sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Modes are compared using Grim.
For more information, please see the following publication:
Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2c29 | NAP | Dihydroflavonol 4-reductase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Mode Similarity |
Align |
|---|---|---|---|---|---|
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 1.486 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 1.440 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.939 | |
| 4pvd | NDP | NADPH-dependent methylglyoxal reductase GRE2 | / | 0.927 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.892 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.888 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.878 | |
| 2p5y | NAD | UDP-glucose 4-epimerase | / | 0.864 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.861 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.860 | |
| 4hxy | NDP | Plm1 | / | 0.852 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.850 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.849 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.848 | |
| 4b4o | NDP | Epimerase family protein SDR39U1 | / | 0.847 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.846 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.845 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.844 | |
| 4u7w | NDP | MxaA | / | 0.843 | |
| 4ej0 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.841 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.840 | |
| 3icp | NAD | NAD-dependent epimerase/dehydratase | / | 0.840 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.840 | |
| 4kwh | NAP | Reductase homolog | / | 0.836 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.835 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.832 | |
| 1w8d | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.830 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.829 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.828 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.827 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.824 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.824 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.824 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.822 | |
| 3ak4 | NAD | NADH-dependent quinuclidinone reductase | / | 0.822 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.818 | |
| 3mje | NDP | AmphB | / | 0.818 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.817 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.815 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.814 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.813 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.812 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.812 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.811 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.809 | |
| 3rj5 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.808 | |
| 5d2e | NAP | MlnE | / | 0.808 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.807 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.807 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.807 | |
| 1geg | NAD | Diacetyl reductase [(S)-acetoin forming] | 1.1.1.304 | 0.805 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.804 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.803 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.803 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.803 | |
| 3h4v | NAP | Pteridine reductase 1 | 1.5.1.33 | 0.802 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.801 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.801 | |
| 2bgm | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.800 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.799 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.798 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.798 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.798 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.798 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.796 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.795 | |
| 3sxp | NAD | ADP-L-glycero-D-mannoheptose-6-epimerase | / | 0.795 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.794 | |
| 3rj9 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.794 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.794 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.794 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.793 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.793 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.792 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.792 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.792 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.791 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.789 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.789 | |
| 4imp | NDP | Polyketide synthase extender modules 3-4 | / | 0.789 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.789 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.788 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.788 | |
| 1i3l | NAD | UDP-glucose 4-epimerase | / | 0.787 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.787 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.787 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.786 | |
| 2ydx | NAP | Methionine adenosyltransferase 2 subunit beta | / | 0.785 | |
| 4qec | NAP | ElxO | / | 0.785 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.784 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.783 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.783 | |
| 3tn7 | NJP | Short-chain alcohol dehydrogenase | / | 0.783 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.783 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.782 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.779 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.779 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.779 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.779 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.778 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.777 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.777 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.777 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.777 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.776 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.776 | |
| 4lis | NAD | UDP-glucose 4-epimerase (Eurofung) | / | 0.775 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.774 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.772 | |
| 5bt9 | NAP | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.772 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.771 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.771 | |
| 2hrb | NAP | Carbonyl reductase [NADPH] 3 | 1.1.1.184 | 0.770 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.770 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.769 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.769 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.768 | |
| 1u7t | TDT | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.768 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.768 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.767 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.766 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.765 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.762 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.760 | |
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.760 | |
| 3pgx | NAD | Uncharacterized NAD-dependent oxidoreductase MAP_4146 | / | 0.758 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.757 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.756 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.756 | |
| 3ko8 | NAD | NAD-dependent epimerase/dehydratase | / | 0.756 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.755 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.754 | |
| 2qx7 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.754 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.754 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.753 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.752 | |
| 1i2b | NAD | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.751 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.750 | |
| 2ztu | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.750 | |
| 3uce | NDP | Dehydrogenase | / | 0.750 | |
| 1ek5 | NAD | UDP-glucose 4-epimerase | / | 0.749 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.749 | |
| 4idg | NAD | Putative UDP-glucose 4-epimerase | / | 0.749 | |
| 3geg | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.748 | |
| 5jyd | NAD | Short chain dehydrogenase | / | 0.748 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.747 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.745 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.745 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.741 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.741 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.740 | |
| 4qed | NAP | ElxO | / | 0.740 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.739 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.739 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.739 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.738 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.738 | |
| 1nff | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.737 | |
| 1nfr | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.733 | |
| 2gn8 | NAP | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.733 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.733 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.732 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.732 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.731 | |
| 2b69 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.729 | |
| 2x6t | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.729 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.729 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.729 | |
| 4l4x | NDP | AmphI | / | 0.729 | |
| 1b15 | NAE | Alcohol dehydrogenase | 1.1.1.1 | 0.728 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.728 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.728 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.728 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.727 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.727 | |
| 4b7x | NAP | Probable oxidoreductase | / | 0.726 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.726 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.725 | |
| 1rpn | NDP | GDP-mannose 4,6-dehydratase | / | 0.724 | |
| 3aut | NAI | Glucose 1-dehydrogenase 4 | 1.1.1.47 | 0.721 | |
| 1fdu | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.720 | |
| 1xkq | NDP | Uncharacterized protein | / | 0.719 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.718 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.717 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.717 | |
| 3sju | NDP | Keto reductase | / | 0.717 | |
| 1iy8 | NAD | Levodione reductase | / | 0.716 | |
| 1sny | NAP | LD36273p | / | 0.716 | |
| 1bdb | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | / | 0.715 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.715 | |
| 2bfo | NDP | Pteridine reductase 1 | 1.5.1.33 | 0.715 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.714 | |
| 3u4c | NDP | NADPH-dependent reductase BacG | / | 0.714 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.714 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.713 | |
| 1eq2 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.712 | |
| 1w73 | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.712 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.712 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.712 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.711 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.711 | |
| 4clo | NAP | Pteridine reductase | / | 0.710 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.709 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.708 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.708 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.708 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.707 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.707 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.706 | |
| 4jbi | NDP | Alcohol dehydrogenase (Zinc) | / | 0.706 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.701 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.701 | |
| 4lk3 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.701 | |
| 1nai | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.700 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.700 | |
| 3pvz | NAD | UDP-N-acetylglucosamine 4,6-dehydratase | / | 0.699 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.699 | |
| 4hfm | NAP | 2-alkenal reductase (NADP(+)-dependent) | / | 0.698 | |
| 3wfj | NAD | 2-dehydropantoate 2-reductase | / | 0.697 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.697 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.696 | |
| 3bmo | NAP | Pteridine reductase | / | 0.696 | |
| 1n7g | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.695 | |
| 2z1m | NDP | GDP-mannose 4,6-dehydratase | / | 0.695 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.694 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.693 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.693 | |
| 1o8c | NDP | Probable acrylyl-CoA reductase AcuI | 1.3.1.84 | 0.692 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.692 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.692 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.691 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.691 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.691 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.690 | |
| 4gkv | NAD | Alcohol dehydrogenase, propanol-preferring | 1.1.1.1 | 0.689 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.688 | |
| 2yjz | NAP | Metalloreductase STEAP4 | 1.16.1 | 0.687 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.685 | |
| 4xyb | NDP | Formate dehydrogenase | / | 0.683 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.680 | |
| 4y1b | NAP | AntE | / | 0.680 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.680 | |
| 1fk8 | NAD | 3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase | 1.1.1.50 | 0.679 | |
| 2z95 | NDP | GDP-mannose 4,6-dehydratase | / | 0.679 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.679 | |
| 5a03 | NDP | Glucose-fructose oxidoreductase | / | 0.679 | |
| 3rfx | NAD | Uronate dehydrogenase | / | 0.677 | |
| 5a05 | NDP | Glucose-fructose oxidoreductase | / | 0.677 | |
| 1ahh | NAD | 7-alpha-hydroxysteroid dehydrogenase | 1.1.1.159 | 0.676 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.676 | |
| 2cvz | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.675 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.675 | |
| 5a02 | NAP | Glucose-fructose oxidoreductase | / | 0.674 | |
| 5a06 | NDP | Glucose-fructose oxidoreductase | / | 0.674 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.673 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.673 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.673 | |
| 4j16 | NAP | NAD(P) transhydrogenase subunit beta | / | 0.673 | |
| 5a04 | NDP | Glucose-fructose oxidoreductase | / | 0.673 | |
| 1h6a | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.672 | |
| 2b35 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.672 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.672 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.672 | |
| 4nfs | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.671 | |
| 1b14 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.670 | |
| 1h2b | NAJ | NAD-dependent alcohol dehydrogenase | / | 0.669 | |
| 2b36 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.669 | |
| 1c1d | NAI | Phenylalanine dehydrogenase | / | 0.668 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.668 | |
| 4ng5 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.668 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.667 | |
| 4e5m | NAP | Phosphonate dehydrogenase | 1.20.1.1 | 0.666 | |
| 4eue | NAI | Trans-2-enoyl-CoA reductase [NADH] | / | 0.666 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.666 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.664 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.664 | |
| 2ixa | NAD | Alpha-N-acetylgalactosaminidase | 3.2.1.49 | 0.664 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.664 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.664 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.664 | |
| 5doz | NDP | JamJ | / | 0.664 | |
| 1lua | NAP | Bifunctional protein MdtA | 1.5.1.5 | 0.663 | |
| 1nah | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.663 | |
| 1wp4 | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.663 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.663 | |
| 4oaq | NDP | R-specific carbonyl reductase | / | 0.663 | |
| 4xgi | NAD | Glutamate dehydrogenase | / | 0.663 | |
| 1wnt | NAP | L-xylulose reductase | 1.1.1.10 | 0.662 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.662 | |
| 3oq6 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.662 | |
| 4nfh | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.662 | |
| 5cdt | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.662 | |
| 5kj1 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.662 | |
| 5kj6 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.662 | |
| 5kjc | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.662 | |
| 5kje | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.662 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.661 | |
| 4bii | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.661 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.661 | |
| 1hyh | NAD | L-2-hydroxyisocaproate dehydrogenase | / | 0.660 | |
| 1pzf | A3D | Lactate dehydrogenase | / | 0.660 | |
| 2ohx | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.660 | |
| 2vhv | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.660 | |
| 3dtt | NAP | NADP oxidoreductase, coenzyme F420-dependent | / | 0.660 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.660 | |
| 4e5n | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.659 | |
| 4y0k | NAP | AntE | / | 0.659 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.658 | |
| 1wvg | APR | CDP-glucose 4,6-dehydratase | 4.2.1.45 | 0.658 | |
| 1zh8 | NAP | Uncharacterized protein | / | 0.658 | |
| 2g76 | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.658 | |
| 1h6b | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.657 | |
| 1t2a | NDP | GDP-mannose 4,6 dehydratase | 4.2.1.47 | 0.657 | |
| 2yw9 | NAP | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.657 | |
| 1j5p | NAD | L-aspartate dehydrogenase | 1.4.1.21 | 0.656 | |
| 2o4c | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.656 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.656 | |
| 4ros | APR | Malate dehydrogenase | / | 0.656 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.656 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.655 | |
| 1h6d | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.655 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.655 | |
| 4xb2 | NDP | 319aa long hypothetical homoserine dehydrogenase | / | 0.655 | |
| 1h6c | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.654 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.654 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.654 | |
| 4id9 | NAD | Putative UDP-glucose 4-epimerase | / | 0.654 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.654 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.653 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.653 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.653 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.652 | |
| 3bgi | SAH | Thiopurine S-methyltransferase | 2.1.1.67 | 0.652 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.652 | |
| 3pzr | NAP | Aspartate-semialdehyde dehydrogenase 1 | / | 0.652 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.652 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.652 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.652 | |
| 1yqx | NAP | Sinapyl alcohol dehydrogenase | / | 0.651 | |
| 1pnq | NDP | NAD(P) transhydrogenase subunit beta | 1.6.1.2 | 0.650 | |
| 1wzi | NDP | Malate dehydrogenase | / | 0.650 | |
| 2oxi | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.650 | |
| 5bsg | NAP | Pyrroline-5-carboxylate reductase | / | 0.650 |