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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ke7LS3Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1ke7LS3Cyclin-dependent kinase 22.7.11.221.000
1ke5LS1Cyclin-dependent kinase 22.7.11.220.782
1ke6LS2Cyclin-dependent kinase 22.7.11.220.745
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.691
2c6o4SPCyclin-dependent kinase 22.7.11.220.653
1ke9LS5Cyclin-dependent kinase 22.7.11.220.645
2btsU32Cyclin-dependent kinase 22.7.11.220.636
2uzoC62Cyclin-dependent kinase 22.7.11.220.634
1ke8LS4Cyclin-dependent kinase 22.7.11.220.630
1di8DTQCyclin-dependent kinase 22.7.11.220.625
4fkpLS5Cyclin-dependent kinase 22.7.11.220.618
2btrU73Cyclin-dependent kinase 22.7.11.220.610
4fkq42KCyclin-dependent kinase 22.7.11.220.609
1oitHDTCyclin-dependent kinase 22.7.11.220.605
4ek816KCyclin-dependent kinase 22.7.11.220.605
3qzhX69Cyclin-dependent kinase 22.7.11.220.599
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.598
4ek610KCyclin-dependent kinase 22.7.11.220.598
1g5sI17Cyclin-dependent kinase 22.7.11.220.597
3r8lZ30Cyclin-dependent kinase 22.7.11.220.597
3sw418KCyclin-dependent kinase 22.7.11.220.595
2w06FRVCyclin-dependent kinase 22.7.11.220.592
4fkt48KCyclin-dependent kinase 22.7.11.220.591
2a0cCK9Cyclin-dependent kinase 22.7.11.220.590
3lfnA27Cyclin-dependent kinase 22.7.11.220.590
3rpo24ZCyclin-dependent kinase 22.7.11.220.590
1pxmCK5Cyclin-dependent kinase 22.7.11.220.588
3sqq99ZCyclin-dependent kinase 22.7.11.220.588
4fkg4CKCyclin-dependent kinase 22.7.11.220.588
2r64740Cyclin-dependent kinase 22.7.11.220.587
3qzgX67Cyclin-dependent kinase 22.7.11.220.587
1h1s4SPCyclin-dependent kinase 22.7.11.220.585
1pxoCK7Cyclin-dependent kinase 22.7.11.220.585
2xmyCDKCyclin-dependent kinase 22.7.11.220.584
1gih1PUCyclin-dependent kinase 22.7.11.220.583
1ykr628Cyclin-dependent kinase 22.7.11.220.583
3r1yX76Cyclin-dependent kinase 22.7.11.220.583
4fkr45KCyclin-dependent kinase 22.7.11.220.583
3rm719ZCyclin-dependent kinase 22.7.11.220.582
2b52D42Cyclin-dependent kinase 22.7.11.220.581
2r3lSCWCyclin-dependent kinase 22.7.11.220.581
3r1sX73Cyclin-dependent kinase 22.7.11.220.580
3s2pPMUCyclin-dependent kinase 22.7.11.220.580
4fkj11KCyclin-dependent kinase 22.7.11.220.577
1ckpPVBCyclin-dependent kinase 22.7.11.220.576
3r73X87Cyclin-dependent kinase 22.7.11.220.576
3rpv26ZCyclin-dependent kinase 22.7.11.220.575
3s1h56ZCyclin-dependent kinase 22.7.11.220.575
4acm7YGCyclin-dependent kinase 22.7.11.220.574
4fkv61KCyclin-dependent kinase 22.7.11.220.572
2vu3LZECyclin-dependent kinase 22.7.11.220.571
3rk708ZCyclin-dependent kinase 22.7.11.220.571
1y91CT9Cyclin-dependent kinase 22.7.11.220.570
2a4lRRCCyclin-dependent kinase 22.7.11.220.570
3qqfX07Cyclin-dependent kinase 22.7.11.220.569
3rk507ZCyclin-dependent kinase 22.7.11.220.569
4bgh3I6Cyclin-dependent kinase 22.7.11.220.569
4fki09KCyclin-dependent kinase 22.7.11.220.568
1pxlCK4Cyclin-dependent kinase 22.7.11.220.567
3qtxX43Cyclin-dependent kinase 22.7.11.220.567
1w0xOLOCyclin-dependent kinase 22.7.11.220.566
3qtzX42Cyclin-dependent kinase 22.7.11.220.566
3rm618ZCyclin-dependent kinase 22.7.11.220.566
3roy22ZCyclin-dependent kinase 22.7.11.220.565
1h1r6CPCyclin-dependent kinase 22.7.11.220.564
1vyzN5BCyclin-dependent kinase 22.7.11.220.563
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.563
4ez30S0Cyclin-dependent kinase 22.7.11.220.563
1w8cN69Cyclin-dependent kinase 22.7.11.220.562
2uznC96Cyclin-dependent kinase 22.7.11.220.561
3rjc06ZCyclin-dependent kinase 22.7.11.220.561
2vthLZ2Cyclin-dependent kinase 22.7.11.220.559
1h0w207Cyclin-dependent kinase 22.7.11.220.558
2w1hL0FCyclin-dependent kinase 22.7.11.220.558
3qtuX44Cyclin-dependent kinase 22.7.11.220.558
3rni21ZCyclin-dependent kinase 22.7.11.220.558
2iw84SPCyclin-dependent kinase 22.7.11.220.556
4fks46KCyclin-dependent kinase 22.7.11.220.556
3fz1B98Cyclin-dependent kinase 22.7.11.220.555
1pxkCK3Cyclin-dependent kinase 22.7.11.220.553
3ddpRC8Cyclin-dependent kinase 22.7.11.220.553
3qu0X40Cyclin-dependent kinase 22.7.11.220.553
1oirHDYCyclin-dependent kinase 22.7.11.220.551
3iggEFQCyclin-dependent kinase 22.7.11.220.551
3lfqA28Cyclin-dependent kinase 22.7.11.220.551
2vttLZDCyclin-dependent kinase 22.7.11.220.550
3qxoX65Cyclin-dependent kinase 22.7.11.220.549
3unk0BYCyclin-dependent kinase 22.7.11.220.549
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.548
1v1k3FPCyclin-dependent kinase 22.7.11.220.547
2exmZIPCyclin-dependent kinase 22.7.11.220.546
3ig7EFPCyclin-dependent kinase 22.7.11.220.546
3r7yZ04Cyclin-dependent kinase 22.7.11.220.546
1urwI1PCyclin-dependent kinase 22.7.11.220.545
3qqkX02Cyclin-dependent kinase 22.7.11.220.545
3r7uX96Cyclin-dependent kinase 22.7.11.220.545
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.544
3r9hZ67Cyclin-dependent kinase 22.7.11.220.544
2r3mSCXCyclin-dependent kinase 22.7.11.220.543
3ddqRRCCyclin-dependent kinase 22.7.11.220.543
3ezvEZVCyclin-dependent kinase 22.7.11.220.543
1r78FMDCyclin-dependent kinase 22.7.11.220.542
3r1qX75Cyclin-dependent kinase 22.7.11.220.542
3rk909ZCyclin-dependent kinase 22.7.11.220.542
1oguST8Cyclin-dependent kinase 22.7.11.220.541
1gii1PUCyclin-dependent kinase 22.7.11.220.540
2vtsLZCCyclin-dependent kinase 22.7.11.220.540
3ezrEZRCyclin-dependent kinase 22.7.11.220.540
4eor4SPCyclin-dependent kinase 22.7.11.220.540
4fko20KCyclin-dependent kinase 22.7.11.220.540
3r7vZ02Cyclin-dependent kinase 22.7.11.220.539
1oiyN41Cyclin-dependent kinase 22.7.11.220.537
3qxpX64Cyclin-dependent kinase 22.7.11.220.537
4lyn1YGCyclin-dependent kinase 22.7.11.220.537
2duv371Cyclin-dependent kinase 22.7.11.220.536
2r3p3SCCyclin-dependent kinase 22.7.11.220.536
1pyePM1Cyclin-dependent kinase 22.7.11.220.535
3pj8404Cyclin-dependent kinase 22.7.11.220.535
3r7eX88Cyclin-dependent kinase 22.7.11.220.535
4kd11QKCyclin-dependent kinase 22.7.11.220.535
1e1xNW1Cyclin-dependent kinase 22.7.11.220.533
1oiuN76Cyclin-dependent kinase 22.7.11.220.533
3rak03ZCyclin-dependent kinase 22.7.11.220.533
3r9dX6BCyclin-dependent kinase 22.7.11.220.532
2r3iSCFCyclin-dependent kinase 22.7.11.220.531
4eok4SPCyclin-dependent kinase 22.7.11.220.531
2w05FRTCyclin-dependent kinase 22.7.11.220.530
3r83Z14Cyclin-dependent kinase 22.7.11.220.530
3rmf20ZCyclin-dependent kinase 22.7.11.220.530
3s0o50ZCyclin-dependent kinase 22.7.11.220.530
2iw94SPCyclin-dependent kinase 22.7.11.220.529
3ral04ZCyclin-dependent kinase 22.7.11.220.529
3unj0BXCyclin-dependent kinase 22.7.11.220.528
3sw719KCyclin-dependent kinase 22.7.11.220.527
3qruX19Cyclin-dependent kinase 22.7.11.220.525
1vyw292Cyclin-dependent kinase 22.7.11.220.524
4eon1ROCyclin-dependent kinase 22.7.11.220.524
2b53D23Cyclin-dependent kinase 22.7.11.220.523
3ti1B49Cyclin-dependent kinase 22.7.11.220.523
1b38ATPCyclin-dependent kinase 22.7.11.220.522
2j9mPY8Cyclin-dependent kinase 22.7.11.220.522
3qx2X63Cyclin-dependent kinase 22.7.11.220.521
3r28XA0Cyclin-dependent kinase 22.7.11.220.521
3r6xX84Cyclin-dependent kinase 22.7.11.220.521
1b39ATPCyclin-dependent kinase 22.7.11.220.520
3wblPDYCyclin-dependent kinase 22.7.11.220.520
2b54D05Cyclin-dependent kinase 22.7.11.220.519
2r3jSCJCyclin-dependent kinase 22.7.11.220.518
3r7iX9ICyclin-dependent kinase 22.7.11.220.518
4fx360KCyclin-dependent kinase 22.7.11.220.518
2c6mDT5Cyclin-dependent kinase 22.7.11.220.517
4bcmT7ZCyclin-dependent kinase 22.7.11.220.517
3r8vZ62Cyclin-dependent kinase 22.7.11.220.516
4fklCK2Cyclin-dependent kinase 22.7.11.220.516
2bhhRYUCyclin-dependent kinase 22.7.11.220.515
1oi9N20Cyclin-dependent kinase 22.7.11.220.514
3qqlX03Cyclin-dependent kinase 22.7.11.220.514
3rpy27ZCyclin-dependent kinase 22.7.11.220.514
3py0SU9Cyclin-dependent kinase 22.7.11.220.512
3rkb12ZCyclin-dependent kinase 22.7.11.220.512
4bcpT3CCyclin-dependent kinase 22.7.11.220.512
3raiX85Cyclin-dependent kinase 22.7.11.220.510
2r3kSCQCyclin-dependent kinase 22.7.11.220.509
2r3r6SCCyclin-dependent kinase 22.7.11.220.509
1unlRRCCyclin-dependent-like kinase 52.7.11.10.508
2vv9IM9Cyclin-dependent kinase 22.7.11.220.508
4fkw62KCyclin-dependent kinase 22.7.11.220.508
2c5nCK8Cyclin-dependent kinase 22.7.11.220.507
2w17I19Cyclin-dependent kinase 22.7.11.220.507
3ql8X01Cyclin-dependent kinase 22.7.11.220.507
1fvt106Cyclin-dependent kinase 22.7.11.220.506
2b55D31Cyclin-dependent kinase 22.7.11.220.506
4nj32KDCyclin-dependent kinase 22.7.11.220.506
1fvv107Cyclin-dependent kinase 22.7.11.220.505
1pxpCK8Cyclin-dependent kinase 22.7.11.220.505
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.505
3rahO1ZCyclin-dependent kinase 22.7.11.220.505
1p2a5BNCyclin-dependent kinase 22.7.11.220.504
1h0vUN4Cyclin-dependent kinase 22.7.11.220.503
1gij2PUCyclin-dependent kinase 22.7.11.220.502
2fvdLIACyclin-dependent kinase 22.7.11.220.501
3qwjX6ACyclin-dependent kinase 22.7.11.220.501
4bcoT6QCyclin-dependent kinase 22.7.11.220.501
2r3gSC9Cyclin-dependent kinase 22.7.11.220.500
3qqhX0ACyclin-dependent kinase 22.7.11.220.500
4qmpDKISerine/threonine-protein kinase 242.7.11.10.500
2wotZZGTGF-beta receptor type-12.7.11.300.499
3qtrX36Cyclin-dependent kinase 22.7.11.220.499
3qwkX62Cyclin-dependent kinase 22.7.11.220.499
3uli1N3Cyclin-dependent kinase 22.7.11.220.499
3r71X86Cyclin-dependent kinase 22.7.11.220.497
3r8pZ46Cyclin-dependent kinase 22.7.11.220.497
3lfsA07Cyclin-dependent kinase 22.7.11.220.496
3qx4X4BCyclin-dependent kinase 22.7.11.220.494
1aq1STUCyclin-dependent kinase 22.7.11.220.493
1h1q2A6Cyclin-dependent kinase 22.7.11.220.492
3dogNNNCyclin-dependent kinase 22.7.11.220.492
3ggfGVDSerine/threonine-protein kinase 26/0.492
3sheI85MAP kinase-activated protein kinase 32.7.11.10.492
3qziX72Cyclin-dependent kinase 22.7.11.220.491
1dm2HMDCyclin-dependent kinase 22.7.11.220.490
2xnbY8LCyclin-dependent kinase 22.7.11.220.490
1vjy460TGF-beta receptor type-12.7.11.300.489
2c6iDT1Cyclin-dependent kinase 22.7.11.220.489
2r3o2SCCyclin-dependent kinase 22.7.11.220.489
5aniES4Cyclin-dependent kinase 22.7.11.220.488
1e9hINRCyclin-dependent kinase 22.7.11.220.487
1hckATPCyclin-dependent kinase 22.7.11.220.487
2wpa889Cyclin-dependent kinase 22.7.11.220.487
3nynSGVG protein-coupled receptor kinase 62.7.11.160.487
2c6kDT2Cyclin-dependent kinase 22.7.11.220.484
4bcnT9NCyclin-dependent kinase 22.7.11.220.484
2c6lDT4Cyclin-dependent kinase 22.7.11.220.482
2eufLQQCyclin-dependent kinase 62.7.11.220.482
3bhtMFRCyclin-dependent kinase 22.7.11.220.482
3pxyJWSCyclin-dependent kinase 22.7.11.220.481
2x1nX1NCyclin-dependent kinase 22.7.11.220.480
4eoi1ROCyclin-dependent kinase 22.7.11.220.475
1h1pCMGCyclin-dependent kinase 22.7.11.220.474
2wihP48Cyclin-dependent kinase 22.7.11.220.474
3r9nZ68Cyclin-dependent kinase 22.7.11.220.474
3rzb02ZCyclin-dependent kinase 22.7.11.220.474
1pkdUCNCyclin-dependent kinase 22.7.11.220.473
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.473
2vtqLZACyclin-dependent kinase 22.7.11.220.473
3gxlQIGTGF-beta receptor type-12.7.11.300.473
3tnwF18Cyclin-dependent kinase 22.7.11.220.473
1finATPCyclin-dependent kinase 22.7.11.220.472
1y8yCT7Cyclin-dependent kinase 22.7.11.220.472
3qtqX35Cyclin-dependent kinase 22.7.11.220.472
3r9oZ71Cyclin-dependent kinase 22.7.11.220.472
2c5yMTWCyclin-dependent kinase 22.7.11.220.471
4cfnJYMCyclin-dependent kinase 22.7.11.220.471
2c69CT8Cyclin-dependent kinase 22.7.11.220.470
2uzeC95Cyclin-dependent kinase 22.7.11.220.470
2xikJ60Serine/threonine-protein kinase 252.7.11.10.469
4eos1ROCyclin-dependent kinase 22.7.11.220.468
2c4g514Cyclin-dependent kinase 22.7.11.220.467
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.467
3tiz3TICyclin-dependent kinase 22.7.11.220.467
4aua4AUCyclin-dependent kinase 62.7.11.220.467
4i22IREEpidermal growth factor receptor2.7.10.10.466
1eh4IC1Casein kinase I homolog 12.7.11.10.465
2c6tDT5Cyclin-dependent kinase 22.7.11.220.465
2r3fSC8Cyclin-dependent kinase 22.7.11.220.464
1oiqHDUCyclin-dependent kinase 22.7.11.220.463
1xjdSTUProtein kinase C theta type2.7.11.130.463
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.463
3r8uZ31Cyclin-dependent kinase 22.7.11.220.463
3s00Z60Cyclin-dependent kinase 22.7.11.220.463
2i40BLZCyclin-dependent kinase 22.7.11.220.462
2pvlP55Casein kinase II subunit alpha2.7.11.10.462
2pvnP63Casein kinase II subunit alpha2.7.11.10.462
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.462
3nux3NVCyclin-dependent kinase 62.7.11.220.462
4y93746Tyrosine-protein kinase/0.462
2uzlC94Cyclin-dependent kinase 22.7.11.220.461
3qzfX66Cyclin-dependent kinase 22.7.11.220.461
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.461
1gz8MBPCyclin-dependent kinase 22.7.11.220.460
3my5RFZCyclin-dependent kinase 22.7.11.220.460
3oom507Activin receptor type-12.7.11.300.460
4c61LMMTyrosine-protein kinase JAK2/0.460
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.459
3gubGUBDeath-associated protein kinase 12.7.11.10.458
2uzbC75Cyclin-dependent kinase 22.7.11.220.457
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.457
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.455
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.454
2f2cAP9Cyclin-dependent kinase 62.7.11.220.453
2uzdC85Cyclin-dependent kinase 22.7.11.220.453
2wouZZFTGF-beta receptor type-12.7.11.300.453
3r8zZ63Cyclin-dependent kinase 22.7.11.220.453
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.453
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.453
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.452
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.452
1py5PY1TGF-beta receptor type-12.7.11.300.451
3qrtX14Cyclin-dependent kinase 22.7.11.220.451
3rpr25ZCyclin-dependent kinase 22.7.11.220.451
3iok1P6Tyrosine-protein kinase JAK2/0.450
1qmzATPCyclin-dependent kinase 22.7.11.220.449
2wxvWXVCyclin-dependent kinase 22.7.11.220.449
2pwlACPFibroblast growth factor receptor 2/0.448
3qqgX06Cyclin-dependent kinase 22.7.11.220.448
4ewhT77Activated CDC42 kinase 1/0.448
1v0pPVBCell division control protein 2 homolog2.7.11.220.447
2h96893Mitogen-activated protein kinase 82.7.11.240.447
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.447
3hmm855TGF-beta receptor type-12.7.11.300.447
4bgg844Activin receptor type-12.7.11.300.447
3eljGS7Mitogen-activated protein kinase 82.7.11.240.446
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.446
4eop1ROCyclin-dependent kinase 22.7.11.220.446
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.446
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.445
2xa4AZ5Tyrosine-protein kinase JAK2/0.445
3fzsB96Protein-tyrosine kinase 2-beta2.7.10.20.445
4jajXU1Aurora kinase A2.7.11.10.445
4dgnLU2Casein kinase II subunit alpha2.7.11.10.444
4ii5ADPCyclin-dependent kinase 22.7.11.220.444
2cchATPCyclin-dependent kinase 22.7.11.220.443
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.443
4c02TAKActivin receptor type-12.7.11.300.443
4ez50RSCyclin-dependent kinase 62.7.11.220.443
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.442
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.442
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.442
3mtlFEFCyclin-dependent kinase 162.7.11.220.442
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.442
4eooATPCyclin-dependent kinase 22.7.11.220.442
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.442
1e1vCMGCyclin-dependent kinase 22.7.11.220.441
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.441
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.441
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.441
5av2KMPDeath-associated protein kinase 12.7.11.10.441
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.440
3gggNADPrephenate dehydrogenase/0.440
4au8Z3RCyclin-dependent-like kinase 52.7.11.10.440
4e4m0NHTyrosine-protein kinase JAK2/0.440