sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3uvv | REA | Retinoic acid receptor RXR-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3uvv | REA | Retinoic acid receptor RXR-alpha | / | 1.000 | |
| 4k4j | 1O8 | Retinoic acid receptor RXR-alpha | / | 0.619 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.607 | |
| 1fby | REA | Retinoic acid receptor RXR-alpha | / | 0.605 | |
| 3oap | REA | Retinoic acid receptor RXR-alpha | / | 0.603 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.602 | |
| 1fm9 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.601 | |
| 1xls | REA | Retinoic acid receptor RXR-alpha | / | 0.590 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.582 | |
| 1k74 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.580 | |
| 4m8e | 29V | Retinoic acid receptor RXR-alpha | / | 0.575 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.569 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.566 | |
| 1xiu | REA | Retinoic acid receptor RXR | / | 0.564 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.563 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.563 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.562 | |
| 4m8h | R4M | Retinoic acid receptor RXR-alpha | / | 0.557 | |
| 1mvc | BM6 | Retinoic acid receptor RXR-alpha | / | 0.553 | |
| 3fc6 | REA | Retinoic acid receptor RXR-alpha | / | 0.548 | |
| 3fal | REA | Retinoic acid receptor RXR-alpha | / | 0.540 | |
| 2p1t | 3TN | Retinoic acid receptor RXR-alpha | / | 0.538 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.510 | |
| 2bxm | IMN | Serum albumin | / | 0.508 | |
| 2bxq | IMN | Serum albumin | / | 0.496 | |
| 2xvw | 9NR | Serum albumin | / | 0.492 | |
| 2xvv | 9DN | Serum albumin | / | 0.491 | |
| 3cse | N22 | Uncharacterized protein | / | 0.489 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.488 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.487 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.486 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.483 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.482 | |
| 3qly | 55V | Uncharacterized protein | / | 0.482 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.481 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.481 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.480 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.479 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.478 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.478 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.476 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.476 | |
| 4p6w | MOF | Glucocorticoid receptor | / | 0.475 | |
| 2p15 | EZT | Estrogen receptor | / | 0.474 | |
| 3b9l | AZZ | Serum albumin | / | 0.474 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.474 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.474 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.471 | |
| 1ysx | 4EB | Serum albumin | / | 0.471 | |
| 2acw | UPG | Glycosyltransferase | / | 0.471 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.470 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.469 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.468 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.468 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.468 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.467 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 3eel | 53T | Uncharacterized protein | / | 0.466 | |
| 3irx | UDR | Gag-Pol polyprotein | 2.7.7.49 | 0.466 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.466 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.466 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.466 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.465 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.465 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.465 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.464 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.464 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.464 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 3ar7 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.463 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.463 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.463 | |
| 5d7p | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.463 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.463 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.463 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.462 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.462 | |
| 3lal | KRV | Gag-Pol polyprotein | 2.7.7.49 | 0.462 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.462 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.462 | |
| 1fml | RTL | Retinol dehydratase | / | 0.461 | |
| 3bjh | NBB | Odorant binding protein ASP1 | / | 0.461 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.461 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.461 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.461 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.461 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.460 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.460 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.460 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.460 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.460 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.460 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.459 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.459 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.459 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.459 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 1sr7 | MOF | Progesterone receptor | / | 0.458 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2jfz | 003 | Glutamate racemase | / | 0.458 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.458 | |
| 3p9t | TCL | Repressor | / | 0.458 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.458 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.458 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.458 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.458 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.458 | |
| 2qd5 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.457 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.457 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.457 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.457 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.457 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.457 | |
| 2dqs | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.456 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.456 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.456 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.455 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.455 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 2puj | HPZ | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase | 3.7.1.8 | 0.455 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.455 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.455 | |
| 4jnc | 1LF | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.455 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.455 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.454 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3h1j | SMA | Cytochrome b | / | 0.454 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.454 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.454 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.454 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.454 | |
| 1e7a | PFL | Serum albumin | / | 0.453 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.453 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.453 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.453 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.453 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.453 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.453 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.453 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4iae | 1DX | Alr2278 protein | / | 0.453 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.453 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1kyo | SMA | Cytochrome b | / | 0.452 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.452 | |
| 1mc5 | AHE | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.452 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.452 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.452 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.452 | |
| 2rht | C1E | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase | 3.7.1.8 | 0.452 | |
| 3eek | 53S | Uncharacterized protein | / | 0.452 | |
| 3h0a | 9RA | Retinoic acid receptor RXR-alpha | / | 0.452 | |
| 3vi7 | CBD | Hematopoietic prostaglandin D synthase | / | 0.452 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.452 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.452 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.451 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 2agv | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.451 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.451 | |
| 3eon | 341 | Glutaryl-CoA dehydrogenase | / | 0.451 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.451 | |
| 3hcr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.451 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.451 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.451 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.451 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.451 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.451 | |
| 1g3m | PCQ | Estrogen sulfotransferase | 2.8.2.4 | 0.450 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.450 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 2vss | ACO | Hydroxycinnamoyl-CoA hydratase-lyase | 4.1.2.41 | 0.450 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.450 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.450 | |
| 3eem | 53V | Uncharacterized protein | / | 0.450 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.450 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.450 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.450 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.449 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.449 | |
| 1vru | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.449 | |
| 4ezl | 0SE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.449 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.449 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.449 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 1nhz | 486 | Glucocorticoid receptor | / | 0.448 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.448 | |
| 1s9q | OHT | Estrogen-related receptor gamma | / | 0.448 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.448 | |
| 2y30 | SM8 | Putative repressor SimReg2 | / | 0.448 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.448 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.448 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1l0l | FMX | Cytochrome b | / | 0.447 | |
| 1nbm | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.447 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.447 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.447 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.447 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.447 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.447 | |
| 4y6g | F6F | Tryptophan synthase alpha chain | / | 0.447 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.446 | |
| 3d78 | NBB | Pheromone-binding protein ASP1 | / | 0.446 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta | / | 0.446 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta' | / | 0.446 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.446 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.446 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.446 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4hw2 | 19H | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.446 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1sqv | UHD | Cytochrome b | / | 0.445 | |
| 1wrl | TFP | Troponin C, slow skeletal and cardiac muscles | / | 0.445 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.445 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 5i2h | AGI | O-methyltransferase family 2 | / | 0.445 | |
| 1fx9 | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.444 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.444 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.444 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.444 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 3l71 | AZO | Cytochrome b | / | 0.444 | |
| 3l9l | L9L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.444 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.444 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.444 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.443 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.443 | |
| 2jkc | FAD | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.443 | |
| 3a0i | AJI | Glucokinase | 2.7.1.2 | 0.443 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.443 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.443 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.443 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1s6q | TPB | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.442 | |
| 2p7z | OHT | Estrogen-related receptor gamma | / | 0.442 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.442 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.442 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.442 | |
| 3ant | S82 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.442 | |
| 3f0a | ACO | Spermidine N(1)-acetyltransferase | / | 0.442 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.442 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.442 | |
| 3w5q | 3KL | Vitamin D3 receptor | / | 0.442 | |
| 4apu | A2K | Progesterone receptor | / | 0.442 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.442 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.441 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.441 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.441 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.441 | |
| 2vrb | NAP | Triphenylmethane reductase | / | 0.441 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.441 | |
| 3eej | 53R | Uncharacterized protein | / | 0.441 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 3fu9 | KIB | Laccase-1 | 1.10.3.2 | 0.441 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.441 | |
| 3nef | PYV | Abscisic acid receptor PYL1 | / | 0.441 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.441 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 4bfp | SWY | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.441 | |
| 4iah | 1DX | Alr2278 protein | / | 0.441 | |
| 4itm | ATP | Tetraacyldisaccharide 4'-kinase | / | 0.441 | |
| 4tzk | 641 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1ezv | SMA | Cytochrome b | / | 0.440 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.440 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.440 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.440 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.440 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 3hf6 | LX0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.440 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.440 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.440 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.440 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.440 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.440 |