sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Modes are compared using Grim.
For more information, please see the following publication:
Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Mode Similarity |
Align |
|---|---|---|---|---|---|
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 1.227 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 1.118 | |
| 4g6h | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 1.108 | |
| 4g6g | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 1.098 | |
| 4g73 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 1.063 | |
| 4gav | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 1.059 | |
| 4gap | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 1.040 | |
| 4hb9 | FAD | Uncharacterized protein | / | 0.841 | |
| 4em3 | FAD | Coenzyme A disulfide reductase | / | 0.828 | |
| 3grs | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.820 | |
| 2w0h | FAD | Trypanothione reductase | / | 0.818 | |
| 1ges | FAD | Glutathione reductase | 1.8.1.7 | 0.816 | |
| 3rnm | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.794 | |
| 2zzc | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.793 | |
| 1dnc | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.791 | |
| 1tdf | FAD | Thioredoxin reductase | 1.8.1.9 | 0.786 | |
| 2rab | FAD | Glutathione amide reductase | / | 0.786 | |
| 3ics | FAD | Coenzyme A disulfide reductase | / | 0.785 | |
| 3icr | FAD | Coenzyme A disulfide reductase | / | 0.783 | |
| 2zz0 | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.779 | |
| 4opt | FDA | Conserved Archaeal protein | / | 0.767 | |
| 1nhp | FAD | NADH peroxidase | 1.11.1.1 | 0.766 | |
| 2hqm | FAD | Glutathione reductase | 1.8.1.7 | 0.763 | |
| 1v59 | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.762 | |
| 3ict | FAD | Coenzyme A disulfide reductase | / | 0.758 | |
| 1nhr | FAD | NADH peroxidase | 1.11.1.1 | 0.757 | |
| 1tde | FAD | Thioredoxin reductase | 1.8.1.9 | 0.756 | |
| 3nt6 | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.753 | |
| 4opu | FDA | Conserved Archaeal protein | / | 0.753 | |
| 3cgb | FAD | Coenzyme A disulfide reductase | / | 0.752 | |
| 5fs7 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.752 | |
| 1fl2 | FAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.751 | |
| 3cge | FAD | Coenzyme A disulfide reductase | / | 0.750 | |
| 3atr | FDA | Conserved Archaeal protein | / | 0.749 | |
| 3cgc | FAD | Coenzyme A disulfide reductase | / | 0.749 | |
| 3lzw | FAD | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.746 | |
| 4bjz | FAD | Probable salicylate monooxygenase | / | 0.744 | |
| 1npx | FAD | NADH peroxidase | 1.11.1.1 | 0.743 | |
| 4b1b | FAD | Thioredoxin reductase | 1.8.1.9 | 0.743 | |
| 1f8w | FAD | NADH peroxidase | 1.11.1.1 | 0.742 | |
| 1trb | FAD | Thioredoxin reductase | 1.8.1.9 | 0.741 | |
| 1zx9 | FAD | Mercuric reductase | 1.16.1.1 | 0.741 | |
| 2npx | FAD | NADH peroxidase | 1.11.1.1 | 0.741 | |
| 4emw | FAD | Coenzyme A disulfide reductase | / | 0.738 | |
| 4eqx | FAD | Coenzyme A disulfide reductase | / | 0.738 | |
| 1nhs | FAD | NADH peroxidase | 1.11.1.1 | 0.737 | |
| 4o5u | FAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.737 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.736 | |
| 4opl | FDA | Conserved Archaeal protein | / | 0.736 | |
| 2j3n | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.735 | |
| 1q1r | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.734 | |
| 3cgd | FAD | Coenzyme A disulfide reductase | / | 0.734 | |
| 1yqz | FAD | Coenzyme A disulfide reductase | / | 0.733 | |
| 4qi7 | FAD | Cellobiose dehydrogenase | / | 0.733 | |
| 4nwz | FAD | FAD-dependent pyridine nucleotide-disulfide oxidoreductase | / | 0.731 | |
| 1nhq | FAD | NADH peroxidase | 1.11.1.1 | 0.729 | |
| 2eq6 | FAD | Dihydrolipoyl dehydrogenase | / | 0.729 | |
| 3atq | FDA | Conserved Archaeal protein | / | 0.729 | |
| 4ccr | FAD | Thioredoxin reductase | / | 0.728 | |
| 4eqw | FAD | Coenzyme A disulfide reductase | / | 0.728 | |
| 2x3n | FAD | Probable FAD-dependent monooxygenase | / | 0.726 | |
| 4eqr | FAD | Coenzyme A disulfide reductase | / | 0.726 | |
| 4gr1 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.726 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.726 | |
| 1bwc | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.725 | |
| 4j2w | FAD | Kynurenine 3-monooxygenase | / | 0.725 | |
| 4j31 | FAD | Kynurenine 3-monooxygenase | / | 0.725 | |
| 4yry | FAD | Glutamate synthase, beta subunit | / | 0.725 | |
| 1gte | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.723 | |
| 3f8d | FAD | NADH oxidase/thioredoxin reductase | / | 0.723 | |
| 3nta | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.722 | |
| 4em4 | FAD | Coenzyme A disulfide reductase | / | 0.722 | |
| 4eqs | FAD | Coenzyme A disulfide reductase | / | 0.722 | |
| 4dna | FAD | Probable glutathione reductase | / | 0.720 | |
| 4h4r | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.720 | |
| 4h4v | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.720 | |
| 2r9z | FAD | Glutathione amide reductase | / | 0.719 | |
| 4cy8 | FDA | 2-hydroxybiphenyl-3-monooxygenase | / | 0.719 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.719 | |
| 1grb | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.718 | |
| 4bk3 | FAD | Probable salicylate monooxygenase | / | 0.718 | |
| 5eow | FAD | 6-hydroxynicotinate 3-monooxygenase | 1.14.13.114 | 0.718 | |
| 1bzl | FAD | Trypanothione reductase | 1.8.1.12 | 0.717 | |
| 1zk7 | FAD | Mercuric reductase | 1.16.1.1 | 0.717 | |
| 4jdr | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.717 | |
| 2f5z | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.716 | |
| 2vou | FAD | 2,6-dihydroxypyridine 3-monooxygenase | 1.14.13.10 | 0.716 | |
| 1get | FAD | Glutathione reductase | 1.8.1.7 | 0.714 | |
| 2v6o | FAD | Thioredoxin glutathione reductase | / | 0.714 | |
| 4fx9 | FAD | Coenzyme A disulfide reductase | 1.8.1.14 | 0.714 | |
| 1e6e | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.713 | |
| 2bac | FAD | Putative aminooxidase | / | 0.710 | |
| 4ocg | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.709 | |
| 1h7w | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.708 | |
| 1m6i | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.707 | |
| 4jq9 | FAD | Dihydrolipoyl dehydrogenase | / | 0.706 | |
| 4cbq | FAD | Thioredoxin reductase | / | 0.705 | |
| 3dh9 | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.703 | |
| 3dk4 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.703 | |
| 3klj | FAD | NADH-rubredoxin oxidoreductase | 1.18.1.1 | 0.703 | |
| 2whd | FAD | Thioredoxin reductase | / | 0.701 | |
| 2bi8 | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.700 | |
| 4o5q | FAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.700 | |
| 4a65 | FAD | Thioredoxin reductase | / | 0.699 | |
| 4ccq | FAD | Thioredoxin reductase | / | 0.699 | |
| 1cl0 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.698 | |
| 1joa | FAD | NADH peroxidase | 1.11.1.1 | 0.698 | |
| 2eq9 | FAD | Dihydrolipoyl dehydrogenase | / | 0.698 | |
| 2x8h | FAD | Thioredoxin glutathione reductase | / | 0.698 | |
| 3dk9 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.697 | |
| 4jnq | FDA | Thioredoxin reductase | / | 0.696 | |
| 3lxd | FAD | FAD-dependent pyridine nucleotide-disulfide oxidoreductase | / | 0.695 | |
| 1geu | FAD | Glutathione reductase | 1.8.1.7 | 0.693 | |
| 4opd | FDA | Conserved Archaeal protein | / | 0.693 | |
| 2cdu | FAD | NADH oxidase | / | 0.692 | |
| 2eq8 | FAD | Dihydrolipoyl dehydrogenase | / | 0.691 | |
| 5fs9 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.691 | |
| 3all | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.690 | |
| 3gd3 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.689 | |
| 3rha | FDA | Putrescine oxidase | / | 0.689 | |
| 4h4t | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.689 | |
| 3fbs | FAD | Oxidoreductase | / | 0.688 | |
| 4a5l | FAD | Thioredoxin reductase | / | 0.688 | |
| 4j33 | FAD | Kynurenine 3-monooxygenase | / | 0.688 | |
| 1gth | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.687 | |
| 3oz2 | FAD | Digeranylgeranylglycerophospholipid reductase | / | 0.687 | |
| 4rsl | FAD | Fructosyl peptide oxidase | / | 0.687 | |
| 2b9x | FAD | Putative aminooxidase | / | 0.686 | |
| 2gh5 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.685 | |
| 3ish | FAD | Thioredoxin reductase | 1.8.1.9 | 0.685 | |
| 4ykg | FAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.685 | |
| 1gra | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.684 | |
| 3ef6 | FAD | Toluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component | 1.18.1.3 | 0.684 | |
| 4j34 | FAD | Kynurenine 3-monooxygenase | / | 0.684 | |
| 4mo2 | FAD | UDP-galactopyranose mutase | / | 0.684 | |
| 1grg | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.683 | |
| 4x4j | FAD | Putative oxygenase | / | 0.682 | |
| 4ykf | FAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.682 | |
| 1onf | FAD | Glutathione reductase | 1.8.1.7 | 0.681 | |
| 1jnr | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.680 | |
| 1mok | FAD | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.680 | |
| 3hdy | FAD | UDP-galactopyranose mutase | / | 0.680 | |
| 4opc | FDA | Conserved Archaeal protein | / | 0.680 | |
| 1q1w | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.679 | |
| 2wow | FAD | Trypanothione reductase | / | 0.679 | |
| 2qa1 | FAD | PgaE | / | 0.678 | |
| 2qa2 | FAD | Polyketide oxygenase CabE | / | 0.678 | |
| 2bi7 | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.677 | |
| 2fje | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.677 | |
| 3sqp | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.677 | |
| 4h4p | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.677 | |
| 5fs8 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.676 | |
| 4u8o | FDA | UDP-galactopyranose mutase | / | 0.675 | |
| 1wam | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.674 | |
| 4h4x | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.674 | |
| 1mo9 | FAD | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.673 | |
| 2zbw | FAD | Ferredoxin--NADP reductase | / | 0.673 | |
| 4nte | FAD | DepH | / | 0.673 | |
| 1f3p | FAD | Ferredoxin reductase | / | 0.672 | |
| 2b9y | FAD | Putative aminooxidase | / | 0.672 | |
| 4lii | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.672 | |
| 4up3 | FAD | Thioredoxin reductase | / | 0.672 | |
| 3ab1 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.671 | |
| 4u8m | FDA | UDP-galactopyranose mutase | / | 0.671 | |
| 4cnj | FAD | L-amino acid oxidase | / | 0.670 | |
| 1k4q | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.669 | |
| 3lzx | FAD | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.669 | |
| 4jy2 | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.669 | |
| 2yvf | FAD | Ferredoxin reductase | / | 0.668 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.668 | |
| 1grh | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.667 | |
| 3oc4 | FAD | Oxidoreductase, pyridine nucleotide-disulfide family | / | 0.667 | |
| 3int | FDA | UDP-galactopyranose mutase | 5.4.99.9 | 0.666 | |
| 4bur | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.666 | |
| 3qj4 | FAD | Renalase | / | 0.665 | |
| 4fwj | FAD | Lysine-specific histone demethylase 1B | 1 | 0.665 | |
| 4nev | FAD | Trypanothione reductase | / | 0.665 | |
| 2c3d | FAD | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.664 | |
| 4h2n | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.664 | |
| 2q0k | FAD | Thioredoxin reductase | 1.8.1.9 | 0.663 | |
| 3qfb | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.663 | |
| 4emj | FAD | Toluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component | 1.18.1.3 | 0.663 | |
| 4gcm | FAD | Thioredoxin reductase | 1.8.1.9 | 0.663 | |
| 4gde | FDA | UDP-galactopyranose mutase | / | 0.663 | |
| 4u8k | FDA | UDP-galactopyranose mutase | / | 0.662 | |
| 1zy8 | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.661 | |
| 3bi5 | FAD | Polyamine oxidase FMS1 | / | 0.661 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.660 | |
| 1k0l | FAD | p-hydroxybenzoate hydroxylase | / | 0.659 | |
| 3fg2 | FAD | Putative rubredoxin reductase | / | 0.659 | |
| 4fwe | FAD | Lysine-specific histone demethylase 1B | 1 | 0.659 | |
| 4la1 | FAD | Thioredoxin glutathione reductase | / | 0.659 | |
| 1xdi | FAD | NAD(P)H dehydrogenase (quinone) | / | 0.656 | |
| 3v76 | FDA | Uncharacterized protein | / | 0.656 | |
| 4u8i | FDA | UDP-galactopyranose mutase | / | 0.656 | |
| 4u8j | FDA | UDP-galactopyranose mutase | / | 0.656 | |
| 4u8n | FDA | UDP-galactopyranose mutase | / | 0.656 | |
| 4u8p | FDA | UDP-galactopyranose mutase | / | 0.656 | |
| 2yr4 | FAD | Phenylalanine 2-monooxygenase precursor | 1.13.12.9 | 0.655 | |
| 3gmb | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.655 | |
| 4bv6 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.653 | |
| 4j36 | FAD | Kynurenine 3-monooxygenase | / | 0.653 | |
| 1b4v | FAD | Cholesterol oxidase | 1.1.3.6 | 0.652 | |
| 1e1k | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.652 | |
| 2fja | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.652 | |
| 3we0 | FAD | Lysine 2-monooxygenase | / | 0.652 | |
| 3rp8 | FAD | FAD-dependent urate hydroxylase | / | 0.650 | |
| 4guv | FAD | TetX family tetracycline inactivation enzyme | / | 0.650 | |
| 4jn9 | FAD | DepH | / | 0.650 | |
| 4ntc | FAD | Thioredoxin reductase gliT | / | 0.650 |