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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1bucFADAcyl-CoA dehydrogenase, short-chain specific1.3.8.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1bucFADAcyl-CoA dehydrogenase, short-chain specific1.3.8.11.000
2d29FADAcyl-CoA dehydrogenase/0.609
2dvlFADAcyl-CoA dehydrogenase/0.530
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.526
2z2w770Wee1-like protein kinase2.7.10.20.495
5jscFADPutative acyl-CoA dehydrogenase/0.488
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.485
2in6839Wee1-like protein kinase2.7.10.20.485
3djlFADPutative acyl-CoA dehydrogenase AidB1.3.990.485
3sf6FDAGlutaryl-CoA dehydrogenase/0.485
1xdsDRAAclacinomycin 10-hydroxylase RdmB4.1.10.484
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.483
3nf4FADAcyl-CoA dehydrogenase domain-containing protein/0.482
3a1l2CCCytochrome P450/0.480
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.475
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.474
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.473
1cf3FADGlucose oxidase1.1.3.40.471
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.471
3vt7VDXVitamin D3 receptor/0.471
1q3gUDAUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.470
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.470
3njoP2MAbscisic acid receptor PYR1/0.470
1suiFRECaffeoyl-CoA O-methyltransferase2.1.1.1040.469
2znnS44Peroxisome proliferator-activated receptor alpha/0.469
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.469
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.468
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.468
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.467
4x28FDAAcyl-CoA dehydrogenase FadE26/0.467
4x28FDAAcyl-CoA dehydrogenase FadE27/0.467
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
2vn1FK5Peptidylprolyl isomerase/0.465
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.465
1x8b824Wee1-like protein kinase2.7.10.20.464
4ryvZEAProtein LlR18A/0.464
1cbsREACellular retinoic acid-binding protein 2/0.463
2cduFADNADH oxidase/0.462
2i9pNAD3-hydroxyisobutyrate dehydrogenase, mitochondrial1.1.1.310.461
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
3slkNDPPolyketide synthase extender module 2/0.461
4j6dTESCytochrome P450 monooxygenase/0.461
4r21STRCytochrome P450 family 17 polypeptide 2/0.461
2iltNN1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
2z3uCRRCytochrome P450/0.460
3oct1N1Tyrosine-protein kinase BTK2.7.10.20.460
3tqhNDPQuinone oxidoreductase/0.460
4a2aATPCell division protein FtsA/0.460
2igoFADPyranose 2-oxidase/0.459
2wo7ASVIsopenicillin N synthase1.21.3.10.459
2y30SM8Putative repressor SimReg2/0.459
3vt9YI4Vitamin D3 receptor/0.459
1p8dCO1Oxysterols receptor LXR-beta/0.458
2vbpVB1Isopenicillin N synthase1.21.3.10.458
4m9aFDAAcyl-CoA dehydrogenase/0.458
4v2gITCTetracycline repressor protein class D/0.458
3zkyWT4Isopenicillin N synthase1.21.3.10.457
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
4j6bPLOCytochrome P450 monooxygenase/0.457
4ocvANPAminoglycoside phosphotransferase/0.457
1ie8KH1Vitamin D3 receptor/0.456
1pkfEPDEpothilone C/D epoxidase1.140.456
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
3p6oETGCamphor 5-monooxygenase1.14.15.10.456
3qj5022Alcohol dehydrogenase class-31.1.1.10.456
4j6cSTRCytochrome P450 monooxygenase/0.456
4r20AERCytochrome P450 family 17 polypeptide 2/0.456
5dp2NAPCurF/0.456
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.455
2ydoADNAdenosine receptor A2a/0.455
3drcMTXDihydrofolate reductase1.5.1.30.455
3l0lHC3Nuclear receptor ROR-gamma/0.455
4iarERM5-hydroxytryptamine receptor 1B/0.455
2g78REACellular retinoic acid-binding protein 2/0.454
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
4iaq2GM5-hydroxytryptamine receptor 1B/0.454
1qiqACCIsopenicillin N synthase1.21.3.10.453
1upw444Oxysterols receptor LXR-beta/0.453
3zuyTCHTransporter/0.453
4nb6444Nuclear receptor ROR-gamma/0.453
1blzACVIsopenicillin N synthase1.21.3.10.452
1oc1ASVIsopenicillin N synthase1.21.3.10.452
2iviACWIsopenicillin N synthase1.21.3.10.452
3tdaPN0Cytochrome P450 2D6/0.452
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
1ezfIN0Squalene synthase2.5.1.210.451
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.451
2xlsFADPutative flavin-containing monooxygenase/0.451
3cr0809Wee1-like protein kinase2.7.10.20.451
3nx4NAPPutative oxidoreductase/0.451
3r7kFDAProbable acyl CoA dehydrogenase/0.451
4b0532DBeta-secretase 13.4.23.460.451
1fmjRTLRetinol dehydratase/0.450
1h36R88Squalene--hopene cyclase4.2.1.1290.450
1kzjCB3Thymidylate synthase/0.450
1o6qR17Squalene--hopene cyclase4.2.1.1290.450
2c12FADNitroalkane oxidase1.7.3.10.450
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.450
2gcgNDPGlyoxylate reductase/hydroxypyruvate reductase1.1.1.790.450
2og81N8Tyrosine-protein kinase Lck2.7.10.20.450
2pmdGNPTranslation initiation factor 2 subunit gamma/0.450
2uxoTACHTH-type transcriptional regulator TtgR/0.450
3cv9VDXVitamin D3 dihydroxylase/0.450
3fl8RARDihydrofolate reductase/0.450
3wv9FEGHmd co-occurring protein HcgE/0.450
4jbtASDCytochrome P450 monooxygenase/0.450
4jpe1M7Beta-secretase 13.4.23.460.450
4myq19TcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.450
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.449
2o7pNAPRiboflavin biosynthesis protein RibD/0.449
3d4bDZDNAD-dependent protein deacetylase/0.449
3e5aVX6Aurora kinase A2.7.11.10.449
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
3vt8YI3Vitamin D3 receptor/0.449
4dl9NADS-(hydroxymethyl)glutathione dehydrogenase/0.449
4hgs15GCasein kinase I isoform gamma-32.7.11.10.449
5e8wSTUTGF-beta receptor type-12.7.11.300.449
1egeFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.448
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1u0hONMAdenylate cyclase type 2/0.448
1u0hONMAdenylate cyclase type 5/0.448
2a4xBLMMitomycin-binding protein/0.448
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.448
2ohjFMNType A flavoprotein FprA10.448
2oxtSAMGenome polyprotein/0.448
2q9fC3SCholesterol 24-hydroxylase/0.448
2wufKEM4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.448
4i3vNADAldehyde dehydrogenase (NAD+)/0.448
4ia2BIVVitamin D3 receptor A/0.448
4nc3ERM5-hydroxytryptamine receptor 2B/0.448
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2dhfDZFDihydrofolate reductase1.5.1.30.447
2uxiG50HTH-type transcriptional regulator TtgR/0.447
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
3issEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.447
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.447
4azy7F3Beta-secretase 13.4.23.460.447
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.447
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1hvyD16Thymidylate synthase2.1.1.450.446
1ppjANYCytochrome b/0.446
1pq944BOxysterols receptor LXR-beta/0.446
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.446
2vbdV10Isopenicillin N synthase1.21.3.10.446
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.446
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4dplNAPMalonyl-CoA reductase1.2.1.750.446
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
1cjcFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.445
1disBDMDihydrofolate reductase1.5.1.30.445
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.445
3ibdCPZCytochrome P450 2B61.14.130.445
3vtdTKDVitamin D3 receptor/0.445
3ziaADPATP synthase subunit beta, mitochondrial3.6.3.140.445
4b00I6XBeta-secretase 13.4.23.460.445
4b7754MBeta-secretase 13.4.23.460.445
4bfyZVYPantothenate kinase2.7.1.330.445
4kqqVPPPeptidoglycan D,D-transpeptidase FtsI/0.445
5a28MYAGlycylpeptide N-tetradecanoyltransferase/0.445
1hb1OCVIsopenicillin N synthase1.21.3.10.444
1iyzNDPProbable quinone oxidoreductase/0.444
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.444
1wxyFRKAdenosine deaminase3.5.4.40.444
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
3g70A5TRenin3.4.23.150.444
3oafOAGDihydrofolate reductase1.5.1.30.444
3p6pA6BCamphor 5-monooxygenase1.14.15.10.444
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.444
3q44D50M1 family aminopeptidase3.4.110.444
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.444
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
5bn3ADPV-type ATP synthase alpha chain/0.444
5bn3ADPNEQ263/0.444
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.444
3qakUKAAdenosine receptor A2a/0.444
1bk0ACVIsopenicillin N synthase1.21.3.10.443
1dhjMTXDihydrofolate reductase1.5.1.30.443
1pmn984Mitogen-activated protein kinase 102.7.11.240.443
1qjfACSIsopenicillin N synthase1.21.3.10.443
1rf9DBRCamphor 5-monooxygenase1.14.15.10.443
1s0zEB1Vitamin D3 receptor/0.443
2yozOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.443
2z1qFADAcyl-CoA dehydrogenase/0.443
3irxUDRGag-Pol polyprotein2.7.7.490.443
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.443
3zbnCOA3-ketoacyl-CoA thiolase-like protein/0.443
3zcnATPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.443
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4bj9UHBTankyrase-22.4.2.300.443
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.443
4ib4ERM5-hydroxytryptamine receptor 2B/0.443
4irnFADAnaB/0.443
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.443
5bp9SAHPutative methyltransferase protein/0.443
1qxlFR8Adenosine deaminase3.5.4.40.442
1tysDHFThymidylate synthase/0.442
2hcdBIVVitamin D3 receptor A/0.442
2ignFADPyranose 2-oxidase/0.442
2wpxACOOrf14/0.442
3a783EVVitamin D3 receptor/0.442
3cbsR12Cellular retinoic acid-binding protein 2/0.442
3vrwYS5Vitamin D3 receptor/0.442
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1uzwCDHIsopenicillin N synthase1.21.3.10.441
2aclL05Oxysterols receptor LXR-alpha/0.441
2bjsACVIsopenicillin N synthase1.21.3.10.441
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
2vkeTACTetracycline repressor protein class D/0.441
2wpwACOOrf14/0.441
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.441
3abaFLICytochrome P450/0.441
3cib314Beta-secretase 13.4.23.460.441
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.441
3jv7NADSecondary alcohol dehydrogenase/0.441
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3wixLC3Induced myeloid leukemia cell differentiation protein Mcl-1/0.441
4h3i10VBeta-secretase 13.4.23.460.441
4kw51W6Decaprenylphosphoryl-beta-D-ribose oxidase/0.441
5itzLOCTubulin beta-2B chain/0.441
1sowNADL-lactate dehydrogenase1.1.1.270.440
2kceD16Thymidylate synthase/0.440
2zl9VDAVitamin D3 receptor/0.440
3v94WYQPhosphodiesterase/0.440
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
4knzCB3Thymidylate synthase/0.440
4phlPILPhosphodiesterase/0.440