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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c5yMTWCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2c5yMTWCyclin-dependent kinase 22.7.11.221.000
3lfqA28Cyclin-dependent kinase 22.7.11.220.673
3lfnA27Cyclin-dependent kinase 22.7.11.220.609
3r8lZ30Cyclin-dependent kinase 22.7.11.220.598
4fki09KCyclin-dependent kinase 22.7.11.220.589
3qqgX06Cyclin-dependent kinase 22.7.11.220.586
1hckATPCyclin-dependent kinase 22.7.11.220.573
3qxoX65Cyclin-dependent kinase 22.7.11.220.573
2xmyCDKCyclin-dependent kinase 22.7.11.220.558
2a4lRRCCyclin-dependent kinase 22.7.11.220.555
3r1yX76Cyclin-dependent kinase 22.7.11.220.554
3pxyJWSCyclin-dependent kinase 22.7.11.220.550
1b38ATPCyclin-dependent kinase 22.7.11.220.547
1pxoCK7Cyclin-dependent kinase 22.7.11.220.543
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.543
4fkq42KCyclin-dependent kinase 22.7.11.220.542
1oirHDYCyclin-dependent kinase 22.7.11.220.541
3r7vZ02Cyclin-dependent kinase 22.7.11.220.539
3rm719ZCyclin-dependent kinase 22.7.11.220.533
4fkj11KCyclin-dependent kinase 22.7.11.220.533
1pxpCK8Cyclin-dependent kinase 22.7.11.220.531
4fkg4CKCyclin-dependent kinase 22.7.11.220.529
4fklCK2Cyclin-dependent kinase 22.7.11.220.529
4fkv61KCyclin-dependent kinase 22.7.11.220.528
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.527
4ek610KCyclin-dependent kinase 22.7.11.220.525
1b39ATPCyclin-dependent kinase 22.7.11.220.523
3lfsA07Cyclin-dependent kinase 22.7.11.220.523
4bcoT6QCyclin-dependent kinase 22.7.11.220.523
2btsU32Cyclin-dependent kinase 22.7.11.220.522
2r3jSCJCyclin-dependent kinase 22.7.11.220.520
3s1h56ZCyclin-dependent kinase 22.7.11.220.520
4ek816KCyclin-dependent kinase 22.7.11.220.520
4fkt48KCyclin-dependent kinase 22.7.11.220.520
3rni21ZCyclin-dependent kinase 22.7.11.220.519
1pxmCK5Cyclin-dependent kinase 22.7.11.220.518
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.518
1oitHDTCyclin-dependent kinase 22.7.11.220.514
3qqlX03Cyclin-dependent kinase 22.7.11.220.514
3r7uX96Cyclin-dependent kinase 22.7.11.220.514
3r83Z14Cyclin-dependent kinase 22.7.11.220.512
1pxlCK4Cyclin-dependent kinase 22.7.11.220.511
3ezvEZVCyclin-dependent kinase 22.7.11.220.511
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
2btrU73Cyclin-dependent kinase 22.7.11.220.508
3r7yZ04Cyclin-dependent kinase 22.7.11.220.507
3qqhX0ACyclin-dependent kinase 22.7.11.220.506
1h1s4SPCyclin-dependent kinase 22.7.11.220.505
2vthLZ2Cyclin-dependent kinase 22.7.11.220.505
2j9mPY8Cyclin-dependent kinase 22.7.11.220.504
2vttLZDCyclin-dependent kinase 22.7.11.220.503
3qzgX67Cyclin-dependent kinase 22.7.11.220.502
3sw719KCyclin-dependent kinase 22.7.11.220.501
1aq1STUCyclin-dependent kinase 22.7.11.220.500
1w0xOLOCyclin-dependent kinase 22.7.11.220.500
1w8cN69Cyclin-dependent kinase 22.7.11.220.500
2c6o4SPCyclin-dependent kinase 22.7.11.220.500
3rak03ZCyclin-dependent kinase 22.7.11.220.500
2c6lDT4Cyclin-dependent kinase 22.7.11.220.499
2exmZIPCyclin-dependent kinase 22.7.11.220.499
3unj0BXCyclin-dependent kinase 22.7.11.220.499
1gii1PUCyclin-dependent kinase 22.7.11.220.498
2a0cCK9Cyclin-dependent kinase 22.7.11.220.497
3fz1B98Cyclin-dependent kinase 22.7.11.220.497
3r7iX9ICyclin-dependent kinase 22.7.11.220.497
3ddqRRCCyclin-dependent kinase 22.7.11.220.496
3unk0BYCyclin-dependent kinase 22.7.11.220.496
2uzeC95Cyclin-dependent kinase 22.7.11.220.495
3ezrEZRCyclin-dependent kinase 22.7.11.220.495
3ral04ZCyclin-dependent kinase 22.7.11.220.495
2w1hL0FCyclin-dependent kinase 22.7.11.220.494
2w06FRVCyclin-dependent kinase 22.7.11.220.493
2w17I19Cyclin-dependent kinase 22.7.11.220.493
4lyn1YGCyclin-dependent kinase 22.7.11.220.493
4acm7YGCyclin-dependent kinase 22.7.11.220.492
4fkpLS5Cyclin-dependent kinase 22.7.11.220.492
1di8DTQCyclin-dependent kinase 22.7.11.220.491
1ke5LS1Cyclin-dependent kinase 22.7.11.220.491
1y91CT9Cyclin-dependent kinase 22.7.11.220.491
2b53D23Cyclin-dependent kinase 22.7.11.220.490
2uzbC75Cyclin-dependent kinase 22.7.11.220.490
2vv9IM9Cyclin-dependent kinase 22.7.11.220.489
3iggEFQCyclin-dependent kinase 22.7.11.220.489
3wblPDYCyclin-dependent kinase 22.7.11.220.489
3s2pPMUCyclin-dependent kinase 22.7.11.220.488
4fkr45KCyclin-dependent kinase 22.7.11.220.487
1g5sI17Cyclin-dependent kinase 22.7.11.220.486
2r3iSCFCyclin-dependent kinase 22.7.11.220.486
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.486
3rk708ZCyclin-dependent kinase 22.7.11.220.486
3ti1B49Cyclin-dependent kinase 22.7.11.220.486
2uznC96Cyclin-dependent kinase 22.7.11.220.485
3sw418KCyclin-dependent kinase 22.7.11.220.485
4dgnLU2Casein kinase II subunit alpha2.7.11.10.485
1ykr628Cyclin-dependent kinase 22.7.11.220.483
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.483
3tiz3TICyclin-dependent kinase 22.7.11.220.483
4bgh3I6Cyclin-dependent kinase 22.7.11.220.483
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.483
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.481
4ii5ADPCyclin-dependent kinase 22.7.11.220.481
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.480
3sqq99ZCyclin-dependent kinase 22.7.11.220.480
1h1r6CPCyclin-dependent kinase 22.7.11.220.479
2vtqLZACyclin-dependent kinase 22.7.11.220.478
4bcpT3CCyclin-dependent kinase 22.7.11.220.478
2uzoC62Cyclin-dependent kinase 22.7.11.220.477
2r3p3SCCyclin-dependent kinase 22.7.11.220.476
3qtuX44Cyclin-dependent kinase 22.7.11.220.476
3rjc06ZCyclin-dependent kinase 22.7.11.220.476
3r1sX73Cyclin-dependent kinase 22.7.11.220.475
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.475
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.474
2r3lSCWCyclin-dependent kinase 22.7.11.220.474
3nynSGVG protein-coupled receptor kinase 62.7.11.160.474
3qwjX6ACyclin-dependent kinase 22.7.11.220.474
3rkb12ZCyclin-dependent kinase 22.7.11.220.474
2cchATPCyclin-dependent kinase 22.7.11.220.473
3qzhX69Cyclin-dependent kinase 22.7.11.220.473
3r8vZ62Cyclin-dependent kinase 22.7.11.220.473
1ke7LS3Cyclin-dependent kinase 22.7.11.220.472
2pvlP55Casein kinase II subunit alpha2.7.11.10.472
2x1nX1NCyclin-dependent kinase 22.7.11.220.472
3qziX72Cyclin-dependent kinase 22.7.11.220.472
4nj32KDCyclin-dependent kinase 22.7.11.220.472
1oiuN76Cyclin-dependent kinase 22.7.11.220.471
2c6iDT1Cyclin-dependent kinase 22.7.11.220.471
2pvnP63Casein kinase II subunit alpha2.7.11.10.471
1oi9N20Cyclin-dependent kinase 22.7.11.220.469
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.469
3qtzX42Cyclin-dependent kinase 22.7.11.220.469
4eon1ROCyclin-dependent kinase 22.7.11.220.469
1oguST8Cyclin-dependent kinase 22.7.11.220.468
1vyzN5BCyclin-dependent kinase 22.7.11.220.468
3be9P04Casein kinase II subunit alpha2.7.11.10.468
3r6xX84Cyclin-dependent kinase 22.7.11.220.468
3r9dX6BCyclin-dependent kinase 22.7.11.220.468
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.468
1gih1PUCyclin-dependent kinase 22.7.11.220.467
2r3fSC8Cyclin-dependent kinase 22.7.11.220.467
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.467
3rmf20ZCyclin-dependent kinase 22.7.11.220.467
2r3r6SCCyclin-dependent kinase 22.7.11.220.466
2wpa889Cyclin-dependent kinase 22.7.11.220.466
3rpv26ZCyclin-dependent kinase 22.7.11.220.466
3rpy27ZCyclin-dependent kinase 22.7.11.220.466
4ez30S0Cyclin-dependent kinase 22.7.11.220.466
1ckpPVBCyclin-dependent kinase 22.7.11.220.465
4fko20KCyclin-dependent kinase 22.7.11.220.465
4fks46KCyclin-dependent kinase 22.7.11.220.465
1om1IQACasein kinase II subunit alpha2.7.11.10.464
3rpo24ZCyclin-dependent kinase 22.7.11.220.464
2r3mSCXCyclin-dependent kinase 22.7.11.220.463
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.463
2vtrLZBCyclin-dependent kinase 22.7.11.220.463
3uyt0CKCasein kinase I isoform delta2.7.11.10.463
1e9hINRCyclin-dependent kinase 22.7.11.220.462
1pyePM1Cyclin-dependent kinase 22.7.11.220.462
2xnbY8LCyclin-dependent kinase 22.7.11.220.462
3rk507ZCyclin-dependent kinase 22.7.11.220.462
2b55D31Cyclin-dependent kinase 22.7.11.220.461
2c6kDT2Cyclin-dependent kinase 22.7.11.220.461
2duv371Cyclin-dependent kinase 22.7.11.220.461
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3r1qX75Cyclin-dependent kinase 22.7.11.220.461
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.461
3ddpRC8Cyclin-dependent kinase 22.7.11.220.460
3rahO1ZCyclin-dependent kinase 22.7.11.220.460
4eooATPCyclin-dependent kinase 22.7.11.220.460
4erwSTUCyclin-dependent kinase 22.7.11.220.460
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.460
1m2pHNACasein kinase II subunit alpha2.7.11.10.459
1vjy460TGF-beta receptor type-12.7.11.300.459
3qtrX36Cyclin-dependent kinase 22.7.11.220.459
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.459
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.458
2b54D05Cyclin-dependent kinase 22.7.11.220.458
2r5tANPSerine/threonine-protein kinase Sgk12.7.11.10.458
2r64740Cyclin-dependent kinase 22.7.11.220.458
4dgo0JWCasein kinase II subunit alpha2.7.11.10.458
4ysjADPCalmodulin-like domain protein kinase/0.458
1y8yCT7Cyclin-dependent kinase 22.7.11.220.457
2c6tDT5Cyclin-dependent kinase 22.7.11.220.457
2pvhP19Casein kinase II subunit alpha2.7.11.10.457
1p2a5BNCyclin-dependent kinase 22.7.11.220.456
2r3gSC9Cyclin-dependent kinase 22.7.11.220.456
3bhtMFRCyclin-dependent kinase 22.7.11.220.456
3r7eX88Cyclin-dependent kinase 22.7.11.220.456
4bgg844Activin receptor type-12.7.11.300.456
1ke6LS2Cyclin-dependent kinase 22.7.11.220.455
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.455
2uzlC94Cyclin-dependent kinase 22.7.11.220.455
2wotZZGTGF-beta receptor type-12.7.11.300.455
3r8pZ46Cyclin-dependent kinase 22.7.11.220.455
4dgmAGICasein kinase II subunit alpha2.7.11.10.455
5aniES4Cyclin-dependent kinase 22.7.11.220.455
2fvdLIACyclin-dependent kinase 22.7.11.220.454
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.454
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.453
3roy22ZCyclin-dependent kinase 22.7.11.220.453
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.453
1vyw292Cyclin-dependent kinase 22.7.11.220.452
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.452
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.452
3mtfA3FActivin receptor type-12.7.11.300.452
3plsANPMacrophage-stimulating protein receptor2.7.10.10.452
3qrtX14Cyclin-dependent kinase 22.7.11.220.452
3rm618ZCyclin-dependent kinase 22.7.11.220.452
2b52D42Cyclin-dependent kinase 22.7.11.220.451
2r3kSCQCyclin-dependent kinase 22.7.11.220.451
1ke9LS5Cyclin-dependent kinase 22.7.11.220.450
2c69CT8Cyclin-dependent kinase 22.7.11.220.450
2iw84SPCyclin-dependent kinase 22.7.11.220.450
2vtsLZCCyclin-dependent kinase 22.7.11.220.450
3i60E86Mitogen-activated protein kinase 12.7.11.240.450
3ortAGSSerine/threonine protein kinase/0.450
4fv6E57Mitogen-activated protein kinase 12.7.11.240.450
1oiyN41Cyclin-dependent kinase 22.7.11.220.449
1urwI1PCyclin-dependent kinase 22.7.11.220.449
1xjdSTUProtein kinase C theta type2.7.11.130.449
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.449
4eomATPCyclin-dependent kinase 22.7.11.220.449
4eor4SPCyclin-dependent kinase 22.7.11.220.449
5e8ySTUTGF-beta receptor type-22.7.11.300.449
2bhhRYUCyclin-dependent kinase 22.7.11.220.448
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.448
1h1q2A6Cyclin-dependent kinase 22.7.11.220.447
2c5nCK8Cyclin-dependent kinase 22.7.11.220.447
2etm7PYFocal adhesion kinase 12.7.10.20.447
2y9qANPMitogen-activated protein kinase 12.7.11.240.447
3my5RFZCyclin-dependent kinase 22.7.11.220.447
3qu0X40Cyclin-dependent kinase 22.7.11.220.447
4bcmT7ZCyclin-dependent kinase 22.7.11.220.447
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.447
4hge15VTyrosine-protein kinase JAK2/0.447
4kd11QKCyclin-dependent kinase 22.7.11.220.447
1v1k3FPCyclin-dependent kinase 22.7.11.220.446
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.446
3pj8404Cyclin-dependent kinase 22.7.11.220.446
3r9oZ71Cyclin-dependent kinase 22.7.11.220.446
4ez50RSCyclin-dependent kinase 62.7.11.220.446
4grb0XGCasein kinase II subunit alpha2.7.11.10.446
4nifANPMitogen-activated protein kinase 12.7.11.240.446
2iw94SPCyclin-dependent kinase 22.7.11.220.445
2uzdC85Cyclin-dependent kinase 22.7.11.220.445
3gxlQIGTGF-beta receptor type-12.7.11.300.445
3r73X87Cyclin-dependent kinase 22.7.11.220.445
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.445
1fvv107Cyclin-dependent kinase 22.7.11.220.444
3axwTIDCasein kinase II subunit alpha2.7.11.10.444
3gubGUBDeath-associated protein kinase 12.7.11.10.444
3hmm855TGF-beta receptor type-12.7.11.300.444
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.444
3q9xEMOCasein kinase II subunit alpha2.7.11.10.444
4anmWULCasein kinase II subunit alpha2.7.11.10.444
4jboWPHAurora kinase A2.7.11.10.444
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.443
2r3o2SCCyclin-dependent kinase 22.7.11.220.443
2wouZZFTGF-beta receptor type-12.7.11.300.443
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.443
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.443
4jia1K3Tyrosine-protein kinase JAK2/0.443
4k8aK8AFocal adhesion kinase 12.7.10.20.443
1e1xNW1Cyclin-dependent kinase 22.7.11.220.442
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.442
3qqfX07Cyclin-dependent kinase 22.7.11.220.442
3r28XA0Cyclin-dependent kinase 22.7.11.220.442
3raiX85Cyclin-dependent kinase 22.7.11.220.442
4dymIYZActivin receptor type-12.7.11.300.442
4qmlANPSerine/threonine-protein kinase 242.7.11.10.442
1eh4IC1Casein kinase I homolog 12.7.11.10.441
2ds11CDCyclin-dependent kinase 22.7.11.220.441
4aua4AUCyclin-dependent kinase 62.7.11.220.441
1ir3ANPInsulin receptor2.7.10.10.440
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2xa4AZ5Tyrosine-protein kinase JAK2/0.440
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.440
3ggfGVDSerine/threonine-protein kinase 26/0.440
3lltANPProtein serine/threonine kinase-1/0.440
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.440
4bcnT9NCyclin-dependent kinase 22.7.11.220.440