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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.11.000
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.609
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.597
4erwSTUCyclin-dependent kinase 22.7.11.220.532
1pkdUCNCyclin-dependent kinase 22.7.11.220.528
3r9dX6BCyclin-dependent kinase 22.7.11.220.528
3uli1N3Cyclin-dependent kinase 22.7.11.220.523
4qmpDKISerine/threonine-protein kinase 242.7.11.10.516
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.514
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.514
1g5sI17Cyclin-dependent kinase 22.7.11.220.513
1gih1PUCyclin-dependent kinase 22.7.11.220.509
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.506
3rmf20ZCyclin-dependent kinase 22.7.11.220.505
2x1nX1NCyclin-dependent kinase 22.7.11.220.504
1oi9N20Cyclin-dependent kinase 22.7.11.220.500
2i40BLZCyclin-dependent kinase 22.7.11.220.500
1aq1STUCyclin-dependent kinase 22.7.11.220.499
1oiyN41Cyclin-dependent kinase 22.7.11.220.498
3roy22ZCyclin-dependent kinase 22.7.11.220.497
2bheBRYCyclin-dependent kinase 22.7.11.220.496
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.496
4gmy0X5Tyrosine-protein kinase JAK2/0.495
4bcqTJFCyclin-dependent kinase 22.7.11.220.494
5e8wSTUTGF-beta receptor type-12.7.11.300.494
3qu0X40Cyclin-dependent kinase 22.7.11.220.493
3rpv26ZCyclin-dependent kinase 22.7.11.220.493
1di8DTQCyclin-dependent kinase 22.7.11.220.492
1h1s4SPCyclin-dependent kinase 22.7.11.220.492
4jqeANPCasein kinase II subunit alpha2.7.11.10.492
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.491
3r9oZ71Cyclin-dependent kinase 22.7.11.220.491
2hog710Serine/threonine-protein kinase Chk12.7.11.10.490
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.490
3rak03ZCyclin-dependent kinase 22.7.11.220.490
4eok4SPCyclin-dependent kinase 22.7.11.220.490
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.490
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.490
3s1h56ZCyclin-dependent kinase 22.7.11.220.489
3zep1NXTyrosine-protein kinase JAK32.7.10.20.489
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.489
1oiuN76Cyclin-dependent kinase 22.7.11.220.488
1urwI1PCyclin-dependent kinase 22.7.11.220.488
2iw84SPCyclin-dependent kinase 22.7.11.220.488
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.488
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.488
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.487
2iw94SPCyclin-dependent kinase 22.7.11.220.487
2pvnP63Casein kinase II subunit alpha2.7.11.10.486
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.486
2uzdC85Cyclin-dependent kinase 22.7.11.220.485
3lfnA27Cyclin-dependent kinase 22.7.11.220.485
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.485
3rk708ZCyclin-dependent kinase 22.7.11.220.485
1bygSTUTyrosine-protein kinase CSK/0.484
3be9P04Casein kinase II subunit alpha2.7.11.10.484
2eufLQQCyclin-dependent kinase 62.7.11.220.483
4fkv61KCyclin-dependent kinase 22.7.11.220.483
4ez50RSCyclin-dependent kinase 62.7.11.220.482
4bcpT3CCyclin-dependent kinase 22.7.11.220.481
1h1r6CPCyclin-dependent kinase 22.7.11.220.480
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.480
3qtzX42Cyclin-dependent kinase 22.7.11.220.480
4hvh19RTyrosine-protein kinase JAK32.7.10.20.480
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.480
2cchATPCyclin-dependent kinase 22.7.11.220.479
2vu3LZECyclin-dependent kinase 22.7.11.220.479
2w05FRTCyclin-dependent kinase 22.7.11.220.479
3ddpRC8Cyclin-dependent kinase 22.7.11.220.479
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.479
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.479
3zh8C58Protein kinase C iota type2.7.11.130.478
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.478
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.478
1xjdSTUProtein kinase C theta type2.7.11.130.477
4dgnLU2Casein kinase II subunit alpha2.7.11.10.477
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.477
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.477
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.477
1v1k3FPCyclin-dependent kinase 22.7.11.220.476
3ggfGVDSerine/threonine-protein kinase 26/0.476
3r9hZ67Cyclin-dependent kinase 22.7.11.220.476
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.476
4bchT7ZCyclin-dependent kinase 92.7.11.220.476
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.476
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.476
1gii1PUCyclin-dependent kinase 22.7.11.220.475
2c5nCK8Cyclin-dependent kinase 22.7.11.220.475
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.475
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.475
4c61LMMTyrosine-protein kinase JAK2/0.474
1e9hINRCyclin-dependent kinase 22.7.11.220.473
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.473
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.473
4anmWULCasein kinase II subunit alpha2.7.11.10.473
4hvi19STyrosine-protein kinase JAK32.7.10.20.473
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.472
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.472
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.471
1y91CT9Cyclin-dependent kinase 22.7.11.220.471
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.471
2wihP48Cyclin-dependent kinase 22.7.11.220.471
3lq5SLQCyclin-dependent kinase 92.7.11.220.471
1pyePM1Cyclin-dependent kinase 22.7.11.220.470
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.20.470
1tj0FADBifunctional protein PutA1.5.5.20.470
2b52D42Cyclin-dependent kinase 22.7.11.220.470
2c6tDT5Cyclin-dependent kinase 22.7.11.220.470
3qxpX64Cyclin-dependent kinase 22.7.11.220.470
4e4m0NHTyrosine-protein kinase JAK2/0.470
2j0m4STFocal adhesion kinase 12.7.10.20.469
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.469
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.469
2wotZZGTGF-beta receptor type-12.7.11.300.469
3rni21ZCyclin-dependent kinase 22.7.11.220.469
2uzlC94Cyclin-dependent kinase 22.7.11.220.468
3ral04ZCyclin-dependent kinase 22.7.11.220.468
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.468
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.468
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.468
2bhhRYUCyclin-dependent kinase 22.7.11.220.467
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.467
3rkb12ZCyclin-dependent kinase 22.7.11.220.467
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.467
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.466
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.466
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.465
2uzbC75Cyclin-dependent kinase 22.7.11.220.465
2uzeC95Cyclin-dependent kinase 22.7.11.220.465
3ezvEZVCyclin-dependent kinase 22.7.11.220.465
4bcoT6QCyclin-dependent kinase 22.7.11.220.465
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.465
2xmyCDKCyclin-dependent kinase 22.7.11.220.464
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.464
4bcnT9NCyclin-dependent kinase 22.7.11.220.464
4jia1K3Tyrosine-protein kinase JAK2/0.464
1gij2PUCyclin-dependent kinase 22.7.11.220.463
2f2cAP9Cyclin-dependent kinase 62.7.11.220.463
3zewSTUEphrin type-B receptor 42.7.10.10.463
4bgg844Activin receptor type-12.7.11.300.463
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
4i22IREEpidermal growth factor receptor2.7.10.10.462
1oguST8Cyclin-dependent kinase 22.7.11.220.461
4qmySTUSerine/threonine-protein kinase 242.7.11.10.461
1ke6LS2Cyclin-dependent kinase 22.7.11.220.460
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.460
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.460
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.460
4fx360KCyclin-dependent kinase 22.7.11.220.460
4hge15VTyrosine-protein kinase JAK2/0.460
1fvv107Cyclin-dependent kinase 22.7.11.220.459
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.459
2pmnK51Protein kinase 7/0.459
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.459
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.459
3l8p0CEAngiopoietin-1 receptor2.7.10.10.459
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.459
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.459
3sheI85MAP kinase-activated protein kinase 32.7.11.10.459
3sqq99ZCyclin-dependent kinase 22.7.11.220.459
3ti1B49Cyclin-dependent kinase 22.7.11.220.459
1oiqHDUCyclin-dependent kinase 22.7.11.220.458
2pvhP19Casein kinase II subunit alpha2.7.11.10.458
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.458
2xnbY8LCyclin-dependent kinase 22.7.11.220.458
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.458
4o8aFADBifunctional protein PutA1.2.1.880.458
2b7aIZATyrosine-protein kinase JAK2/0.457
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.457
3ezrEZRCyclin-dependent kinase 22.7.11.220.457
3rk507ZCyclin-dependent kinase 22.7.11.220.457
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.457
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.457
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.457
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.457
4grb0XGCasein kinase II subunit alpha2.7.11.10.457
4gub0Y4Casein kinase II subunit alpha2.7.11.10.457
4riyADPEpidermal growth factor receptor2.7.10.10.457
5cshATPCasein kinase II subunit alpha2.7.11.10.457
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.456
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.456
2pvlP55Casein kinase II subunit alpha2.7.11.10.456
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.456
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.456
3gxlQIGTGF-beta receptor type-12.7.11.300.456
3le62BZCyclin-dependent kinase 22.7.11.220.456
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.456
4acm7YGCyclin-dependent kinase 22.7.11.220.456
4c62XWWTyrosine-protein kinase JAK2/0.456
4dgmAGICasein kinase II subunit alpha2.7.11.10.456
1h1pCMGCyclin-dependent kinase 22.7.11.220.455
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.455
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.455
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.455
2j0j4STFocal adhesion kinase 12.7.10.20.455
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.455
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.455
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.454
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.454
3oom507Activin receptor type-12.7.11.300.454
3sw418KCyclin-dependent kinase 22.7.11.220.454
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.454
4bbfO19Tyrosine-protein kinase JAK2/0.454
4dymIYZActivin receptor type-12.7.11.300.454
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.454
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.454
5cvhADPCasein kinase II subunit alpha2.7.11.10.454
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.453
2b55D31Cyclin-dependent kinase 22.7.11.220.453
2in6839Wee1-like protein kinase2.7.10.20.453
3qwkX62Cyclin-dependent kinase 22.7.11.220.453
3rk909ZCyclin-dependent kinase 22.7.11.220.453
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.452
1vjy460TGF-beta receptor type-12.7.11.300.452
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.452
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
3at4CCKCasein kinase II subunit alpha2.7.11.10.452
3ddqRRCCyclin-dependent kinase 22.7.11.220.452
3qtuX44Cyclin-dependent kinase 22.7.11.220.452
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.452
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.452
4hvg19QTyrosine-protein kinase JAK32.7.10.20.452
1w0xOLOCyclin-dependent kinase 22.7.11.220.451
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.451
2pmoHMDProtein kinase 7/0.450
2vv9IM9Cyclin-dependent kinase 22.7.11.220.450
2xikJ60Serine/threonine-protein kinase 252.7.11.10.450
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.450
4bgh3I6Cyclin-dependent kinase 22.7.11.220.450
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.450
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.450
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.449
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.449
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.449
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.449
2pmlANPUncharacterized protein/0.449
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.449
3lfqA28Cyclin-dependent kinase 22.7.11.220.449
4wsqKSAAP2-associated protein kinase 12.7.11.10.449
1dm2HMDCyclin-dependent kinase 22.7.11.220.448
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.448
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.448
2wxvWXVCyclin-dependent kinase 22.7.11.220.448
3r1qX75Cyclin-dependent kinase 22.7.11.220.448
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.448
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.448
4ogrADNCyclin-dependent kinase 92.7.11.220.448
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.447
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.447
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.447
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.447
3dogNNNCyclin-dependent kinase 22.7.11.220.447
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.447
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.447
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.447
4gk2L66Ephrin type-A receptor 32.7.10.10.447
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.447
1u4dDBQActivated CDC42 kinase 1/0.446
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.446
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.446
4dgo0JWCasein kinase II subunit alpha2.7.11.10.446
4fkw62KCyclin-dependent kinase 22.7.11.220.446
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.446
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.446
1eh4IC1Casein kinase I homolog 12.7.11.10.445
2duv371Cyclin-dependent kinase 22.7.11.220.445
2fvdLIACyclin-dependent kinase 22.7.11.220.445
2w06FRVCyclin-dependent kinase 22.7.11.220.445
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.445
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.445
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.444
1yvj4STTyrosine-protein kinase JAK32.7.10.20.444
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.444
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.444
3qqkX02Cyclin-dependent kinase 22.7.11.220.444
3qtrX36Cyclin-dependent kinase 22.7.11.220.444
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.444
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.444
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.444
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.444
4b99R4LMitogen-activated protein kinase 72.7.11.240.444
4eor4SPCyclin-dependent kinase 22.7.11.220.444
4eos1ROCyclin-dependent kinase 22.7.11.220.444
4fks46KCyclin-dependent kinase 22.7.11.220.444
1ke7LS3Cyclin-dependent kinase 22.7.11.220.443
1oitHDTCyclin-dependent kinase 22.7.11.220.443
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.443
2wpa889Cyclin-dependent kinase 22.7.11.220.443
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.443
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.443
3iok1P6Tyrosine-protein kinase JAK2/0.443
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.443
3s2pPMUCyclin-dependent kinase 22.7.11.220.443
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.443
1oirHDYCyclin-dependent kinase 22.7.11.220.442
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2w17I19Cyclin-dependent kinase 22.7.11.220.442
3ig7EFPCyclin-dependent kinase 22.7.11.220.442
1zrzBI1Protein kinase C iota type2.7.11.130.441
2j9mPY8Cyclin-dependent kinase 22.7.11.220.441
2of2547Tyrosine-protein kinase Lck2.7.10.20.441
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.441
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.441
3bi6396Wee1-like protein kinase2.7.10.20.441
4fkr45KCyclin-dependent kinase 22.7.11.220.441
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.441
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.441
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.441
1ke5LS1Cyclin-dependent kinase 22.7.11.220.440
1ke9LS5Cyclin-dependent kinase 22.7.11.220.440
1lp4ANPCasein kinase II subunit alpha2.7.11.10.440
1pxpCK8Cyclin-dependent kinase 22.7.11.220.440
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.440
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.440
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.440
3my5RFZCyclin-dependent kinase 22.7.11.220.440
3r83Z14Cyclin-dependent kinase 22.7.11.220.440
3t14FADSulfide-quinone reductase/0.440
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.440
3zdu38RCyclin-dependent kinase-like 32.7.11.220.440
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.440
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.440
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440