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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2nvcITAAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
2nvcITAAldose reductase1.1.1.211.000
2pdj393Aldose reductase1.1.1.210.666
1ekoI84Aldose reductase1.1.1.210.647
2inzOHPAldose reductase1.1.1.210.626
2iqdLPAAldose reductase1.1.1.210.623
3u2cSUZAldose reductase1.1.1.210.620
3p2vDOYAldose reductase1.1.1.210.617
4gabFIDAldo-keto reductase family 1 member B101.1.10.611
2pdkSBIAldose reductase1.1.1.210.610
2f2kTGGAldose reductase1.1.1.210.609
2pdwFIDAldose reductase1.1.1.210.605
1ah0SBIAldose reductase1.1.1.210.604
2pdyFIDAldose reductase1.1.1.210.599
3s3gTLTAldose reductase1.1.1.210.599
1ef3FIDAldose reductase1.1.1.210.594
2is72CLAldose reductase1.1.1.210.594
3v35NTIAldose reductase1.1.1.210.584
1pwmFIDAldose reductase1.1.1.210.581
2pd9FIDAldose reductase1.1.1.210.575
2pdfZSTAldose reductase1.1.1.210.568
2pdh47DAldose reductase1.1.1.210.555
5liu388Aldo-keto reductase family 1 member B101.1.10.555
2pdmZSTAldose reductase1.1.1.210.552
1x96NAPAldose reductase1.1.1.210.540
2hvoZSTAldose reductase1.1.1.210.536
2hvnZSTAldose reductase1.1.1.210.531
2pdiZSTAldose reductase1.1.1.210.530
3mb9ZSTAldose reductase1.1.1.210.530
2pdlTOLAldose reductase1.1.1.210.521
1ah4NAPAldose reductase1.1.1.210.518
2agtFIDAldose reductase1.1.1.210.518
2fz8ZSTAldose reductase1.1.1.210.517
1el3I84Aldose reductase1.1.1.210.511
4wevSUZAldo-keto reductase family 1 member B101.1.10.509
2pdc393Aldose reductase1.1.1.210.497
3v36NAPAldose reductase1.1.1.210.497
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.493
2fzbTOLAldose reductase1.1.1.210.492
3cv7C2UAlcohol dehydrogenase [NADP(+)]1.1.1.20.490
1ah3TOLAldose reductase1.1.1.210.487
1u70MTXDihydrofolate reductase1.5.1.30.487
4kmzFOLFolate receptor beta/0.485
3exfTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.484
3exfTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.484
4bfwZVWPantothenate kinase2.7.1.330.483
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.482
2iki388Aldose reductase1.1.1.210.479
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.479
1isgAGSADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.60.478
1kmsLIHDihydrofolate reductase1.5.1.30.474
2fzdTOLAldose reductase1.1.1.210.474
4uugPXGBranched-chain amino acid aminotransferase, putative/0.474
2bxoOPBSerum albumin/0.472
3r43ID8Aldo-keto reductase family 1 member C3/0.472
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.472
1z3n3NAAldose reductase1.1.1.210.470
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.470
3m4h388Aldose reductase1.1.1.210.470
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.470
4jpg1OXPyruvate kinase PKM2.7.1.400.469
2dv0ZSTAldose reductase1.1.1.210.468
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.468
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.468
4m6kFOLDihydrofolate reductase1.5.1.30.468
5a4vQUEGlutathione S-transferase F22.5.1.180.468
4fam0SZAldo-keto reductase family 1 member C3/0.467
1q83TZ5Acetylcholinesterase3.1.1.70.466
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.466
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.466
3ghsLDTAldose reductase1.1.1.210.466
1u08PLPMethionine aminotransferase/0.465
2pzn393Aldose reductase1.1.1.210.465
2vrjNCWBeta-glucosidase A3.2.1.210.465
2w3mFOLDihydrofolate reductase1.5.1.30.465
3g5eQ74Aldose reductase1.1.1.210.465
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.464
2xupTZ5Acetylcholinesterase3.1.1.70.464
3f3y4OABile salt sulfotransferase2.8.2.140.464
1ry0PG2Aldo-keto reductase family 1 member C3/0.463
2w6cBM4Acetylcholinesterase3.1.1.70.463
3ghuLDTAldose reductase1.1.1.210.463
3lqlLDTAldose reductase1.1.1.210.463
3mauPLRPutative sphingosine-1-phosphate lyase/0.463
1ry8RUTAldo-keto reductase family 1 member C3/0.462
1t40ID5Aldose reductase1.1.1.210.462
1z8962PAldose reductase1.1.1.210.462
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.462
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.461
1s3uTQDDihydrofolate reductase1.5.1.30.461
1ut6A8NAcetylcholinesterase3.1.1.70.461
2hv5ZSTAldose reductase1.1.1.210.461
2pdxZSTAldose reductase1.1.1.210.461
3v94WYQPhosphodiesterase/0.461
4kfjFOLDihydrofolate reductase1.5.1.30.461
1dlsMTXDihydrofolate reductase1.5.1.30.460
1ni4TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.460
1ni4TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.460
1ohjCOPDihydrofolate reductase1.5.1.30.460
2i17LDTAldose reductase1.1.1.210.460
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.460
1e2lTMCThymidine kinase/0.459
1vp5NAPOxidoreductase, aldo/keto reductase family/0.459
2pdp393Aldose reductase1.1.1.210.459
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.600.459
4g2wNI0cGMP-specific 3',5'-cyclic phosphodiesterase/0.459
4kebFOLDihydrofolate reductase1.5.1.30.459
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.458
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.458
1z71L17Prothrombin3.4.21.50.458
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.458
3m64393Aldose reductase1.1.1.210.458
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
4jtqFLPAldo-keto reductase family 1 member C2/0.458
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
2fz9ZSTAldose reductase1.1.1.210.457
2xlpNAPPutative flavin-containing monooxygenase/0.457
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.457
4br0AU1Ectonucleoside triphosphate diphosphohydrolase 2/0.457
4e2yJHZMethyltransferase/0.457
1votHUPAcetylcholinesterase3.1.1.70.456
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
3lenZSTAldose reductase1.1.1.210.456
3m0iZSTAldose reductase1.1.1.210.456
2aouCQAHistamine N-methyltransferase2.1.1.80.455
2gl0ADNUncharacterized protein/0.455
2i16LDTAldose reductase1.1.1.210.455
2y1w849Histone-arginine methyltransferase CARM1/0.455
3gyf51PDihydrofolate reductase1.5.1.30.455
3hl0NADMaleylacetate reductase/0.455
1opmIYGPeptidyl-glycine alpha-amidating monooxygenase1.14.17.30.454
1qvtPRLHTH-type transcriptional regulator QacR/0.454
2xi4AFTAcetylcholinesterase3.1.1.70.454
3bw4FMNPutative 2-nitropropane dioxygenase/0.454
3ghrLDTAldose reductase1.1.1.210.454
4kn104JFolate receptor beta/0.454
1s7gNADNAD-dependent protein deacylase 2/0.453
3lboLDTAldose reductase1.1.1.210.453
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.453
4kn0MTXFolate receptor beta/0.453
1lnmDTXBilin-binding protein/0.452
2fzjDH3Dihydrofolate reductase1.5.1.30.452
2y1x845Histone-arginine methyltransferase CARM1/0.452
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.452
4k4eK4ETankyrase-12.4.2.300.452
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.452
4pnmNU1Tankyrase-22.4.2.300.452
1frbZSTAldose reductase-related protein 2/0.451
1qoqIGPTryptophan synthase alpha chain/0.451
1u72MTXDihydrofolate reductase1.5.1.30.451
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.451
1x2eATXProline iminopeptidase3.4.11.50.451
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
4dbw511Aldo-keto reductase family 1 member C3/0.451
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
4i5xFLFAldo-keto reductase family 1 member B101.1.10.451
1pwlBFIAldose reductase1.1.1.210.450
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.450
2ohhFMNType A flavoprotein FprA10.450
5ds309LPoly [ADP-ribose] polymerase 12.4.2.300.450
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.449
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.449
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.449
3n0hTOPDihydrofolate reductase1.5.1.30.449
3uweVJJAldo-keto reductase family 1 member C3/0.449
4htx19FcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.449
4hx519VCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.449
1d3dBZTProthrombin3.4.21.50.448
1e66HUXAcetylcholinesterase3.1.1.70.448
1zuaTOLAldo-keto reductase family 1 member B101.1.10.448
2b8jADNClass B acid phosphatase3.1.3.20.448
2j3qTFLAcetylcholinesterase3.1.1.70.448
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.448
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.448
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.447
1sqi8694-hydroxyphenylpyruvate dioxygenase/0.447
2gbyBRNHTH-type transcriptional regulator QacR/0.447
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
4n3l2FNProthrombin3.4.21.50.447
4wbdADPPutative cysteine ligase BshC/0.447
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.447
1h66RH1NAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1xngDNDNH(3)-dependent NAD(+) synthetase6.3.1.50.446
2j7cIDEBeta-glucosidase A3.2.1.210.446
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.446
3owxXRARibosyldihydronicotinamide dehydrogenase [quinone]/0.446
3zkuHCVIsopenicillin N synthase1.21.3.10.446
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.446
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.446
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.446
1dgbNDPCatalase1.11.1.60.445
1pj6FOLDimethylglycine oxidase1.5.3.100.445
2bd0BIOSepiapterin reductase/0.445
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.445
2ha6SCKAcetylcholinesterase3.1.1.70.445
2hzqSTRApolipoprotein D/0.445
2zevIPEGeranylgeranyl pyrophosphate synthase/0.445
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.445
3hiiPNTAmiloride-sensitive amine oxidase [copper-containing]/0.445
4dbuBT9Aldo-keto reductase family 1 member C3/0.445
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.445
1pd9CO4Dihydrofolate reductase1.5.1.30.444
1sg0STLRibosyldihydronicotinamide dehydrogenase [quinone]/0.444
1us0LDTAldose reductase1.1.1.210.444
2c97JCL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.444
2ejzSAHDiphthine synthase/0.444
2jl1NAPTriphenylmethane reductase/0.444
2pdbZSTAldose reductase1.1.1.210.444
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.444
3hbfMYCFlavonoid 3-O-glucosyltransferase2.4.10.444
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.444
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.444
1jqdSAHHistamine N-methyltransferase2.1.1.80.443
1u65CP0Acetylcholinesterase3.1.1.70.443
2j7dGI1Beta-glucosidase A3.2.1.210.443
2r04W71Genome polyprotein/0.443
3casASD3-oxo-5-beta-steroid 4-dehydrogenase/0.443
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
4arbC57Acetylcholinesterase3.1.1.70.443
1fmlRTLRetinol dehydratase/0.442
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
1umcTDP2-oxoisovalerate dehydrogenase subunit alpha1.2.4.40.442
1umcTDP2-oxoisovalerate dehydrogenase subunit beta1.2.4.40.442
2ckmAA7Acetylcholinesterase3.1.1.70.442
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
2pdq47DAldose reductase1.1.1.210.442
2qryTPSThiamine-binding periplasmic protein/0.442
3dr4G4MGDP-perosamine synthase/0.442
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.442
4kn2LYAFolate receptor beta/0.442
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
4o7gASCProbable transmembrane ascorbate ferrireductase 21.16.5.10.442
1dgfNDPCatalase1.11.1.60.441
1g3mPCQEstrogen sulfotransferase2.8.2.40.441
1qtiGNTAcetylcholinesterase3.1.1.70.441
1zgcA2EAcetylcholinesterase3.1.1.70.441
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.441
2gywOBIAcetylcholinesterase3.1.1.70.441
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
2y0jAXCcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.441
3e6eDCSAlanine racemase/0.441
3lz5LDTAldose reductase1.1.1.210.441
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.441
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.441
4aoaIK2Beta-phenylalanine transaminase2.6.10.441
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.441
2ycxP32Beta-1 adrenergic receptor/0.441
4u140HKMuscarinic acetylcholine receptor M3/0.441
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.440
1esmCOAPantothenate kinase2.7.1.330.440
1q84TZ4Acetylcholinesterase3.1.1.70.440
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
1zq5E04Aldo-keto reductase family 1 member C3/0.440
2g7yMO9Cathepsin S3.4.22.270.440
2wu4HBPAcetylcholinesterase3.1.1.70.440
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.440
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.440
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.440
4dbs0HVAldo-keto reductase family 1 member C3/0.440
4i9z5BAcGMP-specific 3',5'-cyclic phosphodiesterase/0.440