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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4l091URTankyrase-22.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4l091URTankyrase-22.4.2.301.000
4l10A63Tankyrase-22.4.2.300.657
4l2f1V3Tankyrase-22.4.2.300.637
4kzl20DTankyrase-22.4.2.300.634
4hlg20BTankyrase-22.4.2.300.601
4hlf15ZTankyrase-22.4.2.300.600
4buiW2ETankyrase-22.4.2.300.593
4iueAJ4Tankyrase-22.4.2.300.593
4hlm16STankyrase-22.4.2.300.587
4l0v1V1Tankyrase-22.4.2.300.585
4hmhF94Tankyrase-22.4.2.300.584
4l0t1V0Tankyrase-22.4.2.300.582
4l0i1UWTankyrase-22.4.2.300.579
4j21AJ6Tankyrase-22.4.2.300.575
4l31F08Tankyrase-22.4.2.300.572
4j3mAJ8Tankyrase-22.4.2.300.570
4bus32FTankyrase-22.4.2.300.565
4bu908CTankyrase-22.4.2.300.559
3kr8XAVTankyrase-22.4.2.300.558
4j22AJ7Tankyrase-22.4.2.300.557
4bs4A64Tankyrase-22.4.2.300.556
4bueJQFTankyrase-22.4.2.300.555
4l321VFTankyrase-22.4.2.300.555
4hlh20DTankyrase-22.4.2.300.551
3p0pNNFTankyrase-22.4.2.300.549
4l341VGTankyrase-22.4.2.300.549
4l0s1UZTankyrase-22.4.2.300.547
4buwF33Tankyrase-22.4.2.300.546
4buxF35Tankyrase-22.4.2.300.546
3u9y09LTankyrase-22.4.2.300.545
4krs1SXTankyrase-12.4.2.300.545
4avwG18Tankyrase-22.4.2.300.541
4hknLU2Tankyrase-22.4.2.300.540
4buuF38Tankyrase-22.4.2.300.538
4hlk431Tankyrase-22.4.2.300.538
4j3lAJ5Tankyrase-22.4.2.300.538
4bufF36Tankyrase-22.4.2.300.533
4buv16ITankyrase-22.4.2.300.528
4hl515WTankyrase-22.4.2.300.526
4pnrG18Tankyrase-22.4.2.300.525
4kzuA73Tankyrase-22.4.2.300.522
4l33F70Tankyrase-22.4.2.300.522
4bj9UHBTankyrase-22.4.2.300.520
5aku29FTankyrase-22.4.2.300.518
4l2g1V4Tankyrase-22.4.2.300.512
4pnmNU1Tankyrase-22.4.2.300.509
4bud29FTankyrase-22.4.2.300.507
4l2k1V8Tankyrase-22.4.2.300.505
4tkg09LTankyrase-22.4.2.300.504
4but31FTankyrase-22.4.2.300.498
4hkiFLNTankyrase-22.4.2.300.498
3wqmB29Diterpene synthase3.1.7.80.497
1lnmDTXBilin-binding protein/0.488
4bjbP34Tankyrase-22.4.2.300.485
4avuLDRTankyrase-22.4.2.300.482
1sweBTNStreptavidin/0.481
1zprCB3Thymidylate synthase/0.478
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.477
4msk2C8Tankyrase-12.4.2.300.477
3lkhLT6Genome polyprotein2.7.7.480.476
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.475
2zi63D1Deoxycytidine kinase2.7.1.740.475
3zkyWT4Isopenicillin N synthase1.21.3.10.475
1lkeDOGBilin-binding protein/0.473
1r5hAO2Methionine aminopeptidase 2/0.472
2hdjNDPAldo-keto reductase family 1 member C2/0.472
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.472
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.472
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.472
2y6fM9FIsopenicillin N synthase1.21.3.10.470
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.470
1ygkRRCPyridoxal kinase2.7.1.350.469
3zoiM2WIsopenicillin N synthase1.21.3.10.469
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.468
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.468
3d5qT30Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.468
1bk0ACVIsopenicillin N synthase1.21.3.10.467
1yhjR6CPyridoxal kinase2.7.1.350.467
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.467
4bjcRPBTankyrase-22.4.2.300.467
1pz1NAPGeneral stress protein 69/0.466
2jb4A14Isopenicillin N synthase1.21.3.10.466
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.465
1wl4COAAcetyl-CoA acetyltransferase, cytosolic2.3.1.90.465
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.465
2vbpVB1Isopenicillin N synthase1.21.3.10.464
3h4vDVPPteridine reductase 11.5.1.330.464
2oatPFMOrnithine aminotransferase, mitochondrial2.6.1.130.463
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.463
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.463
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.463
4b63FADL-ornithine N(5)-monooxygenase/0.463
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.463
1oc1ASVIsopenicillin N synthase1.21.3.10.462
3ai0PNWBeta-glucosidase/0.462
3c3xNAPEugenol synthase 11.1.1.3180.462
3pqbVGPPutative oxidoreductase/0.462
4bb3KKAIsopenicillin N synthase1.21.3.10.462
4l1xNAPAldo-keto reductase family 1 member C2/0.462
4mt92D6Tankyrase-12.4.2.300.462
4o6fSAHN-lysine methyltransferase SMYD2/0.462
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.461
2bu9HFVIsopenicillin N synthase1.21.3.10.461
3p82FMNPentaerythritol tetranitrate reductase/0.461
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.461
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.461
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.460
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
3zhtTD9Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.460
1hb3SCVIsopenicillin N synthase1.21.3.10.459
2clmF6FTryptophan synthase alpha chain/0.459
4jtqNAPAldo-keto reductase family 1 member C2/0.459
1h36R88Squalene--hopene cyclase4.2.1.1290.458
1n9mBTNStreptavidin/0.458
2iviACWIsopenicillin N synthase1.21.3.10.458
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.458
1obnASVIsopenicillin N synthase1.21.3.10.457
1txtCAAHMG-CoA synthase/0.457
2h3wHC5Carnitine O-acetyltransferase2.3.1.70.457
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.457
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.457
1x1cSAHC-20 methyltransferase/0.456
2ed3SAHDiphthine synthase/0.456
2g8yNADHydroxycarboxylate dehydrogenase B/0.456
3bgsDIHPurine nucleoside phosphorylase2.4.2.10.456
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.456
1ja1FMNNADPH--cytochrome P450 reductase/0.455
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.455
1rzuADPGlycogen synthase 12.4.1.210.455
3h59H59Genome polyprotein2.7.7.480.455
4e32DWNMethyltransferase/0.455
4eqsCOACoenzyme A disulfide reductase/0.455
1fmlRTLRetinol dehydratase/0.454
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.454
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.454
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.454
4tjy3GNTankyrase-22.4.2.300.454
1c7oPPGHemolysin/0.453
1me6IVSPlasmepsin-23.4.23.390.453
1t3zCAOFormyl-CoA:oxalate CoA-transferase/0.453
2fk8SAMHydroxymycolate synthase MmaA42.1.10.453
3jziJZLBiotin carboxylase6.3.4.140.453
3qe2FMNNADPH--cytochrome P450 reductase/0.453
4fqsLYAThymidylate synthase ThyA/0.453
1jdzFMBPurine nucleoside phosphorylase/0.452
1qjfACSIsopenicillin N synthase1.21.3.10.452
1sdwIYTPeptidyl-glycine alpha-amidating monooxygenase1.14.17.30.452
1xk9P34Exotoxin A2.4.2.360.452
2gjlFMNNitronate monooxygenase1.13.12.160.452
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.452
4eqwCOACoenzyme A disulfide reductase/0.452
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.452
4knzCB3Thymidylate synthase/0.452
4xo7NAPAldo-keto reductase family 1 member C2/0.452
1hb1OCVIsopenicillin N synthase1.21.3.10.451
1k7fIAVTryptophan synthase alpha chain/0.451
3tp0FO5HTH-type transcriptional regulator EthR/0.451
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.451
1blzACVIsopenicillin N synthase1.21.3.10.450
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.450
1zdwFLVPrenyltransferase/0.450
2vbdV10Isopenicillin N synthase1.21.3.10.450
3h3qH13Collagen type IV alpha-3-binding protein/0.450
3qrwNDPPutative ketoacyl reductase1.3.10.450
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.450
4bfvZVVPantothenate kinase2.7.1.330.450
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.449
1ut6A8NAcetylcholinesterase3.1.1.70.449
1z6tADPApoptotic protease-activating factor 1/0.449
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.449
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.449
3p0eBAUUridine phosphorylase 22.4.2.30.449
4xrgNADHomospermidine synthase2.5.1.440.449
5g53NECAdenosine receptor A2a/0.449
2eeqSAHDiphthine synthase/0.448
2ozrGG1Collagenase 33.4.240.448
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.448
4eqrCOACoenzyme A disulfide reductase/0.448
4f32N323-oxoacyl-[acyl-carrier-protein] synthase 2/0.448
4jq3NAPAldo-keto reductase family 1 member C2/0.448
5eghPCEctonucleotide pyrophosphatase/phosphodiesterase family member 6/0.448
5fm7ADPRuvB-like helicase/0.448
1qiqACCIsopenicillin N synthase1.21.3.10.447
1qorNDPQuinone oxidoreductase 1/0.447
1re0AFBADP-ribosylation factor 1/0.447
1re0AFBARF guanine-nucleotide exchange factor 1/0.447
1x1aSAMC-20 methyltransferase/0.447
2gv8NDPThiol-specific monooxygenase1.14.130.447
2h63NAPBiliverdin reductase A1.3.1.240.447
2x7hPFNProstaglandin reductase 310.447
2zitNADExotoxin A2.4.2.360.447
3udj092Beta-secretase 13.4.23.460.447
4cf6CBDNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1qr2FADRibosyldihydronicotinamide dehydrogenase [quinone]/0.446
1xudPB4Collagenase 33.4.240.446
2bf7HBIPteridine reductase 11.5.1.330.446
2fhnBNIAvidin-related protein 4/5/0.446
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
2hp2KE4Glutamate-1-semialdehyde 2,1-aminomutase5.4.3.80.446
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.446
2w4qCBWProstaglandin reductase 21.3.1.480.446
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.446
3q43D66M1 family aminopeptidase3.4.110.446
3zhvTDWMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.446
4ejmNAPPutative zinc-binding dehydrogenase/0.446
1w06W05Isopenicillin N synthase1.21.3.10.445
2e1zB4PPropionate kinase/0.445
2uywBTNAvd protein/0.445
2wo7ASVIsopenicillin N synthase1.21.3.10.445
2ywlFADThioredoxin reductase related protein/0.445
2zscBTNTamavidin2/0.445
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.445
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.445
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.445
1n43BTNStreptavidin/0.444
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.444
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3b9oFMNAlkane monoxygenase/0.444
3cr0809Wee1-like protein kinase2.7.10.20.444
3reoSAH(Iso)eugenol O-methyltransferase2.1.1.1460.444
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
1kvrNADUDP-glucose 4-epimerase5.1.3.20.443
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.443
1txzAPRProbable ADP-ribose 1''-phosphate phosphatase YML087W3.1.3.840.443
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.443
2cvzNDP3-hydroxyisobutyrate dehydrogenase/0.443
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.443
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3hkyIX6Genome polyprotein2.7.7.480.443
4qofFMNRibosyldihydronicotinamide dehydrogenase [quinone]/0.443
5c3jFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.443
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.442
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.442
3arvSAUChitinase A/0.442
3h3sH15Collagen type IV alpha-3-binding protein/0.442
3h3t16HCollagen type IV alpha-3-binding protein/0.442
3jynNDPQuinone oxidoreductase/0.442
3tm5SFGUncharacterized protein/0.442
4cdmFO1Deoxyribodipyrimidine photolyase/0.442
4gl4NAIAlcohol dehydrogenase class-3/0.442
4rvgTYDD-mycarose 3-C-methyltransferase/0.442
5irnADPNucleotide binding oligomerization domain containing 2/0.442
1mp0NADAlcohol dehydrogenase class-31.1.1.10.441
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.441
1nsgRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.441
1nsgRADSerine/threonine-protein kinase mTOR2.7.11.10.441
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.441
1vbiNADMalate/L-lactate dehydrogenase family protein/0.441
1wp4NDP3-hydroxyisobutyrate dehydrogenase/0.441
2bfrADP[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.441
2r8oT5XTransketolase 1/0.441
2xlrFADPutative flavin-containing monooxygenase/0.441
3eq6BCOAcyl-coenzyme A synthetase ACSM2A, mitochondrial6.2.1.20.441
4dvi2IWTankyrase-12.4.2.300.441
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.441
4nmcFADBifunctional protein PutA/0.441
4r81FMNPredicted NADH dehydrogenase/0.441
4u0mGTPCyclic GMP-AMP synthase/0.441
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.441
4xwtU5PRibonuclease J/0.441
5jqhCAUBeta-2 adrenergic receptor/0.441
1n3sGTPGTP cyclohydrolase 13.5.4.160.440
2fj1CTCTetracycline repressor protein class D/0.440
2fxuBIDActin, alpha skeletal muscle/0.440
2ikuLIYRenin3.4.23.150.440
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.440
2uxoTACHTH-type transcriptional regulator TtgR/0.440
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.440
2zrzFNRIsopentenyl-diphosphate delta-isomerase/0.440
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.440
4bv9NDPKetimine reductase mu-crystallin1.5.1.250.440
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.440
4djy0KRBeta-secretase 13.4.23.460.440
4eu8COASuccinyl-CoA:acetate CoA-transferase/0.440
4l0qNADAlcohol dehydrogenase class-3/0.440
4li81XQTankyrase-12.4.2.300.440
4q71FADBifunctional protein PutA/0.440