11.220.575
3r28XA0Cyclin-dependent kinase 22.7.11.220.574
1urwI1PCyclin-dependent kinase 22.7.11.220.573
3r1sX73Cyclin-dependent kinase 22.7.11.220.572
3rpv26ZCyclin-dependent kinase 22.7.11.220.571
3s1h56ZCyclin-dependent kinase 22.7.11.220.569
1pxmCK5Cyclin-dependent kinase 22.7.11.220.568
3qzhX69Cyclin-dependent kinase 22.7.11.220.568
3r9dX6BCyclin-dependent kinase 22.7.11.220.568
1h1r6CPCyclin-dependent kinase 22.7.11.220.566
1gih1PUCyclin-dependent kinase 22.7.11.220.565
4eor4SPCyclin-dependent kinase 22.7.11.220.564
4fkj11KCyclin-dependent kinase 22.7.11.220.564
4fkq42KCyclin-dependent kinase 22.7.11.220.562
4bgh3I6Cyclin-dependent kinase 22.7.11.220.561
1g5sI17Cyclin-dependent kinase 22.7.11.220.560
4fkg4CKCyclin-dependent kinase 22.7.11.220.559
1ke9LS5Cyclin-dependent kinase 22.7.11.220.557
3r1qX75Cyclin-dependent kinase 22.7.11.220.556
2c6o4SPCyclin-dependent kinase 22.7.11.220.555
3ddpRC8Cyclin-dependent kinase 22.7.11.220.555
3lfnA27Cyclin-dependent kinase 22.7.11.220.555
3rak03ZCyclin-dependent kinase 22.7.11.220.554
4fki09KCyclin-dependent kinase 22.7.11.220.554
1oguST8Cyclin-dependent kinase 22.7.11.220.553
1p2a5BNCyclin-dependent kinase 22.7.11.220.553
3rpr25ZCyclin-dependent kinase 22.7.11.220.552
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.549
3qwjX6ACyclin-dependent kinase 22.7.11.220.549
2iw94SPCyclin-dependent kinase 22.7.11.220.548
3r8lZ30Cyclin-dependent kinase 22.7.11.220.548
3rahO1ZCyclin-dependent kinase 22.7.11.220.548
3ezrEZRCyclin-dependent kinase 22.7.11.220.547
3ig7EFPCyclin-dependent kinase 22.7.11.220.547
3qtuX44Cyclin-dependent kinase 22.7.11.220.547
3rpy27ZCyclin-dependent kinase 22.7.11.220.546
4fkr45KCyclin-dependent kinase 22.7.11.220.546
4fx360KCyclin-dependent kinase 22.7.11.220.545
2a0cCK9Cyclin-dependent kinase 22.7.11.220.543
2r64740Cyclin-dependent kinase 22.7.11.220.543
3ddqRRCCyclin-dependent kinase 22.7.11.220.543
3qtxX43Cyclin-dependent kinase 22.7.11.220.543
2b55D31Cyclin-dependent kinase 22.7.11.220.542
3sw418KCyclin-dependent kinase 22.7.11.220.542
4eos1ROCyclin-dependent kinase 22.7.11.220.542
4fkpLS5Cyclin-dependent kinase 22.7.11.220.542
1vyw292Cyclin-dependent kinase 22.7.11.220.539
1w0xOLOCyclin-dependent kinase 22.7.11.220.539
3r7eX88Cyclin-dependent kinase 22.7.11.220.539
3ti1B49Cyclin-dependent kinase 22.7.11.220.539
1oi9N20Cyclin-dependent kinase 22.7.11.220.538
3rzb02ZCyclin-dependent kinase 22.7.11.220.537
4eon1ROCyclin-dependent kinase 22.7.11.220.537
1ke5LS1Cyclin-dependent kinase 22.7.11.220.536
1r78FMDCyclin-dependent kinase 22.7.11.220.536
1oiyN41Cyclin-dependent kinase 22.7.11.220.535
3qqhX0ACyclin-dependent kinase 22.7.11.220.535
5aniES4Cyclin-dependent kinase 22.7.11.220.535
1di8DTQCyclin-dependent kinase 22.7.11.220.534
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.534
3qrtX14Cyclin-dependent kinase 22.7.11.220.534
3raiX85Cyclin-dependent kinase 22.7.11.220.534
1ke7LS3Cyclin-dependent kinase 22.7.11.220.533
2iw84SPCyclin-dependent kinase 22.7.11.220.533
3r7vZ02Cyclin-dependent kinase 22.7.11.220.533
4eoi1ROCyclin-dependent kinase 22.7.11.220.533
1vyzN5BCyclin-dependent kinase 22.7.11.220.531
3s2pPMUCyclin-dependent kinase 22.7.11.220.531
4lyn1YGCyclin-dependent kinase 22.7.11.220.531
1gii1PUCyclin-dependent kinase 22.7.11.220.529
2btrU73Cyclin-dependent kinase 22.7.11.220.528
2w1hL0FCyclin-dependent kinase 22.7.11.220.527
1ckpPVBCyclin-dependent kinase 22.7.11.220.526
1unlRRCCyclin-dependent-like kinase 52.7.11.10.526
3qwkX62Cyclin-dependent kinase 22.7.11.220.526
2b52D42Cyclin-dependent kinase 22.7.11.220.525
2fvdLIACyclin-dependent kinase 22.7.11.220.525
2uzoC62Cyclin-dependent kinase 22.7.11.220.525
2xmyCDKCyclin-dependent kinase 22.7.11.220.525
2duv371Cyclin-dependent kinase 22.7.11.220.524
2wxvWXVCyclin-dependent kinase 22.7.11.220.524
3qtrX36Cyclin-dependent kinase 22.7.11.220.524
3r7yZ04Cyclin-dependent kinase 22.7.11.220.524
4acm7YGCyclin-dependent kinase 22.7.11.220.524
4ek816KCyclin-dependent kinase 22.7.11.220.523
2r3lSCWCyclin-dependent kinase 22.7.11.220.522
4bcpT3CCyclin-dependent kinase 22.7.11.220.522
2vthLZ2Cyclin-dependent kinase 22.7.11.220.520
3r8vZ62Cyclin-dependent kinase 22.7.11.220.520
2r3kSCQCyclin-dependent kinase 22.7.11.220.519
4eok4SPCyclin-dependent kinase 22.7.11.220.519
1b38ATPCyclin-dependent kinase 22.7.11.220.518
3qtqX35Cyclin-dependent kinase 22.7.11.220.517
1ke8LS4Cyclin-dependent kinase 22.7.11.220.516
1pxkCK3Cyclin-dependent kinase 22.7.11.220.516
3qx2X63Cyclin-dependent kinase 22.7.11.220.516
4eop1ROCyclin-dependent kinase 22.7.11.220.516
3r1yX76Cyclin-dependent kinase 22.7.11.220.515
1dm2HMDCyclin-dependent kinase 22.7.11.220.514
2bhhRYUCyclin-dependent kinase 22.7.11.220.514
3qzfX66Cyclin-dependent kinase 22.7.11.220.514
4fkw62KCyclin-dependent kinase 22.7.11.220.514
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.513
3rkb12ZCyclin-dependent kinase 22.7.11.220.513
1fvt106Cyclin-dependent kinase 22.7.11.220.512
1oiqHDUCyclin-dependent kinase 22.7.11.220.512
3wblPDYCyclin-dependent kinase 22.7.11.220.512
1oitHDTCyclin-dependent kinase 22.7.11.220.511
3s00Z60Cyclin-dependent kinase 22.7.11.220.511
1e9hINRCyclin-dependent kinase 22.7.11.220.510
1h1pCMGCyclin-dependent kinase 22.7.11.220.510
1w8cN69Cyclin-dependent kinase 22.7.11.220.510
3r71X86Cyclin-dependent kinase 22.7.11.220.510
1gij2PUCyclin-dependent kinase 22.7.11.220.509
1oiuN76Cyclin-dependent kinase 22.7.11.220.509
3dogNNNCyclin-dependent kinase 22.7.11.220.509
2a4lRRCCyclin-dependent kinase 22.7.11.220.508
3uli1N3Cyclin-dependent kinase 22.7.11.220.508
4bcmT7ZCyclin-dependent kinase 22.7.11.220.508
3r8uZ31Cyclin-dependent kinase 22.7.11.220.507
1pxoCK7Cyclin-dependent kinase 22.7.11.220.505
3bhtMFRCyclin-dependent kinase 22.7.11.220.505
1pkdUCNCyclin-dependent kinase 22.7.11.220.504
3py0SU9Cyclin-dependent kinase 22.7.11.220.504
4fko20KCyclin-dependent kinase 22.7.11.220.504
1h0vUN4Cyclin-dependent kinase 22.7.11.220.503
2wpa889Cyclin-dependent kinase 22.7.11.220.503
2i40BLZCyclin-dependent kinase 22.7.11.220.502
3my5RFZCyclin-dependent kinase 22.7.11.220.502
3r8zZ63Cyclin-dependent kinase 22.7.11.220.502
4fkv61KCyclin-dependent kinase 22.7.11.220.502
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.500
3ezvEZVCyclin-dependent kinase 22.7.11.220.500
3pxyJWSCyclin-dependent kinase 22.7.11.220.500
3rm618ZCyclin-dependent kinase 22.7.11.220.500
4fkt48KCyclin-dependent kinase 22.7.11.220.500
2c4g514Cyclin-dependent kinase 22.7.11.220.499
4bcoT6QCyclin-dependent kinase 22.7.11.220.499
4erwSTUCyclin-dependent kinase 22.7.11.220.499
1h1q2A6Cyclin-dependent kinase 22.7.11.220.498
2c6mDT5Cyclin-dependent kinase 22.7.11.220.498
3fz1B98Cyclin-dependent kinase 22.7.11.220.498
1pxpCK8Cyclin-dependent kinase 22.7.11.220.497
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.497
3pj8404Cyclin-dependent kinase 22.7.11.220.497
3qziX72Cyclin-dependent kinase 22.7.11.220.497
3r8pZ46Cyclin-dependent kinase 22.7.11.220.497
4eol1ROCyclin-dependent kinase 22.7.11.220.496
1ykr628Cyclin-dependent kinase 22.7.11.220.495
2c6iDT1Cyclin-dependent kinase 22.7.11.220.495
3r9oZ71Cyclin-dependent kinase 22.7.11.220.495
1aq1STUCyclin-dependent kinase 22.7.11.220.494
3lfsA07Cyclin-dependent kinase 22.7.11.220.494
4qmpDKISerine/threonine-protein kinase 242.7.11.10.494
2c5nCK8Cyclin-dependent kinase 22.7.11.220.493
3tiz3TICyclin-dependent kinase 22.7.11.220.492
2x1nX1NCyclin-dependent kinase 22.7.11.220.490
3tnwF18Cyclin-dependent kinase 22.7.11.220.489
2w17I19Cyclin-dependent kinase 22.7.11.220.488
4nj32KDCyclin-dependent kinase 22.7.11.220.488
1pyePM1Cyclin-dependent kinase 22.7.11.220.486
2xnbY8LCyclin-dependent kinase 22.7.11.220.483
2r3p3SCCyclin-dependent kinase 22.7.11.220.481
3qx4X4BCyclin-dependent kinase 22.7.11.220.480
3r7iX9ICyclin-dependent kinase 22.7.11.220.479
2c69CT8Cyclin-dependent kinase 22.7.11.220.478
2vtsLZCCyclin-dependent kinase 22.7.11.220.478
1e1vCMGCyclin-dependent kinase 22.7.11.220.477
2r3o2SCCyclin-dependent kinase 22.7.11.220.476
2uznC96Cyclin-dependent kinase 22.7.11.220.476
2uzdC85Cyclin-dependent kinase 22.7.11.220.475
2wihP48Cyclin-dependent kinase 22.7.11.220.475
4bcnT9NCyclin-dependent kinase 22.7.11.220.475
2uzbC75Cyclin-dependent kinase 22.7.11.220.474
3ggfGVDSerine/threonine-protein kinase 26/0.474
3r9nZ68Cyclin-dependent kinase 22.7.11.220.474
4cfnJYMCyclin-dependent kinase 22.7.11.220.474
1unhIXMCyclin-dependent-like kinase 52.7.11.10.473
2bheBRYCyclin-dependent kinase 22.7.11.220.473
2uzlC94Cyclin-dependent kinase 22.7.11.220.470
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.470
1b39ATPCyclin-dependent kinase 22.7.11.220.469
2cchATPCyclin-dependent kinase 22.7.11.220.468
2r3iSCFCyclin-dependent kinase 22.7.11.220.468
4fks46KCyclin-dependent kinase 22.7.11.220.468
3qtsX46Cyclin-dependent kinase 22.7.11.220.467
1finATPCyclin-dependent kinase 22.7.11.220.466
1qmzATPCyclin-dependent kinase 22.7.11.220.466
2b54D05Cyclin-dependent kinase 22.7.11.220.466
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.465
2wotZZGTGF-beta receptor type-12.7.11.300.464
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.463
1gz8MBPCyclin-dependent kinase 22.7.11.220.462
1v0pPVBCell division control protein 2 homolog2.7.11.220.462
2c6tDT5Cyclin-dependent kinase 22.7.11.220.462
3mtfA3FActivin receptor type-12.7.11.300.461
3qtwX3ACyclin-dependent kinase 22.7.11.220.461
4i22IREEpidermal growth factor receptor2.7.10.10.461
2r3gSC9Cyclin-dependent kinase 22.7.11.220.460
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.459
2c5yMTWCyclin-dependent kinase 22.7.11.220.458
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.458
4bcqTJFCyclin-dependent kinase 22.7.11.220.457
1fvv107Cyclin-dependent kinase 22.7.11.220.456
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.456
2r3r6SCCyclin-dependent kinase 22.7.11.220.456
3r7uX96Cyclin-dependent kinase 22.7.11.220.455
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.454
4eomATPCyclin-dependent kinase 22.7.11.220.454
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.454
4fv9E71Mitogen-activated protein kinase 12.7.11.240.454
1xjdSTUProtein kinase C theta type2.7.11.130.453
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.453
2uzeC95Cyclin-dependent kinase 22.7.11.220.453
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.453
4g170VNCasein kinase I isoform gamma-32.7.11.10.453
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.452
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.452
2xikJ60Serine/threonine-protein kinase 252.7.11.10.452
3gubGUBDeath-associated protein kinase 12.7.11.10.452
4au8Z3RCyclin-dependent-like kinase 52.7.11.10.452
2eufLQQCyclin-dependent kinase 62.7.11.220.451
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.451
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.451
2izsBRQCasein kinase I isoform gamma-32.7.11.10.450
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.450
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.450
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.450
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.450
4bgg844Activin receptor type-12.7.11.300.450
1gy3ATPCyclin-dependent kinase 22.7.11.220.449
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.449
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.449
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.448
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.446
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
4dgo0JWCasein kinase II subunit alpha2.7.11.10.446
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.444
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.444
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.444
4g160VMCasein kinase I isoform gamma-32.7.11.10.444
4ivc1J6Tyrosine-protein kinase JAK1/0.444
2vv9IM9Cyclin-dependent kinase 22.7.11.220.443
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.443
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.442
1v0oINRCell division control protein 2 homolog2.7.11.220.441
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.441
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.441
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.441
1y8yCT7Cyclin-dependent kinase 22.7.11.220.440
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.440
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.440