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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hyu1BKMitogen-activated protein kinase 82.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4hyu1BKMitogen-activated protein kinase 82.7.11.241.000
4izy1J2Mitogen-activated protein kinase 82.7.11.240.649
4hys1BJMitogen-activated protein kinase 82.7.11.240.645
4e730NRMitogen-activated protein kinase 82.7.11.240.626
4g1wG1WMitogen-activated protein kinase 82.7.11.240.617
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.547
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.530
4jia1K3Tyrosine-protein kinase JAK2/0.530
1pmn984Mitogen-activated protein kinase 102.7.11.240.524
4c4f7CEDual specificity protein kinase TTK2.7.12.10.520
2p33J07Mitogen-activated protein kinase 102.7.11.240.511
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.511
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.510
4c4h7RODual specificity protein kinase TTK2.7.12.10.510
3cgfJNFMitogen-activated protein kinase 102.7.11.240.507
4gmy0X5Tyrosine-protein kinase JAK2/0.507
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.507
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.506
4qmlANPSerine/threonine-protein kinase 242.7.11.10.505
2hog710Serine/threonine-protein kinase Chk12.7.11.10.501
3uvqFS8Mitogen-activated protein kinase 14/0.501
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.500
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.499
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.498
2excJNKMitogen-activated protein kinase 102.7.11.240.497
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.497
3kvxFMYMitogen-activated protein kinase 102.7.11.240.494
4cd0AWJALK tyrosine kinase receptor2.7.10.10.492
2c6eHPMAurora kinase A2.7.11.10.488
4c4iX20Dual specificity protein kinase TTK2.7.12.10.488
4nks2M2Fibroblast growth factor receptor 1/0.488
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.486
2bujSTUSerine/threonine-protein kinase 16/0.485
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.484
2xrwANPMitogen-activated protein kinase 82.7.11.240.484
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.484
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.484
3ttiKBIMitogen-activated protein kinase 102.7.11.240.483
2henADPEphrin type-B receptor 22.7.10.10.481
4c4g7RODual specificity protein kinase TTK2.7.12.10.480
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.480
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.480
2j0m4STFocal adhesion kinase 12.7.10.20.479
3eljGS7Mitogen-activated protein kinase 82.7.11.240.479
3q9xEMOCasein kinase II subunit alpha2.7.11.10.479
3t8oATPRhodopsin kinase/0.479
2xs0ANPMitogen-activated protein kinase 82.7.11.240.478
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.478
4f640S8Fibroblast growth factor receptor 1/0.478
3bqr4RBDeath-associated protein kinase 3/0.477
4bi1ZO6Dual specificity protein kinase TTK2.7.12.10.477
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.476
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.475
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.475
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.475
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.475
3gc9B45Mitogen-activated protein kinase 112.7.11.240.475
3js2VM1Fibroblast growth factor receptor 1/0.475
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.475
3ttjJBIMitogen-activated protein kinase 102.7.11.240.475
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.475
3flsFLSMitogen-activated protein kinase 14/0.474
3igoANPCalmodulin-domain protein kinase 1, putative/0.474
5auwQUEDeath-associated protein kinase 12.7.11.10.474
1zrzBI1Protein kinase C iota type2.7.11.130.473
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.473
2qoqANPEphrin type-A receptor 32.7.10.10.473
3at4CCKCasein kinase II subunit alpha2.7.11.10.472
3vjoANPEpidermal growth factor receptor2.7.10.10.472
4fv9E71Mitogen-activated protein kinase 12.7.11.240.472
4anqVGHALK tyrosine kinase receptor2.7.10.10.471
1bygSTUTyrosine-protein kinase CSK/0.470
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.470
4bcmT7ZCyclin-dependent kinase 22.7.11.220.470
4ic7ANPMitogen-activated protein kinase 72.7.11.240.470
4j99ACPFibroblast growth factor receptor 2/0.470
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.470
3ormAGSSerine/threonine protein kinase/0.469
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.469
4b99R4LMitogen-activated protein kinase 72.7.11.240.469
4fob0USALK tyrosine kinase receptor2.7.10.10.469
2itnANPEpidermal growth factor receptor2.7.10.10.468
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.468
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.468
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.468
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.468
5cvfATPCasein kinase II subunit alpha2.7.11.10.468
2h96893Mitogen-activated protein kinase 82.7.11.240.467
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.467
3vquO22Dual specificity protein kinase TTK2.7.12.10.467
4gk3L87Ephrin type-A receptor 32.7.10.10.467
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.467
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.466
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.466
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.465
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.465
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.465
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.465
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.465
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
4hvi19STyrosine-protein kinase JAK32.7.10.20.465
2qo7ANPEphrin type-A receptor 32.7.10.10.464
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.464
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.464
3w0pADPHygromycin-B 4-O-kinase2.7.1.1630.464
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.464
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.463
2xp2VGHALK tyrosine kinase receptor2.7.10.10.463
4nka2K7Fibroblast growth factor receptor 1/0.463
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
4jqeANPCasein kinase II subunit alpha2.7.11.10.462
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.461
2yfxVGHALK tyrosine kinase receptor2.7.10.10.461
3i60E86Mitogen-activated protein kinase 12.7.11.240.461
4grb0XGCasein kinase II subunit alpha2.7.11.10.461
5ap57RODual specificity protein kinase TTK2.7.12.10.461
5ap7SVEDual specificity protein kinase TTK2.7.12.10.461
5awmANPStress-activated protein kinase JNK2.7.11.240.461
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.460
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.460
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.460
2izsBRQCasein kinase I isoform gamma-32.7.11.10.459
2izuP01Casein kinase I isoform gamma-32.7.11.10.459
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.459
4j97ACPFibroblast growth factor receptor 2/0.459
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.458
2zdt46CMitogen-activated protein kinase 102.7.11.240.458
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.458
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.457
2j0lANPFocal adhesion kinase 12.7.10.20.457
2j7t274Serine/threonine-protein kinase 102.7.11.10.457
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.457
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.457
4aguD15Cyclin-dependent kinase-like 1/0.457
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
5e8ySTUTGF-beta receptor type-22.7.11.300.457
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.456
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
4ansVGHALK tyrosine kinase receptor2.7.10.10.456
4c3pACPAurora kinase A2.7.11.10.456
4ux9ANPMitogen-activated protein kinase 82.7.11.240.456
2qo9ANPEphrin type-A receptor 32.7.10.10.455
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.455
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.455
5av3KMPDeath-associated protein kinase 12.7.11.10.455
1wvySTUDeath-associated protein kinase 12.7.11.10.454
2x6dX6DAurora kinase A2.7.11.10.454
3u9eCOALmo1369 protein/0.454
3uvp048Mitogen-activated protein kinase 14/0.454
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.454
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.454
2ojj82AMitogen-activated protein kinase 12.7.11.240.453
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.453
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.453
5av2KMPDeath-associated protein kinase 12.7.11.10.453
2b1pAIZMitogen-activated protein kinase 102.7.11.240.452
3cgoJNOMitogen-activated protein kinase 102.7.11.240.452
4gk2L66Ephrin type-A receptor 32.7.10.10.452
5cu6ATPCasein kinase II subunit alpha2.7.11.10.452
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
3u4uLNHCasein kinase II subunit alpha2.7.11.10.451
4btkDTQTau-tubulin kinase 12.7.11.10.451
4eym0RXMitogen-activated protein kinase 132.7.11.240.451
4ez50RSCyclin-dependent kinase 62.7.11.220.451
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.451
4gk4L90Ephrin type-A receptor 32.7.10.10.451
5aaaVGHALK tyrosine kinase receptor2.7.10.10.451
1pmv537Mitogen-activated protein kinase 102.7.11.240.450
1zyjBI5Mitogen-activated protein kinase 14/0.450
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.450
2pvlP55Casein kinase II subunit alpha2.7.11.10.450
2vd5BI8Myotonin-protein kinase2.7.11.10.450
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.450
4c57FEFCyclin-G-associated kinase2.7.11.10.450
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.450
1jnkANPMitogen-activated protein kinase 102.7.11.240.449
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.449
2ghmLICMitogen-activated protein kinase 14/0.449
2ijmATPFocal adhesion kinase 12.7.10.20.449
2xa4AZ5Tyrosine-protein kinase JAK2/0.449
2yn8STUEphrin type-B receptor 42.7.10.10.449
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.449
3c4xATPRhodopsin kinase/0.449
3mvl38PMitogen-activated protein kinase 14/0.449
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.449
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.449
4ccbOFGALK tyrosine kinase receptor2.7.10.10.449
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.449
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.448
2e9cB75Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.448
2y3rTIRTamL/0.448
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.448
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.448
3k5uPFQAurora kinase A2.7.11.10.448
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.448
4j95ACPFibroblast growth factor receptor 2/0.448
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.447
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.447
2zmd537Dual specificity protein kinase TTK2.7.12.10.447
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.447
4c62XWWTyrosine-protein kinase JAK2/0.447
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.447
4zhqACPTubulin tyrosine ligase/0.447
2vwu7X1Ephrin type-B receptor 42.7.10.10.446
3axwTIDCasein kinase II subunit alpha2.7.11.10.446
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.446
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3ls8AJZPhosphatidylinositol 3-kinase catalytic subunit type 32.7.1.1370.446
3s4qNK0Mitogen-activated protein kinase 14/0.446
3w0nANPHygromycin-B 4-O-kinase2.7.1.1630.446
4dtaADNAPH(2'')-Id/0.446
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.446
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.446
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.446
4w9wYDJBMP-2-inducible protein kinase2.7.11.10.446
1k6cMK1Gag-Pol polyprotein3.4.23.160.445
2py3ACPFibroblast growth factor receptor 2/0.445
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.445
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.445
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.445
4aotGW8Serine/threonine-protein kinase 102.7.11.10.445
4dce0JFALK tyrosine kinase receptor2.7.10.10.445
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.445
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.444
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.444
2rgjFADFlavin-containing monooxygenase/0.444
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.444
3a7hATPSerine/threonine-protein kinase 242.7.11.10.444
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.444
3tnwF18Cyclin-dependent kinase 22.7.11.220.444
3w33W19Epidermal growth factor receptor2.7.10.10.444
3zxtACPDeath-associated protein kinase 12.7.11.10.444
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.444
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.444
4hvg19QTyrosine-protein kinase JAK32.7.10.20.444
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.444
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.444
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.444
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.443
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.443
1wvxBD4Death-associated protein kinase 12.7.11.10.443
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.443
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.443
2eb3ANPEpidermal growth factor receptor2.7.10.10.443
2ittAEEEpidermal growth factor receptor2.7.10.10.443
2itzIREEpidermal growth factor receptor2.7.10.10.443
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.443
2pvnP63Casein kinase II subunit alpha2.7.11.10.443
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.443
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.443
3zewSTUEphrin type-B receptor 42.7.10.10.443
3ztxZTXAurora kinase B-A2.7.11.10.443
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
4fyn0VETyrosine-protein kinase SYK2.7.10.20.443
4hnc0UTMandelate racemase/0.443
4jajXU1Aurora kinase A2.7.11.10.443
5aabVGHALK tyrosine kinase receptor2.7.10.10.443
5auvAGIDeath-associated protein kinase 12.7.11.10.443
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.442
2of4979Tyrosine-protein kinase Lck2.7.10.20.442
2pvhP19Casein kinase II subunit alpha2.7.11.10.442
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.442
3a62STURibosomal protein S6 kinase beta-12.7.11.10.442
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.442
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.442
4eevL1XHepatocyte growth factor receptor2.7.10.10.442
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.442
4hvh19RTyrosine-protein kinase JAK32.7.10.20.442
4jboWPHAurora kinase A2.7.11.10.442
4tv3ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.442
4wkqIREEpidermal growth factor receptor2.7.10.10.442
4yuqKS1Calmodulin-like domain protein kinase/0.442
5dr9SKEAurora kinase A2.7.11.10.442
1i44ACPInsulin receptor2.7.10.10.441
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2hk51BMTyrosine-protein kinase HCK2.7.10.20.441
2vrx447Aurora kinase B-A2.7.11.10.441
2vtqLZACyclin-dependent kinase 22.7.11.220.441
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
3mpaSB2Mitogen-activated protein kinase 14/0.441
4btjATPTau-tubulin kinase 12.7.11.10.441
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.440
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.440
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.440
2y6o1N1Ephrin type-A receptor 42.7.10.10.440
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.440
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.440
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.440
4k33ACPFibroblast growth factor receptor 32.7.10.10.440
4nj32KDCyclin-dependent kinase 22.7.11.220.440