sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Modes are compared using Grim.
For more information, please see the following publication:
Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2xyo | FAD | TetX family tetracycline inactivation enzyme |
| PDB ID | HET | Uniprot Name | EC Number | Binding Mode Similarity |
Align |
|---|---|---|---|---|---|
| 2xyo | FAD | TetX family tetracycline inactivation enzyme | / | 1.124 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.924 | |
| 3p9u | FAD | TetX family tetracycline inactivation enzyme | / | 0.877 | |
| 2xdo | FAD | TetX family tetracycline inactivation enzyme | / | 0.830 | |
| 4guv | FAD | TetX family tetracycline inactivation enzyme | / | 0.802 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.791 | |
| 3ept | FDA | Putative FAD-monooxygenase | / | 0.776 | |
| 2eq8 | FAD | Dihydrolipoyl dehydrogenase | / | 0.771 | |
| 5eow | FAD | 6-hydroxynicotinate 3-monooxygenase | 1.14.13.114 | 0.744 | |
| 3urh | FAD | Dihydrolipoyl dehydrogenase | / | 0.743 | |
| 5buk | FAD | FADH2-dependent halogenase | / | 0.740 | |
| 1k0j | FAD | p-hydroxybenzoate hydroxylase | / | 0.737 | |
| 4j36 | FAD | Kynurenine 3-monooxygenase | / | 0.734 | |
| 4k2x | FAD | Polyketide oxygenase/hydroxylase | / | 0.734 | |
| 3atq | FDA | Conserved Archaeal protein | / | 0.732 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.731 | |
| 1ebd | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.730 | |
| 2yqu | FAD | Dihydrolipoyl dehydrogenase | / | 0.730 | |
| 1zmd | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.729 | |
| 3rnm | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.729 | |
| 2eq6 | FAD | Dihydrolipoyl dehydrogenase | / | 0.725 | |
| 4jq9 | FAD | Dihydrolipoyl dehydrogenase | / | 0.725 | |
| 4gr1 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.722 | |
| 3dgz | FAD | Thioredoxin reductase 2, mitochondrial | 1.8.1.9 | 0.720 | |
| 3atr | FDA | Conserved Archaeal protein | / | 0.718 | |
| 3klj | FAD | NADH-rubredoxin oxidoreductase | 1.18.1.1 | 0.717 | |
| 2wow | FAD | Trypanothione reductase | / | 0.715 | |
| 3oc4 | FAD | Oxidoreductase, pyridine nucleotide-disulfide family | / | 0.715 | |
| 4j57 | FAD | Thioredoxin reductase 2 | 1.8.1.9 | 0.715 | |
| 4j33 | FAD | Kynurenine 3-monooxygenase | / | 0.714 | |
| 4jdr | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.711 | |
| 4m52 | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.711 | |
| 4nev | FAD | Trypanothione reductase | / | 0.711 | |
| 1grb | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.709 | |
| 1jeh | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.709 | |
| 4k5r | FAD | Oxygenase | / | 0.709 | |
| 2x8g | FAD | Thioredoxin glutathione reductase | / | 0.707 | |
| 1d7l | RFL | p-hydroxybenzoate hydroxylase | / | 0.706 | |
| 2eq7 | FAD | Dihydrolipoyl dehydrogenase | / | 0.706 | |
| 3dk9 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.706 | |
| 1gra | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.705 | |
| 2a8x | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.705 | |
| 1xdi | FAD | NAD(P)H dehydrogenase (quinone) | / | 0.704 | |
| 3qfa | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.704 | |
| 4j31 | FAD | Kynurenine 3-monooxygenase | / | 0.704 | |
| 3all | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.703 | |
| 2qae | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.702 | |
| 2v6o | FAD | Thioredoxin glutathione reductase | / | 0.701 | |
| 2x8h | FAD | Thioredoxin glutathione reductase | / | 0.701 | |
| 2wp5 | FAD | Trypanothione reductase | / | 0.700 | |
| 3dk4 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.700 | |
| 1geu | FAD | Glutathione reductase | 1.8.1.7 | 0.698 | |
| 1v59 | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.697 | |
| 4opd | FDA | Conserved Archaeal protein | / | 0.697 | |
| 3cgc | FAD | Coenzyme A disulfide reductase | / | 0.696 | |
| 4j2w | FAD | Kynurenine 3-monooxygenase | / | 0.696 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.695 | |
| 3grs | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.695 | |
| 4opc | FDA | Conserved Archaeal protein | / | 0.695 | |
| 2hqm | FAD | Glutathione reductase | 1.8.1.7 | 0.694 | |
| 2jk6 | FAD | Trypanothione reductase | / | 0.694 | |
| 3ean | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.694 | |
| 3nta | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.694 | |
| 3fmw | FAD | Oxygenase | / | 0.693 | |
| 3lad | FAD | Dihydrolipoyl dehydrogenase | / | 0.693 | |
| 3nix | FAD | Flavoprotein/dehydrogenase | / | 0.693 | |
| 4gcm | FAD | Thioredoxin reductase | 1.8.1.9 | 0.692 | |
| 2eq9 | FAD | Dihydrolipoyl dehydrogenase | / | 0.691 | |
| 3sm8 | FNK | FAD-dependent catabolic D-arginine dehydrogenase DauA | / | 0.691 | |
| 4kpr | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.691 | |
| 1zmc | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.690 | |
| 2rab | FAD | Glutathione amide reductase | / | 0.690 | |
| 2wba | FAD | Trypanothione reductase | 1.8.1.12 | 0.690 | |
| 3ab1 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.690 | |
| 2j3n | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.689 | |
| 2q0k | FAD | Thioredoxin reductase | 1.8.1.9 | 0.689 | |
| 2zbw | FAD | Ferredoxin--NADP reductase | / | 0.689 | |
| 1nhs | FAD | NADH peroxidase | 1.11.1.1 | 0.688 | |
| 3cge | FAD | Coenzyme A disulfide reductase | / | 0.688 | |
| 4hb9 | FAD | Uncharacterized protein | / | 0.688 | |
| 3dgh | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.687 | |
| 1fec | FAD | Trypanothione reductase | 1.8.1.12 | 0.686 | |
| 3cgb | FAD | Coenzyme A disulfide reductase | / | 0.686 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.686 | |
| 1bwc | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.685 | |
| 1rp0 | AHZ | Thiamine thiazole synthase, chloroplastic | / | 0.685 | |
| 2f5z | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.685 | |
| 4bjz | FAD | Probable salicylate monooxygenase | / | 0.685 | |
| 4x4j | FAD | Putative oxygenase | / | 0.685 | |
| 3c4a | FAD | Protodeoxyviolaceinate monooxygenase | 1 | 0.684 | |
| 5fs8 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.684 | |
| 1zy8 | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.683 | |
| 3dk8 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.683 | |
| 3nt6 | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.683 | |
| 1ger | FAD | Glutathione reductase | 1.8.1.7 | 0.682 | |
| 4cy8 | FDA | 2-hydroxybiphenyl-3-monooxygenase | / | 0.682 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.681 | |
| 4fx9 | FAD | Coenzyme A disulfide reductase | 1.8.1.14 | 0.681 | |
| 4ntc | FAD | Thioredoxin reductase gliT | / | 0.681 | |
| 1lpf | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.680 | |
| 1grh | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.678 | |
| 2zz0 | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.678 | |
| 4icy | FAD | PgaE | / | 0.678 | |
| 1ges | FAD | Glutathione reductase | 1.8.1.7 | 0.677 | |
| 2qa2 | FAD | Polyketide oxygenase CabE | / | 0.677 | |
| 3ish | FAD | Thioredoxin reductase | 1.8.1.9 | 0.677 | |
| 3sqp | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.677 | |
| 1tyt | FAD | Trypanothione reductase | 1.8.1.12 | 0.676 | |
| 1cl0 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.675 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.675 | |
| 2qa1 | FAD | PgaE | / | 0.675 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.675 | |
| 1zk7 | FAD | Mercuric reductase | 1.16.1.1 | 0.674 | |
| 4b1b | FAD | Thioredoxin reductase | 1.8.1.9 | 0.673 | |
| 4bk2 | FAD | Probable salicylate monooxygenase | / | 0.673 | |
| 4bk3 | FAD | Probable salicylate monooxygenase | / | 0.673 | |
| 3ics | FAD | Coenzyme A disulfide reductase | / | 0.672 | |
| 1k0l | FAD | p-hydroxybenzoate hydroxylase | / | 0.671 | |
| 3icr | FAD | Coenzyme A disulfide reductase | / | 0.671 | |
| 1ryi | FAD | Glycine oxidase | 1.4.3.19 | 0.670 | |
| 2r9z | FAD | Glutathione amide reductase | / | 0.670 | |
| 4o5q | FAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.670 | |
| 1feb | FAD | Trypanothione reductase | 1.8.1.12 | 0.669 | |
| 1npx | FAD | NADH peroxidase | 1.11.1.1 | 0.669 | |
| 4a5l | FAD | Thioredoxin reductase | / | 0.669 | |
| 4cnk | FAD | L-amino acid oxidase | / | 0.669 | |
| 5dbj | FAD | FADH2-dependent halogenase PltA | / | 0.669 | |
| 4h2n | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.668 | |
| 5fs9 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.668 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.667 | |
| 3lzw | FAD | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.667 | |
| 4la1 | FAD | Thioredoxin glutathione reductase | / | 0.667 | |
| 2nvk | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.666 | |
| 3rp8 | FAD | FAD-dependent urate hydroxylase | / | 0.666 | |
| 1gxf | FAD | Trypanothione reductase | 1.8.1.12 | 0.665 | |
| 2yg6 | FAD | Putrescine oxidase | / | 0.662 | |
| 3dh9 | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.662 | |
| 1dnc | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.660 | |
| 1k4q | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.660 | |
| 1nhr | FAD | NADH peroxidase | 1.11.1.1 | 0.659 | |
| 1zx9 | FAD | Mercuric reductase | 1.16.1.1 | 0.659 | |
| 2npx | FAD | NADH peroxidase | 1.11.1.1 | 0.659 | |
| 2tpr | FAD | Trypanothione reductase | 1.8.1.12 | 0.659 | |
| 4usr | FAD | Monooxygenase | / | 0.659 | |
| 1nhp | FAD | NADH peroxidase | 1.11.1.1 | 0.658 | |
| 1nhq | FAD | NADH peroxidase | 1.11.1.1 | 0.658 | |
| 2i0z | FAD | NAD(FAD)-utilizing dehydrogenases | / | 0.658 | |
| 3gd3 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.658 | |
| 4jn9 | FAD | DepH | / | 0.658 | |
| 4up3 | FAD | Thioredoxin reductase | / | 0.658 | |
| 4ykf | FAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.658 | |
| 1gsn | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.657 | |
| 1ps9 | FAD | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.657 | |
| 3f8d | FAD | NADH oxidase/thioredoxin reductase | / | 0.657 | |
| 1onf | FAD | Glutathione reductase | 1.8.1.7 | 0.656 | |
| 3djg | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.655 | |
| 1fl2 | FAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.654 | |
| 2b9y | FAD | Putative aminooxidase | / | 0.654 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.654 | |
| 3fbs | FAD | Oxidoreductase | / | 0.654 | |
| 1e1n | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.652 | |
| 1f8s | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.651 | |
| 4ykg | FAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.651 | |
| 1q1w | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.650 | |
| 2dki | FAD | 3-hydroxybenzoate 4-monooxygenase | 1.14.13.23 | 0.650 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.650 |