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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3lb8 FAD Putidaredoxin reductase 1.18.1.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
3lb8 FADPutidaredoxin reductase 1.18.1.5 1.401
1q1w FADPutidaredoxin reductase 1.18.1.5 1.133
1q1r FADPutidaredoxin reductase 1.18.1.5 1.013
3fg2 FADPutative rubredoxin reductase / 0.933
2gqw FADFerredoxin reductase / 0.891
1d7y FADFerredoxin reductase / 0.864
2yvf FADFerredoxin reductase / 0.859
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.857
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.853
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.853
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.847
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.842
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.842
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.836
2yvj FADFerredoxin reductase / 0.833
4h4w FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.831
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.823
4h4q FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.820
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.818
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.812
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.806
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.803
1f3p FADFerredoxin reductase / 0.796
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.791
2gr0 FADFerredoxin reductase / 0.789
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.788
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.783
4yry FADGlutamate synthase, beta subunit / 0.781
4bur FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.780
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.779
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.775
3cgb FADCoenzyme A disulfide reductase / 0.774
4em3 FADCoenzyme A disulfide reductase / 0.765
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.764
4h4u FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.763
1f8w FADNADH peroxidase 1.11.1.1 0.758
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.758
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.758
2gr1 FADFerredoxin reductase / 0.752
3vqr FADPutative oxidoreductase / 0.752
3icr FADCoenzyme A disulfide reductase / 0.750
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.747
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.747
4eqx FADCoenzyme A disulfide reductase / 0.747
4h4y FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.743
4h50 FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.743
2gr3 FADFerredoxin reductase / 0.739
1rsg FADPolyamine oxidase FMS1 / 0.737
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.737
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.736
1npx FADNADH peroxidase 1.11.1.1 0.734
3cgc FADCoenzyme A disulfide reductase / 0.734
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.734
2dw4 FADLysine-specific histone demethylase 1A 1 0.733
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.732
3fbs FADOxidoreductase / 0.731
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.730
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.728
2wp5 FADTrypanothione reductase / 0.728
3f8d FADNADH oxidase/thioredoxin reductase / 0.727
2cdu FADNADH oxidase / 0.726
3f8p NADNADH oxidase/thioredoxin reductase / 0.726
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.724
4em4 FADCoenzyme A disulfide reductase / 0.723
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.722
3kpf FADPolyamine oxidase 1.5.3.14 0.722
4k2x FADPolyketide oxygenase/hydroxylase / 0.722
3cge FADCoenzyme A disulfide reductase / 0.720
2tpr FADTrypanothione reductase 1.8.1.12 0.719
1nhp FADNADH peroxidase 1.11.1.1 0.717
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.717
2qa1 FADPgaE / 0.716
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.715
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.715
4j31 FADKynurenine 3-monooxygenase / 0.714
1get FADGlutathione reductase 1.8.1.7 0.713
4emw FADCoenzyme A disulfide reductase / 0.713
1nhr FADNADH peroxidase 1.11.1.1 0.712
2hqm FADGlutathione reductase 1.8.1.7 0.712
1ger FADGlutathione reductase 1.8.1.7 0.711
4j2w FADKynurenine 3-monooxygenase / 0.711
3atr FDAConserved Archaeal protein / 0.709
4eqw FADCoenzyme A disulfide reductase / 0.709
4j56 FADThioredoxin reductase 2 1.8.1.9 0.709
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.708
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.707
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.707
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.706
3f8r NAPNADH oxidase/thioredoxin reductase / 0.706
4opi FDAConserved Archaeal protein / 0.705
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.704
4opg FDAConserved Archaeal protein / 0.704
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.703
4j33 FADKynurenine 3-monooxygenase / 0.703
3atq FDAConserved Archaeal protein / 0.701
2q0k FADThioredoxin reductase 1.8.1.9 0.700
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.699
1k0j FADp-hydroxybenzoate hydroxylase / 0.699
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.699
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.699
1nhs FADNADH peroxidase 1.11.1.1 0.698
2jae FADL-amino acid oxidase / 0.698
2jb1 FADL-amino acid oxidase / 0.698
3cgd FADCoenzyme A disulfide reductase / 0.698
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.698
4mo2 FADUDP-galactopyranose mutase / 0.697
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.696
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.696
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.695
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.695
3bi5 FADPolyamine oxidase FMS1 / 0.693
4nzh FADL-ornithine N(5)-monooxygenase / 0.693
1d7l RFLp-hydroxybenzoate hydroxylase / 0.692
2q7v FADThioredoxin reductase / 0.692
1yqz FADCoenzyme A disulfide reductase / 0.690
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.690
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.690
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.690
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.689
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.689
4rsl FADFructosyl peptide oxidase / 0.689
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.688
4dsg FADUncharacterized protein / 0.688
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.687
2x3n FADProbable FAD-dependent monooxygenase / 0.687
4bjz FADProbable salicylate monooxygenase / 0.687
4gus FADLysine-specific histone demethylase 1B 1 0.687
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.686
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.685
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.685
1f8s FADL-amino-acid oxidase 1.4.3.2 0.684
2apg FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.684
1c0l FADD-amino-acid oxidase 1.4.3.3 0.683
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.683
3rha FDAPutrescine oxidase / 0.683
2jk6 FADTrypanothione reductase / 0.682
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.680
2xdo FADTetX family tetracycline inactivation enzyme / 0.680
4jn9 FADDepH / 0.680
4up3 FADThioredoxin reductase / 0.680
4x4j FADPutative oxygenase / 0.680
2npx FADNADH peroxidase 1.11.1.1 0.679
4wct FADFructosyl amine:oxygen oxidoreductase / 0.679
1ojt FADDihydrolipoyl dehydrogenase / 0.678
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.677
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.677
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.677
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.676
1geu FADGlutathione reductase 1.8.1.7 0.676
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.675
1typ FADTrypanothione reductase 1.8.1.12 0.675
1zk7 FADMercuric reductase 1.16.1.1 0.675
4nte FADDepH / 0.675
1nhq FADNADH peroxidase 1.11.1.1 0.674
1zx9 FADMercuric reductase 1.16.1.1 0.674
4z26 FADPutative GMC-type oxidoreductase R135 1 0.674
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.674
1kif FADD-amino-acid oxidase 1.4.3.3 0.673
4j36 FADKynurenine 3-monooxygenase / 0.673
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.672
3ics FADCoenzyme A disulfide reductase / 0.672
4bk2 FADProbable salicylate monooxygenase / 0.672
2ohh FMNType A flavoprotein FprA 1 0.671
2yg5 FADPutrescine oxidase / 0.671
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.671
4fwj FADLysine-specific histone demethylase 1B 1 0.670
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.669
1wam FADUDP-galactopyranose mutase 5.4.99.9 0.669
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.669
3axb FADPutative oxidoreductase / 0.669
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.669
4qi7 FADCellobiose dehydrogenase / 0.669
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.669
2x8g FADThioredoxin glutathione reductase / 0.668
3urh FADDihydrolipoyl dehydrogenase / 0.668
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.668
1k0l FADp-hydroxybenzoate hydroxylase / 0.667
3lad FADDihydrolipoyl dehydrogenase / 0.667
4a5l FADThioredoxin reductase / 0.667
4b1b FADThioredoxin reductase 1.8.1.9 0.667
4dna FADProbable glutathione reductase / 0.667
4j34 FADKynurenine 3-monooxygenase / 0.667
4jq9 FADDihydrolipoyl dehydrogenase / 0.667
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.666
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.666
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.666
4opc FDAConserved Archaeal protein / 0.666
5j60 FADThioredoxin reductase / 0.666
1ges FADGlutathione reductase 1.8.1.7 0.665
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.665
1joa FADNADH peroxidase 1.11.1.1 0.665
2eq6 FADDihydrolipoyl dehydrogenase / 0.665
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.665
2qa2 FADPolyketide oxygenase CabE / 0.665
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.665
4cnk FADL-amino acid oxidase / 0.665
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.663
4gav FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.663
1yy5 FADPolyamine oxidase FMS1 / 0.662
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.662
3kve FADL-amino-acid oxidase / 0.662
3t2k FADSulfide-quinone reductase / 0.662
4k5r FADOxygenase / 0.662
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.662
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.661
4tlz FADKtzI / 0.661
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.660
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.660
4bk3 FADProbable salicylate monooxygenase / 0.660
1h83 FADPolyamine oxidase 1.5.3.14 0.659
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.659
2ba9 FADPutative aminooxidase / 0.659
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.659
2wow FADTrypanothione reductase / 0.659
4eqs FADCoenzyme A disulfide reductase / 0.659
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.658
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.658
2q0l FADThioredoxin reductase 1.8.1.9 0.658
3zdn FADMonoamine oxidase N 1.4.3.4 0.658
4a65 FADThioredoxin reductase / 0.658
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.658
5hxw FADL-amino acid deaminase / 0.658
2vvl FADMonoamine oxidase N 1.4.3.4 0.657
2yg3 FADPutrescine oxidase / 0.657
2ohi FMNType A flavoprotein FprA 1 0.656
2yqu FADDihydrolipoyl dehydrogenase / 0.656
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.656
4ntc FADThioredoxin reductase gliT / 0.656
1trb FADThioredoxin reductase 1.8.1.9 0.655
2oa1 FADFlavin-dependent tryptophan halogenase RebH 1.14.19.9 0.655
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.655
3dme FADPutative conserved exported protein / 0.655
3ish FADThioredoxin reductase 1.8.1.9 0.655
3k30 ADPHistamine dehydrogenase / 0.655
4tm3 FADKtzI / 0.655
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.654
3alm FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.654
3kpk FADSulfide-quinone reductase / 0.654
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.653
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.653
3sz0 FADSulfide-quinone reductase / 0.653
4b63 FADL-ornithine N(5)-monooxygenase / 0.653
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.652
1i7p FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.652
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.652
2eq8 FADDihydrolipoyl dehydrogenase / 0.652
3cty FADProbable thioredoxin reductase / 0.652
4gcm FADThioredoxin reductase 1.8.1.9 0.652
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.651
2aqj FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.651
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.650
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.650
2jb2 FADL-amino acid oxidase / 0.650
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.650
3t2z FADSulfide-quinone reductase / 0.650
4nev FADTrypanothione reductase / 0.650
4nwz FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.650
4xoo FMNCoenzyme F420:L-glutamate ligase / 0.650