sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2pdc | 393 | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 1.000 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.696 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.691 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.686 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.679 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.676 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.657 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.650 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.649 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.648 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.647 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.646 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.641 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.640 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.640 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.638 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.638 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.638 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.637 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.636 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.635 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.635 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.634 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.632 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.629 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.628 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.628 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.627 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.627 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.626 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.626 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.626 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.626 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.625 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.625 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.625 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.622 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.622 | |
| 2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.621 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.619 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.619 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.617 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.615 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.615 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.614 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.612 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.611 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.609 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.601 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.600 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.592 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.586 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.563 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.561 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.561 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.560 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.540 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.524 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.519 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.516 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.507 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.507 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.501 | |
| 4phl | PIL | Phosphodiesterase | / | 0.500 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.498 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.494 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.493 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.493 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.493 | |
| 4mm7 | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.492 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.490 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.489 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.489 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.489 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.486 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.485 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.484 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.483 | |
| 4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.482 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.480 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.480 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.480 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.480 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.479 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.479 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.479 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.479 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.478 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.477 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 4xwt | U5P | Ribonuclease J | / | 0.477 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.476 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.476 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.475 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.475 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.475 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.474 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.474 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.474 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.474 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.473 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.473 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.473 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.473 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.472 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.471 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.471 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.470 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.470 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.469 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.469 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.469 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.468 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.468 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.467 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.467 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.467 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 1hqt | NAP | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.466 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.466 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.466 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.466 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.466 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.466 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.465 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 4kxj | P34 | Nucleoprotein | / | 0.465 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.464 | |
| 4msk | 2C8 | Tankyrase-1 | 2.4.2.30 | 0.464 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.463 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.463 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.462 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 3gf4 | UPG | UDP-galactopyranose mutase | 5.4.99.9 | 0.462 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.462 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.462 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.461 | |
| 2aj4 | ANP | Galactokinase | 2.7.1.6 | 0.461 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.461 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.461 | |
| 4e32 | DWN | Methyltransferase | / | 0.461 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 5ds3 | 09L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.461 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.459 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.459 | |
| 3ndj | JHZ | Methyltransferase | / | 0.459 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.459 | |
| 1pwm | FID | Aldose reductase | 1.1.1.21 | 0.458 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.458 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.458 | |
| 2wmd | ZZ0 | NmrA-like family domain-containing protein 1 | / | 0.458 | |
| 2xnv | VU3 | Soluble acetylcholine receptor | / | 0.458 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 4lng | JAN | CaaX farnesyltransferase beta subunit Ram1 | / | 0.458 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 2jf6 | S55 | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.457 | |
| 2vt4 | P32 | Beta-1 adrenergic receptor | / | 0.457 | |
| 3c1o | NAP | Eugenol synthase | / | 0.457 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.457 | |
| 4l6s | 1WQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.457 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.456 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 5jqh | CAU | Beta-2 adrenergic receptor | / | 0.456 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 2v0m | KLN | Cytochrome P450 3A4 | / | 0.455 | |
| 2xje | U5P | Cytosolic purine 5'-nucleotidase | 3.1.3.5 | 0.455 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.455 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.455 | |
| 4a6e | ASE | Acetylserotonin O-methyltransferase | 2.1.1.4 | 0.455 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.454 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.454 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.454 | |
| 1s36 | CEI | Obelin | / | 0.454 | |
| 3gg2 | UGA | Sugar dehydrogenase, UDP-glucose/GDP-mannose dehydrogenase family | / | 0.454 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.454 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.454 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 4paa | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.454 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.454 | |
| 1al7 | HST | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.453 | |
| 1lvu | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.453 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.453 | |
| 2xq0 | BES | Leukotriene A-4 hydrolase homolog | 3.3.2.6 | 0.453 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 5d5a | CAU | Beta-2 adrenergic receptor | / | 0.453 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.452 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.452 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.452 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.452 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 4h7c | 10H | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.451 | |
| 4jq1 | NPS | Aldo-keto reductase family 1 member C2 | / | 0.451 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 1thz | 326 | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.450 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.450 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.450 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2zit | NAD | Exotoxin A | 2.4.2.36 | 0.450 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.450 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.450 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.450 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.450 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.450 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.450 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.449 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.449 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.449 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.449 | |
| 4xo7 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.449 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.449 | |
| 5a4w | QCT | Glutathione S-transferase F2 | 2.5.1.18 | 0.449 | |
| 1rxj | BNI | Streptavidin | / | 0.448 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 3jq8 | DX3 | Pteridine reductase, putative | / | 0.448 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4jtr | IBP | Aldo-keto reductase family 1 member C2 | / | 0.448 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.448 | |
| 1lke | DOG | Bilin-binding protein | / | 0.447 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.447 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.447 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.447 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 3abx | RCB | Glucanase | / | 0.447 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.447 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.447 | |
| 4e2y | JHZ | Methyltransferase | / | 0.447 | |
| 4fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.447 | |
| 4fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.447 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.447 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.447 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 1qv0 | CZH | Obelin | / | 0.446 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 2hzq | STR | Apolipoprotein D | / | 0.446 | |
| 2pdy | FID | Aldose reductase | 1.1.1.21 | 0.446 | |
| 2v5u | FMN | Flavodoxin | / | 0.446 | |
| 3gx9 | TXD | Morphinone reductase | / | 0.446 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.446 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.446 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.446 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.445 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.445 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.444 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.444 | |
| 2rcw | AAI | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.444 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.444 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.444 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.444 | |
| 4kn1 | 04J | Folate receptor beta | / | 0.444 | |
| 4uy6 | SAH | Histidine N-alpha-methyltransferase | / | 0.444 | |
| 5p2p | DHG | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.444 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.444 | |
| 2ycx | P32 | Beta-1 adrenergic receptor | / | 0.444 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.443 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3hdq | GDU | UDP-galactopyranose mutase | / | 0.443 | |
| 3mj4 | URM | UDP-galactopyranose mutase | / | 0.443 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.443 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.442 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.442 | |
| 1swg | BTN | Streptavidin | / | 0.442 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.442 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 2tpl | HPP | Tyrosine phenol-lyase | 4.1.99.2 | 0.442 | |
| 2vrj | NCW | Beta-glucosidase A | 3.2.1.21 | 0.442 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 2ycw | CAU | Beta-1 adrenergic receptor | / | 0.442 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.442 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.442 | |
| 3p9t | TCL | Repressor | / | 0.442 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.442 | |
| 5cto | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.442 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.442 | |
| 1ah0 | SBI | Aldose reductase | 1.1.1.21 | 0.441 | |
| 1fnb | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.441 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.441 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.441 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.441 | |
| 3pn1 | IVH | DNA ligase | / | 0.441 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.441 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4bvn | P32 | Beta-1 adrenergic receptor | / | 0.441 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 4kmz | FOL | Folate receptor beta | / | 0.441 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.440 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.440 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.440 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.440 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.440 | |
| 3x04 | GNP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.440 | |
| 4d1o | H4B | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.440 | |
| 4lxb | 7R9 | Prothrombin | 3.4.21.5 | 0.440 | |
| 4zvn | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.440 | |
| 5c1g | GDU | Histo-blood group ABO system transferase | / | 0.440 | |
| 2y04 | 68H | Beta-1 adrenergic receptor | / | 0.440 |