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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2a0cCK9Cyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2a0cCK9Cyclin-dependent kinase 22.7.11.221.000
2b55D31Cyclin-dependent kinase 22.7.11.220.649
1oitHDTCyclin-dependent kinase 22.7.11.220.638
1v1k3FPCyclin-dependent kinase 22.7.11.220.636
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.628
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.611
3lfnA27Cyclin-dependent kinase 22.7.11.220.610
2c6o4SPCyclin-dependent kinase 22.7.11.220.609
4fklCK2Cyclin-dependent kinase 22.7.11.220.602
1oiqHDUCyclin-dependent kinase 22.7.11.220.601
1pxmCK5Cyclin-dependent kinase 22.7.11.220.598
1w8cN69Cyclin-dependent kinase 22.7.11.220.596
2r64740Cyclin-dependent kinase 22.7.11.220.596
3r8lZ30Cyclin-dependent kinase 22.7.11.220.595
3r7yZ04Cyclin-dependent kinase 22.7.11.220.592
4fkq42KCyclin-dependent kinase 22.7.11.220.587
3qxoX65Cyclin-dependent kinase 22.7.11.220.586
1pxlCK4Cyclin-dependent kinase 22.7.11.220.584
2w06FRVCyclin-dependent kinase 22.7.11.220.584
1g5sI17Cyclin-dependent kinase 22.7.11.220.583
1w0xOLOCyclin-dependent kinase 22.7.11.220.583
2r3jSCJCyclin-dependent kinase 22.7.11.220.583
3s2pPMUCyclin-dependent kinase 22.7.11.220.583
4ek816KCyclin-dependent kinase 22.7.11.220.582
1ke6LS2Cyclin-dependent kinase 22.7.11.220.581
2r3p3SCCyclin-dependent kinase 22.7.11.220.580
2a4lRRCCyclin-dependent kinase 22.7.11.220.575
2r3kSCQCyclin-dependent kinase 22.7.11.220.575
2w05FRTCyclin-dependent kinase 22.7.11.220.574
2r3lSCWCyclin-dependent kinase 22.7.11.220.573
3roy22ZCyclin-dependent kinase 22.7.11.220.572
3s1h56ZCyclin-dependent kinase 22.7.11.220.572
1gii1PUCyclin-dependent kinase 22.7.11.220.570
4lyn1YGCyclin-dependent kinase 22.7.11.220.570
4acm7YGCyclin-dependent kinase 22.7.11.220.568
3lfqA28Cyclin-dependent kinase 22.7.11.220.567
3ral04ZCyclin-dependent kinase 22.7.11.220.567
3rni21ZCyclin-dependent kinase 22.7.11.220.567
3lfsA07Cyclin-dependent kinase 22.7.11.220.566
3r7uX96Cyclin-dependent kinase 22.7.11.220.565
1ke7LS3Cyclin-dependent kinase 22.7.11.220.563
3r6xX84Cyclin-dependent kinase 22.7.11.220.562
1urwI1PCyclin-dependent kinase 22.7.11.220.561
3r9dX6BCyclin-dependent kinase 22.7.11.220.561
3sw418KCyclin-dependent kinase 22.7.11.220.561
3qwjX6ACyclin-dependent kinase 22.7.11.220.560
3qzhX69Cyclin-dependent kinase 22.7.11.220.560
3rak03ZCyclin-dependent kinase 22.7.11.220.560
3r7vZ02Cyclin-dependent kinase 22.7.11.220.559
3ezvEZVCyclin-dependent kinase 22.7.11.220.558
3rpo24ZCyclin-dependent kinase 22.7.11.220.558
3ezrEZRCyclin-dependent kinase 22.7.11.220.557
3iggEFQCyclin-dependent kinase 22.7.11.220.557
3qtzX42Cyclin-dependent kinase 22.7.11.220.556
1pxpCK8Cyclin-dependent kinase 22.7.11.220.555
2duv371Cyclin-dependent kinase 22.7.11.220.554
3le62BZCyclin-dependent kinase 22.7.11.220.554
3rmf20ZCyclin-dependent kinase 22.7.11.220.554
3qqhX0ACyclin-dependent kinase 22.7.11.220.553
3r83Z14Cyclin-dependent kinase 22.7.11.220.553
3r73X87Cyclin-dependent kinase 22.7.11.220.552
4fks46KCyclin-dependent kinase 22.7.11.220.552
3qu0X40Cyclin-dependent kinase 22.7.11.220.551
3rjc06ZCyclin-dependent kinase 22.7.11.220.550
3sqq99ZCyclin-dependent kinase 22.7.11.220.549
2r3mSCXCyclin-dependent kinase 22.7.11.220.546
2uzoC62Cyclin-dependent kinase 22.7.11.220.546
1h1s4SPCyclin-dependent kinase 22.7.11.220.544
2xmyCDKCyclin-dependent kinase 22.7.11.220.544
3qzgX67Cyclin-dependent kinase 22.7.11.220.544
3r1qX75Cyclin-dependent kinase 22.7.11.220.543
3rk507ZCyclin-dependent kinase 22.7.11.220.543
4fkt48KCyclin-dependent kinase 22.7.11.220.543
3r71X86Cyclin-dependent kinase 22.7.11.220.542
3rk708ZCyclin-dependent kinase 22.7.11.220.542
4eor4SPCyclin-dependent kinase 22.7.11.220.542
2exmZIPCyclin-dependent kinase 22.7.11.220.541
3ddpRC8Cyclin-dependent kinase 22.7.11.220.541
3qqfX07Cyclin-dependent kinase 22.7.11.220.541
3rpv26ZCyclin-dependent kinase 22.7.11.220.541
3s0o50ZCyclin-dependent kinase 22.7.11.220.541
1gih1PUCyclin-dependent kinase 22.7.11.220.540
3r7iX9ICyclin-dependent kinase 22.7.11.220.540
4fkr45KCyclin-dependent kinase 22.7.11.220.540
1ykr628Cyclin-dependent kinase 22.7.11.220.538
2b53D23Cyclin-dependent kinase 22.7.11.220.538
2vtsLZCCyclin-dependent kinase 22.7.11.220.538
3r8vZ62Cyclin-dependent kinase 22.7.11.220.538
4fkpLS5Cyclin-dependent kinase 22.7.11.220.538
1y91CT9Cyclin-dependent kinase 22.7.11.220.537
3r1sX73Cyclin-dependent kinase 22.7.11.220.537
1h1r6CPCyclin-dependent kinase 22.7.11.220.536
3qruX19Cyclin-dependent kinase 22.7.11.220.536
3rm719ZCyclin-dependent kinase 22.7.11.220.536
1h0w207Cyclin-dependent kinase 22.7.11.220.535
1oguST8Cyclin-dependent kinase 22.7.11.220.535
3qtuX44Cyclin-dependent kinase 22.7.11.220.535
3r1yX76Cyclin-dependent kinase 22.7.11.220.535
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.534
2b52D42Cyclin-dependent kinase 22.7.11.220.533
2c6lDT4Cyclin-dependent kinase 22.7.11.220.533
1oi9N20Cyclin-dependent kinase 22.7.11.220.532
1oiyN41Cyclin-dependent kinase 22.7.11.220.532
1p2a5BNCyclin-dependent kinase 22.7.11.220.532
2vtqLZACyclin-dependent kinase 22.7.11.220.532
3sw719KCyclin-dependent kinase 22.7.11.220.532
3unk0BYCyclin-dependent kinase 22.7.11.220.531
2r3iSCFCyclin-dependent kinase 22.7.11.220.530
4fko20KCyclin-dependent kinase 22.7.11.220.530
3ig7EFPCyclin-dependent kinase 22.7.11.220.528
2ds11CDCyclin-dependent kinase 22.7.11.220.527
3qqkX02Cyclin-dependent kinase 22.7.11.220.527
3qtrX36Cyclin-dependent kinase 22.7.11.220.527
1di8DTQCyclin-dependent kinase 22.7.11.220.526
3rahO1ZCyclin-dependent kinase 22.7.11.220.526
4erwSTUCyclin-dependent kinase 22.7.11.220.526
4fki09KCyclin-dependent kinase 22.7.11.220.526
2vv9IM9Cyclin-dependent kinase 22.7.11.220.525
3r28XA0Cyclin-dependent kinase 22.7.11.220.525
3rkb12ZCyclin-dependent kinase 22.7.11.220.525
3rm618ZCyclin-dependent kinase 22.7.11.220.524
4fkv61KCyclin-dependent kinase 22.7.11.220.524
3rk909ZCyclin-dependent kinase 22.7.11.220.523
1e1xNW1Cyclin-dependent kinase 22.7.11.220.522
1oirHDYCyclin-dependent kinase 22.7.11.220.522
1vyw292Cyclin-dependent kinase 22.7.11.220.522
2btrU73Cyclin-dependent kinase 22.7.11.220.522
4eok4SPCyclin-dependent kinase 22.7.11.220.520
3qqlX03Cyclin-dependent kinase 22.7.11.220.519
4bgh3I6Cyclin-dependent kinase 22.7.11.220.519
1h1q2A6Cyclin-dependent kinase 22.7.11.220.518
3qrtX14Cyclin-dependent kinase 22.7.11.220.518
1e9hINRCyclin-dependent kinase 22.7.11.220.516
2iw84SPCyclin-dependent kinase 22.7.11.220.516
2c6iDT1Cyclin-dependent kinase 22.7.11.220.515
3ti1B49Cyclin-dependent kinase 22.7.11.220.514
4bcpT3CCyclin-dependent kinase 22.7.11.220.514
4fkw62KCyclin-dependent kinase 22.7.11.220.514
1aq1STUCyclin-dependent kinase 22.7.11.220.511
3ddqRRCCyclin-dependent kinase 22.7.11.220.511
3pxyJWSCyclin-dependent kinase 22.7.11.220.511
1h1pCMGCyclin-dependent kinase 22.7.11.220.510
2w1hL0FCyclin-dependent kinase 22.7.11.220.510
2r3gSC9Cyclin-dependent kinase 22.7.11.220.509
2w17I19Cyclin-dependent kinase 22.7.11.220.508
2fvdLIACyclin-dependent kinase 22.7.11.220.507
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.507
3fz1B98Cyclin-dependent kinase 22.7.11.220.507
3r7eX88Cyclin-dependent kinase 22.7.11.220.507
3raiX85Cyclin-dependent kinase 22.7.11.220.506
1oiuN76Cyclin-dependent kinase 22.7.11.220.505
1pyePM1Cyclin-dependent kinase 22.7.11.220.505
2c5yMTWCyclin-dependent kinase 22.7.11.220.505
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.505
3pj8404Cyclin-dependent kinase 22.7.11.220.505
3qx2X63Cyclin-dependent kinase 22.7.11.220.505
1hckATPCyclin-dependent kinase 22.7.11.220.504
1fvt106Cyclin-dependent kinase 22.7.11.220.503
2uznC96Cyclin-dependent kinase 22.7.11.220.503
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.503
3qxpX64Cyclin-dependent kinase 22.7.11.220.503
1vyzN5BCyclin-dependent kinase 22.7.11.220.501
2iw94SPCyclin-dependent kinase 22.7.11.220.501
3dogNNNCyclin-dependent kinase 22.7.11.220.501
1ke9LS5Cyclin-dependent kinase 22.7.11.220.500
2r3r6SCCyclin-dependent kinase 22.7.11.220.500
1b38ATPCyclin-dependent kinase 22.7.11.220.499
2r3fSC8Cyclin-dependent kinase 22.7.11.220.499
3qx4X4BCyclin-dependent kinase 22.7.11.220.499
2j9mPY8Cyclin-dependent kinase 22.7.11.220.498
2pvnP63Casein kinase II subunit alpha2.7.11.10.498
3my5RFZCyclin-dependent kinase 22.7.11.220.498
2bheBRYCyclin-dependent kinase 22.7.11.220.497
3qtxX43Cyclin-dependent kinase 22.7.11.220.497
2pvlP55Casein kinase II subunit alpha2.7.11.10.496
4eon1ROCyclin-dependent kinase 22.7.11.220.495
4fx360KCyclin-dependent kinase 22.7.11.220.494
1pxkCK3Cyclin-dependent kinase 22.7.11.220.493
3qwkX62Cyclin-dependent kinase 22.7.11.220.493
4bcmT7ZCyclin-dependent kinase 22.7.11.220.493
4fkj11KCyclin-dependent kinase 22.7.11.220.493
3qziX72Cyclin-dependent kinase 22.7.11.220.492
1gij2PUCyclin-dependent kinase 22.7.11.220.491
2c68CT6Cyclin-dependent kinase 22.7.11.220.491
3nynSGVG protein-coupled receptor kinase 62.7.11.160.491
2btsU32Cyclin-dependent kinase 22.7.11.220.490
1ckpPVBCyclin-dependent kinase 22.7.11.220.489
1ke5LS1Cyclin-dependent kinase 22.7.11.220.489
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.489
4ek610KCyclin-dependent kinase 22.7.11.220.488
1pxoCK7Cyclin-dependent kinase 22.7.11.220.487
1unlRRCCyclin-dependent-like kinase 52.7.11.10.486
3qqgX06Cyclin-dependent kinase 22.7.11.220.486
2c6kDT2Cyclin-dependent kinase 22.7.11.220.485
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.485
3nux3NVCyclin-dependent kinase 62.7.11.220.485
3r8pZ46Cyclin-dependent kinase 22.7.11.220.485
3r9nZ68Cyclin-dependent kinase 22.7.11.220.484
5dr6SKEAurora kinase A2.7.11.10.484
1pkdUCNCyclin-dependent kinase 22.7.11.220.482
1r78FMDCyclin-dependent kinase 22.7.11.220.482
3py0SU9Cyclin-dependent kinase 22.7.11.220.482
1b39ATPCyclin-dependent kinase 22.7.11.220.481
3r9hZ67Cyclin-dependent kinase 22.7.11.220.481
3tiz3TICyclin-dependent kinase 22.7.11.220.481
4gfg0XFTyrosine-protein kinase SYK2.7.10.20.481
2wpa889Cyclin-dependent kinase 22.7.11.220.480
4bcoT6QCyclin-dependent kinase 22.7.11.220.479
2bhhRYUCyclin-dependent kinase 22.7.11.220.477
2eufLQQCyclin-dependent kinase 62.7.11.220.477
2r3q5SCCyclin-dependent kinase 22.7.11.220.475
3r9oZ71Cyclin-dependent kinase 22.7.11.220.475
2vtrLZBCyclin-dependent kinase 22.7.11.220.474
2r3o2SCCyclin-dependent kinase 22.7.11.220.473
2x1nX1NCyclin-dependent kinase 22.7.11.220.473
3ql8X01Cyclin-dependent kinase 22.7.11.220.473
3unj0BXCyclin-dependent kinase 22.7.11.220.473
3uli1N3Cyclin-dependent kinase 22.7.11.220.472
2vthLZ2Cyclin-dependent kinase 22.7.11.220.471
3r8zZ63Cyclin-dependent kinase 22.7.11.220.470
3rpy27ZCyclin-dependent kinase 22.7.11.220.470
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.470
3wblPDYCyclin-dependent kinase 22.7.11.220.470
1v0pPVBCell division control protein 2 homolog2.7.11.220.469
2c6tDT5Cyclin-dependent kinase 22.7.11.220.468
2xngA0HAurora kinase A2.7.11.10.468
3be9P04Casein kinase II subunit alpha2.7.11.10.468
2i40BLZCyclin-dependent kinase 22.7.11.220.467
5dt0SKEAurora kinase A2.7.11.10.467
3lq5SLQCyclin-dependent kinase 92.7.11.220.465
3qtsX46Cyclin-dependent kinase 22.7.11.220.465
4anmWULCasein kinase II subunit alpha2.7.11.10.465
4fkg4CKCyclin-dependent kinase 22.7.11.220.465
3sheI85MAP kinase-activated protein kinase 32.7.11.10.464
4fv6E57Mitogen-activated protein kinase 12.7.11.240.464
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.464
1h0vUN4Cyclin-dependent kinase 22.7.11.220.463
1ke8LS4Cyclin-dependent kinase 22.7.11.220.463
1pxjCK2Cyclin-dependent kinase 22.7.11.220.463
2uzbC75Cyclin-dependent kinase 22.7.11.220.463
4cfnJYMCyclin-dependent kinase 22.7.11.220.463
4eol1ROCyclin-dependent kinase 22.7.11.220.463
4jajXU1Aurora kinase A2.7.11.10.463
4kd11QKCyclin-dependent kinase 22.7.11.220.463
2c5nCK8Cyclin-dependent kinase 22.7.11.220.462
3tnwF18Cyclin-dependent kinase 22.7.11.220.462
4ez30S0Cyclin-dependent kinase 22.7.11.220.462
4qmpDKISerine/threonine-protein kinase 242.7.11.10.462
1eh4IC1Casein kinase I homolog 12.7.11.10.460
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.460
3mtfA3FActivin receptor type-12.7.11.300.460
4bcnT9NCyclin-dependent kinase 22.7.11.220.460
4ez50RSCyclin-dependent kinase 62.7.11.220.460
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.460
1xjdSTUProtein kinase C theta type2.7.11.130.459
1y8yCT7Cyclin-dependent kinase 22.7.11.220.459
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.459
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.459
5dr9SKEAurora kinase A2.7.11.10.459
2c6mDT5Cyclin-dependent kinase 22.7.11.220.458
3r8uZ31Cyclin-dependent kinase 22.7.11.220.458
3qzfX66Cyclin-dependent kinase 22.7.11.220.457
2pvhP19Casein kinase II subunit alpha2.7.11.10.455
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.455
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.454
3rzb02ZCyclin-dependent kinase 22.7.11.220.454
4bcqTJFCyclin-dependent kinase 22.7.11.220.454
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.454
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.454
2b54D05Cyclin-dependent kinase 22.7.11.220.453
2pmoHMDProtein kinase 7/0.453
2vu3LZECyclin-dependent kinase 22.7.11.220.453
3ggfGVDSerine/threonine-protein kinase 26/0.453
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.452
1v0oINRCell division control protein 2 homolog2.7.11.220.452
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.452
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
4ii5ADPCyclin-dependent kinase 22.7.11.220.452
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.452
1fvv107Cyclin-dependent kinase 22.7.11.220.451
2csnCKICasein kinase I homolog 12.7.11.10.451
2uzeC95Cyclin-dependent kinase 22.7.11.220.451
3nga3NGCasein kinase II subunit alpha2.7.11.10.451
2cchATPCyclin-dependent kinase 22.7.11.220.450
2wxvWXVCyclin-dependent kinase 22.7.11.220.450
4gub0Y4Casein kinase II subunit alpha2.7.11.10.450
4dgnLU2Casein kinase II subunit alpha2.7.11.10.449
4eoi1ROCyclin-dependent kinase 22.7.11.220.448
4eos1ROCyclin-dependent kinase 22.7.11.220.448
4hge15VTyrosine-protein kinase JAK2/0.448
2xa4AZ5Tyrosine-protein kinase JAK2/0.447
3u4uLNHCasein kinase II subunit alpha2.7.11.10.447
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.447
3at4CCKCasein kinase II subunit alpha2.7.11.10.446
4fv9E71Mitogen-activated protein kinase 12.7.11.240.446
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.445
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.445
4ivb1J5Tyrosine-protein kinase JAK1/0.445
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.445
3iok1P6Tyrosine-protein kinase JAK2/0.444
3zh8C58Protein kinase C iota type2.7.11.130.444
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.444
2wtjWTJSerine/threonine-protein kinase Chk22.7.11.10.443
4nj32KDCyclin-dependent kinase 22.7.11.220.443
5cnnANPEpidermal growth factor receptor2.7.10.10.443
1dm2HMDCyclin-dependent kinase 22.7.11.220.442
3s00Z60Cyclin-dependent kinase 22.7.11.220.442
4aqc88ATyrosine-protein kinase JAK2/0.442
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.442
4nifANPMitogen-activated protein kinase 12.7.11.240.442
2zjwREFCasein kinase II subunit alpha2.7.11.10.441
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.441
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.441
4gmy0X5Tyrosine-protein kinase JAK2/0.441
4y93746Tyrosine-protein kinase/0.441
1xl5190Gag-Pol polyprotein3.4.23.160.440
2c69CT8Cyclin-dependent kinase 22.7.11.220.440
3el51UNGag-Pol polyprotein/0.440
3nup3NUCyclin-dependent kinase 62.7.11.220.440
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440