sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4dsc | A8S | Abscisic acid receptor PYL3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 1.000 | |
| 4dsb | A8S | Abscisic acid receptor PYL3 | / | 0.602 | |
| 3njo | P2M | Abscisic acid receptor PYR1 | / | 0.601 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.579 | |
| 4jda | A9S | Abscisic acid receptor PYL3 | / | 0.573 | |
| 3ujl | A8S | Abscisic acid receptor PYL2 | / | 0.564 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.562 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.562 | |
| 3r6p | A8S | Abscisic acid receptor PYL10 | / | 0.558 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.554 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.548 | |
| 3kdi | A8S | Abscisic acid receptor PYL2 | / | 0.517 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.517 | |
| 3kb0 | A8S | Abscisic acid receptor PYL2 | / | 0.509 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.504 | |
| 3nef | PYV | Abscisic acid receptor PYL1 | / | 0.502 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.500 | |
| 3kb3 | A8S | Abscisic acid receptor PYL2 | / | 0.500 | |
| 3nmh | PYV | Abscisic acid receptor PYL2 | / | 0.500 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.499 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.497 | |
| 3w9r | A8S | Abscisic acid receptor PYL9 | / | 0.496 | |
| 4oic | A8S | Bet v I allergen-like | / | 0.496 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.495 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.494 | |
| 3nmn | PYV | Abscisic acid receptor PYL1 | / | 0.494 | |
| 3oqu | A8S | Abscisic acid receptor PYL9 | / | 0.494 | |
| 3zvu | A8S | Abscisic acid receptor PYR1 | / | 0.494 | |
| 3h6k | 33T | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.493 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.488 | |
| 4ds8 | A8S | Abscisic acid receptor PYL3 | / | 0.488 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.488 | |
| 1xu7 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.487 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.487 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.486 | |
| 2bel | CBO | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.485 | |
| 4lg5 | A1O | Abscisic acid receptor PYL2 | / | 0.485 | |
| 4lga | A2O | Abscisic acid receptor PYL2 | / | 0.484 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.483 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.482 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.482 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.481 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.479 | |
| 3k3k | A8S | Abscisic acid receptor PYR1 | / | 0.479 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.479 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.478 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.478 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.478 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.477 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.477 | |
| 3cxh | SMA | Cytochrome b | / | 0.476 | |
| 3qn1 | A8S | Abscisic acid receptor PYR1 | / | 0.476 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.476 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.476 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.476 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.475 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.475 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.475 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.474 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.474 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.474 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.474 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.473 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.473 | |
| 3h1j | SMA | Cytochrome b | / | 0.473 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.473 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.473 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.472 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.471 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.471 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 1m9k | 7NI | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.470 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.470 | |
| 1tlc | F89 | Thymidylate synthase | / | 0.470 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.470 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.470 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
| 2f4j | VX6 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.469 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.469 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.468 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.468 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.468 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.468 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.468 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.468 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.468 | |
| 3ey4 | 352 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.467 | |
| 3kdj | A8S | Abscisic acid receptor PYL1 | / | 0.467 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.467 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.467 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.467 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.467 | |
| 2q7g | CCL | Pyrrolysine--tRNA ligase | / | 0.466 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.466 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.466 | |
| 3irx | UDR | Gag-Pol polyprotein | 2.7.7.49 | 0.466 | |
| 3l70 | JZV | Cytochrome b | / | 0.466 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.466 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.466 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.466 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.465 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.465 | |
| 2wle | COA | Polysialic acid O-acetyltransferase | / | 0.464 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.464 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.464 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.464 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.463 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.463 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.463 | |
| 3k90 | A8S | Abscisic acid receptor PYR1 | / | 0.463 | |
| 3mee | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.463 | |
| 1e3v | DXC | Steroid Delta-isomerase | 5.3.3.1 | 0.462 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.462 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.462 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.462 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.462 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.462 | |
| 1lco | PPY | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.461 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.461 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.461 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.461 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.461 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.460 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 3qly | 55V | Uncharacterized protein | / | 0.460 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.460 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.460 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.460 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.460 | |
| 4f70 | 0ST | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.460 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.460 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.459 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.459 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.458 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.458 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 3dl9 | V2H | Vitamin D 25-hydroxylase | / | 0.458 | |
| 3iw5 | DF3 | Mitogen-activated protein kinase 14 | / | 0.458 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.458 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.458 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.458 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.458 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1nbm | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.457 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.457 | |
| 2itt | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.457 | |
| 3l08 | ZIG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.457 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.457 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.457 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.457 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.456 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.456 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.456 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.456 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.456 | |
| 4f1s | F1S | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.456 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.456 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.455 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2e9c | B75 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.455 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.455 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.455 | |
| 2imk | GTX | AGAP009194-PA | / | 0.455 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.455 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.455 | |
| 3fgo | CZA | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.455 | |
| 3i0r | RT3 | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.455 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.455 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.455 | |
| 4i7f | NVE | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 4jlt | 8PR | Cytochrome P450 2B4 | 1.14.14.1 | 0.455 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.455 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 1kb9 | SMA | Cytochrome b | / | 0.454 | |
| 1kyz | FER | Caffeic acid 3-O-methyltransferase | 2.1.1.68 | 0.454 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 1q4x | G24 | Thyroid hormone receptor beta | / | 0.454 | |
| 2bik | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.454 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3dei | RXB | Caspase-3 | 3.4.22.56 | 0.454 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.454 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.454 | |
| 3tgu | WF3 | Cytochrome b | / | 0.454 | |
| 3ubd | SL0 | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.454 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.454 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.454 | |
| 3w5q | 3KL | Vitamin D3 receptor | / | 0.454 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.454 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.454 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.454 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.454 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.454 | |
| 1ysx | 4EB | Serum albumin | / | 0.453 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.453 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.453 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.453 | |
| 3anl | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.453 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.453 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.453 | |
| 4ig3 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.453 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.453 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.453 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.452 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.452 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.452 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.452 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.452 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.452 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.451 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.451 | |
| 2bil | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.451 | |
| 2x6d | X6D | Aurora kinase A | 2.7.11.1 | 0.451 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.451 | |
| 3nmv | PYV | Abscisic acid receptor PYL2 | / | 0.451 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4ajw | VWN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.7.1.153 | 0.451 | |
| 4bkj | STI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.451 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.451 | |
| 5dq8 | FLF | Transcriptional enhancer factor TEF-4 | / | 0.451 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.451 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.450 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 1pp9 | SMA | Cytochrome b | / | 0.450 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.450 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.450 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.450 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.450 | |
| 4la7 | A1O | Abscisic acid receptor PYL2 | / | 0.450 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.450 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.450 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.449 | |
| 1tw4 | CHD | Fatty acid-binding protein, liver | / | 0.449 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.449 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.449 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.449 | |
| 3k9u | ACO | Spermidine N(1)-acetyltransferase | / | 0.449 | |
| 3qlh | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.449 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.449 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.448 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2cd8 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.448 | |
| 2hk5 | 1BM | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.448 | |
| 2hnz | PC0 | Gag-Pol polyprotein | 2.7.7.49 | 0.448 | |
| 3cse | N22 | Uncharacterized protein | / | 0.448 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.448 | |
| 4b1f | KRH | Glutamate racemase | / | 0.448 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.448 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.448 | |
| 4iv4 | 1GS | Estrogen receptor | / | 0.448 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.448 | |
| 1fml | RTL | Retinol dehydratase | / | 0.447 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.447 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.447 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 1xws | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.447 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.447 | |
| 2agv | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.447 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.447 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.447 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.447 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 4czt | CPS | CBL-interacting serine/threonine-protein kinase 23 | 2.7.11.1 | 0.447 | |
| 4i2p | G73 | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 4i3w | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.447 | |
| 1cjc | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.446 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.446 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.446 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.446 | |
| 2i0e | PDS | Protein kinase C beta type | 2.7.11.13 | 0.446 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.446 | |
| 2jbl | SMA | Reaction center protein L chain | / | 0.446 | |
| 2oax | SNL | Mineralocorticoid receptor | / | 0.446 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 2wqb | QQ1 | Angiopoietin-1 receptor | 2.7.10.1 | 0.446 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.446 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.446 | |
| 3mg3 | ECH | Orange carotenoid-binding protein | / | 0.446 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4dk5 | 0KO | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4h6p | FMN | Chromate reductase | / | 0.446 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 4mcv | 29K | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.446 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.446 | |
| 4rbs | 0RV | Metallo-beta-lactamase type 2 | / | 0.446 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.446 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1dkf | BMS | Retinoic acid receptor alpha | / | 0.445 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.445 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.445 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.445 | |
| 1zdw | FLV | Prenyltransferase | / | 0.445 | |
| 2dqs | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.445 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.445 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.445 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 4d7e | FAD | Putative lysine-N-oxygenase | / | 0.445 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.445 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.445 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.445 | |
| 1e6e | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.444 | |
| 1ezv | SMA | Cytochrome b | / | 0.444 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.444 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.444 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.444 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.444 | |
| 3b9l | AZZ | Serum albumin | / | 0.444 | |
| 3cz0 | 9OD | Pheromone-binding protein ASP1 | / | 0.444 | |
| 3lal | KRV | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.444 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.444 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.444 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.444 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.444 | |
| 4bew | CZA | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.444 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.444 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.444 | |
| 1kyo | SMA | Cytochrome b | / | 0.443 | |
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 1s9q | OHT | Estrogen-related receptor gamma | / | 0.443 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.443 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.443 | |
| 3c6u | M22 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 3f5p | 741 | Insulin-like growth factor 1 receptor | 2.7.10.1 | 0.443 | |
| 3gxo | MQA | Mitomycin biosynthesis 6-O-methyltransferase | / | 0.443 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.443 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.443 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.443 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.443 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.443 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.443 | |
| 4v12 | POG | MaoC like domain protein | / | 0.443 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.443 | |
| 1e1n | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.442 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.442 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.442 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.442 | |
| 1osv | CHC | Bile acid receptor | / | 0.442 | |
| 1w78 | PD8 | Dihydrofolate synthase/folylpolyglutamate synthase | 6.3.2.12 | 0.442 | |
| 1x7j | GEN | Estrogen receptor beta | / | 0.442 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2vcz | VC3 | Hematopoietic prostaglandin D synthase | / | 0.442 | |
| 2vu3 | LZE | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.442 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.442 | |
| 4bc6 | XZN | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.442 | |
| 4ma6 | 28E | Ara h 8 allergen | / | 0.442 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 1nhz | 486 | Glucocorticoid receptor | / | 0.441 | |
| 2cl5 | BIE | Catechol O-methyltransferase | 2.1.1.6 | 0.441 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.441 | |
| 2p15 | EZT | Estrogen receptor | / | 0.441 | |
| 2x7g | PVB | SRSF protein kinase 2 | 2.7.11.1 | 0.441 | |
| 2y00 | Y01 | Beta-1 adrenergic receptor | / | 0.441 | |
| 2zce | PYL | Pyrrolysine--tRNA ligase | / | 0.441 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.441 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3ipq | 965 | Oxysterols receptor LXR-alpha | / | 0.441 | |
| 3l71 | AZO | Cytochrome b | / | 0.441 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.441 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.441 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.441 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4qmn | DB8 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.441 | |
| 4ubs | DIF | Pentalenic acid synthase | 1.14.15.11 | 0.441 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.441 | |
| 1err | RAL | Estrogen receptor | / | 0.440 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.440 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.440 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.440 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.440 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2zd1 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.440 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 3bej | MUF | Bile acid receptor | / | 0.440 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.440 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.440 | |
| 3e6o | A55 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.440 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.440 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.440 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.440 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4l23 | X6K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | / | 0.440 | |
| 4lmu | QUE | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 4xwt | U5P | Ribonuclease J | / | 0.440 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.440 |