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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fkr45KCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fkr45KCyclin-dependent kinase 22.7.11.221.000
3s2pPMUCyclin-dependent kinase 22.7.11.220.631
1w0xOLOCyclin-dependent kinase 22.7.11.220.620
3rak03ZCyclin-dependent kinase 22.7.11.220.611
2w06FRVCyclin-dependent kinase 22.7.11.220.604
3qu0X40Cyclin-dependent kinase 22.7.11.220.600
3sw418KCyclin-dependent kinase 22.7.11.220.595
3s1h56ZCyclin-dependent kinase 22.7.11.220.590
4acm7YGCyclin-dependent kinase 22.7.11.220.590
4fkv61KCyclin-dependent kinase 22.7.11.220.589
3qtzX42Cyclin-dependent kinase 22.7.11.220.587
3rmf20ZCyclin-dependent kinase 22.7.11.220.586
3ti1B49Cyclin-dependent kinase 22.7.11.220.582
3r9dX6BCyclin-dependent kinase 22.7.11.220.576
2r64740Cyclin-dependent kinase 22.7.11.220.575
4fkw62KCyclin-dependent kinase 22.7.11.220.571
3r71X86Cyclin-dependent kinase 22.7.11.220.569
4fkq42KCyclin-dependent kinase 22.7.11.220.568
3r8lZ30Cyclin-dependent kinase 22.7.11.220.567
3ral04ZCyclin-dependent kinase 22.7.11.220.567
3rk507ZCyclin-dependent kinase 22.7.11.220.565
1urwI1PCyclin-dependent kinase 22.7.11.220.562
3rpv26ZCyclin-dependent kinase 22.7.11.220.562
1oitHDTCyclin-dependent kinase 22.7.11.220.561
2c6iDT1Cyclin-dependent kinase 22.7.11.220.561
2r3iSCFCyclin-dependent kinase 22.7.11.220.560
3rk708ZCyclin-dependent kinase 22.7.11.220.559
1ke7LS3Cyclin-dependent kinase 22.7.11.220.557
1pxmCK5Cyclin-dependent kinase 22.7.11.220.557
4fkt48KCyclin-dependent kinase 22.7.11.220.557
3r73X87Cyclin-dependent kinase 22.7.11.220.556
2r3lSCWCyclin-dependent kinase 22.7.11.220.555
1p2a5BNCyclin-dependent kinase 22.7.11.220.554
2w1hL0FCyclin-dependent kinase 22.7.11.220.554
4ek816KCyclin-dependent kinase 22.7.11.220.553
3qxoX65Cyclin-dependent kinase 22.7.11.220.552
3rni21ZCyclin-dependent kinase 22.7.11.220.552
1ke6LS2Cyclin-dependent kinase 22.7.11.220.550
3qtxX43Cyclin-dependent kinase 22.7.11.220.550
1di8DTQCyclin-dependent kinase 22.7.11.220.548
2r3kSCQCyclin-dependent kinase 22.7.11.220.548
3r9oZ71Cyclin-dependent kinase 22.7.11.220.548
4bgh3I6Cyclin-dependent kinase 22.7.11.220.548
3qzhX69Cyclin-dependent kinase 22.7.11.220.547
4fks46KCyclin-dependent kinase 22.7.11.220.547
2c6o4SPCyclin-dependent kinase 22.7.11.220.546
3lfnA27Cyclin-dependent kinase 22.7.11.220.546
3sqq99ZCyclin-dependent kinase 22.7.11.220.546
2j9mPY8Cyclin-dependent kinase 22.7.11.220.545
3qxpX64Cyclin-dependent kinase 22.7.11.220.545
3rjc06ZCyclin-dependent kinase 22.7.11.220.543
3r7uX96Cyclin-dependent kinase 22.7.11.220.539
3rkb12ZCyclin-dependent kinase 22.7.11.220.539
3roy22ZCyclin-dependent kinase 22.7.11.220.539
2w17I19Cyclin-dependent kinase 22.7.11.220.538
4erwSTUCyclin-dependent kinase 22.7.11.220.538
2r3o2SCCyclin-dependent kinase 22.7.11.220.537
1y91CT9Cyclin-dependent kinase 22.7.11.220.535
2vv9IM9Cyclin-dependent kinase 22.7.11.220.535
3r7iX9ICyclin-dependent kinase 22.7.11.220.535
3sw719KCyclin-dependent kinase 22.7.11.220.535
2w05FRTCyclin-dependent kinase 22.7.11.220.534
3qtuX44Cyclin-dependent kinase 22.7.11.220.534
3r7vZ02Cyclin-dependent kinase 22.7.11.220.533
1gih1PUCyclin-dependent kinase 22.7.11.220.532
1g5sI17Cyclin-dependent kinase 22.7.11.220.531
2a0cCK9Cyclin-dependent kinase 22.7.11.220.531
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.530
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.530
3qqkX02Cyclin-dependent kinase 22.7.11.220.530
1fvv107Cyclin-dependent kinase 22.7.11.220.529
3r7yZ04Cyclin-dependent kinase 22.7.11.220.529
1oiyN41Cyclin-dependent kinase 22.7.11.220.528
2r3p3SCCyclin-dependent kinase 22.7.11.220.527
2uzoC62Cyclin-dependent kinase 22.7.11.220.527
3rm719ZCyclin-dependent kinase 22.7.11.220.527
1v1k3FPCyclin-dependent kinase 22.7.11.220.526
1h1s4SPCyclin-dependent kinase 22.7.11.220.523
1ke9LS5Cyclin-dependent kinase 22.7.11.220.523
1pxlCK4Cyclin-dependent kinase 22.7.11.220.523
1fvt106Cyclin-dependent kinase 22.7.11.220.522
1oiqHDUCyclin-dependent kinase 22.7.11.220.522
3r1sX73Cyclin-dependent kinase 22.7.11.220.522
3rpy27ZCyclin-dependent kinase 22.7.11.220.522
3iggEFQCyclin-dependent kinase 22.7.11.220.521
4fkpLS5Cyclin-dependent kinase 22.7.11.220.521
1oguST8Cyclin-dependent kinase 22.7.11.220.520
2iw84SPCyclin-dependent kinase 22.7.11.220.520
3unk0BYCyclin-dependent kinase 22.7.11.220.520
3unj0BXCyclin-dependent kinase 22.7.11.220.519
4fx360KCyclin-dependent kinase 22.7.11.220.519
2b52D42Cyclin-dependent kinase 22.7.11.220.518
3ezvEZVCyclin-dependent kinase 22.7.11.220.518
3r6xX84Cyclin-dependent kinase 22.7.11.220.518
3rpo24ZCyclin-dependent kinase 22.7.11.220.518
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.517
3qruX19Cyclin-dependent kinase 22.7.11.220.517
1ckpPVBCyclin-dependent kinase 22.7.11.220.516
1h1r6CPCyclin-dependent kinase 22.7.11.220.516
3ddpRC8Cyclin-dependent kinase 22.7.11.220.516
3qwjX6ACyclin-dependent kinase 22.7.11.220.516
3qwkX62Cyclin-dependent kinase 22.7.11.220.516
2r3mSCXCyclin-dependent kinase 22.7.11.220.515
3r1yX76Cyclin-dependent kinase 22.7.11.220.515
3rm618ZCyclin-dependent kinase 22.7.11.220.515
1ke5LS1Cyclin-dependent kinase 22.7.11.220.514
1ykr628Cyclin-dependent kinase 22.7.11.220.514
3wblPDYCyclin-dependent kinase 22.7.11.220.514
2wihP48Cyclin-dependent kinase 22.7.11.220.513
3qtrX36Cyclin-dependent kinase 22.7.11.220.513
3r83Z14Cyclin-dependent kinase 22.7.11.220.513
2vttLZDCyclin-dependent kinase 22.7.11.220.512
3qqfX07Cyclin-dependent kinase 22.7.11.220.512
1oirHDYCyclin-dependent kinase 22.7.11.220.511
2xmyCDKCyclin-dependent kinase 22.7.11.220.511
3qx2X63Cyclin-dependent kinase 22.7.11.220.511
4fko20KCyclin-dependent kinase 22.7.11.220.511
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.510
2bheBRYCyclin-dependent kinase 22.7.11.220.509
2r3jSCJCyclin-dependent kinase 22.7.11.220.509
2uznC96Cyclin-dependent kinase 22.7.11.220.509
3pj8404Cyclin-dependent kinase 22.7.11.220.509
3rk909ZCyclin-dependent kinase 22.7.11.220.509
3py0SU9Cyclin-dependent kinase 22.7.11.220.508
4eor4SPCyclin-dependent kinase 22.7.11.220.508
4qmpDKISerine/threonine-protein kinase 242.7.11.10.508
1pxpCK8Cyclin-dependent kinase 22.7.11.220.507
3le62BZCyclin-dependent kinase 22.7.11.220.507
3r9hZ67Cyclin-dependent kinase 22.7.11.220.506
4fki09KCyclin-dependent kinase 22.7.11.220.506
1oi9N20Cyclin-dependent kinase 22.7.11.220.505
2c6lDT4Cyclin-dependent kinase 22.7.11.220.505
3ddqRRCCyclin-dependent kinase 22.7.11.220.505
3raiX85Cyclin-dependent kinase 22.7.11.220.505
4fkg4CKCyclin-dependent kinase 22.7.11.220.505
2btrU73Cyclin-dependent kinase 22.7.11.220.504
3qqhX0ACyclin-dependent kinase 22.7.11.220.504
4eok4SPCyclin-dependent kinase 22.7.11.220.504
3r1qX75Cyclin-dependent kinase 22.7.11.220.502
1vyzN5BCyclin-dependent kinase 22.7.11.220.501
2x1nX1NCyclin-dependent kinase 22.7.11.220.501
3lfsA07Cyclin-dependent kinase 22.7.11.220.501
3r9nZ68Cyclin-dependent kinase 22.7.11.220.501
3uli1N3Cyclin-dependent kinase 22.7.11.220.501
4ek610KCyclin-dependent kinase 22.7.11.220.501
1pxkCK3Cyclin-dependent kinase 22.7.11.220.500
2b53D23Cyclin-dependent kinase 22.7.11.220.500
2bhhRYUCyclin-dependent kinase 22.7.11.220.500
2wxvWXVCyclin-dependent kinase 22.7.11.220.500
3lfqA28Cyclin-dependent kinase 22.7.11.220.500
3r7eX88Cyclin-dependent kinase 22.7.11.220.500
3s0o50ZCyclin-dependent kinase 22.7.11.220.500
1dm2HMDCyclin-dependent kinase 22.7.11.220.499
2fvdLIACyclin-dependent kinase 22.7.11.220.499
3qziX72Cyclin-dependent kinase 22.7.11.220.499
1e9hINRCyclin-dependent kinase 22.7.11.220.498
2duv371Cyclin-dependent kinase 22.7.11.220.498
2vtsLZCCyclin-dependent kinase 22.7.11.220.498
2wpa889Cyclin-dependent kinase 22.7.11.220.498
3ezrEZRCyclin-dependent kinase 22.7.11.220.498
3qzfX66Cyclin-dependent kinase 22.7.11.220.498
4ez30S0Cyclin-dependent kinase 22.7.11.220.497
3rahO1ZCyclin-dependent kinase 22.7.11.220.496
2r3r6SCCyclin-dependent kinase 22.7.11.220.495
3fz1B98Cyclin-dependent kinase 22.7.11.220.495
1aq1STUCyclin-dependent kinase 22.7.11.220.494
3tiz3TICyclin-dependent kinase 22.7.11.220.494
1gii1PUCyclin-dependent kinase 22.7.11.220.493
3qqlX03Cyclin-dependent kinase 22.7.11.220.493
1pyePM1Cyclin-dependent kinase 22.7.11.220.491
2r3fSC8Cyclin-dependent kinase 22.7.11.220.491
1ke8LS4Cyclin-dependent kinase 22.7.11.220.490
3qzgX67Cyclin-dependent kinase 22.7.11.220.490
4bcpT3CCyclin-dependent kinase 22.7.11.220.490
1vyw292Cyclin-dependent kinase 22.7.11.220.488
3ig7EFPCyclin-dependent kinase 22.7.11.220.488
3ql8X01Cyclin-dependent kinase 22.7.11.220.488
2a4lRRCCyclin-dependent kinase 22.7.11.220.487
2eufLQQCyclin-dependent kinase 62.7.11.220.487
2b55D31Cyclin-dependent kinase 22.7.11.220.486
2btsU32Cyclin-dependent kinase 22.7.11.220.486
2vu3LZECyclin-dependent kinase 22.7.11.220.486
2c6tDT5Cyclin-dependent kinase 22.7.11.220.485
4kd11QKCyclin-dependent kinase 22.7.11.220.485
2r3q5SCCyclin-dependent kinase 22.7.11.220.484
3qtwX3ACyclin-dependent kinase 22.7.11.220.484
1h0w207Cyclin-dependent kinase 22.7.11.220.483
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.483
5dr6SKEAurora kinase A2.7.11.10.482
2r3gSC9Cyclin-dependent kinase 22.7.11.220.481
3r8vZ62Cyclin-dependent kinase 22.7.11.220.481
4lyn1YGCyclin-dependent kinase 22.7.11.220.481
1w8cN69Cyclin-dependent kinase 22.7.11.220.480
3ggfGVDSerine/threonine-protein kinase 26/0.479
3pxyJWSCyclin-dependent kinase 22.7.11.220.479
2uzlC94Cyclin-dependent kinase 22.7.11.220.478
3r8pZ46Cyclin-dependent kinase 22.7.11.220.478
2vthLZ2Cyclin-dependent kinase 22.7.11.220.477
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.477
1pxoCK7Cyclin-dependent kinase 22.7.11.220.476
2c5yMTWCyclin-dependent kinase 22.7.11.220.476
3dogNNNCyclin-dependent kinase 22.7.11.220.476
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.475
1unlRRCCyclin-dependent-like kinase 52.7.11.10.474
3r28XA0Cyclin-dependent kinase 22.7.11.220.474
3r8zZ63Cyclin-dependent kinase 22.7.11.220.472
4bcmT7ZCyclin-dependent kinase 22.7.11.220.472
4bcnT9NCyclin-dependent kinase 22.7.11.220.472
2dwbANPAurora kinase A2.7.11.10.471
2iw94SPCyclin-dependent kinase 22.7.11.220.469
3s00Z60Cyclin-dependent kinase 22.7.11.220.469
1oiuN76Cyclin-dependent kinase 22.7.11.220.467
2b54D05Cyclin-dependent kinase 22.7.11.220.467
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.467
2pvnP63Casein kinase II subunit alpha2.7.11.10.467
3gxlQIGTGF-beta receptor type-12.7.11.300.466
1gij2PUCyclin-dependent kinase 22.7.11.220.465
1pkdUCNCyclin-dependent kinase 22.7.11.220.465
3be9P04Casein kinase II subunit alpha2.7.11.10.465
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.464
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.464
2c6kDT2Cyclin-dependent kinase 22.7.11.220.463
2c6mDT5Cyclin-dependent kinase 22.7.11.220.463
2cchATPCyclin-dependent kinase 22.7.11.220.463
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.462
3qtqX35Cyclin-dependent kinase 22.7.11.220.461
4au8Z3RCyclin-dependent-like kinase 52.7.11.10.460
1y8yCT7Cyclin-dependent kinase 22.7.11.220.459
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.459
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.459
2i40BLZCyclin-dependent kinase 22.7.11.220.458
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.458
2b7aIZATyrosine-protein kinase JAK2/0.456
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.456
4eon1ROCyclin-dependent kinase 22.7.11.220.456
5dr9SKEAurora kinase A2.7.11.10.456
5dt0SKEAurora kinase A2.7.11.10.456
1v0oINRCell division control protein 2 homolog2.7.11.220.455
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.455
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.454
4fkj11KCyclin-dependent kinase 22.7.11.220.454
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.454
2uzeC95Cyclin-dependent kinase 22.7.11.220.453
3qrtX14Cyclin-dependent kinase 22.7.11.220.453
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.453
3tnwF18Cyclin-dependent kinase 22.7.11.220.453
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.452
1xjdSTUProtein kinase C theta type2.7.11.130.451
2c69CT8Cyclin-dependent kinase 22.7.11.220.451
2uzbC75Cyclin-dependent kinase 22.7.11.220.451
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4eol1ROCyclin-dependent kinase 22.7.11.220.451
4eos1ROCyclin-dependent kinase 22.7.11.220.451
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.451
1h1pCMGCyclin-dependent kinase 22.7.11.220.450
1h1q2A6Cyclin-dependent kinase 22.7.11.220.450
2c5nCK8Cyclin-dependent kinase 22.7.11.220.450
4aqc88ATyrosine-protein kinase JAK2/0.450
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.450
5dpvSKEAurora kinase A2.7.11.10.450
2vtrLZBCyclin-dependent kinase 22.7.11.220.449
1r78FMDCyclin-dependent kinase 22.7.11.220.448
2p83MR0Beta-secretase 13.4.23.460.448
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.448
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.447
3rzb02ZCyclin-dependent kinase 22.7.11.220.447
1dawANPCasein kinase II subunit alpha2.7.11.10.446
2uzdC85Cyclin-dependent kinase 22.7.11.220.446
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.446
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.446
3sheI85MAP kinase-activated protein kinase 32.7.11.10.446
3at4CCKCasein kinase II subunit alpha2.7.11.10.445
3t3c017Gag-Pol polyprotein3.4.23.160.445
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.445
4btjATPTau-tubulin kinase 12.7.11.10.445
4gmy0X5Tyrosine-protein kinase JAK2/0.445
2zdt46CMitogen-activated protein kinase 102.7.11.240.444
3pe2E1BCasein kinase II subunit alpha2.7.11.10.444
1kkq471Peroxisome proliferator-activated receptor alpha/0.443
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.443
5e8wSTUTGF-beta receptor type-12.7.11.300.443
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3eljGS7Mitogen-activated protein kinase 82.7.11.240.442
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.442
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.442
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.442
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.442
2bkzSBCCyclin-dependent kinase 22.7.11.220.441
2p33J07Mitogen-activated protein kinase 102.7.11.240.441
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.440
1tj2FADBifunctional protein PutA1.5.5.20.440
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.440
2xnbY8LCyclin-dependent kinase 22.7.11.220.440
3cgfJNFMitogen-activated protein kinase 102.7.11.240.440
3hazFADBifunctional protein PutA/0.440
3k5uPFQAurora kinase A2.7.11.10.440
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.440