sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3q5p | TAC | Multidrug-efflux transporter 1 regulator |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3q5p | TAC | Multidrug-efflux transporter 1 regulator | / | 1.000 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.506 | |
| 4xwt | U5P | Ribonuclease J | / | 0.503 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.489 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.487 | |
| 4mt9 | 2D6 | Tankyrase-1 | 2.4.2.30 | 0.484 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.481 | |
| 1nen | DNT | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.479 | |
| 1nen | DNT | Succinate dehydrogenase cytochrome b556 subunit | / | 0.479 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.479 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.479 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.478 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.477 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.475 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.474 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.471 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.471 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.470 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.470 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.469 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.469 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.469 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.468 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.467 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.467 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.466 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.465 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.465 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.465 | |
| 1fml | RTL | Retinol dehydratase | / | 0.464 | |
| 1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.464 | |
| 1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.464 | |
| 3fu8 | 3DM | Laccase-1 | 1.10.3.2 | 0.464 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.464 | |
| 4dri | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.464 | |
| 4dri | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.464 | |
| 4b67 | NAP | L-ornithine N(5)-monooxygenase | / | 0.463 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.463 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.463 | |
| 1dlj | UGA | UDP-glucose 6-dehydrogenase | / | 0.462 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.462 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.462 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.462 | |
| 4iyg | 1HU | Strictosidine synthase | 4.3.3.2 | 0.462 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.461 | |
| 1sre | HAB | Streptavidin | / | 0.461 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.461 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.461 | |
| 3dd1 | 25D | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.461 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.461 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.461 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.460 | |
| 1zx1 | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.460 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.460 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.460 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.460 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.459 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1m52 | P17 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.459 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 1c7o | PPG | Hemolysin | / | 0.458 | |
| 1osv | CHC | Bile acid receptor | / | 0.458 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.458 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.458 | |
| 3c6t | M14 | Gag-Pol polyprotein | 2.7.7.49 | 0.458 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.458 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.457 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3v2u | ATP | Protein GAL3 | / | 0.457 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.457 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.456 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.456 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.456 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.456 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.456 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.456 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.455 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.455 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.455 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.455 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 3dle | GFA | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.455 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.455 | |
| 3up0 | D7S | aceDAF-12 | / | 0.455 | |
| 4c1f | X8Z | Metallo-beta-lactamase type 2 | / | 0.455 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.455 | |
| 1khr | VIR | Streptogramin A acetyltransferase | 2.3.1 | 0.454 | |
| 2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.454 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 3dmj | GWE | Pol protein | / | 0.454 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.453 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.453 | |
| 2b36 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.453 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.453 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1dkf | BMS | Retinoic acid receptor alpha | / | 0.452 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.452 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.452 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.452 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.452 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.452 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.452 | |
| 4rrw | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.452 | |
| 4rrz | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.452 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.451 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 4b45 | GSP | Tubulin-like protein CetZ2 | / | 0.451 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.451 | |
| 4kw5 | 1W6 | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.451 | |
| 4mr6 | 1K0 | Bromodomain-containing protein 2 | / | 0.451 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.451 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.450 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.450 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.450 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.450 | |
| 3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.450 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 3n5x | XFK | Nitric oxide synthase, brain | 1.14.13.39 | 0.450 | |
| 3ojw | FAD | NADPH--cytochrome P450 reductase | / | 0.450 | |
| 3qbw | ADP | Anhydro-N-acetylmuramic acid kinase | / | 0.450 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.450 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.449 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1qvu | PRL | HTH-type transcriptional regulator QacR | / | 0.449 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.449 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.449 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.448 | |
| 1nl4 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2be2 | R22 | Gag-Pol polyprotein | 2.7.7.49 | 0.448 | |
| 2ea1 | GPG | Ribonuclease I | 3.1.27.6 | 0.448 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.448 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.448 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4ajw | VWN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.7.1.153 | 0.448 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.447 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.447 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.447 | |
| 4h6p | FMN | Chromate reductase | / | 0.447 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.447 | |
| 4zm6 | ACO | N-acetyl-beta-D glucosaminidase | / | 0.447 | |
| 6cox | S58 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.447 | |
| 1jla | TNK | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.446 | |
| 2amb | 17H | Androgen receptor | / | 0.446 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.446 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.446 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.446 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4gtr | 7TR | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.446 | |
| 4v12 | POG | MaoC like domain protein | / | 0.446 | |
| 4wx2 | F6F | Tryptophan synthase alpha chain | / | 0.446 | |
| 4wx2 | F6F | Tryptophan synthase beta chain | 4.2.1.20 | 0.446 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.446 | |
| 2on6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.445 | |
| 3b9l | AZZ | Serum albumin | / | 0.445 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.445 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.445 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.445 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3ln1 | CEL | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.445 | |
| 3o96 | IQO | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.445 | |
| 4h4o | 506 | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 4oty | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.445 | |
| 1be4 | PCG | Nucleoside diphosphate kinase A 2 | 2.7.4.6 | 0.444 | |
| 1enp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.444 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.444 | |
| 1rt1 | MKC | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 1rz1 | NAD | Phenol 2-hydroxylase component B | / | 0.444 | |
| 1tkz | H16 | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 2jkc | FAD | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.444 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.444 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.444 | |
| 3n62 | XFJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.444 | |
| 3ov4 | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.444 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.444 | |
| 4fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.444 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.444 | |
| 1c1b | GCA | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 1efa | NPF | Lactose operon repressor | / | 0.443 | |
| 1pz1 | NAP | General stress protein 69 | / | 0.443 | |
| 1r2j | FAD | FkbI | / | 0.443 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.443 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 2bxq | IMN | Serum albumin | / | 0.443 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.443 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 3irx | UDR | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.443 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.443 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.443 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.443 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.442 | |
| 1itz | TPP | Transketolase, chloroplastic | 2.2.1.1 | 0.442 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.442 | |
| 1pxx | DIF | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.442 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.442 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.442 | |
| 2nr4 | FMN | Conserved protein | / | 0.442 | |
| 3n60 | XFN | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.442 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.442 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.441 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 1qjg | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.441 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 3cse | N22 | Uncharacterized protein | / | 0.441 | |
| 3djf | BC3 | Purine nucleoside phosphorylase | / | 0.441 | |
| 3dol | GWI | Pol protein | / | 0.441 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3h59 | H59 | Genome polyprotein | 2.7.7.48 | 0.441 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.441 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.441 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.441 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.440 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.440 | |
| 1q13 | TES | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.440 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.440 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.440 | |
| 3k14 | 535 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.440 | |
| 3k7m | FAD | 6-hydroxy-L-nicotine oxidase | / | 0.440 | |
| 3nhx | ASD | Steroid Delta-isomerase | 5.3.3.1 | 0.440 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.440 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.440 | |
| 4jvn | YUG | Estrogen sulfotransferase | 2.8.2.4 | 0.440 | |
| 4kwh | NAP | Reductase homolog | / | 0.440 |