sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1oh0 | EQU | Steroid Delta-isomerase | 5.3.3.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1oh0 | EQU | Steroid Delta-isomerase | 5.3.3.1 | 1.000 | |
| 1e3v | DXC | Steroid Delta-isomerase | 5.3.3.1 | 0.673 | |
| 1w6y | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.627 | |
| 1e3r | AND | Steroid Delta-isomerase | 5.3.3.1 | 0.588 | |
| 1cqs | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.569 | |
| 3ows | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.554 | |
| 1ogx | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.552 | |
| 3fzw | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.550 | |
| 3nhx | ASD | Steroid Delta-isomerase | 5.3.3.1 | 0.550 | |
| 3owy | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.534 | |
| 1gs3 | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.522 | |
| 1oho | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.513 | |
| 4iyg | 1HU | Strictosidine synthase | 4.3.3.2 | 0.508 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.503 | |
| 4oic | A8S | Bet v I allergen-like | / | 0.502 | |
| 3vgn | FNN | Steroid Delta-isomerase | 5.3.3.1 | 0.501 | |
| 3ipt | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.500 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.496 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.493 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 3njo | P2M | Abscisic acid receptor PYR1 | / | 0.490 | |
| 3nmn | PYV | Abscisic acid receptor PYL1 | / | 0.489 | |
| 3pp1 | IZG | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.489 | |
| 3ujl | A8S | Abscisic acid receptor PYL2 | / | 0.488 | |
| 4jrv | KJV | Epidermal growth factor receptor | 2.7.10.1 | 0.488 | |
| 3kb0 | A8S | Abscisic acid receptor PYL2 | / | 0.487 | |
| 4ds8 | A8S | Abscisic acid receptor PYL3 | / | 0.487 | |
| 3kb3 | A8S | Abscisic acid receptor PYL2 | / | 0.479 | |
| 3kdi | A8S | Abscisic acid receptor PYL2 | / | 0.479 | |
| 4mm7 | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.479 | |
| 1qjg | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.478 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.478 | |
| 3nef | PYV | Abscisic acid receptor PYL1 | / | 0.476 | |
| 3ov4 | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.476 | |
| 3btj | DEQ | HTH-type transcriptional regulator QacR | / | 0.475 | |
| 3nmh | PYV | Abscisic acid receptor PYL2 | / | 0.475 | |
| 3qly | 55V | Uncharacterized protein | / | 0.475 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.475 | |
| 2f6r | ACO | Bifunctional coenzyme A synthase | / | 0.474 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.474 | |
| 3roe | THM | NAD(P)H-hydrate epimerase | 5.1.99.6 | 0.474 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.474 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.474 | |
| 3k3k | A8S | Abscisic acid receptor PYR1 | / | 0.473 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.472 | |
| 3zvu | A8S | Abscisic acid receptor PYR1 | / | 0.472 | |
| 1jum | BER | HTH-type transcriptional regulator QacR | / | 0.470 | |
| 3v1s | 0LH | Strictosidine synthase | 4.3.3.2 | 0.470 | |
| 3bgp | VX1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.469 | |
| 2cd8 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.468 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.468 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.468 | |
| 2wkm | PFY | Hepatocyte growth factor receptor | 2.7.10.1 | 0.467 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.466 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.466 | |
| 2zaz | GK1 | Mitogen-activated protein kinase 14 | / | 0.466 | |
| 3m8c | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.466 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.466 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.466 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.464 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.464 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.464 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.464 | |
| 1jt6 | DEQ | HTH-type transcriptional regulator QacR | / | 0.463 | |
| 1yqd | NAP | Sinapyl alcohol dehydrogenase | / | 0.463 | |
| 2f4j | VX6 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.463 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 4bch | T7Z | Cyclin-dependent kinase 9 | 2.7.11.22 | 0.463 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.463 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.461 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1yho | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3h03 | UBP | Glutamate receptor 2 | / | 0.459 | |
| 3kdj | A8S | Abscisic acid receptor PYL1 | / | 0.459 | |
| 4lga | A2O | Abscisic acid receptor PYL2 | / | 0.459 | |
| 1kv2 | B96 | Mitogen-activated protein kinase 14 | / | 0.458 | |
| 1m7q | DQO | Mitogen-activated protein kinase 14 | / | 0.458 | |
| 2eau | CZA | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.458 | |
| 3fzp | AGS | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.458 | |
| 3k90 | A8S | Abscisic acid receptor PYR1 | / | 0.458 | |
| 3p5k | P5K | Mitogen-activated protein kinase 14 | / | 0.458 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.458 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.458 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.458 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.457 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3n0t | OPY | Dipeptidyl peptidase 2 | 3.4.14.2 | 0.457 | |
| 4pb1 | RBV | Nucleoside permease | / | 0.457 | |
| 4trj | 665 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 1zar | ADP | RIO-type serine/threonine-protein kinase Rio2 | 2.7.11.1 | 0.456 | |
| 3anl | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.456 | |
| 3gxo | MQA | Mitomycin biosynthesis 6-O-methyltransferase | / | 0.456 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.456 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4mm9 | FVX | Na(+):neurotransmitter symporter (Snf family) | / | 0.456 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1th6 | OIN | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.455 | |
| 4hvb | 19P | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 4jda | A9S | Abscisic acid receptor PYL3 | / | 0.455 | |
| 1w84 | L12 | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 2ouz | C3D | Estrogen receptor | / | 0.454 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 3tij | URI | Nucleoside permease | / | 0.454 | |
| 4lg5 | A1O | Abscisic acid receptor PYL2 | / | 0.454 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.454 | |
| 1eqb | FFO | Serine hydroxymethyltransferase | 2.1.2.1 | 0.453 | |
| 1ne6 | SP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.453 | |
| 2uzu | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.453 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.453 | |
| 3cyz | 9OD | Pheromone-binding protein ASP1 | / | 0.453 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.453 | |
| 3juq | AKD | Phenazine biosynthesis protein A/B | / | 0.453 | |
| 3m4n | PA9 | N-acetylornithine carbamoyltransferase | 2.1.3.9 | 0.453 | |
| 3p78 | P78 | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.453 | |
| 4hw7 | 64M | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.453 | |
| 4k18 | 1OB | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.453 | |
| 1tg2 | H2B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.452 | |
| 2b5v | NAP | Glucose 1-dehydrogenase | / | 0.452 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.452 | |
| 2vss | ACO | Hydroxycinnamoyl-CoA hydratase-lyase | 4.1.2.41 | 0.452 | |
| 3bgq | VX2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.452 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.452 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 1y5v | NE8 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.451 | |
| 1yqj | 6NP | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.451 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.451 | |
| 3owu | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.451 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.451 | |
| 4pda | CTN | Nucleoside permease | / | 0.451 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.451 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.450 | |
| 3bgz | VX3 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.450 | |
| 3rga | LSB | Epoxide hydrolase LasB | 5.5.1 | 0.450 | |
| 3vf9 | 477 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.450 | |
| 4jhz | 1KV | Beta-glucuronidase | 3.2.1.31 | 0.450 | |
| 5d12 | G97 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.450 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.449 | |
| 2xvv | 9DN | Serum albumin | / | 0.449 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.449 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 3qn1 | A8S | Abscisic acid receptor PYR1 | / | 0.449 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 4gg5 | 0J3 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.449 | |
| 4h4u | NDP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.449 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.449 | |
| 4pd5 | GEO | Nucleoside permease | / | 0.449 | |
| 4rtm | SAM | DNA adenine methylase | 2.1.1.72 | 0.449 | |
| 1bl7 | SB4 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1lhv | NOG | Sex hormone-binding globulin | / | 0.448 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3hv7 | 1AU | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.448 | |
| 3tm4 | SAM | Uncharacterized protein | / | 0.448 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.448 | |
| 4nm9 | FAD | Bifunctional protein PutA | / | 0.448 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.448 | |
| 4pb2 | 5UD | Nucleoside permease | / | 0.448 | |
| 4qa1 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.448 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.448 | |
| 5i2h | AGI | O-methyltransferase family 2 | / | 0.448 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.448 | |
| 1ouy | 094 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.447 | |
| 2oyf | IAC | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.447 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.447 | |
| 3fnu | 006 | HAP protein | / | 0.447 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.447 | |
| 3glu | LYS_VAL_MET | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.447 | |
| 3nmv | PYV | Abscisic acid receptor PYL2 | / | 0.447 | |
| 3pre | 3RE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 3r6p | A8S | Abscisic acid receptor PYL10 | / | 0.447 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3v04 | V04 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.447 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.447 | |
| 4dtk | 7LI | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.447 | |
| 4hfn | CIY | 2-alkenal reductase (NADP(+)-dependent) | / | 0.447 | |
| 1ci7 | UMP | Thymidylate synthase | 2.1.1.45 | 0.446 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.446 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1yol | S03 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.446 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2qgt | EED | Estrogen receptor | / | 0.446 | |
| 3c4e | C4E | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 3cse | N22 | Uncharacterized protein | / | 0.446 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.446 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1v0p | PVB | Cell division control protein 2 homolog | 2.7.11.22 | 0.445 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2ohj | FMN | Type A flavoprotein FprA | 1 | 0.445 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.445 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.445 | |
| 4dsb | A8S | Abscisic acid receptor PYL3 | / | 0.445 | |
| 4f64 | 0S8 | Fibroblast growth factor receptor 1 | / | 0.445 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.445 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.445 | |
| 4l7s | G7K | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.445 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.445 | |
| 5c7o | NAD | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific | 1.2.1.12 | 0.445 | |
| 1mc5 | AHE | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.444 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.444 | |
| 1x7j | GEN | Estrogen receptor beta | / | 0.444 | |
| 2apc | UDM | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.444 | |
| 3dcv | 55E | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.444 | |
| 3q2m | CKI | Spectinomycin phosphotransferase | / | 0.444 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.444 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.444 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.444 | |
| 4i41 | MIX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 1d2s | DHT | Sex hormone-binding globulin | / | 0.443 | |
| 1fd0 | 254 | Retinoic acid receptor gamma | / | 0.443 | |
| 1t02 | LVA | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.443 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.443 | |
| 2pui | ADP | Methylthioribose kinase | 2.7.1.100 | 0.443 | |
| 3e8e | G98 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3gi3 | B10 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.443 | |
| 3k14 | 535 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.443 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.443 | |
| 4aac | AAV | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 4au7 | SAH | Histone-lysine N-methyltransferase KMT5C | 2.1.1.43 | 0.443 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.443 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.443 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.442 | |
| 1td2 | PXL | Pyridoxal kinase PdxY | / | 0.442 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2g1p | SAH | DNA adenine methylase | 2.1.1.72 | 0.442 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.442 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3fgo | ACP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.442 | |
| 3hf6 | LX0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.442 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.442 | |
| 3p9t | TCL | Repressor | / | 0.442 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.442 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.442 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.442 | |
| 4h1j | 0YH | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.442 | |
| 4isk | UMP | Thymidylate synthase | / | 0.442 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4l17 | DNQ | Glutamate receptor 2 | / | 0.442 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 1k7f | IAV | Tryptophan synthase alpha chain | / | 0.441 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.441 | |
| 1ori | SAH | Protein arginine N-methyltransferase 1 | / | 0.441 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1xqc | AEJ | Estrogen receptor | / | 0.441 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2qe4 | JJ3 | Estrogen receptor | / | 0.441 | |
| 2zce | PYL | Pyrrolysine--tRNA ligase | / | 0.441 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3qyw | 6PB | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.441 | |
| 3swr | SFG | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.441 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.441 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.441 | |
| 4mmc | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.441 | |
| 4rtj | SFG | DNA adenine methylase | 2.1.1.72 | 0.441 | |
| 4tx9 | AMZ | Phosphoribosyl isomerase A | / | 0.441 | |
| 1ouk | 084 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 1sm2 | STU | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.440 | |
| 1yi3 | LY2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 2gu8 | 796 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.440 | |
| 2ow3 | BIM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.440 | |
| 2x7g | PVB | SRSF protein kinase 2 | 2.7.11.1 | 0.440 | |
| 2zwv | SAH | Probable ribosomal RNA small subunit methyltransferase | / | 0.440 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3l71 | AZO | Cytochrome b | / | 0.440 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.440 | |
| 4ap7 | F47 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.440 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.440 | |
| 4iw8 | KN3 | Estrogen receptor | / | 0.440 | |
| 4jr3 | KJR | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4nks | 2M2 | Fibroblast growth factor receptor 1 | / | 0.440 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.440 |