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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2q94A04Methionine aminopeptidase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2q94A04Methionine aminopeptidase/1.000
2q92B23Methionine aminopeptidase/0.783
2evmFC2Methionine aminopeptidase/0.776
2evcFC3Methionine aminopeptidase/0.744
2p98YE7Methionine aminopeptidase/0.698
2gg8U15Methionine aminopeptidase/0.693
2q96A18Methionine aminopeptidase/0.680
2q93B21Methionine aminopeptidase/0.663
3iu7FCDMethionine aminopeptidase 2/0.654
2p99YE6Methionine aminopeptidase/0.648
1xnzFCDMethionine aminopeptidase/0.643
3d27W29Methionine aminopeptidase/0.624
3iu8T03Methionine aminopeptidase 2/0.621
2ggbU17Methionine aminopeptidase/0.602
2gg2U12Methionine aminopeptidase/0.601
2gg0U11Methionine aminopeptidase/0.595
2gg9U16Methionine aminopeptidase/0.588
3pkeY10Methionine aminopeptidase 2/0.586
3pkdY10Methionine aminopeptidase 2/0.585
2g6pHM2Methionine aminopeptidase 1/0.580
4flkY10Methionine aminopeptidase 1/0.580
2gg3U13Methionine aminopeptidase/0.568
4fljY08Methionine aminopeptidase 1/0.561
4fllYZ6Methionine aminopeptidase 1/0.557
3pkbY16Methionine aminopeptidase 2/0.554
4fliY16Methionine aminopeptidase 1/0.554
4iksTFDMethionine aminopeptidase 1/0.549
1c23MPHMethionine aminopeptidase/0.546
4hxx1AYMethionine aminopeptidase 1/0.539
3pkaY02Methionine aminopeptidase 2/0.538
4iktTFVMethionine aminopeptidase 1/0.534
4ikuSHXMethionine aminopeptidase 1/0.522
2nq7HM5Methionine aminopeptidase 1/0.521
3pkcY08Methionine aminopeptidase 2/0.520
1r5gAO1Methionine aminopeptidase 2/0.517
4ikrPVPMethionine aminopeptidase 1/0.513
2ea2F77Methionine aminopeptidase 2/0.490
2jf0HBPAcetylcholinesterase3.1.1.70.481
2xuiTZ5Acetylcholinesterase3.1.1.70.481
2xukTZ5Acetylcholinesterase3.1.1.70.481
1zgbA1EAcetylcholinesterase3.1.1.70.477
1r58AO5Methionine aminopeptidase 2/0.476
2ea4F79Methionine aminopeptidase 2/0.476
2w6cBM4Acetylcholinesterase3.1.1.70.476
2xuoTZ4Acetylcholinesterase3.1.1.70.475
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.474
4nv14TGFormyl transferase/0.474
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.472
2xuqTZ4Acetylcholinesterase3.1.1.70.469
4ey7E20Acetylcholinesterase3.1.1.70.469
1odcA8BAcetylcholinesterase3.1.1.70.468
2xugTZ4Acetylcholinesterase3.1.1.70.468
3iu9T07Methionine aminopeptidase 2/0.468
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.468
1q84TZ4Acetylcholinesterase3.1.1.70.467
2cekN8TAcetylcholinesterase3.1.1.70.467
2gywOBIAcetylcholinesterase3.1.1.70.467
3uzzASD3-oxo-5-beta-steroid 4-dehydrogenase/0.466
1qzyTDEMethionine aminopeptidase 2/0.465
2oazI96Methionine aminopeptidase 2/0.465
2pb1NFGGlucan 1,3-beta-glucosidase/0.464
2xujTZ5Acetylcholinesterase3.1.1.70.463
1yw8A75Methionine aminopeptidase 2/0.462
1amoFMNNADPH--cytochrome P450 reductase/0.460
1u65CP0Acetylcholinesterase3.1.1.70.460
5ao1DG3Deoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.459
1yw7A41Methionine aminopeptidase 2/0.457
2ga2A19Methionine aminopeptidase 2/0.457
2xuhTZ4Acetylcholinesterase3.1.1.70.457
1eveE20Acetylcholinesterase3.1.1.70.456
2xupTZ5Acetylcholinesterase3.1.1.70.455
2vd7PD2Lysine-specific demethylase 4A1.14.110.454
2xufTZ4Acetylcholinesterase3.1.1.70.454
4q7f3D1Uncharacterized protein/0.454
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
1yw9A84Methionine aminopeptidase 2/0.452
2wzySQXSoluble acetylcholine receptor/0.452
4m0f1YKAcetylcholinesterase3.1.1.70.452
4nv1TYDFormyl transferase/0.452
1ro98BRcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.451
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.451
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
4b7zQ4QAcetylcholinesterase3.1.1.70.451
4ey6GNTAcetylcholinesterase3.1.1.70.451
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.450
4araC56Acetylcholinesterase3.1.1.70.450
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.449
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.449
1r5hAO2Methionine aminopeptidase 2/0.448
1i9c5ADGlutamate mutase epsilon subunit/0.447
2aot2PMHistamine N-methyltransferase2.1.1.80.447
4nv10FXFormyl transferase/0.447
2g1n1IGRenin3.4.23.150.446
3mj4URMUDP-galactopyranose mutase/0.446
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.446
2j3qTFLAcetylcholinesterase3.1.1.70.445
4gd40WSLysine-specific demethylase 4A1.14.110.445
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.444
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
3wqmB29Diterpene synthase3.1.7.80.444
4d6qPD2Lysine-specific demethylase 4D1.14.110.444
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.444
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.444
2ixkTDOdTDP-4-dehydrorhamnose 3,5-epimerase5.1.3.130.443
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.443
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3s8pSAMHistone-lysine N-methyltransferase KMT5B2.1.1.430.443
3uzxAOM3-oxo-5-beta-steroid 4-dehydrogenase/0.443
4u163C0Muscarinic acetylcholine receptor M3/0.443
2ha6SCKAcetylcholinesterase3.1.1.70.442
3af1GDPPantothenate kinase2.7.1.330.442
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.441
1zgcA2EAcetylcholinesterase3.1.1.70.441
2qimZEAClass 10 plant pathogenesis-related protein/0.441
2vf3GVS4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.441
2xq0BESLeukotriene A-4 hydrolase homolog3.3.2.60.441
1vkgCRIHistone deacetylase 83.5.1.980.440
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
2whqHI6Acetylcholinesterase3.1.1.70.440
3hl0NADMaleylacetate reductase/0.440