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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pgtGPRGlutathione S-transferase P2.5.1.18

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2pgtGPRGlutathione S-transferase P2.5.1.181.000
13gsSASGlutathione S-transferase P2.5.1.180.630
1aqv0HGGlutathione S-transferase P2.5.1.180.618
3gusN11Glutathione S-transferase P2.5.1.180.614
1pgtGTXGlutathione S-transferase P2.5.1.180.611
1aqxGTDGlutathione S-transferase P2.5.1.180.610
3csjCBLGlutathione S-transferase P2.5.1.180.605
4pgtGBXGlutathione S-transferase P2.5.1.180.597
1gtiGTBGlutathione S-transferase P 12.5.1.180.588
3ie3N11Glutathione S-transferase P2.5.1.180.584
3o76GTBGlutathione S-transferase P 12.5.1.180.584
3pgtGBXGlutathione S-transferase P2.5.1.180.580
20gsCBDGlutathione S-transferase P2.5.1.180.577
9gssGTXGlutathione S-transferase P2.5.1.180.577
17gsGTXGlutathione S-transferase P2.5.1.180.573
2j9hGTXGlutathione S-transferase P2.5.1.180.570
2oadGTBGlutathione S-transferase P 12.5.1.180.570
2oa7GTXGlutathione S-transferase P 12.5.1.180.568
3n9jEAAGlutathione S-transferase P2.5.1.180.560
2a2sGSNGlutathione S-transferase P2.5.1.180.559
2glrGTXGlutathione S-transferase P 12.5.1.180.549
12gs0HHGlutathione S-transferase P2.5.1.180.545
1tu8GTXGlutathione S-transferase 22.5.1.180.511
2oacGTBGlutathione S-transferase P 12.5.1.180.502
2j3qTFLAcetylcholinesterase3.1.1.70.495
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.493
4bfzZVZPantothenate kinase2.7.1.330.493
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.487
4jlm1NNDeoxycytidine kinase2.7.1.740.487
1qoqIGPTryptophan synthase alpha chain/0.486
4iah1DXAlr2278 protein/0.486
3dgqEAAGlutathione S-transferase P2.5.1.180.482
4nieNBHNuclear receptor ROR-gamma/0.480
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.478
4bfwZVWPantothenate kinase2.7.1.330.477
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.475
2zsaADPPantothenate kinase2.7.1.330.475
2g226IGRenin3.4.23.150.474
2po3T4K4-dehydrase/0.474
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.474
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.474
2lfoGCHFatty acid-binding protein, liver/0.473
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.473
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.472
4bfvZVVPantothenate kinase2.7.1.330.471
1mtcGPRGlutathione S-transferase Mu 12.5.1.180.470
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.470
4b68NAPL-ornithine N(5)-monooxygenase/0.470
4b4vL34Bifunctional protein FolD/0.469
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.468
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.468
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.468
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.468
3oagLPQRenin3.4.23.150.467
3cmfPDN3-oxo-5-beta-steroid 4-dehydrogenase/0.466
4iae1DXAlr2278 protein/0.465
3oadLPORenin3.4.23.150.464
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.463
4ipw1G7Mycocyclosin synthase1.14.21.90.463
5kgpACOPredicted acetyltransferase/0.463
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.462
1h60STRPentaerythritol tetranitrate reductase/0.460
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
3rtnRTNBeta-secretase 13.4.23.460.460
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.459
2uxoTACHTH-type transcriptional regulator TtgR/0.459
2wzySQXSoluble acetylcholine receptor/0.459
3cotSTR3-oxo-5-beta-steroid 4-dehydrogenase/0.459
3v2uATPProtein GAL3/0.459
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.459
4xguADPPutative pachytene checkpoint protein 2/0.459
2abaSTRPentaerythritol tetranitrate reductase/0.458
2bktRPFRenin3.4.23.150.458
2gywOBIAcetylcholinesterase3.1.1.70.458
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
3gf4UPGUDP-galactopyranose mutase5.4.99.90.458
1c7oPPGHemolysin/0.457
1eiiRTLRetinol-binding protein 2/0.457
1gtrATPGlutamine--tRNA ligase6.1.1.180.457
3g72A6TRenin3.4.23.150.457
3wagTYDGlycosyltransferase/0.457
4k88HFGBifunctional glutamate/proline--tRNA ligase6.1.1.150.457
2g1n1IGRenin3.4.23.150.456
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.456
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
4na4A1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.456
1aquESTEstrogen sulfotransferase, testis isoform2.8.2.40.455
1z7yAA5Cysteine synthase 12.5.1.470.455
2g1o2IGRenin3.4.23.150.455
2stdCRPScytalone dehydratase4.2.1.940.455
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3p0fBAUUridine phosphorylase 22.4.2.30.455
3zcnATPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.455
4bfxZVXPantothenate kinase2.7.1.330.455
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.455
4uy6SAHHistidine N-alpha-methyltransferase/0.455
1n4pCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.454
2cekN8TAcetylcholinesterase3.1.1.70.454
3aezGDPPantothenate kinase2.7.1.330.454
3q43D66M1 family aminopeptidase3.4.110.454
3ska053Genome polyprotein2.7.7.480.454
4b4w9L9Bifunctional protein FolD/0.454
4bfuZVUPantothenate kinase2.7.1.330.454
1nqw5YL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.453
2gv8NDPThiol-specific monooxygenase1.14.130.453
2v16C47Renin3.4.23.150.453
3iocA5DPantothenate synthetase6.3.2.10.453
3qgf46FGenome polyprotein2.7.7.480.453
3r7kFDAProbable acyl CoA dehydrogenase/0.453
1w19T5P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.452
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.452
3imgBZ3Pantothenate synthetase6.3.2.10.452
3rviRVIBeta-secretase 13.4.23.460.452
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.452
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.452
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
4ohwATPProtein clpf-1/0.452
1joaFADNADH peroxidase1.11.1.10.451
1l2tATPUncharacterized ABC transporter ATP-binding protein MJ0796/0.451
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.451
1x1aSAMC-20 methyltransferase/0.451
1xddAAYIntegrin alpha-L/0.451
1xzqFONtRNA modification GTPase MnmE3.6.50.451
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.451
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.451
3pqbVGPPutative oxidoreductase/0.451
4b6uM7GEukaryotic translation initiation factor 4E type 3/0.451
4bb3KKAIsopenicillin N synthase1.21.3.10.451
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
1ad3NADAldehyde dehydrogenase, dimeric NADP-preferring/0.450
1x1cSAHC-20 methyltransferase/0.450
1zdwFLVPrenyltransferase/0.450
2h3wHC5Carnitine O-acetyltransferase2.3.1.70.450
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.450
2z4sADPChromosomal replication initiator protein DnaA/0.450
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3tzaTZGGlutamate receptor 2/0.450
4brgGNPEctonucleoside triphosphate diphosphohydrolase I/0.450
4jb1NAPUDP-N-acetylenolpyruvoylglucosamine reductase/0.450
1nhrFADNADH peroxidase1.11.1.10.449
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.449
2fs4PZ1Renin3.4.23.150.449
2qimZEAClass 10 plant pathogenesis-related protein/0.449
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3zoiM2WIsopenicillin N synthase1.21.3.10.449
4b63FADL-ornithine N(5)-monooxygenase/0.449
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.449
5irnADPNucleotide binding oligomerization domain containing 2/0.449
1blzACVIsopenicillin N synthase1.21.3.10.448
1oc1ASVIsopenicillin N synthase1.21.3.10.448
2v7qATPATP synthase subunit alpha, mitochondrial/0.448
2v7qATPATP synthase subunit beta, mitochondrial3.6.3.140.448
3s5wFADL-ornithine N(5)-monooxygenase/0.448
3ske054Genome polyprotein2.7.7.480.448
4a802ANMajor pollen allergen Bet v 1-A/0.448
4b1e6T6Beta-secretase 13.4.23.460.448
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.448
1g6oADPCag alpha/0.447
1z6tADPApoptotic protease-activating factor 1/0.447
2gstGPSGlutathione S-transferase Mu 12.5.1.180.447
2xysSY9Soluble acetylcholine receptor/0.447
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.447
3hl0NADMaleylacetate reductase/0.447
3n0bFADFlavin-dependent thymidylate synthase2.1.1.1480.447
3zbzOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.447
4bftZVTPantothenate kinase2.7.1.330.447
1digL37C-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.446
1dqaCOA3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.446
2dxiATPGlutamate--tRNA ligase6.1.1.170.446
2ft0ACOdTDP-fucosamine acetyltransferase/0.446
2rh9IGPTryptophan synthase alpha chain/0.446
3g70A5TRenin3.4.23.150.446
3rsv3RSBeta-secretase 13.4.23.460.446
3u4o08EGenome polyprotein2.7.7.480.446
4jln18VDeoxycytidine kinase2.7.1.740.446
4oi2ADPProtein clpf-1/0.446
1drfFOLDihydrofolate reductase1.5.1.30.445
2c9bPUG6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.445
2dvlFADAcyl-CoA dehydrogenase/0.445
2i7pACOPantothenate kinase 32.7.1.330.445
2wu4HBPAcetylcholinesterase3.1.1.70.445
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.445
3k1wBFXRenin3.4.23.150.445
4n1gCEIObelin/0.445
4obwSAM2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial/0.445
5choFADFlavin reductase/0.445
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.444
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.444
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.444
2q1tNADPutative nucleotide sugar epimerase/ dehydratase/0.444
3cb2GDPTubulin gamma-1 chain/0.444
3qwbNDPProbable quinone oxidoreductase1.6.5.50.444
4dz5NAPAldo-keto reductase family 1 member C3/0.444
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
4ohvANPProtein clpf-1/0.444
5dp2NAPCurF/0.444
5f54TMPSingle-stranded-DNA-specific exonuclease/0.444
2c27ACOMycothiol acetyltransferase2.3.1.1890.443
2getCOKPantothenate kinase2.7.1.330.443
2wzwNDPNitroreductase NfnB/0.443
2y6fM9FIsopenicillin N synthase1.21.3.10.443
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
3jszUPGUncharacterized protein/0.443
4gi2NAPCrotonyl-CoA carboxylase/reductase/0.443
1beuIPLTryptophan synthase alpha chain/0.442
1q84TZ4Acetylcholinesterase3.1.1.70.442
2a5hSAML-lysine 2,3-aminomutase5.4.3.20.442
2g1r3IGRenin3.4.23.150.442
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.442
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.442
4fx9COACoenzyme A disulfide reductase1.8.1.140.442
4g3jVNTLanosterol 14-alpha-demethylase/0.442
1n77ATPGlutamate--tRNA ligase6.1.1.170.441
1xmmM7Gm7GpppX diphosphatase3.6.1.590.441
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
2g263LGRenin3.4.23.150.441
2g5w8PG12-oxophytodienoate reductase 31.3.1.420.441
2he5NDPAldo-keto reductase family 1 member C211.1.10.441
2qs4LY5Glutamate receptor ionotropic, kainate 1/0.441
2uuk897Prothrombin3.4.21.50.441
3eksCY9Actin-5C/0.441
3g5hYTTMycocyclosin synthase1.14.21.90.441
3lnsNAPNAD(P)-dependent benzaldehyde dehydrogenase1.2.1.280.441
3q70RITCandidapepsin-23.4.23.240.441
3zksWZVBeta-secretase 23.4.23.450.441
1hb1OCVIsopenicillin N synthase1.21.3.10.440
1nsgRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.440
1nsgRADSerine/threonine-protein kinase mTOR2.7.11.10.440
1p0hACOMycothiol acetyltransferase2.3.1.1890.440
1tehNADAlcohol dehydrogenase class-31.1.1.10.440
1u65CP0Acetylcholinesterase3.1.1.70.440
2g8yNADHydroxycarboxylate dehydrogenase B/0.440
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.440
2xvhNAPPutative flavin-containing monooxygenase/0.440
3iwjNADAminoaldehyde dehydrogenase/0.440
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.440
4ohxADPProtein clpf-1/0.440