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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4avlTMPPolymerase acidic protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4avlTMPPolymerase acidic protein/1.000
5ccyTMPPolymerase acidic protein/0.502
4awkCI1Polymerase acidic protein/0.498
4e5lDBHPolymerase acidic protein/0.493
4e5j581Polymerase acidic protein/0.489
5fdg0N8Polymerase acidic protein/0.483
4e5f0N7Polymerase acidic protein/0.482
2vkvTDCTetracycline repressor protein class D/0.469
4awmKDHPolymerase acidic protein/0.469
4egbNADdTDP-glucose 4,6-dehydratase/0.469
4pzrCOAHistone acetyltransferase p300/0.469
1fmlRTLRetinol dehydratase/0.467
1nzdUPGDNA beta-glucosyltransferase/0.467
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.466
1nzfUPGDNA beta-glucosyltransferase/0.465
4awgCI3Polymerase acidic protein/0.460
1g1aNADdTDP-glucose 4,6-dehydratase/0.455
5d9j0N8Polymerase acidic protein/0.455
2vutNADNitrogen metabolite repression protein nmrA/0.453
2zdyADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.453
3fr4F8AFatty acid-binding protein, adipocyte/0.453
3lm8VIBThiamine pyrophosphokinase2.7.6.20.452
3qiyQI1Botulinum neurotoxin type A3.4.24.690.452
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.451
3cluFADElectron transfer flavoprotein subunit alpha/0.451
1h50FMNPentaerythritol tetranitrate reductase/0.450
2ejzSAHDiphthine synthase/0.450
3fktSIIBeta-secretase 13.4.23.460.450
4wriOKAOkadaic acid binding protein 2-alpha/0.450
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.449
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.448
2f3rG5PGuanylate kinase2.7.4.80.448
2pamTYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.448
3imgBZ2Pantothenate synthetase6.3.2.10.447
4df2FMNNADPH dehydrogenase/0.446
1tehNADAlcohol dehydrogenase class-31.1.1.10.445
2g226IGRenin3.4.23.150.445
4e5i0N9Polymerase acidic protein/0.445
4gz612VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.444
4kbyC2EStimulator of interferon genes protein/0.444
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.443
3bl7DD1m7GpppX diphosphatase3.6.1.590.443
3d8vUD1Bifunctional protein GlmU/0.443
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1ma0NADAlcohol dehydrogenase class-31.1.1.10.442
1udaUFGUDP-glucose 4-epimerase5.1.3.20.442
1x1cSAHC-20 methyltransferase/0.442
3fr28CAFatty acid-binding protein, adipocyte/0.442
1vyrFMNPentaerythritol tetranitrate reductase/0.441
3qizQI2Botulinum neurotoxin type A3.4.24.690.441
5d4gU5PPolymerase acidic protein/0.441
5dp2NAPCurF/0.441
5fm7ADPRuvB-like helicase/0.441
1h51FMNPentaerythritol tetranitrate reductase/0.440
1h63FMNPentaerythritol tetranitrate reductase/0.440
1lrjUD1UDP-glucose 4-epimerase5.1.3.20.440
3h06VBPGlutamate receptor 2/0.440
4xr9NADCalS8/0.440
4xnw2IDP2Y purinoceptor 1/0.440