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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4l091URTankyrase-22.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4l091URTankyrase-22.4.2.301.000
4l2f1V3Tankyrase-22.4.2.300.635
4kzl20DTankyrase-22.4.2.300.633
4hlf15ZTankyrase-22.4.2.300.598
4iueAJ4Tankyrase-22.4.2.300.587
4hlm16STankyrase-22.4.2.300.586
4hmhF94Tankyrase-22.4.2.300.583
4l0v1V1Tankyrase-22.4.2.300.582
4hlg20BTankyrase-22.4.2.300.578
4l0i1UWTankyrase-22.4.2.300.575
4j21AJ6Tankyrase-22.4.2.300.572
4bus32FTankyrase-22.4.2.300.564
4j3mAJ8Tankyrase-22.4.2.300.560
4bs4A64Tankyrase-22.4.2.300.556
4l321VFTankyrase-22.4.2.300.552
4l31F08Tankyrase-22.4.2.300.551
4avwG18Tankyrase-22.4.2.300.549
4hlh20DTankyrase-22.4.2.300.548
3p0pNNFTankyrase-22.4.2.300.547
4buwF33Tankyrase-22.4.2.300.546
4hkkAGITankyrase-22.4.2.300.546
4pnrG18Tankyrase-22.4.2.300.546
4buxF35Tankyrase-22.4.2.300.545
3u9y09LTankyrase-22.4.2.300.543
4j3lAJ5Tankyrase-22.4.2.300.538
4pnmNU1Tankyrase-22.4.2.300.533
4krs1SXTankyrase-12.4.2.300.530
4buv16ITankyrase-22.4.2.300.528
4hl515WTankyrase-22.4.2.300.526
4l0s1UZTankyrase-22.4.2.300.526
4hknLU2Tankyrase-22.4.2.300.522
4bj9UHBTankyrase-22.4.2.300.519
4l33F70Tankyrase-22.4.2.300.519
5aku29FTankyrase-22.4.2.300.515
4bufF36Tankyrase-22.4.2.300.513
4buuF38Tankyrase-22.4.2.300.512
4l2g1V4Tankyrase-22.4.2.300.512
4l2k1V8Tankyrase-22.4.2.300.504
4hkiFLNTankyrase-22.4.2.300.497
3wqmB29Diterpene synthase3.1.7.80.495
4avuLDRTankyrase-22.4.2.300.495
4tkg09LTankyrase-22.4.2.300.491
1lnmDTXBilin-binding protein/0.488
4bjbP34Tankyrase-22.4.2.300.481
4tjy3GNTankyrase-22.4.2.300.481
4bjcRPBTankyrase-22.4.2.300.480
1zprCB3Thymidylate synthase/0.477
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.475
1lkeDOGBilin-binding protein/0.473
1ni4TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.472
1ni4TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.472
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.472
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.472
4eqsCOACoenzyme A disulfide reductase/0.472
1r5hAO2Methionine aminopeptidase 2/0.471
3q3cNADNAD-dependent L-serine dehydrogenase/0.471
3lkhLT6Genome polyprotein2.7.7.480.470
4msk2C8Tankyrase-12.4.2.300.468
1ex75GPGuanylate kinase2.7.4.80.466
1wl4COAAcetyl-CoA acetyltransferase, cytosolic2.3.1.90.465
3h4vDVPPteridine reductase 11.5.1.330.465
1yqzCOACoenzyme A disulfide reductase/0.464
4xbfFADLysine-specific histone demethylase 1A10.464
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.463
4eqwCOACoenzyme A disulfide reductase/0.462
4mt92D6Tankyrase-12.4.2.300.462
1dfoPLGSerine hydroxymethyltransferase2.1.2.10.461
3bw4FMNPutative 2-nitropropane dioxygenase/0.461
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.461
4fweFADLysine-specific histone demethylase 1B10.461
2clmF6FTryptophan synthase alpha chain/0.459
2h3wHC5Carnitine O-acetyltransferase2.3.1.70.459
3ai0PNWBeta-glucosidase/0.459
1qoqIGPTryptophan synthase alpha chain/0.458
2hdjNDPAldo-keto reductase family 1 member C2/0.458
4fam0SZAldo-keto reductase family 1 member C3/0.458
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.458
1txtCAAHMG-CoA synthase/0.457
2vbpVB1Isopenicillin N synthase1.21.3.10.457
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.457
1fmlRTLRetinol dehydratase/0.456
1rfgGMPPurine nucleoside phosphorylase2.4.2.10.456
3bgsDIHPurine nucleoside phosphorylase2.4.2.10.456
1h36R88Squalene--hopene cyclase4.2.1.1290.455
2y6fM9FIsopenicillin N synthase1.21.3.10.455
2zi63D1Deoxycytidine kinase2.7.1.740.455
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.455
3zoiM2WIsopenicillin N synthase1.21.3.10.455
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
4o6fSAHN-lysine methyltransferase SMYD2/0.455
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.454
1rzuADPGlycogen synthase 12.4.1.210.454
2dw4FADLysine-specific histone demethylase 1A10.454
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.453
1t3zCAOFormyl-CoA:oxalate CoA-transferase/0.453
2ed3SAHDiphthine synthase/0.453
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.453
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.453
2r5nTPPTransketolase 1/0.453
3mauPLRPutative sphingosine-1-phosphate lyase/0.453
3nx2FERFerulic acid decarboxylase/0.453
4fqsLYAThymidylate synthase ThyA/0.453
1jdzFMBPurine nucleoside phosphorylase/0.452
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.452
1t7o152Carnitine O-acetyltransferase2.3.1.70.452
2bb3SAHCobalamin biosynthesis precorrin-6Y methylase (CbiE)/0.452
2ejzSAHDiphthine synthase/0.452
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.452
3h3qH13Collagen type IV alpha-3-binding protein/0.452
3h3r14HCollagen type IV alpha-3-binding protein/0.452
3p82FMNPentaerythritol tetranitrate reductase/0.452
4wecNADShort chain dehydrogenase/0.452
1nqvLMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.451
1zdwFLVPrenyltransferase/0.451
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.451
3tp0FO5HTH-type transcriptional regulator EthR/0.451
4b63FADL-ornithine N(5)-monooxygenase/0.451
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.451
1ppjANYCytochrome b/0.450
2bf7HBIPteridine reductase 11.5.1.330.450
1dgbNDPCatalase1.11.1.60.449
1pz1NAPGeneral stress protein 69/0.449
3nmpPYVAbscisic acid receptor PYL2/0.449
4e32DWNMethyltransferase/0.449
4uthFMNXenobiotic reductase/0.449
4wxfPLGSerine hydroxymethyltransferase/0.449
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.448
2ozrGG1Collagenase 33.4.240.448
2xjeU5PCytosolic purine 5'-nucleotidase3.1.3.50.448
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.448
5choFADFlavin reductase/0.448
1xk9P34Exotoxin A2.4.2.360.447
1z6tADPApoptotic protease-activating factor 1/0.447
3h59H59Genome polyprotein2.7.7.480.447
1bk0ACVIsopenicillin N synthase1.21.3.10.446
1oc1ASVIsopenicillin N synthase1.21.3.10.446
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.446
2fhnBNIAvidin-related protein 4/5/0.446
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3k8q22APurine nucleoside phosphorylase2.4.2.10.446
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.446
4bfvZVVPantothenate kinase2.7.1.330.446
4br0AU1Ectonucleoside triphosphate diphosphohydrolase 2/0.446
4f32N323-oxoacyl-[acyl-carrier-protein] synthase 2/0.446
4knzCB3Thymidylate synthase/0.446
1ut6A8NAcetylcholinesterase3.1.1.70.445
2e1zB4PPropionate kinase/0.445
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
4jtqNAPAldo-keto reductase family 1 member C2/0.445
4n4v2GYTankyrase-12.4.2.300.445
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.445
1qjfACSIsopenicillin N synthase1.21.3.10.444
2bxoOPBSerum albumin/0.444
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2zitNADExotoxin A2.4.2.360.444
3jq6DX1Pteridine reductase, putative/0.444
4eph0RKCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.444
4n4t2GVTankyrase-12.4.2.300.444
1obnASVIsopenicillin N synthase1.21.3.10.443
1x1cSAHC-20 methyltransferase/0.443
1xudPB4Collagenase 33.4.240.443
2dshSAHDiphthine synthase/0.443
2qimZEAClass 10 plant pathogenesis-related protein/0.443
2tctCTCTetracycline repressor protein class D/0.443
2uywBTNAvd protein/0.443
2wo7ASVIsopenicillin N synthase1.21.3.10.443
3cr0809Wee1-like protein kinase2.7.10.20.443
3h3sH15Collagen type IV alpha-3-binding protein/0.443
3hkyIX6Genome polyprotein2.7.7.480.443
3mcvMCVPteridine reductase/0.443
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.443
4k4eK4ETankyrase-12.4.2.300.443
5c3jFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.443
1k27MTMS-methyl-5'-thioadenosine phosphorylase/0.442
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
1txzAPRProbable ADP-ribose 1''-phosphate phosphatase YML087W3.1.3.840.442
2x93X93Angiotensin-converting enzyme3.4.15.10.442
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
3reoSAH(Iso)eugenol O-methyltransferase2.1.1.1460.442
3to3ATPPetrobactin biosynthesis protein AsbB/0.442
7stdCRPScytalone dehydratase4.2.1.940.442
1e66HUXAcetylcholinesterase3.1.1.70.441
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.441
1xzqFONtRNA modification GTPase MnmE3.6.50.441
1yhjR6CPyridoxal kinase2.7.1.350.441
1yzqGNPRas-related protein Rab-6A/0.441
2qx7NAPEugenol synthase 11.1.1.3180.441
3b6pTMPThree-prime repair exonuclease 13.1.11.20.441
3p67FMNPentaerythritol tetranitrate reductase/0.441
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.441
4dvi2IWTankyrase-12.4.2.300.441
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.441
5eghPCEctonucleotide pyrophosphatase/phosphodiesterase family member 6/0.441
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.440
1dfoFFOSerine hydroxymethyltransferase2.1.2.10.440
1p0ySAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.440
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.440
1qr2FADRibosyldihydronicotinamide dehydrogenase [quinone]/0.440
2fj1CTCTetracycline repressor protein class D/0.440
2ft0ACOdTDP-fucosamine acetyltransferase/0.440
2fxuBIDActin, alpha skeletal muscle/0.440
2gjlFMNNitronate monooxygenase1.13.12.160.440
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.440
3e8xNAPBH1520 protein/0.440
3i0pNADMalate dehydrogenase, putative/0.440
3qgi33FGenome polyprotein2.7.7.480.440
4a8v2ANMajor pollen allergen Bet v 1-J/0.440
4eqrCOACoenzyme A disulfide reductase/0.440
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.440
5g53NECAdenosine receptor A2a/0.440