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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3qqfX07Cyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3qqfX07Cyclin-dependent kinase 22.7.11.221.000
3r73X87Cyclin-dependent kinase 22.7.11.220.777
3r7eX88Cyclin-dependent kinase 22.7.11.220.672
3r7yZ04Cyclin-dependent kinase 22.7.11.220.668
3rpo24ZCyclin-dependent kinase 22.7.11.220.666
3r1sX73Cyclin-dependent kinase 22.7.11.220.664
3r71X86Cyclin-dependent kinase 22.7.11.220.654
3rm719ZCyclin-dependent kinase 22.7.11.220.654
3roy22ZCyclin-dependent kinase 22.7.11.220.650
3qzhX69Cyclin-dependent kinase 22.7.11.220.646
3rk708ZCyclin-dependent kinase 22.7.11.220.639
3qzgX67Cyclin-dependent kinase 22.7.11.220.634
3sqq99ZCyclin-dependent kinase 22.7.11.220.633
3qxoX65Cyclin-dependent kinase 22.7.11.220.630
3r7uX96Cyclin-dependent kinase 22.7.11.220.626
4ek610KCyclin-dependent kinase 22.7.11.220.623
1ke6LS2Cyclin-dependent kinase 22.7.11.220.620
3r1yX76Cyclin-dependent kinase 22.7.11.220.619
3r6xX84Cyclin-dependent kinase 22.7.11.220.613
1vyzN5BCyclin-dependent kinase 22.7.11.220.612
1pxkCK3Cyclin-dependent kinase 22.7.11.220.610
1ke5LS1Cyclin-dependent kinase 22.7.11.220.609
3s0o50ZCyclin-dependent kinase 22.7.11.220.608
3iggEFQCyclin-dependent kinase 22.7.11.220.607
3qqkX02Cyclin-dependent kinase 22.7.11.220.606
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.605
1ke7LS3Cyclin-dependent kinase 22.7.11.220.603
3s2pPMUCyclin-dependent kinase 22.7.11.220.603
3ezrEZRCyclin-dependent kinase 22.7.11.220.601
1ykr628Cyclin-dependent kinase 22.7.11.220.599
3qwjX6ACyclin-dependent kinase 22.7.11.220.599
3qruX19Cyclin-dependent kinase 22.7.11.220.597
1pxmCK5Cyclin-dependent kinase 22.7.11.220.596
3ql8X01Cyclin-dependent kinase 22.7.11.220.595
2w05FRTCyclin-dependent kinase 22.7.11.220.594
3qtuX44Cyclin-dependent kinase 22.7.11.220.594
3r28XA0Cyclin-dependent kinase 22.7.11.220.594
2r64740Cyclin-dependent kinase 22.7.11.220.593
4fkq42KCyclin-dependent kinase 22.7.11.220.592
2c6o4SPCyclin-dependent kinase 22.7.11.220.591
3rk909ZCyclin-dependent kinase 22.7.11.220.591
1gih1PUCyclin-dependent kinase 22.7.11.220.590
1v1k3FPCyclin-dependent kinase 22.7.11.220.590
2btrU73Cyclin-dependent kinase 22.7.11.220.590
2w06FRVCyclin-dependent kinase 22.7.11.220.590
3rk507ZCyclin-dependent kinase 22.7.11.220.590
1oguST8Cyclin-dependent kinase 22.7.11.220.589
3qtzX42Cyclin-dependent kinase 22.7.11.220.589
3raiX85Cyclin-dependent kinase 22.7.11.220.588
3lfnA27Cyclin-dependent kinase 22.7.11.220.587
1h0w207Cyclin-dependent kinase 22.7.11.220.585
4lyn1YGCyclin-dependent kinase 22.7.11.220.585
3qx4X4BCyclin-dependent kinase 22.7.11.220.584
4fkpLS5Cyclin-dependent kinase 22.7.11.220.584
3r8lZ30Cyclin-dependent kinase 22.7.11.220.580
3r9hZ67Cyclin-dependent kinase 22.7.11.220.580
2a0cCK9Cyclin-dependent kinase 22.7.11.220.579
1oitHDTCyclin-dependent kinase 22.7.11.220.578
3ezvEZVCyclin-dependent kinase 22.7.11.220.577
3qu0X40Cyclin-dependent kinase 22.7.11.220.577
3rpv26ZCyclin-dependent kinase 22.7.11.220.577
3r1qX75Cyclin-dependent kinase 22.7.11.220.575
3qxpX64Cyclin-dependent kinase 22.7.11.220.574
3qziX72Cyclin-dependent kinase 22.7.11.220.574
3r7vZ02Cyclin-dependent kinase 22.7.11.220.574
4ek816KCyclin-dependent kinase 22.7.11.220.574
1w0xOLOCyclin-dependent kinase 22.7.11.220.573
4bgh3I6Cyclin-dependent kinase 22.7.11.220.573
1p2a5BNCyclin-dependent kinase 22.7.11.220.571
3le62BZCyclin-dependent kinase 22.7.11.220.571
3ral04ZCyclin-dependent kinase 22.7.11.220.571
3rni21ZCyclin-dependent kinase 22.7.11.220.570
3sw418KCyclin-dependent kinase 22.7.11.220.568
1oiqHDUCyclin-dependent kinase 22.7.11.220.567
1vyw292Cyclin-dependent kinase 22.7.11.220.567
2btsU32Cyclin-dependent kinase 22.7.11.220.567
3qtxX43Cyclin-dependent kinase 22.7.11.220.566
2r3iSCFCyclin-dependent kinase 22.7.11.220.565
3qx2X63Cyclin-dependent kinase 22.7.11.220.565
3r7iX9ICyclin-dependent kinase 22.7.11.220.565
3ti1B49Cyclin-dependent kinase 22.7.11.220.565
1urwI1PCyclin-dependent kinase 22.7.11.220.564
2uzoC62Cyclin-dependent kinase 22.7.11.220.564
3rmf20ZCyclin-dependent kinase 22.7.11.220.564
4fkr45KCyclin-dependent kinase 22.7.11.220.564
2bhhRYUCyclin-dependent kinase 22.7.11.220.562
3s1h56ZCyclin-dependent kinase 22.7.11.220.562
4acm7YGCyclin-dependent kinase 22.7.11.220.559
4ez30S0Cyclin-dependent kinase 22.7.11.220.559
1h1s4SPCyclin-dependent kinase 22.7.11.220.556
1oi9N20Cyclin-dependent kinase 22.7.11.220.555
3ddqRRCCyclin-dependent kinase 22.7.11.220.555
3lfqA28Cyclin-dependent kinase 22.7.11.220.555
3qrtX14Cyclin-dependent kinase 22.7.11.220.555
2r3p3SCCyclin-dependent kinase 22.7.11.220.553
1ke8LS4Cyclin-dependent kinase 22.7.11.220.552
4fki09KCyclin-dependent kinase 22.7.11.220.552
3qwkX62Cyclin-dependent kinase 22.7.11.220.551
3rkb12ZCyclin-dependent kinase 22.7.11.220.551
2a4lRRCCyclin-dependent kinase 22.7.11.220.549
2wxvWXVCyclin-dependent kinase 22.7.11.220.549
4bcmT7ZCyclin-dependent kinase 22.7.11.220.549
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.548
4kd11QKCyclin-dependent kinase 22.7.11.220.548
3ddpRC8Cyclin-dependent kinase 22.7.11.220.547
1g5sI17Cyclin-dependent kinase 22.7.11.220.546
1y91CT9Cyclin-dependent kinase 22.7.11.220.546
2fvdLIACyclin-dependent kinase 22.7.11.220.546
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.545
3rak03ZCyclin-dependent kinase 22.7.11.220.545
2iw94SPCyclin-dependent kinase 22.7.11.220.544
1ke9LS5Cyclin-dependent kinase 22.7.11.220.543
2c6iDT1Cyclin-dependent kinase 22.7.11.220.543
2vtsLZCCyclin-dependent kinase 22.7.11.220.543
4cfnJYMCyclin-dependent kinase 22.7.11.220.543
4fkj11KCyclin-dependent kinase 22.7.11.220.543
4fx360KCyclin-dependent kinase 22.7.11.220.543
1di8DTQCyclin-dependent kinase 22.7.11.220.542
2j9mPY8Cyclin-dependent kinase 22.7.11.220.542
3ig7EFPCyclin-dependent kinase 22.7.11.220.542
1oiyN41Cyclin-dependent kinase 22.7.11.220.541
2r3lSCWCyclin-dependent kinase 22.7.11.220.541
4erwSTUCyclin-dependent kinase 22.7.11.220.541
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.540
2wpa889Cyclin-dependent kinase 22.7.11.220.540
3wblPDYCyclin-dependent kinase 22.7.11.220.540
1h1r6CPCyclin-dependent kinase 22.7.11.220.539
1oirHDYCyclin-dependent kinase 22.7.11.220.539
3r83Z14Cyclin-dependent kinase 22.7.11.220.539
3rm618ZCyclin-dependent kinase 22.7.11.220.539
4fkt48KCyclin-dependent kinase 22.7.11.220.539
2vu3LZECyclin-dependent kinase 22.7.11.220.538
2xmyCDKCyclin-dependent kinase 22.7.11.220.538
1w8cN69Cyclin-dependent kinase 22.7.11.220.536
3fz1B98Cyclin-dependent kinase 22.7.11.220.536
3r8pZ46Cyclin-dependent kinase 22.7.11.220.536
1ckpPVBCyclin-dependent kinase 22.7.11.220.535
2r3mSCXCyclin-dependent kinase 22.7.11.220.535
4bcpT3CCyclin-dependent kinase 22.7.11.220.535
3uli1N3Cyclin-dependent kinase 22.7.11.220.534
3qqlX03Cyclin-dependent kinase 22.7.11.220.533
3rahO1ZCyclin-dependent kinase 22.7.11.220.533
4fkg4CKCyclin-dependent kinase 22.7.11.220.533
2r3kSCQCyclin-dependent kinase 22.7.11.220.531
2uznC96Cyclin-dependent kinase 22.7.11.220.530
1pxlCK4Cyclin-dependent kinase 22.7.11.220.529
2r3o2SCCyclin-dependent kinase 22.7.11.220.529
3rpy27ZCyclin-dependent kinase 22.7.11.220.529
4eok4SPCyclin-dependent kinase 22.7.11.220.528
2iw84SPCyclin-dependent kinase 22.7.11.220.526
4eor4SPCyclin-dependent kinase 22.7.11.220.525
3qzfX66Cyclin-dependent kinase 22.7.11.220.524
4bcnT9NCyclin-dependent kinase 22.7.11.220.524
2b52D42Cyclin-dependent kinase 22.7.11.220.522
2w1hL0FCyclin-dependent kinase 22.7.11.220.521
3r8vZ62Cyclin-dependent kinase 22.7.11.220.521
1fvt106Cyclin-dependent kinase 22.7.11.220.520
2c69CT8Cyclin-dependent kinase 22.7.11.220.520
3unj0BXCyclin-dependent kinase 22.7.11.220.520
4fkw62KCyclin-dependent kinase 22.7.11.220.520
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.519
3qtqX35Cyclin-dependent kinase 22.7.11.220.519
2wihP48Cyclin-dependent kinase 22.7.11.220.518
1gij2PUCyclin-dependent kinase 22.7.11.220.517
1r78FMDCyclin-dependent kinase 22.7.11.220.517
4fko20KCyclin-dependent kinase 22.7.11.220.517
2c4g514Cyclin-dependent kinase 22.7.11.220.516
2r3r6SCCyclin-dependent kinase 22.7.11.220.516
2uzlC94Cyclin-dependent kinase 22.7.11.220.515
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.515
3qtwX3ACyclin-dependent kinase 22.7.11.220.515
3rjc06ZCyclin-dependent kinase 22.7.11.220.515
1e9hINRCyclin-dependent kinase 22.7.11.220.514
2b54D05Cyclin-dependent kinase 22.7.11.220.514
1pyePM1Cyclin-dependent kinase 22.7.11.220.513
2c6mDT5Cyclin-dependent kinase 22.7.11.220.513
3lfsA07Cyclin-dependent kinase 22.7.11.220.513
3sw719KCyclin-dependent kinase 22.7.11.220.513
1fvv107Cyclin-dependent kinase 22.7.11.220.512
2bheBRYCyclin-dependent kinase 22.7.11.220.512
1pkdUCNCyclin-dependent kinase 22.7.11.220.510
3r8uZ31Cyclin-dependent kinase 22.7.11.220.510
1aq1STUCyclin-dependent kinase 22.7.11.220.509
1gii1PUCyclin-dependent kinase 22.7.11.220.509
1unlRRCCyclin-dependent-like kinase 52.7.11.10.509
3r9dX6BCyclin-dependent kinase 22.7.11.220.509
2b55D31Cyclin-dependent kinase 22.7.11.220.508
3pj8404Cyclin-dependent kinase 22.7.11.220.507
4fkv61KCyclin-dependent kinase 22.7.11.220.507
1oiuN76Cyclin-dependent kinase 22.7.11.220.506
4nj32KDCyclin-dependent kinase 22.7.11.220.506
3unk0BYCyclin-dependent kinase 22.7.11.220.504
4fks46KCyclin-dependent kinase 22.7.11.220.504
4qmpDKISerine/threonine-protein kinase 242.7.11.10.504
2duv371Cyclin-dependent kinase 22.7.11.220.503
2i40BLZCyclin-dependent kinase 22.7.11.220.503
3my5RFZCyclin-dependent kinase 22.7.11.220.502
3dogNNNCyclin-dependent kinase 22.7.11.220.501
2vttLZDCyclin-dependent kinase 22.7.11.220.500
2vv9IM9Cyclin-dependent kinase 22.7.11.220.500
3tiz3TICyclin-dependent kinase 22.7.11.220.500
3tnwF18Cyclin-dependent kinase 22.7.11.220.500
3py0SU9Cyclin-dependent kinase 22.7.11.220.499
3rzb02ZCyclin-dependent kinase 22.7.11.220.499
3r8zZ63Cyclin-dependent kinase 22.7.11.220.497
2c5nCK8Cyclin-dependent kinase 22.7.11.220.496
4eon1ROCyclin-dependent kinase 22.7.11.220.496
2w17I19Cyclin-dependent kinase 22.7.11.220.495
1pxoCK7Cyclin-dependent kinase 22.7.11.220.493
2r3q5SCCyclin-dependent kinase 22.7.11.220.492
2uzdC85Cyclin-dependent kinase 22.7.11.220.492
2x1nX1NCyclin-dependent kinase 22.7.11.220.492
1pxpCK8Cyclin-dependent kinase 22.7.11.220.491
2r3gSC9Cyclin-dependent kinase 22.7.11.220.491
4bcoT6QCyclin-dependent kinase 22.7.11.220.491
2b53D23Cyclin-dependent kinase 22.7.11.220.489
4eos1ROCyclin-dependent kinase 22.7.11.220.489
2c6kDT2Cyclin-dependent kinase 22.7.11.220.487
3r9nZ68Cyclin-dependent kinase 22.7.11.220.487
2xnbY8LCyclin-dependent kinase 22.7.11.220.486
1h1q2A6Cyclin-dependent kinase 22.7.11.220.485
2vthLZ2Cyclin-dependent kinase 22.7.11.220.485
1dm2HMDCyclin-dependent kinase 22.7.11.220.482
3rpr25ZCyclin-dependent kinase 22.7.11.220.481
3sheI85MAP kinase-activated protein kinase 32.7.11.10.481
2c6lDT4Cyclin-dependent kinase 22.7.11.220.480
1b39ATPCyclin-dependent kinase 22.7.11.220.479
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.479
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.478
2vtqLZACyclin-dependent kinase 22.7.11.220.477
4eol1ROCyclin-dependent kinase 22.7.11.220.477
1e1xNW1Cyclin-dependent kinase 22.7.11.220.476
2wotZZGTGF-beta receptor type-12.7.11.300.475
3ggfGVDSerine/threonine-protein kinase 26/0.475
3pxyJWSCyclin-dependent kinase 22.7.11.220.475
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.475
3nynSGVG protein-coupled receptor kinase 62.7.11.160.474
1h0vUN4Cyclin-dependent kinase 22.7.11.220.473
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.473
5aacVGHALK tyrosine kinase receptor2.7.10.10.473
5dr6SKEAurora kinase A2.7.11.10.473
1e1vCMGCyclin-dependent kinase 22.7.11.220.472
1finATPCyclin-dependent kinase 22.7.11.220.472
2c6tDT5Cyclin-dependent kinase 22.7.11.220.471
4eomATPCyclin-dependent kinase 22.7.11.220.469
1gz8MBPCyclin-dependent kinase 22.7.11.220.468
2r3jSCJCyclin-dependent kinase 22.7.11.220.468
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.468
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.468
4bcqTJFCyclin-dependent kinase 22.7.11.220.468
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.468
2uzeC95Cyclin-dependent kinase 22.7.11.220.467
4qmySTUSerine/threonine-protein kinase 242.7.11.10.467
3qqhX0ACyclin-dependent kinase 22.7.11.220.466
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
1eh4IC1Casein kinase I homolog 12.7.11.10.464
4fob0USALK tyrosine kinase receptor2.7.10.10.464
2xikJ60Serine/threonine-protein kinase 252.7.11.10.463
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.463
4e4m0NHTyrosine-protein kinase JAK2/0.462
5aaaVGHALK tyrosine kinase receptor2.7.10.10.462
1y8yCT7Cyclin-dependent kinase 22.7.11.220.461
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.461
2c5yMTWCyclin-dependent kinase 22.7.11.220.460
2cchATPCyclin-dependent kinase 22.7.11.220.460
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.460
4au8Z3RCyclin-dependent-like kinase 52.7.11.10.460
2bkzSBCCyclin-dependent kinase 22.7.11.220.459
2r3fSC8Cyclin-dependent kinase 22.7.11.220.458
2uzbC75Cyclin-dependent kinase 22.7.11.220.458
3be9P04Casein kinase II subunit alpha2.7.11.10.458
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.458
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.457
3qtrX36Cyclin-dependent kinase 22.7.11.220.456
3r9oZ71Cyclin-dependent kinase 22.7.11.220.456
4eoi1ROCyclin-dependent kinase 22.7.11.220.456
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.455
1vjy460TGF-beta receptor type-12.7.11.300.454
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.454
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.453
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.452
3lq5SLQCyclin-dependent kinase 92.7.11.220.452
3s00Z60Cyclin-dependent kinase 22.7.11.220.452
2wipP49Cyclin-dependent kinase 22.7.11.220.451
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.451
4gub0Y4Casein kinase II subunit alpha2.7.11.10.451
4gmy0X5Tyrosine-protein kinase JAK2/0.450
5e8wSTUTGF-beta receptor type-12.7.11.300.450
4anqVGHALK tyrosine kinase receptor2.7.10.10.449
1hckATPCyclin-dependent kinase 22.7.11.220.448
3qtsX46Cyclin-dependent kinase 22.7.11.220.448
3zh8C58Protein kinase C iota type2.7.11.130.448
4eop1ROCyclin-dependent kinase 22.7.11.220.448
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.448
1xjdSTUProtein kinase C theta type2.7.11.130.447
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.447
3gxlQIGTGF-beta receptor type-12.7.11.300.447
4jajXU1Aurora kinase A2.7.11.10.447
4qmzB49Serine/threonine-protein kinase 242.7.11.10.447
2c68CT6Cyclin-dependent kinase 22.7.11.220.446
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
2csnCKICasein kinase I homolog 12.7.11.10.445
4c61LMMTyrosine-protein kinase JAK2/0.445
4fv9E71Mitogen-activated protein kinase 12.7.11.240.445
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.445
2hog710Serine/threonine-protein kinase Chk12.7.11.10.444
3nux3NVCyclin-dependent kinase 62.7.11.220.444
4ivb1J5Tyrosine-protein kinase JAK1/0.444
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.444
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/0.443
4ansVGHALK tyrosine kinase receptor2.7.10.10.443
4ez50RSCyclin-dependent kinase 62.7.11.220.443
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.443
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.442
1unhIXMCyclin-dependent-like kinase 52.7.11.10.442
1v0pPVBCell division control protein 2 homolog2.7.11.220.442
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.442
3mvl38PMitogen-activated protein kinase 14/0.442
5aniES4Cyclin-dependent kinase 22.7.11.220.442
2f2cAP9Cyclin-dependent kinase 62.7.11.220.441
2vtrLZBCyclin-dependent kinase 22.7.11.220.441
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.441
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.441
1h1pCMGCyclin-dependent kinase 22.7.11.220.440
2j0j4STFocal adhesion kinase 12.7.10.20.440
2j0m4STFocal adhesion kinase 12.7.10.20.440
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.440
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.440
5e8xSTUTGF-beta receptor type-12.7.11.300.440