sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3k9l | GNP | GTPase HRas |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3k9l | GNP | GTPase HRas | / | 1.000 | |
| 2rgg | GNP | GTPase HRas | / | 0.647 | |
| 3kkq | GDP | Ras-related protein M-Ras | / | 0.641 | |
| 4hdq | GNP | Ras-related protein Rap-1b | / | 0.625 | |
| 4lpk | GDP | GTPase KRas | / | 0.624 | |
| 2ce2 | GDP | GTPase HRas | / | 0.621 | |
| 4xvr | GNP | GTPase HRas | / | 0.615 | |
| 4l8g | GDP | GTPase KRas | / | 0.605 | |
| 4q02 | GDP | GTPase KRas | / | 0.605 | |
| 4xvq | GNP | GTPase HRas | / | 0.605 | |
| 3tgp | GNP | GTPase HRas | / | 0.600 | |
| 3kko | GNP | Ras-related protein M-Ras | / | 0.595 | |
| 4luc | GDP | GTPase KRas | / | 0.592 | |
| 3lbh | GNP | GTPase HRas | / | 0.583 | |
| 4epw | GDP | GTPase KRas | / | 0.582 | |
| 1mh1 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.579 | |
| 4tq9 | GDP | GTPase KRas | / | 0.579 | |
| 3ddc | GNP | GTPase HRas | / | 0.576 | |
| 4lrw | GDP | GTPase KRas | / | 0.576 | |
| 4wa7 | GDP | GTPase KRas | / | 0.575 | |
| 4l9s | GDP | GTPase HRas | / | 0.571 | |
| 3i3s | GNP | GTPase HRas | / | 0.567 | |
| 4g0n | GNP | GTPase HRas | / | 0.567 | |
| 2c5l | GTP | GTPase HRas | / | 0.563 | |
| 4lv6 | GDP | GTPase KRas | / | 0.559 | |
| 1n6l | GTP | Ras-related protein Rab-5A | / | 0.552 | |
| 4dsn | GCP | GTPase KRas | / | 0.549 | |
| 4epx | GDP | GTPase KRas | / | 0.549 | |
| 4ldj | GDP | GTPase KRas | / | 0.547 | |
| 4obe | GDP | GTPase KRas | / | 0.547 | |
| 3k8y | GNP | GTPase HRas | / | 0.544 | |
| 4ql3 | GDP | GTPase KRas | / | 0.544 | |
| 3lbi | GNP | GTPase HRas | / | 0.542 | |
| 3oiv | GNP | GTPase HRas | / | 0.540 | |
| 3qbt | GNP | Ras-related protein Rab-8A | / | 0.539 | |
| 3rs4 | GNP | GTPase HRas | / | 0.538 | |
| 2fg5 | GNP | Ras-related protein Rab-31 | / | 0.537 | |
| 3l8y | GNP | GTPase HRas | / | 0.537 | |
| 2rge | GNP | GTPase HRas | / | 0.536 | |
| 3pit | GNP | Ras-related protein M-Ras | / | 0.536 | |
| 1yu9 | GNP | Ras-related protein Rab-4A | / | 0.535 | |
| 4q03 | GDP | GTPase KRas | / | 0.535 | |
| 3oiw | GNP | GTPase HRas | / | 0.534 | |
| 2p2l | GDP | Ras-related C3 botulinum toxin substrate 1 | / | 0.533 | |
| 2fe4 | GDP | Ras-related protein Rab-6B | / | 0.530 | |
| 5b2z | GNP | GTPase HRas | / | 0.530 | |
| 2msc | GDP | MHC class I alpha chain | / | 0.528 | |
| 4o2r | GDP | GTP-binding protein Rheb | / | 0.526 | |
| 4dlt | GNP | GTPase HRas | / | 0.524 | |
| 1lfd | GNP | GTPase HRas | / | 0.523 | |
| 1x1r | GDP | Ras-related protein M-Ras | / | 0.523 | |
| 3v4f | GNP | GTPase HRas | / | 0.519 | |
| 2q3f | GNP | Ras-related GTP-binding protein D | / | 0.518 | |
| 3sbd | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.518 | |
| 2rgb | GNP | GTPase HRas | / | 0.517 | |
| 4dlz | GNP | GTPase HRas | / | 0.516 | |
| 1xts | GTP | GTP-binding protein Rheb | / | 0.515 | |
| 3x1z | GNP | Ras-related protein Rap-1b | / | 0.514 | |
| 2qme | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.512 | |
| 4nyj | GNP | GTPase HRas | / | 0.512 | |
| 3vhx | GTP | ADP-ribosylation factor 6 | / | 0.509 | |
| 3oiu | GNP | GTPase HRas | / | 0.508 | |
| 1zd9 | GDP | ADP-ribosylation factor-like protein 8A | / | 0.507 | |
| 3ref | GDP | Rho family GTPase | / | 0.506 | |
| 5dif | GNP | GTP-binding nuclear protein Ran | / | 0.506 | |
| 3x1w | GDP | Ras-related protein Rap-1b | / | 0.504 | |
| 2bme | GNP | Ras-related protein Rab-4A | / | 0.503 | |
| 1z2a | GDP | Ras-related protein Rab-23 | / | 0.502 | |
| 4dlx | GNP | GTPase HRas | / | 0.502 | |
| 4hdo | GNP | Ras-related protein Rap-1b | / | 0.502 | |
| 1oix | GDP | Ras-related protein Rab-11A | / | 0.500 | |
| 2msd | GNP | MHC class I alpha chain | / | 0.499 | |
| 2ov2 | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.499 | |
| 3rs5 | GNP | GTPase HRas | / | 0.499 | |
| 4uj3 | GNP | Ras-related protein Rab-11A | / | 0.496 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 1am4 | GNP | Cell division control protein 42 homolog | / | 0.490 | |
| 3a58 | GNP | GTP-binding protein RHO1 | / | 0.490 | |
| 3cph | GDP | Ras-related protein SEC4 | / | 0.490 | |
| 3rs7 | GNP | GTPase HRas | / | 0.490 | |
| 1ky2 | GNP | GTP-binding protein YPT7 | / | 0.489 | |
| 3pcr | GTP | ADP-ribosylation factor 6 | / | 0.489 | |
| 5dha | GNP | GTP-binding nuclear protein Ran | / | 0.489 | |
| 1zbd | GTP | Ras-related protein Rab-3A | / | 0.488 | |
| 1rxh | BNI | Streptavidin | / | 0.487 | |
| 2rgc | GNP | GTPase HRas | / | 0.487 | |
| 2ic5 | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.485 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.485 | |
| 3rsl | GNP | GTPase HRas | / | 0.484 | |
| 3w3z | GTP | GTP-binding nuclear protein Ran | / | 0.484 | |
| 1e96 | GTP | Ras-related C3 botulinum toxin substrate 1 | / | 0.482 | |
| 4bwx | AGS | PAB-dependent poly(A)-specific ribonuclease subunit pan3 | / | 0.482 | |
| 3moh | GDP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.479 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.479 | |
| 3kuc | GDP | Ras-related protein Rap-1A | / | 0.478 | |
| 3e5h | GNP | Ras-related protein Rab-28 | / | 0.477 | |
| 3ums | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.477 | |
| 4dlw | GNP | GTPase HRas | / | 0.477 | |
| 4obu | PLP | Pyridoxal-dependent decarboxylase domain protein | / | 0.477 | |
| 2wu5 | CBE | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.476 | |
| 2wu5 | CBE | Succinate dehydrogenase cytochrome b556 subunit | / | 0.476 | |
| 5hpy | GDP | Transforming protein RhoA | / | 0.476 | |
| 5iqh | GNP | Bifunctional AAC/APH | 2.3.1 | 0.476 | |
| 1a8p | FAD | Ferredoxin--NADP reductase | / | 0.475 | |
| 1m7b | GTP | Rho-related GTP-binding protein RhoE | / | 0.475 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.475 | |
| 3d45 | GDP | Poly(A)-specific ribonuclease PARN | 3.1.13.4 | 0.475 | |
| 4dls | GNP | GTPase HRas | / | 0.475 | |
| 4l9w | GNP | GTPase HRas | / | 0.475 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.475 | |
| 5iqd | GNP | Bifunctional AAC/APH | 2.3.1 | 0.475 | |
| 2rc6 | NAP | Ferredoxin--NADP reductase | / | 0.474 | |
| 4j49 | NAI | Uncharacterized protein | / | 0.474 | |
| 4pl0 | ANP | Microcin-J25 export ATP-binding/permease protein McjD | / | 0.473 | |
| 1a2b | GSP | Transforming protein RhoA | / | 0.472 | |
| 3kud | GDP | GTPase HRas | / | 0.472 | |
| 4o2l | GTP | GTP-binding protein Rheb | / | 0.472 | |
| 3x2w | ATP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.471 | |
| 4dlv | GNP | GTPase HRas | / | 0.471 | |
| 5di3 | GNP | ADP-ribosylation factor-like protein 3 | / | 0.471 | |
| 1d5c | GDP | GTPase (Rab6) | / | 0.470 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.470 | |
| 2bgi | FAD | NADPH:ferredoxin reductase | / | 0.470 | |
| 1equ | EQI | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.469 | |
| 2fju | GSP | Ras-related C3 botulinum toxin substrate 1 | / | 0.469 | |
| 4cid | ANP | EH domain-containing protein 2 | / | 0.469 | |
| 4rkf | GNP | Ras-related protein Rab-3 | / | 0.469 | |
| 3k7m | FAD | 6-hydroxy-L-nicotine oxidase | / | 0.468 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.468 | |
| 4fk8 | FAD | Ferredoxin--NADP reductase | / | 0.468 | |
| 5iot | UMP | Flavin-dependent thymidylate synthase | 2.1.1.148 | 0.468 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.466 | |
| 3rs0 | GNP | GTPase HRas | / | 0.465 | |
| 2qf2 | GDP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.464 | |
| 3pt9 | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.464 | |
| 1cul | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.463 | |
| 1e0j | ANP | DNA primase/helicase | 2.7.7 | 0.463 | |
| 1v8k | ANP | Kinesin-like protein KIF2C | / | 0.463 | |
| 3agl | A03 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.463 | |
| 3bbp | GTP | Ras-related protein Rab-6A | / | 0.463 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.462 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 5iqi | GNP | Bifunctional AAC/APH | 2.3.1 | 0.461 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 2xvv | 9DN | Serum albumin | / | 0.460 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.460 | |
| 1svw | GTP | Probable GTP-binding protein EngB | / | 0.459 | |
| 2vnj | FAD | NADPH:ferredoxin reductase | / | 0.459 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.458 | |
| 3p9c | SAH | Caffeic acid O-methyltransferase | / | 0.458 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 4iac | ACP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.458 | |
| 4qxa | GTP | Ras-related protein Rab-9A | / | 0.458 | |
| 1ewy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.457 | |
| 1svg | I04 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.457 | |
| 3r8u | Z31 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 4wxx | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.457 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.456 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.456 | |
| 2gu8 | 796 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.456 | |
| 2qoq | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.456 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3mjh | GTP | Ras-related protein Rab-5A | / | 0.456 | |
| 3q71 | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.456 | |
| 2bxm | IMN | Serum albumin | / | 0.455 | |
| 3ckx | STU | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.455 | |
| 5ab6 | CAA | Nonspecific lipid-transfer protein, putative | / | 0.455 | |
| 1wdt | GTP | Elongation factor G (EF-G-2) | / | 0.454 | |
| 3fro | NHF | GlgA glycogen synthase | / | 0.454 | |
| 3qx2 | X63 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 3r7v | Z02 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 3v2b | AR6 | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.454 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.454 | |
| 4crz | ACO | PanD regulatory factor | / | 0.454 | |
| 4goj | GNP | ADP-ribosylation factor-like protein 3 | / | 0.454 | |
| 5iqg | GDP | Bifunctional AAC/APH | 2.3.1 | 0.454 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.453 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.453 | |
| 3ews | ADP | ATP-dependent RNA helicase DDX19B | 3.6.4.13 | 0.453 | |
| 3vqx | BLK | Pyrrolysine--tRNA ligase | / | 0.453 | |
| 4rsl | FAD | Fructosyl peptide oxidase | / | 0.453 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.452 | |
| 4fkv | 61K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 1a4r | GNH | Cell division control protein 42 homolog | / | 0.451 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.451 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.451 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.451 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.451 | |
| 4i3v | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.451 | |
| 5cb3 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.451 | |
| 1gil | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.450 | |
| 1toj | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.450 | |
| 1z6l | FAD | Polyamine oxidase FMS1 | / | 0.450 | |
| 2gzl | 2AA | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.450 | |
| 2xxv | KAI | Glutamate receptor ionotropic, kainate 2 | / | 0.450 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4pao | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.450 | |
| 4ubu | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.450 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2gsd | NAD | Formate dehydrogenase | / | 0.449 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 2qdx | FAD | Ferredoxin--NADP+ reductase | / | 0.449 | |
| 2yph | QQY | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.449 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 3eku | CY9 | Actin-5C | / | 0.449 | |
| 3lcd | BDY | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.449 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.449 | |
| 4pan | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.449 | |
| 4x2d | ATP | Fic family protein putative filamentation induced by cAMP protein | / | 0.449 | |
| 5djt | FMN | NPH1-2 | / | 0.449 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2b35 | TCL | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 2hck | QUE | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.448 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.448 | |
| 2ogi | GDP | Uncharacterized protein | / | 0.448 | |
| 2oo7 | AP5 | Adenylate kinase | / | 0.448 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.448 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.448 | |
| 3fnh | JPJ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 3ldf | SAH | Uncharacterized protein | / | 0.448 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.448 | |
| 3oes | GNP | GTPase RhebL1 | / | 0.448 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.448 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 4i4b | 1CV | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.448 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.448 | |
| 2ci0 | 1CM | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.447 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.447 | |
| 3cwk | REA | Cellular retinoic acid-binding protein 2 | / | 0.447 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.447 | |
| 3wyf | GTP | GTP-binding nuclear protein | / | 0.447 | |
| 4apu | A2K | Progesterone receptor | / | 0.447 | |
| 4bdr | KAI | Glutamate receptor ionotropic, kainate 2 | / | 0.447 | |
| 4ho8 | THM | Glucose-1-phosphate thymidylyltransferase | / | 0.447 | |
| 4iaf | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 4l98 | LRG | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.447 | |
| 4v02 | ATP | Site-determining protein | / | 0.447 | |
| 2hxq | 373 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2r26 | CMC | Citrate synthase | 2.3.3.16 | 0.446 | |
| 2vo4 | GTB | 2,4-D inducible glutathione S-transferase | / | 0.446 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4f70 | 0ST | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.446 | |
| 4f9w | LM4 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.446 | |
| 4gkm | 683 | Anthranilate phosphoribosyltransferase | / | 0.446 | |
| 4l4x | NDP | AmphI | / | 0.446 | |
| 4mit | GTP | Rho-related protein racC | / | 0.446 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.445 | |
| 3a6p | GTP | GTP-binding nuclear protein Ran | / | 0.445 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 3qd0 | 3Q4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.445 | |
| 3s87 | DGT | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.445 | |
| 3u8d | U8D | Phospholipase A2, membrane associated | / | 0.445 | |
| 4hpt | ANP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 4iyg | 1HU | Strictosidine synthase | 4.3.3.2 | 0.445 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4ug9 | 1EW | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.445 | |
| 4xw4 | ANP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 1efv | FAD | Electron transfer flavoprotein subunit alpha, mitochondrial | / | 0.444 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.444 | |
| 2a1u | FAD | Electron transfer flavoprotein subunit alpha, mitochondrial | / | 0.444 | |
| 2uze | C95 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 3i64 | DNA | 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase | / | 0.444 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.444 | |
| 3x2u | ATP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 4c3y | FAD | 3-ketosteroid dehydrogenase | / | 0.444 | |
| 4ovi | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.444 | |
| 5ej9 | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.444 | |
| 1bwf | ATF | Glycerol kinase | / | 0.443 | |
| 1g6c | IFP | Thiamine-phosphate synthase | / | 0.443 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.443 | |
| 1ojt | FAD | Dihydrolipoyl dehydrogenase | / | 0.443 | |
| 1qm5 | PLP | Maltodextrin phosphorylase | 2.4.1.1 | 0.443 | |
| 1rej | B1L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1s1v | TNK | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 1sez | OMN | Protoporphyrinogen oxidase, mitochondrial | 1.3.3.4 | 0.443 | |
| 1wn3 | HXC | Phenylacetic acid degradation protein PaaI | / | 0.443 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.443 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.443 | |
| 3rsr | N5P | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.443 | |
| 4axa | RKD | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.443 | |
| 4iak | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 4kq2 | U5P | Glycogen [starch] synthase isoform 2 | 2.4.1.11 | 0.443 | |
| 4p2l | FAD | Sulfhydryl oxidase 1 | 1.8.3.2 | 0.443 | |
| 5iqb | GNP | Bifunctional AAC/APH | 2.3.1 | 0.443 | |
| 5jlj | GNP | GTP-binding nuclear protein Ran | / | 0.443 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1wli | FMN | FMN-binding protein | / | 0.442 | |
| 2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.442 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.442 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.442 | |
| 3cjf | SAV | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.442 | |
| 3di6 | PDZ | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 3pju | C2E | Diguanylate cyclase/phosphodiesterase | / | 0.442 | |
| 3rm7 | 19Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3tif | ADP | Uncharacterized ABC transporter ATP-binding protein MJ0796 | / | 0.442 | |
| 3uq9 | TBN | Putative adenosine kinase | / | 0.442 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.442 | |
| 4r1f | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.442 | |
| 4wqm | FAD | Toluene-4-monooxygenase electron transfer component | 1.18.1.3 | 0.442 | |
| 4k5y | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.442 | |
| 1dxr | MST | Reaction center protein L chain | / | 0.441 | |
| 1g69 | TZP | Thiamine-phosphate synthase | / | 0.441 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.441 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.441 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2wdq | CBE | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.441 | |
| 2wdq | CBE | Succinate dehydrogenase cytochrome b556 subunit | / | 0.441 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3ez2 | ADP | Plasmid partition protein A | / | 0.441 | |
| 3gkj | HC3 | Niemann-Pick C1 protein | / | 0.441 | |
| 3pcg | 4HP | Protocatechuate 3,4-dioxygenase alpha chain | 1.13.11.3 | 0.441 | |
| 3pcg | 4HP | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.441 | |
| 3r9n | Z68 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 4jky | ADP | Adenylate kinase | / | 0.441 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.441 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.441 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.441 | |
| 5iqe | GNP | Bifunctional AAC/APH | 2.3.1 | 0.441 | |
| 1db5 | 6IN | Phospholipase A2, membrane associated | / | 0.440 | |
| 1ne6 | SP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.440 | |
| 1osv | CHC | Bile acid receptor | / | 0.440 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.440 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 1z0d | GDP | Ras-related protein Rab-5C | / | 0.440 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.440 | |
| 2an9 | GDP | Guanylate kinase | 2.7.4.8 | 0.440 | |
| 2j0v | GDP | Rac-like GTP-binding protein ARAC7 | / | 0.440 | |
| 2v7q | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 | |
| 2yfe | YFE | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 3cvy | FAD | RE11660p | / | 0.440 | |
| 3cx6 | GDP | Guanine nucleotide-binding protein subunit alpha-13 | / | 0.440 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.440 | |
| 3sbe | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.440 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.440 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.440 | |
| 4pzd | NAD | 3-Hydroxyacyl-CoA dehydrogenase | / | 0.440 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.440 | |
| 4s26 | SAH | Phosphomethylpyrimidine synthase, chloroplastic | 4.1.99.17 | 0.440 | |
| 4wq5 | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.440 |