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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4qknJMSAlpha-ketoglutarate-dependent dioxygenase FTO

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4qknJMSAlpha-ketoglutarate-dependent dioxygenase FTO/1.000
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.574
4zs2FLUAlpha-ketoglutarate-dependent dioxygenase FTO/0.530
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.528
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.524
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.505
1qiqACCIsopenicillin N synthase1.21.3.10.504
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.486
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.484
4ie6UN9Alpha-ketoglutarate-dependent dioxygenase FTO/0.480
1e8xATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.479
2y6fM9FIsopenicillin N synthase1.21.3.10.478
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.478
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.477
3vt8YI3Vitamin D3 receptor/0.475
4h9814QUncharacterized protein/0.475
3qlxQLRUncharacterized protein/0.474
2vcmM11Isopenicillin N synthase1.21.3.10.473
2vn0TDZCytochrome P450 2C8/0.473
4cd2FOLDihydrofolate reductase1.5.1.30.473
3icsCOACoenzyme A disulfide reductase/0.472
2a4zBYMPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
3eek53SUncharacterized protein/0.471
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.470
2hw2RFPRifampin ADP-ribosyl transferase/0.470
2vbpVB1Isopenicillin N synthase1.21.3.10.469
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.468
4ia2BIVVitamin D3 receptor A/0.468
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.467
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.467
1e7qNAPGDP-L-fucose synthase/0.466
4cukNAID-lactate dehydrogenase/0.466
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.466
1rkhVD2Vitamin D3 receptor/0.465
2hc4VDXVitamin D3 receptor A/0.465
2zbzVDXVitamin D3 dihydroxylase/0.465
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.465
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.465
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.465
1hk1T44Serum albumin/0.464
1ie4T44Transthyretin/0.464
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.464
3mqe416Prostaglandin G/H synthase 21.14.99.10.464
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
3vt9YI4Vitamin D3 receptor/0.464
3w5tLHPVitamin D3 receptor/0.464
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
4bb3KKAIsopenicillin N synthase1.21.3.10.464
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.464
4nmbFADBifunctional protein PutA/0.464
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.463
4fhh0U3Vitamin D3 receptor A/0.463
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
1pd9CO4Dihydrofolate reductase1.5.1.30.462
3at4CCKCasein kinase II subunit alpha2.7.11.10.462
3ielU5PRibonuclease TTHA02523.10.462
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
3vt7VDXVitamin D3 receptor/0.462
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
4rupH97Vitamin D3 receptor A/0.462
1txiTX5Vitamin D3 receptor/0.461
3uozNAP2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.461
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
4kwi1TJReductase homolog/0.461
1ictT44Transthyretin/0.460
1iyzNDPProbable quinone oxidoreductase/0.460
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.460
4hee14RPeroxisome proliferator-activated receptor gamma/0.460
4ia3BIVVitamin D3 receptor A/0.460
1efvFADElectron transfer flavoprotein subunit alpha, mitochondrial/0.459
2o4rVD5Vitamin D3 receptor/0.459
3owk18ECasein kinase II subunit alpha2.7.11.10.459
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.459
1l2jETCEstrogen receptor beta/0.458
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.458
3w5rLOAVitamin D3 receptor/0.458
4e37NDPCatalase1.11.1.60.458
4enhFVXCholesterol 24-hydroxylase/0.458
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.457
1blzACVIsopenicillin N synthase1.21.3.10.456
1s19MC9Vitamin D3 receptor/0.456
2bx8AZQSerum albumin/0.456
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.456
2q9fC3SCholesterol 24-hydroxylase/0.456
3dpd41APhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.456
3vrwYS5Vitamin D3 receptor/0.456
4g1z0VPVitamin D3 receptor A/0.456
1db1VDXVitamin D3 receptor/0.455
1jpaANPEphrin type-B receptor 22.7.10.10.455
1osvCHCBile acid receptor/0.455
1u54ACPActivated CDC42 kinase 1/0.455
2hamC33Vitamin D3 receptor/0.455
2hcdBIVVitamin D3 receptor A/0.455
3axwTIDCasein kinase II subunit alpha2.7.11.10.455
3mdvCL6Cholesterol 24-hydroxylase/0.455
3nj0PYVAbscisic acid receptor PYL2/0.455
3nr4PYVAbscisic acid receptor PYL2/0.455
3tqhNDPQuinone oxidoreductase/0.455
3u4uLNHCasein kinase II subunit alpha2.7.11.10.455
4nb6444Nuclear receptor ROR-gamma/0.455
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.455
2pulACPMethylthioribose kinase2.7.1.1000.454
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.454
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.454
3qarQARPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.454
4ez50RSCyclin-dependent kinase 62.7.11.220.454
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.454
1rkgVD1Vitamin D3 receptor/0.453
3a1l2CCCytochrome P450/0.453
3mtfA3FActivin receptor type-12.7.11.300.453
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.453
3w33W19Epidermal growth factor receptor2.7.10.10.453
4ia7BIVVitamin D3 receptor A/0.453
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.453
4lva20MNicotinamide phosphoribosyltransferase2.4.2.120.453
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.453
1ju6LYAThymidylate synthase2.1.1.450.452
2bxnIDBSerum albumin/0.452
2i9pNAD3-hydroxyisobutyrate dehydrogenase, mitochondrial1.1.1.310.452
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.452
1fnnADPORC1-type DNA replication protein/0.451
1tduCB3Thymidylate synthase/0.451
1x8lOXRRetinol dehydratase/0.451
2w6nOA2Biotin carboxylase6.3.4.140.451
3nga3NGCasein kinase II subunit alpha2.7.11.10.451
3pre3REPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
3umvFADDeoxyribodipyrimidine photo-lyase4.1.99.30.451
4pkl1GHUncharacterized protein/0.451
4xumIMNPeroxisome proliferator-activated receptor gamma/0.451
1dhjMTXDihydrofolate reductase1.5.1.30.450
1ie8KH1Vitamin D3 receptor/0.450
1mf0GDPAdenylosuccinate synthetase isozyme 1/0.450
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
2uxpCLMHTH-type transcriptional regulator TtgR/0.450
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.450
3du8553Glycogen synthase kinase-3 beta2.7.11.260.450
3icrCOACoenzyme A disulfide reductase/0.450
3s79ASDAromatase1.14.14.140.450
3vtdTKDVitamin D3 receptor/0.450
4fa60TAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.450
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
1ht834CProstaglandin G/H synthase 11.14.99.10.449
1jutLYDThymidylate synthase/0.449
2lbaCHOFatty acid binding protein 6/0.449
2uxoTACHTH-type transcriptional regulator TtgR/0.449
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.449
3lu6IMXSerum albumin/0.449
3te4ACODopamine N-acetyltransferase/0.449
4nm9FADBifunctional protein PutA/0.449
5awmANPStress-activated protein kinase JNK2.7.11.240.449
1eioGCHGastrotropin/0.448
1sn0T44Transthyretin/0.448
1uzwCDHIsopenicillin N synthase1.21.3.10.448
1zmdNAIDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.448
2bu9HFVIsopenicillin N synthase1.21.3.10.448
2q61SF1Peroxisome proliferator-activated receptor gamma/0.448
2vf0F89Thymidylate synthase/0.448
3a783EVVitamin D3 receptor/0.448
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.448
4j6dTESCytochrome P450 monooxygenase/0.448
4plpNADHomospermidine synthase2.5.1.440.448
4q0a4OAVitamin D3 receptor A/0.448
1ot7CHCBile acid receptor/0.447
1qjfACSIsopenicillin N synthase1.21.3.10.447
2hb8MVDVitamin D3 receptor/0.447
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.447
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.447
3vjhJ35Peroxisome proliferator-activated receptor gamma/0.447
4dgmAGICasein kinase II subunit alpha2.7.11.10.447
4ezl0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.447
4oavACP2-5A-dependent ribonuclease3.1.260.447
4v2gITCTetracycline repressor protein class D/0.447
1n4hREANuclear receptor ROR-beta/0.446
1p31EPUUDP-N-acetylmuramate--L-alanine ligase6.3.2.80.446
1tlcF89Thymidylate synthase/0.446
1zx1CB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.446
2o4jVD4Vitamin D3 receptor/0.446
2p33J07Mitogen-activated protein kinase 102.7.11.240.446
2puiADPMethylthioribose kinase2.7.1.1000.446
2w2lNADD-mandelate dehydrogenase/0.446
2zbaZBATrichothecene 3-O-acetyltransferase/0.446
3m8p65BGag-Pol polyprotein2.7.7.490.446
3mnrSD1Heat shock protein HSP 90-alpha/0.446
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.446
3vtcTK3Vitamin D3 receptor/0.446
3w0jT08Vitamin D3 receptor/0.446
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4f9mFCMPeroxisome proliferator-activated receptor gamma/0.446
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
7catNDPCatalase1.11.1.60.446
1g6cTZPThiamine-phosphate synthase/0.445
1jolFFODihydrofolate reductase1.5.1.30.445
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1rb3MTXDihydrofolate reductase1.5.1.30.445
1s60COAAminoglycoside N(6')-acetyltransferase type 1/0.445
2hbhXE4Vitamin D3 receptor A/0.445
2w3wVG9Dihydrofolate reductase/0.445
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.445
3dxjNE6DNA-directed RNA polymerase subunit beta/0.445
3dxjNE6DNA-directed RNA polymerase subunit beta'/0.445
3hcrCHDFerrochelatase, mitochondrial4.99.1.10.445
3m8qDJZGag-Pol polyprotein2.7.7.490.445
3qly55VUncharacterized protein/0.445
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.445
3vtbTKAVitamin D3 receptor/0.445
4ez72ANCyclin-dependent kinase 22.7.11.220.445
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.445
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.445
4o701QKBromodomain-containing protein 4/0.445
4r20AERCytochrome P450 family 17 polypeptide 2/0.445
4ri1ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase2.3.1.2020.445
4k5y1Q5Corticotropin-releasing factor receptor 1/0.445
1o8cNDPProbable acrylyl-CoA reductase AcuI1.3.1.840.444
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.444
2bxmIMNSerum albumin/0.444
2hb7O1CVitamin D3 receptor/0.444
3s1cZIRCytokinin dehydrogenase 11.5.99.120.444
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.444
4eevL1XHepatocyte growth factor receptor2.7.10.10.444
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4j6cSTRCytochrome P450 monooxygenase/0.444
4jazSTLPeroxisome proliferator-activated receptor gamma/0.444
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.444
5cvhADPCasein kinase II subunit alpha2.7.11.10.444
1nptNADGlyceraldehyde-3-phosphate dehydrogenase/0.443
1oc1ASVIsopenicillin N synthase1.21.3.10.443
1sejF89Bifunctional dihydrofolate reductase-thymidylate synthase/0.443
2jn3JN3Fatty acid-binding protein, liver/0.443
2rhrEMOPutative ketoacyl reductase1.3.10.443
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.443
4ia1BIVVitamin D3 receptor A/0.443
4iteTEYVitamin D3 receptor/0.443
4j6i1JVPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4jlj1NMDeoxycytidine kinase2.7.1.740.443
4ruoBIVVitamin D3 receptor A/0.443
4tv3ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.443
1e92HBIPteridine reductase 11.5.1.330.442
1nq24HYThyroid hormone receptor beta/0.442
1qrrUPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.442
2vzmNRBCytochrome P450 monooxygenase PikC/0.442
2wugHPK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.442
2xvw9NRSerum albumin/0.442
3eej53RUncharacterized protein/0.442
3mpaSB2Mitogen-activated protein kinase 14/0.442
3nwyGTPUridylate kinase/0.442
3oafOAGDihydrofolate reductase1.5.1.30.442
3p3zP3ZPutative cytochrome P450/0.442
3pm0BHFCytochrome P450 1B1/0.442
3slkNDPPolyketide synthase extender module 2/0.442
3stv3HOMethylketone synthase I/0.442
4dymIYZActivin receptor type-12.7.11.300.442
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.442
4iui1GQEstrogen receptor/0.442
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.442
4o95245Cytokinin dehydrogenase 4/0.442
1kzjCB3Thymidylate synthase/0.441
1mvsDTMDihydrofolate reductase1.5.1.30.441
1rd4L08Integrin alpha-L/0.441
1rk3VDXVitamin D3 receptor/0.441
1s0zEB1Vitamin D3 receptor/0.441
1s3uTQDDihydrofolate reductase1.5.1.30.441
1yw2PGJMitogen-activated protein kinase 14/0.441
2aibERGBeta-elicitin cinnamomin/0.441
2c3qGTXGlutathione S-transferase theta-12.5.1.180.441
2fgjATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.441
2fziDH3Dihydrofolate reductase1.5.1.30.441
2pmdGNPTranslation initiation factor 2 subunit gamma/0.441
3vt3VDXVitamin D3 receptor/0.441
4ipw1G7Mycocyclosin synthase1.14.21.90.441
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.441
4o0mATPCircadian clock protein kinase KaiC2.7.11.10.441
1dz6CAMCamphor 5-monooxygenase1.14.15.10.440
1q4xG24Thyroid hormone receptor beta/0.440
1xddAAYIntegrin alpha-L/0.440
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.440
2harOCCVitamin D3 receptor/0.440
2p7zOHTEstrogen-related receptor gamma/0.440
2yfeYFEPeroxisome proliferator-activated receptor gamma/0.440
3cgeNDPCoenzyme A disulfide reductase/0.440
3jziJZLBiotin carboxylase6.3.4.140.440
3poz03PEpidermal growth factor receptor2.7.10.10.440
3s7a684Dihydrofolate reductase1.5.1.30.440
3vt5YI2Vitamin D3 receptor/0.440
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.440
4cf7ADPAdenylate kinase/0.440
4fhi0S4Vitamin D3 receptor A/0.440
4nmdFDABifunctional protein PutA/0.440
5cu6ATPCasein kinase II subunit alpha2.7.11.10.440