sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 1.000 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.594 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.593 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.586 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.575 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.567 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.551 | |
| 5hwp | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.522 | |
| 1ysl | COA | Hydroxymethylglutaryl-CoA synthase | 2.3.3.10 | 0.506 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.503 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.500 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.494 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.494 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.493 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.492 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.489 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.489 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.484 | |
| 1qy5 | NEC | Endoplasmin | / | 0.482 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.482 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.480 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.480 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.479 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.479 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.478 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.478 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.477 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.477 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.477 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.476 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.476 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.476 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.475 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.474 | |
| 3eks | CY9 | Actin-5C | / | 0.474 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.474 | |
| 4qi7 | FAD | Cellobiose dehydrogenase | / | 0.474 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.474 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.473 | |
| 2gh5 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.473 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.473 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.473 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.473 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.472 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.471 | |
| 2hps | CTZ | Ca2+-triggered coelenterazine-binding protein 1 | / | 0.471 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.471 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.471 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.471 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.470 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.470 | |
| 3eku | CY9 | Actin-5C | / | 0.470 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.470 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.470 | |
| 1h6d | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.469 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.469 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.468 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.468 | |
| 5c2t | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.468 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.467 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.467 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.467 | |
| 4i0h | 1BL | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 6cts | CIC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.467 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.466 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.466 | |
| 4xo7 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.466 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.465 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.465 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.465 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.465 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.464 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.463 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.463 | |
| 2psw | COA | N-alpha-acetyltransferase 50 | / | 0.463 | |
| 2wd9 | IBP | Acyl-coenzyme A synthetase ACSM2A, mitochondrial | 6.2.1.2 | 0.463 | |
| 3p4t | FAO | Putative acyl-CoA dehydrogenase | / | 0.463 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.462 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.462 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 4k8s | 1QT | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.461 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.461 | |
| 4n6b | COA | Uncharacterized protein | / | 0.461 | |
| 5c7h | NDP | Putative oxidoreductase | / | 0.461 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.461 | |
| 1pz1 | NAP | General stress protein 69 | / | 0.460 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.460 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.460 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.459 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.459 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.458 | |
| 2cts | COA | Citrate synthase, mitochondrial | 2.3.3.1 | 0.458 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.458 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.458 | |
| 5cts | CMC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.458 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.457 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.457 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.457 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.457 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.457 | |
| 3up0 | D7S | aceDAF-12 | / | 0.457 | |
| 3veu | 0GO | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.457 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.457 | |
| 4nv1 | 4TG | Formyl transferase | / | 0.457 | |
| 1sst | COA | Serine acetyltransferase | 2.3.1.30 | 0.456 | |
| 1zdw | FLV | Prenyltransferase | / | 0.456 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.456 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.456 | |
| 2rc4 | ACO | Histone acetyltransferase KAT6A | / | 0.456 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.456 | |
| 3v9y | 24L | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.456 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.456 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.456 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.456 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.455 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.455 | |
| 2ien | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 2ob0 | ACO | N-alpha-acetyltransferase 50 | / | 0.455 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.455 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.455 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.455 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.455 | |
| 4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.455 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.454 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.454 | |
| 2b4r | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.454 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.454 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3pdq | KC6 | Lysine-specific demethylase 4A | 1.14.11 | 0.454 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.454 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.454 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.454 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.454 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.454 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.453 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.453 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.453 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.453 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.453 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.453 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.453 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.453 | |
| 4phl | PIL | Phosphodiesterase | / | 0.453 | |
| 5dp2 | NAP | CurF | / | 0.453 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.452 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.452 | |
| 3dm6 | 757 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 3wag | TYD | Glycosyltransferase | / | 0.452 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.452 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.452 | |
| 4n3r | 2GU | Tankyrase-1 | 2.4.2.30 | 0.452 | |
| 4ubv | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.452 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.451 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.451 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.451 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.451 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.451 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.451 | |
| 3bgc | LJH | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 3q8u | ADP | Nucleoside diphosphate kinase | / | 0.451 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.451 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.451 | |
| 4dpf | 0LG | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4ejn | 0R4 | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.451 | |
| 4wji | NAP | Putative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase | / | 0.451 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.451 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.451 | |
| 1esv | LAR | Actin, alpha skeletal muscle | / | 0.450 | |
| 1jqi | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.450 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.450 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.450 | |
| 3bi5 | FAD | Polyamine oxidase FMS1 | / | 0.450 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.450 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.450 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.450 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.450 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.450 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.449 | |
| 2gf6 | COA | Uncharacterized protein | / | 0.449 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.449 | |
| 2xgs | 44P | Uncharacterized protein | / | 0.449 | |
| 2ym2 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.449 | |
| 3bl7 | DD1 | m7GpppX diphosphatase | 3.6.1.59 | 0.449 | |
| 3d2p | COA | Amino-acid acetyltransferase | / | 0.449 | |
| 3wcz | NAP | Aldo-keto reductase AKR2E4 | / | 0.449 | |
| 3zhs | TD6 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.449 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.448 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.448 | |
| 1o8c | NDP | Probable acrylyl-CoA reductase AcuI | 1.3.1.84 | 0.448 | |
| 1qy8 | RDI | Endoplasmin | / | 0.448 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 3dme | FAD | Putative conserved exported protein | / | 0.448 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.448 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.448 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.448 | |
| 3uwl | FOZ | Thymidylate synthase | / | 0.448 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.448 | |
| 4blr | UTP | NTPase P4 | / | 0.448 | |
| 4qi4 | FAD | Cellobiose dehydrogenase | / | 0.448 | |
| 5af7 | FAD | Acyl-CoA dehydrogenase | / | 0.448 | |
| 5dmh | ADP | 3-oxo-tetronate kinase | / | 0.448 | |
| 3pbl | ETQ | D(3) dopamine receptor | / | 0.448 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.447 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.447 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.447 | |
| 2fa3 | ACO | Hydroxymethylglutaryl-CoA synthase | / | 0.447 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2tct | CTC | Tetracycline repressor protein class D | / | 0.447 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.447 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.447 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.446 | |
| 1dxy | NAD | D-2-hydroxyisocaproate dehydrogenase | 1.1.1 | 0.446 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.446 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.446 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 3dgh | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.446 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.446 | |
| 3i59 | N6S | CRP-like cAMP-activated global transcriptional regulator | / | 0.446 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.446 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.446 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.446 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.446 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4z26 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.446 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.446 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.445 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 2a4n | COA | Aac(6')-Ii protein | / | 0.445 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.445 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.445 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3mj4 | FAD | UDP-galactopyranose mutase | / | 0.445 | |
| 3mkh | FAD | Nitroalkane oxidase | / | 0.445 | |
| 3tqc | ADP | Pantothenate kinase | / | 0.445 | |
| 3v2u | ATP | Protein GAL3 | / | 0.445 | |
| 4fdn | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.445 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.445 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.444 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.444 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.444 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.444 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3r5y | F42 | Uncharacterized protein | / | 0.444 | |
| 4irn | FAD | AnaB | / | 0.444 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.444 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.444 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.443 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.443 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.443 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.443 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.443 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.443 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 2wp9 | CBE | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.443 | |
| 2wp9 | CBE | Succinate dehydrogenase cytochrome b556 subunit | / | 0.443 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3hu1 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.443 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.443 | |
| 3skg | PB8 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.443 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.443 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.443 | |
| 4qof | FMN | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.443 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.443 | |
| 1csc | CMC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.442 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.442 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.442 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.442 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 2y3r | TRK | TamL | / | 0.442 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.442 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.442 | |
| 4dja | FAD | (6-4) photolyase | / | 0.442 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.442 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 4lj6 | ACP | Chaperone protein ClpB | / | 0.442 | |
| 4nu5 | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.442 | |
| 4tm1 | FDA | KtzI | / | 0.442 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.442 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.442 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 1osv | CHC | Bile acid receptor | / | 0.441 | |
| 1w4a | APC | NTPase P4 | / | 0.441 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.441 | |
| 2ge3 | ACO | Probable acetyltransferase | / | 0.441 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2hej | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.441 | |
| 2uzf | CAA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.441 | |
| 2xpv | MIY | Tetracycline repressor protein class D | / | 0.441 | |
| 2ylt | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.441 | |
| 3csc | ACO | Citrate synthase, mitochondrial | 2.3.3.1 | 0.441 | |
| 3cz7 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.441 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.441 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.441 | |
| 3mb7 | 14I | Casein kinase II subunit alpha | 2.7.11.1 | 0.441 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.441 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.441 | |
| 4djy | 0KR | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4mo2 | FAD | UDP-galactopyranose mutase | / | 0.441 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.441 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 4xgi | NAD | Glutamate dehydrogenase | / | 0.441 | |
| 5doz | NDP | JamJ | / | 0.441 | |
| 1iy8 | NAD | Levodione reductase | / | 0.440 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.440 | |
| 1v0j | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.440 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.440 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.440 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.440 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.440 | |
| 2xf0 | 4UB | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.440 | |
| 3jzi | JZL | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 3qv1 | NAD | Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic | 1.2.1.13 | 0.440 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.440 | |
| 4e2y | JHZ | Methyltransferase | / | 0.440 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 4l4x | NDP | AmphI | / | 0.440 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.440 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.440 |