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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3lt0FT1Enoyl-ACP reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3lt0FT1Enoyl-ACP reductase/1.000
3lt2FT3Enoyl-ACP reductase/0.763
3lt1FT2Enoyl-ACP reductase/0.725
3am3TCLEnoyl-ACP reductase/0.648
4igeCHJEnoyl-acyl carrier reductase/0.640
2ol4JPNEnoyl-ACP reductase/0.621
1nnuTCTEnoyl-ACP reductase/0.617
3am5TCLEnoyl-ACP reductase/0.613
3f4bTCLEnoyl-acyl carrier protein reductase/0.592
1zw1TN5Enoyl-ACP reductase/0.581
3nj8NJ8Enoyl-acyl carrier reductase/0.576
1nhgTCLEnoyl-ACP reductase/0.575
2o2yTCLEnoyl-ACP reductase/0.573
1uh5TCLEnoyl-ACP reductase/0.572
1zxlJP1Enoyl-ACP reductase/0.570
3am4FT1Enoyl-ACP reductase/0.569
2foiJPAEnoyl-acyl carrier reductase/0.567
1zsnTN2Enoyl-ACP reductase/0.554
2o2sTCLEnoyl-acyl carrier reductase/0.554
2op07PCEnoyl-ACP reductase/0.548
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.538
1nhwTCCEnoyl-ACP reductase/0.534
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.513
3lsyFT0Enoyl-ACP reductase/0.511
1ye4NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.494
3nrcTCLEnoyl-[acyl-carrier-protein] reductase [NADH]/0.491
3q0uLL3HTH-type transcriptional regulator EthR/0.490
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.485
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.485
3kjm245Cytokinin dehydrogenase 11.5.99.120.482
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.481
5coqTCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.481
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.478
4phlPILPhosphodiesterase/0.478
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.477
1p0hCOAMycothiol acetyltransferase2.3.1.1890.475
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.473
3q0vLL4HTH-type transcriptional regulator EthR/0.473
3gkjHC3Niemann-Pick C1 protein/0.472
3q44D50M1 family aminopeptidase3.4.110.472
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
4jbtASDCytochrome P450 monooxygenase/0.471
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.470
1hk5T44Serum albumin/0.468
3uhmRFNUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.468
2z97CAMCamphor 5-monooxygenase1.14.15.10.467
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.467
4qi5FADCellobiose dehydrogenase/0.467
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.464
2z3uCRRCytochrome P450/0.464
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.464
3fne8PCEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.464
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.464
4j6dTESCytochrome P450 monooxygenase/0.464
3bg7FADPyranose 2-oxidase/0.463
1s7nCOAAcetyl transferase/0.462
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.462
3p6mDSOCamphor 5-monooxygenase1.14.15.10.462
3qtsX46Cyclin-dependent kinase 22.7.11.220.462
4dc0NDPPutative ketoacyl reductase1.3.10.462
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.461
1re9DSOCamphor 5-monooxygenase1.14.15.10.461
2q4wFADCytokinin dehydrogenase 71.5.99.120.461
3gwfFADCyclohexanone monooxygenase/0.461
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.459
1sm9NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.459
3a1l2CCCytochrome P450/0.459
3bgrT27Gag-Pol polyprotein2.7.7.490.459
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.459
3o8gO8GHTH-type transcriptional regulator EthR/0.459
4ib4ERM5-hydroxytryptamine receptor 2B/0.459
4u2lSFDCholesterol oxidase1.1.3.60.459
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.458
3is9AC7Gag-Pol polyprotein2.7.7.490.458
4g1z0VPVitamin D3 receptor A/0.458
2zl9VDAVitamin D3 receptor/0.457
3cz7ACOHistone acetyltransferase RTT1092.3.1.480.457
3s1dZIRCytokinin dehydrogenase 11.5.99.120.457
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.456
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.456
2b35NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
2ftoCB3Thymidylate synthase/0.455
3g1mRF3HTH-type transcriptional regulator EthR/0.455
4h9753SDihydrofolate reductase1.5.1.30.455
4j6cSTRCytochrome P450 monooxygenase/0.455
1powFADPyruvate oxidase1.2.3.30.454
1v35NAIEnoyl-ACP reductase/0.454
1zgaHMKIsoflavone 4'-O-methyltransferase/0.454
3slkNDPPolyketide synthase extender module 2/0.454
3w2eNADNADH-cytochrome b5 reductase 31.6.2.20.454
4ez8DHFThymidylate synthase2.1.1.450.454
1rkhVD2Vitamin D3 receptor/0.453
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.453
1z9aNADNAD(P)H-dependent D-xylose reductase1.1.1.3070.453
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.453
2vqoTFGHistone deacetylase 43.5.1.980.453
4awq592Heat shock protein HSP 90-alpha/0.453
4g20484Vitamin D3 receptor A/0.453
4ubuCOASteroid 3-ketoacyl-CoA thiolase/0.453
5dp2NAPCurF/0.453
1e7qNAPGDP-L-fucose synthase/0.452
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.452
1poxFADPyruvate oxidase1.2.3.30.452
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
3jzdNADMaleylacetate reductase/0.452
3oafOAGDihydrofolate reductase1.5.1.30.452
3rbqGLY_ALA_GLY_DAOProtein unc-119 homolog A/0.452
3sfi3SFHTH-type transcriptional regulator EthR/0.452
1eioGCHGastrotropin/0.451
1sqi8694-hydroxyphenylpyruvate dioxygenase/0.451
3p6oETGCamphor 5-monooxygenase1.14.15.10.451
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
4hx519VCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
3emlZMAAdenosine receptor A2a/0.451
1fmlRTLRetinol dehydratase/0.450
3p3zP3ZPutative cytochrome P450/0.450
3tp0FO5HTH-type transcriptional regulator EthR/0.450
3ziaATPATP synthase subunit alpha, mitochondrial/0.450
4an4DUDPutative glycosyl transferase/0.450
4bquCLRJapanin/0.450
4j6bPLOCytochrome P450 monooxygenase/0.450
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.449
4dsgFADUncharacterized protein/0.449
4ez30S0Cyclin-dependent kinase 22.7.11.220.449
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.448
2mm3CHOGastrotropin/0.448
2vn0TDZCytochrome P450 2C8/0.448
2ykbYKBHeat shock protein HSP 90-alpha/0.448
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.448
3fznD7KBenzoylformate decarboxylase4.1.1.70.448
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.448
3ijdC2FMethylenetetrahydrofolate reductase/0.448
3k4nFADPyranose 2-oxidase/0.448
4fhh0U3Vitamin D3 receptor A/0.448
4g2i0VQVitamin D3 receptor/0.448
4rupH97Vitamin D3 receptor A/0.448
5uviZMAAdenosine receptor A2a/0.448
1dkfBMSRetinoic acid receptor alpha/0.447
1ie9VDXVitamin D3 receptor/0.447
1kkq471Peroxisome proliferator-activated receptor alpha/0.447
1rf9DBRCamphor 5-monooxygenase1.14.15.10.447
2hl0A3SThreonine--tRNA ligase6.1.1.30.447
3p6pA6BCamphor 5-monooxygenase1.14.15.10.447
3pm0BHFCytochrome P450 1B1/0.447
3w0hW12Vitamin D3 receptor/0.447
4fue7UPUrokinase-type plasminogen activator3.4.21.730.447
4haiI23Bifunctional epoxide hydrolase 23.1.3.760.447
4isk1JYThymidylate synthase/0.447
1e1kFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.446
1kzjCB3Thymidylate synthase/0.446
1vrwNAIEnoyl-ACP reductase/0.446
2yk2YJXHeat shock protein HSP 90-alpha/0.446
3deiRXBCaspase-33.4.22.560.446
3gphOIDCytochrome P450 2E11.14.130.446
4a95NHWGlycylpeptide N-tetradecanoyltransferase/0.446
4dhyS41Glucokinase2.7.1.20.446
4g2h0VQVitamin D3 receptor A/0.446
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.446
5kgpACOPredicted acetyltransferase/0.446
1mi3NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.445
1ozpACOMycothiol acetyltransferase2.3.1.1890.445
1xuoLA1Integrin alpha-L/0.445
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.445
2hasC3OVitamin D3 receptor/0.445
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2yjxYJXHeat shock protein HSP 90-alpha/0.445
2z4w749Geranylgeranyl pyrophosphate synthase/0.445
4fogC2FThymidylate synthase ThyA/0.445
1f4fTP3Thymidylate synthase/0.444
1pt8ACOFormyl-CoA:oxalate CoA-transferase/0.444
1z6tADPApoptotic protease-activating factor 1/0.444
2gvcFADThiol-specific monooxygenase1.14.130.444
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.444
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.444
3gbk2PQPeroxisome proliferator-activated receptor gamma/0.444
3kybFADUDP-galactopyranose mutase5.4.99.90.444
3p99LNPLanosterol 14-alpha-demethylase/0.444
4b4w9L9Bifunctional protein FolD/0.444
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.444
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.444
1bwlFMNNADPH dehydrogenase 11.6.99.10.443
1kceCB3Thymidylate synthase/0.443
1n83CLRNuclear receptor ROR-alpha/0.443
1rx1NAPDihydrofolate reductase1.5.1.30.443
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.443
2b35TCLEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
2g0bNLTLong-chain N-acyl amino acid synthase/0.443
2hb8MVDVitamin D3 receptor/0.443
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.443
2qboCAMCamphor 5-monooxygenase1.14.15.10.443
3g5hYTTMycocyclosin synthase1.14.21.90.443
3gkiCLRNiemann-Pick C1 protein/0.443
3s2pPMUCyclin-dependent kinase 22.7.11.220.443
3w5p4OAVitamin D3 receptor/0.443
4a32MYAGlycylpeptide N-tetradecanoyltransferase/0.443
4at0FADPossible succinate dehydrogenase/0.443
4bb3KKAIsopenicillin N synthase1.21.3.10.443
4enhFVXCholesterol 24-hydroxylase/0.443
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.443
4ia2BIVVitamin D3 receptor A/0.443
4iaq2GM5-hydroxytryptamine receptor 1B/0.443
4kdrSAHUbiquinone biosynthesis O-methyltransferase/0.443
1ie8KH1Vitamin D3 receptor/0.442
1txiTX5Vitamin D3 receptor/0.442
2a4nCOAAac(6')-Ii protein/0.442
2c29NAPDihydroflavonol 4-reductase/0.442
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.442
2gpvOHTEstrogen-related receptor gamma/0.442
2o4rVD5Vitamin D3 receptor/0.442
2q7hYLYPyrrolysine--tRNA ligase/0.442
2w0bCMWLanosterol 14-alpha demethylase1.14.13.700.442
2zaxCAMCamphor 5-monooxygenase1.14.15.10.442
2zb3NDPProstaglandin reductase 21.3.1.480.442
3stv3HOMethylketone synthase I/0.442
3w78CBDFMN-dependent NADH-azoreductase/0.442
4g3jVNTLanosterol 14-alpha-demethylase/0.442
4h4o506Gag-Pol polyprotein2.7.7.490.442
4ly91YYGlucokinase regulatory protein/0.442
4myq19TcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.442
5ag5MYAGlycylpeptide N-tetradecanoyltransferase/0.442
5jscFADPutative acyl-CoA dehydrogenase/0.442
5iua6DXAdenosine receptor A2a/0.442
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.441
1ijhFADCholesterol oxidase1.1.3.60.441
1zeoC01Peroxisome proliferator-activated receptor gamma/0.441
2dqsTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.441
2hcdBIVVitamin D3 receptor A/0.441
2opsHBQGag-Pol polyprotein2.7.7.490.441
2yncYNCGlycylpeptide N-tetradecanoyltransferase/0.441
3a783EVVitamin D3 receptor/0.441
3bgxMEFThymidylate synthase/0.441
3h3sH15Collagen type IV alpha-3-binding protein/0.441
3r8zZ63Cyclin-dependent kinase 22.7.11.220.441
4eb4D16Thymidylate synthase2.1.1.450.441
4tuvCPZCytochrome P450 1191.140.441
5cp4CAMCamphor 5-monooxygenase1.14.15.10.441
4zj8SUVOrexin receptor type 1/0.441
1ib0NADNADH-cytochrome b5 reductase 31.6.2.20.440
1n4uFAECholesterol oxidase1.1.3.60.440
1xddAAYIntegrin alpha-L/0.440
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2gqfFADUncharacterized protein HI_0933/0.440
2vssACOHydroxycinnamoyl-CoA hydratase-lyase4.1.2.410.440
3lqfNADGalactitol dehydrogenase/0.440
3mj5GRMReplicase polyprotein 1a3.4.220.440
3p6nDSOCamphor 5-monooxygenase1.14.15.10.440
3pe2E1BCasein kinase II subunit alpha2.7.11.10.440
3qwiCUE17beta-hydroxysteroid dehydrogenase/0.440
4i2q1BTGag-Pol polyprotein2.7.7.490.440
4iq71G9Mycocyclosin synthase1.14.21.90.440
4kxjP34Nucleoprotein/0.440
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.440
4wboANWRhodopsin kinase/0.440
4zm6ACON-acetyl-beta-D glucosaminidase/0.440
5ag7MYAGlycylpeptide N-tetradecanoyltransferase/0.440
5ahsFADAcyl-CoA dehydrogenase/0.440