sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1lua | NAP | Bifunctional protein MdtA | 1.5.1.5 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1lua | NAP | Bifunctional protein MdtA | 1.5.1.5 | 1.000 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.499 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.497 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.494 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.494 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.491 | |
| 4i8z | G08 | Gag-Pol polyprotein | 3.4.23.16 | 0.489 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.486 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.481 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.481 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.481 | |
| 4xnh | ACO | N-terminal acetyltransferase A complex subunit NAT5 | 2.3.1 | 0.481 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.480 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.479 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.478 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.476 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.476 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.475 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.474 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.473 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.473 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.473 | |
| 3em3 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.472 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.471 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.471 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.471 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.471 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.471 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.471 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.469 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.469 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.469 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.469 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.469 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.468 | |
| 1xl5 | 190 | Gag-Pol polyprotein | 3.4.23.16 | 0.468 | |
| 2ien | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.468 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.468 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.467 | |
| 1wwk | NAD | 307aa long hypothetical phosphoglycerate dehydrogenase | / | 0.467 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.467 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.467 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.466 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.466 | |
| 1vik | BAY | Gag-Pol polyprotein | / | 0.465 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.465 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.465 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.465 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.464 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 4ejv | LCL | Transcriptional regulator TcaR | / | 0.464 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.463 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.463 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.462 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.462 | |
| 1w2x | RCP | Acetyl-CoA carboxylase | / | 0.462 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.462 | |
| 3r4b | 74T | Gag-Pol polyprotein | / | 0.462 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.462 | |
| 4kb9 | G79 | Protease | / | 0.462 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.461 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.461 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.461 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.461 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.460 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.460 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.460 | |
| 4qi7 | FAD | Cellobiose dehydrogenase | / | 0.460 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 1tv8 | SAM | GTP 3',8-cyclase | 4.1.99.18 | 0.459 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.459 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.459 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.459 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.458 | |
| 4qi4 | FAD | Cellobiose dehydrogenase | / | 0.458 | |
| 5eb5 | FAD | (R)-mandelonitrile lyase 1 | 4.1.2.10 | 0.458 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.457 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.457 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.457 | |
| 1pmn | 984 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.457 | |
| 1xkq | NDP | Uncharacterized protein | / | 0.457 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.457 | |
| 3bgb | LJG | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 3cis | ATP | Universal stress protein Rv2623 | / | 0.457 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.457 | |
| 3ieu | GDP | GTPase Era | / | 0.457 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.457 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.457 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.457 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.457 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.456 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.456 | |
| 1rm4 | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.456 | |
| 2fb2 | SAM | GTP 3',8-cyclase | 4.1.99.18 | 0.456 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.456 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.455 | |
| 2y3r | TRK | TamL | / | 0.455 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.455 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.455 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.455 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.455 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.454 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 3lzs | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.454 | |
| 4djh | JDC | Kappa-type opioid receptor | / | 0.454 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.453 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.453 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.453 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.453 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.453 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.452 | |
| 1nbo | NAD | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.452 | |
| 1rbq | KEU | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.452 | |
| 1wng | SAH | Diphthine synthase | / | 0.452 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.452 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.452 | |
| 3d8x | FAD | Thioredoxin reductase 1 | 1.8.1.9 | 0.452 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 3slz | 3TL | Putative gag-pro-pol polyprotein | / | 0.452 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.452 | |
| 1hbv | GAN | Gag-Pol polyprotein | / | 0.451 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.451 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 2gmj | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.451 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.451 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.451 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.451 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.451 | |
| 3d64 | NAD | Adenosylhomocysteinase | / | 0.451 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4oh4 | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.451 | |
| 4qec | NAP | ElxO | / | 0.451 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.450 | |
| 1tj1 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.450 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.450 | |
| 2gz7 | D3F | Orf1a polyprotein | / | 0.450 | |
| 2uuv | FAD | Alkyldihydroxyacetonephosphate synthase | 2.5.1.26 | 0.450 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.450 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.450 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.450 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.450 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.450 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.450 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.450 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.450 | |
| 5doz | NDP | JamJ | / | 0.450 | |
| 1c2t | NHS | Phosphoribosylglycinamide formyltransferase | / | 0.449 | |
| 1civ | NAP | Malate dehydrogenase [NADP], chloroplastic | 1.1.1.82 | 0.449 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.449 | |
| 2hqp | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.449 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.449 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.449 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.449 | |
| 4iv6 | FDA | Isovaleryl-CoA dehydrogenase | / | 0.449 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 4wdg | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.449 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.448 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.448 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.448 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 2f81 | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.448 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.448 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.448 | |
| 3pwm | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.448 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.448 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.448 | |
| 3zdf | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.448 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.448 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.447 | |
| 1rc0 | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.447 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.447 | |
| 2ie0 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 3vx4 | ATP | Putative ABC transporter, ATP-binding protein ComA | / | 0.447 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.447 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.447 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.447 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA2 | 3.6.3 | 0.447 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA1 | / | 0.447 | |
| 5hg0 | SAM | Pantothenate synthetase | / | 0.447 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.446 | |
| 1ha3 | MAU | Elongation factor Tu-A | / | 0.446 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 2ejz | SAH | Diphthine synthase | / | 0.446 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.446 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.446 | |
| 2z54 | AB1 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3bmo | NAP | Pteridine reductase | / | 0.446 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 3o9g | F53 | Gag-Pol polyprotein | / | 0.446 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.446 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.446 | |
| 4jji | NAD | Alcohol dehydrogenase class-3 | / | 0.446 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.446 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.446 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.445 | |
| 2fgj | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.445 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.445 | |
| 2gnf | Y27 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 2p3b | 3TL | V-1 PROTEASE protein | / | 0.445 | |
| 2p3b | 3TL | V-1 protease | / | 0.445 | |
| 2uzt | SS3 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 2y3s | TIR | TamL | / | 0.445 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.445 | |
| 3i25 | MV7 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.445 | |
| 3liv | E16 | Protease | / | 0.445 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4er6 | AW2 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.445 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.445 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.445 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.444 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.444 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.444 | |
| 1t57 | FMN | Conserved protein | / | 0.444 | |
| 2huv | SAH | Diphthine synthase | / | 0.444 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.444 | |
| 3dbv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.444 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.444 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.444 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.444 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.444 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.444 | |
| 4wri | OKA | Okadaic acid binding protein 2-alpha | / | 0.444 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 5ftf | ADP | TPR domain protein | / | 0.444 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.443 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.443 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1kzk | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2uzv | SS5 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.443 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.443 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.442 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.442 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.442 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.442 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.442 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3geg | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.442 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.442 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3ocp | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.442 | |
| 3omu | IBD | Heat shock protein 83 | / | 0.442 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.442 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.442 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.442 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.442 | |
| 4f07 | FAD | Styrene monooxygenase component 2 | / | 0.442 | |
| 4fry | NAD | Putative signal-transduction protein with CBS domains | / | 0.442 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.442 | |
| 4ohx | ADP | Protein clpf-1 | / | 0.442 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.442 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.442 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1joa | FAD | NADH peroxidase | 1.11.1.1 | 0.441 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1q8u | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 2fon | FAD | Acyl-coenzyme A oxidase | / | 0.441 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.441 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.441 | |
| 3b8z | 294 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.441 | |
| 3lvf | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1 | / | 0.441 | |
| 3o9h | K2E | Gag-Pol polyprotein | / | 0.441 | |
| 3ogx | H1S | Peptidoglycan recognition protein 1 | / | 0.441 | |
| 3toh | 079 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3tri | NAP | Pyrroline-5-carboxylate reductase | / | 0.441 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.441 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.441 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.440 | |
| 1knu | YPA | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.440 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.440 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.440 | |
| 2ep7 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.440 | |
| 2hb3 | GRL | Protease | / | 0.440 | |
| 2owg | SAH | Diphthine synthase | / | 0.440 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.440 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.440 | |
| 3gob | HXX | DdmC | / | 0.440 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3u33 | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.440 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.440 | |
| 4yek | THM | Thymidine phosphorylase | / | 0.440 |