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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3zmmF9JTyrosine-protein kinase JAK2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3zmmF9JTyrosine-protein kinase JAK2/1.000
4aqc88ATyrosine-protein kinase JAK2/0.621
3lpbNVBTyrosine-protein kinase JAK2/0.591
4f081RSTyrosine-protein kinase JAK2/0.559
4e6d0NUTyrosine-protein kinase JAK2/0.553
4hge15VTyrosine-protein kinase JAK2/0.538
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.532
2xa4AZ5Tyrosine-protein kinase JAK2/0.531
3hmm855TGF-beta receptor type-12.7.11.300.528
4ji91M3Tyrosine-protein kinase JAK2/0.528
4bgg844Activin receptor type-12.7.11.300.525
4jia1K3Tyrosine-protein kinase JAK2/0.524
2b7aIZATyrosine-protein kinase JAK2/0.521
3iok1P6Tyrosine-protein kinase JAK2/0.521
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.519
3pxkPXKFocal adhesion kinase 12.7.10.20.518
4hvi19STyrosine-protein kinase JAK32.7.10.20.518
5e8ySTUTGF-beta receptor type-22.7.11.300.518
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.517
2pvhP19Casein kinase II subunit alpha2.7.11.10.517
2pvmP29Casein kinase II subunit alpha2.7.11.10.516
4btmF8ETau-tubulin kinase 12.7.11.10.513
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.512
4c61LMMTyrosine-protein kinase JAK2/0.512
4c62XWWTyrosine-protein kinase JAK2/0.512
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.510
3eyhIZATyrosine-protein kinase JAK1/0.510
4btjADPTau-tubulin kinase 12.7.11.10.509
1g5sI17Cyclin-dependent kinase 22.7.11.220.508
4iva1J5Tyrosine-protein kinase JAK2/0.506
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.503
4dgnLU2Casein kinase II subunit alpha2.7.11.10.502
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.500
3le62BZCyclin-dependent kinase 22.7.11.220.499
4y93746Tyrosine-protein kinase/0.499
1om1IQACasein kinase II subunit alpha2.7.11.10.498
1vjy460TGF-beta receptor type-12.7.11.300.498
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.498
3be9P04Casein kinase II subunit alpha2.7.11.10.498
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.497
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.497
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.497
2vttLZDCyclin-dependent kinase 22.7.11.220.496
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.496
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.496
1eh4IC1Casein kinase I homolog 12.7.11.10.495
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.495
4dgmAGICasein kinase II subunit alpha2.7.11.10.495
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.494
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.493
3rvg17PTyrosine-protein kinase JAK2/0.493
3mtfA3FActivin receptor type-12.7.11.300.492
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
4y95746Tyrosine-protein kinase/0.491
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.490
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.490
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.489
2v7a627Tyrosine-protein kinase ABL12.7.10.20.487
3zep1NXTyrosine-protein kinase JAK32.7.10.20.487
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.487
3nynSGVG protein-coupled receptor kinase 62.7.11.160.486
3zh8C58Protein kinase C iota type2.7.11.130.486
1aq1STUCyclin-dependent kinase 22.7.11.220.485
4anmWULCasein kinase II subunit alpha2.7.11.10.485
4e5w0NTTyrosine-protein kinase JAK1/0.485
4fv6E57Mitogen-activated protein kinase 12.7.11.240.485
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.484
2xb7GUIALK tyrosine kinase receptor2.7.10.10.484
4ewhT77Activated CDC42 kinase 1/0.484
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.484
4ivc1J6Tyrosine-protein kinase JAK1/0.484
5dt0SKEAurora kinase A2.7.11.10.484
1oirHDYCyclin-dependent kinase 22.7.11.220.483
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.483
3ezvEZVCyclin-dependent kinase 22.7.11.220.483
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.482
4ehzJAKTyrosine-protein kinase JAK1/0.482
2vv9IM9Cyclin-dependent kinase 22.7.11.220.481
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.481
2pvlP55Casein kinase II subunit alpha2.7.11.10.479
3rak03ZCyclin-dependent kinase 22.7.11.220.479
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.477
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.477
4jajXU1Aurora kinase A2.7.11.10.476
2xrwANPMitogen-activated protein kinase 82.7.11.240.475
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.475
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.475
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.474
3gxlQIGTGF-beta receptor type-12.7.11.300.474
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.474
4e6q0NVTyrosine-protein kinase JAK2/0.474
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.474
1m2pHNACasein kinase II subunit alpha2.7.11.10.473
3at4CCKCasein kinase II subunit alpha2.7.11.10.473
4iwd1JCHepatocyte growth factor receptor2.7.10.10.473
1oecAA2Fibroblast growth factor receptor 2/0.472
4btjATPTau-tubulin kinase 12.7.11.10.472
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.472
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.471
1gii1PUCyclin-dependent kinase 22.7.11.220.471
1w0xOLOCyclin-dependent kinase 22.7.11.220.471
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.471
3uimANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 12.7.10.10.471
4f650S9Fibroblast growth factor receptor 1/0.471
4fk60UJTyrosine-protein kinase JAK1/0.471
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.471
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.471
2pvnP63Casein kinase II subunit alpha2.7.11.10.470
2uzbC75Cyclin-dependent kinase 22.7.11.220.470
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.470
2b53D23Cyclin-dependent kinase 22.7.11.220.469
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.469
4dgo0JWCasein kinase II subunit alpha2.7.11.10.469
4hvh19RTyrosine-protein kinase JAK32.7.10.20.469
4ivb1J5Tyrosine-protein kinase JAK1/0.469
5dpvSKEAurora kinase A2.7.11.10.469
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.468
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.468
2x1nX1NCyclin-dependent kinase 22.7.11.220.468
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.468
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.468
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.468
4foc0UUALK tyrosine kinase receptor2.7.10.10.467
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.466
4gk3L87Ephrin type-A receptor 32.7.10.10.466
1yvj4STTyrosine-protein kinase JAK32.7.10.20.465
2c6lDT4Cyclin-dependent kinase 22.7.11.220.465
2ijmADPFocal adhesion kinase 12.7.10.20.465
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.465
4qnyANPMitogen activated protein kinase, putative/0.465
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.465
3fz1B98Cyclin-dependent kinase 22.7.11.220.464
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.464
3i60E86Mitogen-activated protein kinase 12.7.11.240.464
3zewSTUEphrin type-B receptor 42.7.10.10.464
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.464
4wsqKSAAP2-associated protein kinase 12.7.11.10.464
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.463
1py5PY1TGF-beta receptor type-12.7.11.300.463
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.463
2c5yMTWCyclin-dependent kinase 22.7.11.220.462
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.462
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.462
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.462
3rkb12ZCyclin-dependent kinase 22.7.11.220.462
3s1h56ZCyclin-dependent kinase 22.7.11.220.462
4e1z0MXNon-receptor tyrosine-protein kinase TYK22.7.10.20.462
4ux9ANPMitogen-activated protein kinase 82.7.11.240.462
4nk92K5Fibroblast growth factor receptor 1/0.461
5e8xSTUTGF-beta receptor type-12.7.11.300.461
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.460
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.460
2w17I19Cyclin-dependent kinase 22.7.11.220.460
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.460
3sheI85MAP kinase-activated protein kinase 32.7.11.10.460
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.459
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.459
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.458
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.458
2pvjP44Casein kinase II subunit alpha2.7.11.10.458
2pwlACPFibroblast growth factor receptor 2/0.458
4c02TAKActivin receptor type-12.7.11.300.458
2btrU73Cyclin-dependent kinase 22.7.11.220.457
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.457
2xmyCDKCyclin-dependent kinase 22.7.11.220.457
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.457
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.457
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.457
4fki09KCyclin-dependent kinase 22.7.11.220.457
4fob0USALK tyrosine kinase receptor2.7.10.10.457
4jqeANPCasein kinase II subunit alpha2.7.11.10.456
1fvv107Cyclin-dependent kinase 22.7.11.220.455
3kvxFMYMitogen-activated protein kinase 102.7.11.240.455
3lfqA28Cyclin-dependent kinase 22.7.11.220.455
1bwsNDPGDP-L-fucose synthase/0.454
1dawANPCasein kinase II subunit alpha2.7.11.10.454
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.454
1y91CT9Cyclin-dependent kinase 22.7.11.220.454
2p5cSAHDiphthine synthase/0.454
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.454
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.454
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.454
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.454
4gub0Y4Casein kinase II subunit alpha2.7.11.10.454
4ivd15TTyrosine-protein kinase JAK1/0.454
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.453
1m2rMNYCasein kinase II subunit alpha2.7.11.10.453
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.453
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3axwTIDCasein kinase II subunit alpha2.7.11.10.453
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.453
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.453
4dymIYZActivin receptor type-12.7.11.300.453
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.453
4gmy0X5Tyrosine-protein kinase JAK2/0.453
4grb0XGCasein kinase II subunit alpha2.7.11.10.453
4k8aK8AFocal adhesion kinase 12.7.10.20.453
4qmpDKISerine/threonine-protein kinase 242.7.11.10.453
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
1pxoCK7Cyclin-dependent kinase 22.7.11.220.452
1w8cN69Cyclin-dependent kinase 22.7.11.220.452
3q9xEMOCasein kinase II subunit alpha2.7.11.10.452
3qxpX64Cyclin-dependent kinase 22.7.11.220.452
4e4m0NHTyrosine-protein kinase JAK2/0.452
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
2g1r3IGRenin3.4.23.150.451
2i40BLZCyclin-dependent kinase 22.7.11.220.451
2w1hL0FCyclin-dependent kinase 22.7.11.220.451
3qtrX36Cyclin-dependent kinase 22.7.11.220.451
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.451
3tnwF18Cyclin-dependent kinase 22.7.11.220.451
3zdu38RCyclin-dependent kinase-like 32.7.11.220.451
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.451
4qmlANPSerine/threonine-protein kinase 242.7.11.10.451
5cnnANPEpidermal growth factor receptor2.7.10.10.451
1i44ACPInsulin receptor2.7.10.10.450
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.450
2c6o4SPCyclin-dependent kinase 22.7.11.220.450
2cchATPCyclin-dependent kinase 22.7.11.220.450
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.450
2yn8STUEphrin type-B receptor 42.7.10.10.450
3uyt0CKCasein kinase I isoform delta2.7.11.10.450
4fkv61KCyclin-dependent kinase 22.7.11.220.450
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.450
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.450
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.450
4ockANPN-acetylhexosamine 1-kinase2.7.1.1620.450
1oitHDTCyclin-dependent kinase 22.7.11.220.449
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.449
3ig6438Urokinase-type plasminogen activator3.4.21.730.449
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.449
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.449
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.449
3vf80JETyrosine-protein kinase SYK2.7.10.20.449
4ek610KCyclin-dependent kinase 22.7.11.220.449
4gk2L66Ephrin type-A receptor 32.7.10.10.449
4k771Q4Tyrosine-protein kinase JAK1/0.449
2btsU32Cyclin-dependent kinase 22.7.11.220.448
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.448
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.448
3my5RFZCyclin-dependent kinase 22.7.11.220.448
4fklCK2Cyclin-dependent kinase 22.7.11.220.448
4fod0UVALK tyrosine kinase receptor2.7.10.10.448
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.448
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.448
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.448
1fxsNAPGDP-L-fucose synthase/0.447
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.447
2uzdC85Cyclin-dependent kinase 22.7.11.220.447
2wouZZFTGF-beta receptor type-12.7.11.300.447
2ydkYDKSerine/threonine-protein kinase Chk12.7.11.10.447
3cgfJNFMitogen-activated protein kinase 102.7.11.240.447
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.447
3r1yX76Cyclin-dependent kinase 22.7.11.220.447
3r7uX96Cyclin-dependent kinase 22.7.11.220.447
3r7vZ02Cyclin-dependent kinase 22.7.11.220.447
4bgh3I6Cyclin-dependent kinase 22.7.11.220.447
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.447
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.447
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.447
4jr7GNPCasein kinase II subunit alpha2.7.11.10.447
4lfiGNPCasein kinase II subunit alpha2.7.11.10.447
5e92ANPTGF-beta receptor type-22.7.11.300.447
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.446
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.446
2eufLQQCyclin-dependent kinase 62.7.11.220.446
2hog710Serine/threonine-protein kinase Chk12.7.11.10.446
2j9mPY8Cyclin-dependent kinase 22.7.11.220.446
3r83Z14Cyclin-dependent kinase 22.7.11.220.446
4bbfO19Tyrosine-protein kinase JAK2/0.446
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
4erwSTUCyclin-dependent kinase 22.7.11.220.446
4fkt48KCyclin-dependent kinase 22.7.11.220.446
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.446
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.446
1dayGNPCasein kinase II subunit alpha2.7.11.10.445
2a0cCK9Cyclin-dependent kinase 22.7.11.220.445
2w05FRTCyclin-dependent kinase 22.7.11.220.445
3a62STURibosomal protein S6 kinase beta-12.7.11.10.445
3lfnA27Cyclin-dependent kinase 22.7.11.220.445
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.445
4bcmT7ZCyclin-dependent kinase 22.7.11.220.445
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.445
4j98ACPFibroblast growth factor receptor 2/0.445
4mv8ACPBiotin carboxylase6.3.4.140.445
1xjdSTUProtein kinase C theta type2.7.11.130.444
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3eb0DRKUncharacterized protein/0.444
3w33W19Epidermal growth factor receptor2.7.10.10.444
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.444
4ez50RSCyclin-dependent kinase 62.7.11.220.444
4ks7X4ZSerine/threonine-protein kinase PAK 62.7.11.10.444
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.444
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.443
2ghlLIBMitogen-activated protein kinase 14/0.443
2j0m4STFocal adhesion kinase 12.7.10.20.443
3lfsA07Cyclin-dependent kinase 22.7.11.220.443
3pxyJWSCyclin-dependent kinase 22.7.11.220.443
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.442
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.442
2ijmATPFocal adhesion kinase 12.7.10.20.442
2in6839Wee1-like protein kinase2.7.10.20.442
2wipP49Cyclin-dependent kinase 22.7.11.220.442
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.442
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.442
3qqlX03Cyclin-dependent kinase 22.7.11.220.442
3rmf20ZCyclin-dependent kinase 22.7.11.220.442
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.442
5dr6SKEAurora kinase A2.7.11.10.442
1bsvNDPGDP-L-fucose synthase/0.441
1e9hINRCyclin-dependent kinase 22.7.11.220.441
2bkzSBCCyclin-dependent kinase 22.7.11.220.441
2vtqLZACyclin-dependent kinase 22.7.11.220.441
3vs3VSETyrosine-protein kinase HCK2.7.10.20.441
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.441
4nj32KDCyclin-dependent kinase 22.7.11.220.441
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.441
1ykr628Cyclin-dependent kinase 22.7.11.220.440
2bfyH1NAurora kinase B-A2.7.11.10.440
2c5nCK8Cyclin-dependent kinase 22.7.11.220.440
2ckeIQUDeath-associated protein kinase 2/0.440
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.440
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.440
3eljGS7Mitogen-activated protein kinase 82.7.11.240.440
3lltANPProtein serine/threonine kinase-1/0.440
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.440
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.440