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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4paoGSPGuanine nucleotide-binding protein G(i) subunit alpha-1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4paoGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/1.000
3umsGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.602
1giaGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.596
3qe0GDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.594
1aztGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.581
4panGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.577
3vhxGTPADP-ribosylation factor 6/0.574
3c16GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.569
1gilGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.566
3c15GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.561
1culGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.545
3c14GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.544
1y3aGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.543
2xtzGSPGuanine nucleotide-binding protein alpha-1 subunit/0.543
1cs4GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.538
1u0hGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.537
1bofGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.534
4fidGDPG protein alpha subunit, putative/0.512
1gp2GDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.511
2gvdGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.511
3tjzGNPADP-ribosylation factor 1/0.507
3pcrGTPADP-ribosylation factor 6/0.503
1gotGDPGuanine nucleotide-binding protein G(t) subunit alpha-1/0.500
1n6lGTPRas-related protein Rab-5A/0.496
1ae1NAPTropinone reductase 1/0.485
2q3fGNPRas-related GTP-binding protein D/0.482
2w3bNDPDihydrofolate reductase1.5.1.30.482
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.482
2fe4GDPRas-related protein Rab-6B/0.481
3cx6GDPGuanine nucleotide-binding protein subunit alpha-13/0.480
3d84NDPDihydrofolate reductase1.5.1.30.480
2fg5GNPRas-related protein Rab-31/0.479
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.479
3mjhGTPRas-related protein Rab-5A/0.478
1zd9GDPADP-ribosylation factor-like protein 8A/0.476
3r9xGNPGTPase Era/0.476
5di3GNPADP-ribosylation factor-like protein 3/0.475
4gyy12VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.474
4du82P0Mevalonate diphosphate decarboxylase/0.472
4e07ACPPlasmid partitioning protein ParF/0.472
1qf5RPLAdenylosuccinate synthetase/0.471
1adfTADAlcohol dehydrogenase E chain1.1.1.10.470
5k5zANPUncharacterized protein/0.470
4ambDUDPutative glycosyl transferase/0.469
4jldADPAdenylate kinase/0.469
4uj3GNPRas-related protein Rab-11A/0.469
1m2oGNPSmall COPII coat GTPase SAR13.6.50.468
4wudANPDNA gyrase subunit B/0.468
1ky2GNPGTP-binding protein YPT7/0.467
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.467
1obnASVIsopenicillin N synthase1.21.3.10.467
1ykfNAPNADP-dependent isopropanol dehydrogenase1.1.1.800.467
4oztP1AEcdysone receptor, putative/0.467
1oixGDPRas-related protein Rab-11A/0.466
3pb3SAH16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.466
3q9lATPSeptum site-determining protein MinD/0.466
4hdqGNPRas-related protein Rap-1b/0.466
3f3sNADLambda-crystallin homolog/0.465
3p2eSAH16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.465
4v02ATPSite-determining protein/0.465
1ha3MAUElongation factor Tu-A/0.464
3hyoADPPyridoxal kinase/0.464
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.464
4bb3KKAIsopenicillin N synthase1.21.3.10.464
4gojGNPADP-ribosylation factor-like protein 3/0.464
4ji91M3Tyrosine-protein kinase JAK2/0.464
4o2rGDPGTP-binding protein Rheb/0.464
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.464
1qf4RPDAdenylosuccinate synthetase/0.463
2a94AP0L-lactate dehydrogenase1.1.1.270.463
3f1kNAPUncharacterized oxidoreductase YciK10.463
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.463
3clrFADElectron transfer flavoprotein subunit alpha/0.462
3rabGNPRas-related protein Rab-3A/0.462
4pd6URINucleoside permease/0.462
5ch7MD1DMSO reductase family type II enzyme, molybdopterin subunit/0.462
1okkGCPSignal recognition particle protein/0.461
1okkGCPSignal recognition particle receptor FtsY/0.461
1xddAAYIntegrin alpha-L/0.461
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.461
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.461
2z6cFMNPhototropin-12.7.11.10.461
4lj9ACPChaperone protein ClpB/0.461
2gilGTPRas-related protein Rab-6A/0.460
2y0mACOHistone acetyltransferase KAT8/0.460
3kybFADUDP-galactopyranose mutase5.4.99.90.460
1jq5NADGlycerol dehydrogenase1.1.1.60.459
4wucANPDNA gyrase subunit B/0.459
4y0vGDPADP-ribosylation factor 1, putative/0.459
5jlaNADPutative short-chain dehydrogenase/reductase/0.459
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.458
1t0lNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.458
1tu3GNPRas-related protein Rab-5A/0.458
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.458
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.458
5a3cNADSIR2 family protein/0.458
1piwNAPNADP-dependent alcohol dehydrogenase 61.1.1.20.457
3cluFADElectron transfer flavoprotein subunit alpha/0.457
4e8yIHAD-beta-D-heptose 7-phosphate kinase/0.457
1oc1ASVIsopenicillin N synthase1.21.3.10.456
2z54AB1Gag-Pol polyprotein3.4.23.160.456
3qlrNDPDihydrofolate reductase1.5.1.30.456
4an4DUDPutative glycosyl transferase/0.456
4fv6E57Mitogen-activated protein kinase 12.7.11.240.456
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.455
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.455
2vn0TDZCytochrome P450 2C8/0.455
2y9qANPMitogen-activated protein kinase 12.7.11.240.455
3kkoGNPRas-related protein M-Ras/0.455
2jkvNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.454
2wo7ASVIsopenicillin N synthase1.21.3.10.454
3b70NAPEnoyl reductase LovC10.454
3ge1ADPGlycerol kinase/0.454
3kgcLY7Glutamate receptor 2/0.454
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.454
3tvuB37Acetyl-CoA carboxylase/0.454
4hwkNAPSepiapterin reductase1.1.1.1530.454
4zirANPEnergy-coupling factor transporter ATP-binding protein EcfA23.6.30.454
4zirANPEnergy-coupling factor transporter ATP-binding protein EcfA1/0.454
5l3rGCPCell division protein FtsY homolog, chloroplastic/0.454
1dg8NDPDihydrofolate reductase1.5.1.30.453
2cduFADNADH oxidase/0.453
2pd7FADVivid PAS protein VVD/0.453
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.453
3w2eNADNADH-cytochrome b5 reductase 31.6.2.20.453
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.453
4hj6FMNLOV protein/0.453
4xd2NAIAlcohol dehydrogenase E chain1.1.1.10.453
5cdtNAJAlcohol dehydrogenase E chain1.1.1.10.453
1me6IVSPlasmepsin-23.4.23.390.452
2pr5FMNBlue-light photoreceptor/0.452
3sdkP3NProteasome subunit beta type-53.4.25.10.452
3sdkP3NProteasome subunit beta type-63.4.25.10.452
4dpuAGSMevalonate diphosphate decarboxylase/0.452
4hiaFMNLOV protein/0.452
4loi1YCStimulator of interferon genes protein/0.452
4mihFADPyranose 2-oxidase1.1.3.100.452
1cgpCMPcAMP-activated global transcriptional regulator CRP/0.451
1q0qNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.451
1rj9GCPSignal recognition particle receptor FtsY/0.451
2p9cNAID-3-phosphoglycerate dehydrogenase1.1.1.950.451
2xrlDXTTetracycline repressor protein class D/0.451
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.451
3d3wNAPL-xylulose reductase1.1.1.100.451
3dmeFADPutative conserved exported protein/0.451
3e5hGNPRas-related protein Rab-28/0.451
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.451
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.451
4nxvGDPMitochondrial dynamics protein MID51/0.451
4nxwADPMitochondrial dynamics protein MID51/0.451
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.451
5c46GSPRas-related protein Rab-11A/0.451
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.451
1nzdUPGDNA beta-glucosyltransferase/0.450
1u3cFADCryptochrome-1/0.450
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.450
3b6zCO7Enoyl reductase LovC10.450
3k4nFADPyranose 2-oxidase/0.450
4dzzADPPlasmid partitioning protein ParF/0.450
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.450
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.449
1o8cNDPProbable acrylyl-CoA reductase AcuI1.3.1.840.449
1svwGTPProbable GTP-binding protein EngB/0.449
1yu9GNPRas-related protein Rab-4A/0.449
2c29NAPDihydroflavonol 4-reductase/0.449
2givACOHistone acetyltransferase KAT8/0.449
2q4bNAPUncharacterized protein At5g02240/0.449
2ym1FADPhenylacetone monooxygenase1.14.13.920.449
3is2FADVivid PAS protein VVD/0.449
3uceNDPDehydrogenase/0.449
4cidANPEH domain-containing protein 2/0.449
5dozNDPJamJ/0.449
1hetNADAlcohol dehydrogenase E chain1.1.1.10.448
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.448
1yonA2R2-dehydropantoate 2-reductase1.1.1.1690.448
2b69NADUDP-glucuronic acid decarboxylase 14.1.1.350.448
2fjdSFDAdenylylsulfate reductase, subunit A (AprA)/0.448
2rcyNAPPyrroline-5-carboxylate reductase/0.448
3jvvACPTwitching mobility protein/0.448
3r83Z14Cyclin-dependent kinase 22.7.11.220.448
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.448
4kl9NDPDihydrofolate reductase1.5.1.30.448
4ylgGDPADP-ribosylation factor 1, putative/0.448
5kj1NAJAlcohol dehydrogenase E chain1.1.1.10.448
1dirNADDihydropteridine reductase1.5.1.340.447
1x1rGDPRas-related protein M-Ras/0.447
1xtsGTPGTP-binding protein Rheb/0.447
1z0dGDPRas-related protein Rab-5C/0.447
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.447
2hqpNDPDihydrofolate reductase1.5.1.30.447
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.447
3etdNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.447
3ieuGDPGTPase Era/0.447
3wfjNAD2-dehydropantoate 2-reductase/0.447
4d0lGSPRas-related protein Rab-11A/0.447
2q5g1FAPeroxisome proliferator-activated receptor delta/0.446
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.446
4fv7E94Mitogen-activated protein kinase 12.7.11.240.446
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.446
4wujFMNGlycoside hydrolase family 15, cellulose signaling associated protein envoy/0.446
4yddMD1DMSO reductase family type II enzyme, molybdopterin subunit/0.446
5kczNAJAlcohol dehydrogenase E chain1.1.1.10.446
1dr2TAPDihydrofolate reductase1.5.1.30.445
1hdrNADDihydropteridine reductase1.5.1.340.445
1i8tFADUDP-galactopyranose mutase5.4.99.90.445
1jubFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.445
1nhtPGSAdenylosuccinate synthetase/0.445
1njfAGSDNA polymerase III subunit tau2.7.7.70.445
1w5sADPORC1-type DNA replication protein 2/0.445
1z7yAA5Cysteine synthase 12.5.1.470.445
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
2fj1CTCTetracycline repressor protein class D/0.445
2xhd7T9Glutamate receptor 2/0.445
2xpvMIYTetracycline repressor protein class D/0.445
3clsFADElectron transfer flavoprotein subunit alpha/0.445
3cvuFADRE11660p/0.445
3he3FADUDP-galactopyranose mutase/0.445
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.445
3vfqAR6Poly [ADP-ribose] polymerase 142.4.2.300.445
4djaFAD(6-4) photolyase/0.445
4dxhNAJAlcohol dehydrogenase E chain1.1.1.10.445
4e5yNDPGDP-L-fucose synthase1.1.1.2710.445
4e8wIHAD-beta-D-heptose 7-phosphate kinase/0.445
4qi4FADCellobiose dehydrogenase/0.445
4rgqNDPGlycerol-1-phosphate dehydrogenase [NAD(P)+]/0.445
4z5wILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.445
5kjcNAJAlcohol dehydrogenase E chain1.1.1.10.445
1v0jFADUDP-galactopyranose mutase5.4.99.90.444
2qf2GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.444
2ylzFADPhenylacetone monooxygenase1.14.13.920.444
3gqvNAPEnoyl reductase LovC10.444
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
3rm618ZCyclin-dependent kinase 22.7.11.220.444
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.444
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
4eo3FMNBacterioferritin comigratory protein/NADH dehydrogenase/0.444
4iijGTPTubulin alpha-1B chain/0.444
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.444
4lrjANPUncharacterized protein/0.444
4nd4NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.444
4oagADPMitochondrial dynamics protein MID51/0.444
5dp2NAPCurF/0.444
1dorFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.443
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.443
1p0fNAPNADP-dependent alcohol dehydrogenase1.1.1.20.443
1sq5ADPPantothenate kinase2.7.1.330.443
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.443
1z2aGDPRas-related protein Rab-23/0.443
2hfuMEVMevalonate kinase/0.443
2jih097A disintegrin and metalloproteinase with thrombospondin motifs 13.4.240.443
2oz57XYUncharacterized protein/0.443
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.443
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.443
3mpt1GKMitogen-activated protein kinase 14/0.443
3rypCMPcAMP-activated global transcriptional regulator CRP/0.443
3vs3VSETyrosine-protein kinase HCK2.7.10.20.443
1ipeNDPTropinone reductase 21.1.1.2360.442
1k5dGNPGTP-binding nuclear protein Ran/0.442
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.442
2bueCOAAAC(6')-Ib/0.442
2j3kNAPNADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.442
2q7vFADThioredoxin reductase/0.442
3itzP66Mitogen-activated protein kinase 14/0.442
3k4cFADPyranose 2-oxidase/0.442
3lovFADProtoporphyrinogen oxidase/0.442
4c04SFGProtein arginine N-methyltransferase 6/0.442
4mo2FADUDP-galactopyranose mutase/0.442
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.442
4tlbAGSCircadian clock protein kinase KaiC2.7.11.10.442
5eb5FAD(R)-mandelonitrile lyase 14.1.2.100.442
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.442
5ijzNAPNADP-specific glutamate dehydrogenase1.4.1.40.442
5kjfNAJAlcohol dehydrogenase E chain1.1.1.10.442
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.441
1gqtACPRibokinase/0.441
1ju9NADAlcohol dehydrogenase E chain1.1.1.10.441
1njfADPDNA polymerase III subunit tau2.7.7.70.441
1pj2NAINAD-dependent malic enzyme, mitochondrial1.1.1.380.441
1qo8FADFumarate reductase flavoprotein subunit/0.441
1yb5NAPQuinone oxidoreductase1.6.5.50.441
2hdjNDPAldo-keto reductase family 1 member C2/0.441
2ic5GNPRas-related C3 botulinum toxin substrate 3/0.441
2rirNAPDipicolinate synthase subunit A/0.441
2vbpVB1Isopenicillin N synthase1.21.3.10.441
2zbaZBATrichothecene 3-O-acetyltransferase/0.441
3coy53HPantothenate synthetase6.3.2.10.441
3nxxNDPDihydrofolate reductase1.5.1.30.441
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
3t1tGDPProbable gliding protein mglA/0.441
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.441
4jbiNDPAlcohol dehydrogenase (Zinc)/0.441
4prvADPDNA gyrase subunit B/0.441
4q71FADBifunctional protein PutA/0.441
4tuvCPZCytochrome P450 1191.140.441
4xumIMNPeroxisome proliferator-activated receptor gamma/0.441
5fl3ADPPili retraction protein PilT/0.441
5iu4ZMAAdenosine receptor A2a/0.441
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1lbcCYZGlutamate receptor 2/0.440
1qjfACSIsopenicillin N synthase1.21.3.10.440
1t91GTPRas-related protein Rab-7a/0.440
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.440
2fsvNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.440
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
2xlrFADPutative flavin-containing monooxygenase/0.440
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.440
2zdyADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.440
3u9eCOALmo1369 protein/0.440
3vob9PCCell division protein FtsZ/0.440
4jalSAHtRNA (cytidine(34)-2'-O)-methyltransferase/0.440
4qi5FADCellobiose dehydrogenase/0.440
5iw5NMNNADH pyrophosphatase/0.440