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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ti1B49Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3ti1B49Cyclin-dependent kinase 22.7.11.221.000
3qtzX42Cyclin-dependent kinase 22.7.11.220.640
4fkr45KCyclin-dependent kinase 22.7.11.220.626
3qu0X40Cyclin-dependent kinase 22.7.11.220.614
1ckpPVBCyclin-dependent kinase 22.7.11.220.608
4fkv61KCyclin-dependent kinase 22.7.11.220.598
1gih1PUCyclin-dependent kinase 22.7.11.220.596
1p2a5BNCyclin-dependent kinase 22.7.11.220.592
3unj0BXCyclin-dependent kinase 22.7.11.220.590
2xmyCDKCyclin-dependent kinase 22.7.11.220.589
3qqkX02Cyclin-dependent kinase 22.7.11.220.589
1v1k3FPCyclin-dependent kinase 22.7.11.220.587
2r64740Cyclin-dependent kinase 22.7.11.220.587
3qxoX65Cyclin-dependent kinase 22.7.11.220.586
3s2pPMUCyclin-dependent kinase 22.7.11.220.584
3ral04ZCyclin-dependent kinase 22.7.11.220.583
1ke9LS5Cyclin-dependent kinase 22.7.11.220.582
3rjc06ZCyclin-dependent kinase 22.7.11.220.582
4erwSTUCyclin-dependent kinase 22.7.11.220.581
1pxmCK5Cyclin-dependent kinase 22.7.11.220.578
3qzgX67Cyclin-dependent kinase 22.7.11.220.574
3rpv26ZCyclin-dependent kinase 22.7.11.220.571
3r6xX84Cyclin-dependent kinase 22.7.11.220.569
3rni21ZCyclin-dependent kinase 22.7.11.220.568
3lfnA27Cyclin-dependent kinase 22.7.11.220.566
3py0SU9Cyclin-dependent kinase 22.7.11.220.566
3sqq99ZCyclin-dependent kinase 22.7.11.220.566
1dm2HMDCyclin-dependent kinase 22.7.11.220.565
4fko20KCyclin-dependent kinase 22.7.11.220.565
3rm719ZCyclin-dependent kinase 22.7.11.220.564
3rmf20ZCyclin-dependent kinase 22.7.11.220.564
1g5sI17Cyclin-dependent kinase 22.7.11.220.563
4fkt48KCyclin-dependent kinase 22.7.11.220.563
3qqhX0ACyclin-dependent kinase 22.7.11.220.562
3rak03ZCyclin-dependent kinase 22.7.11.220.562
3rk708ZCyclin-dependent kinase 22.7.11.220.561
2r3lSCWCyclin-dependent kinase 22.7.11.220.560
3s1h56ZCyclin-dependent kinase 22.7.11.220.560
3r9dX6BCyclin-dependent kinase 22.7.11.220.559
3rk507ZCyclin-dependent kinase 22.7.11.220.559
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.557
3qqfX07Cyclin-dependent kinase 22.7.11.220.556
1oiqHDUCyclin-dependent kinase 22.7.11.220.554
3qzhX69Cyclin-dependent kinase 22.7.11.220.553
1ke6LS2Cyclin-dependent kinase 22.7.11.220.552
2b52D42Cyclin-dependent kinase 22.7.11.220.552
2c6o4SPCyclin-dependent kinase 22.7.11.220.552
4ek610KCyclin-dependent kinase 22.7.11.220.552
1ke5LS1Cyclin-dependent kinase 22.7.11.220.551
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.551
1pxkCK3Cyclin-dependent kinase 22.7.11.220.550
4bgh3I6Cyclin-dependent kinase 22.7.11.220.550
2w06FRVCyclin-dependent kinase 22.7.11.220.549
3r1sX73Cyclin-dependent kinase 22.7.11.220.549
4lyn1YGCyclin-dependent kinase 22.7.11.220.549
1vyzN5BCyclin-dependent kinase 22.7.11.220.548
3roy22ZCyclin-dependent kinase 22.7.11.220.548
4fkg4CKCyclin-dependent kinase 22.7.11.220.548
1ke7LS3Cyclin-dependent kinase 22.7.11.220.547
1urwI1PCyclin-dependent kinase 22.7.11.220.547
3raiX85Cyclin-dependent kinase 22.7.11.220.547
2duv371Cyclin-dependent kinase 22.7.11.220.545
2j9mPY8Cyclin-dependent kinase 22.7.11.220.545
2vthLZ2Cyclin-dependent kinase 22.7.11.220.543
3rkb12ZCyclin-dependent kinase 22.7.11.220.543
3rpy27ZCyclin-dependent kinase 22.7.11.220.542
3unk0BYCyclin-dependent kinase 22.7.11.220.542
4acm7YGCyclin-dependent kinase 22.7.11.220.542
1h1r6CPCyclin-dependent kinase 22.7.11.220.541
3iggEFQCyclin-dependent kinase 22.7.11.220.541
3r9oZ71Cyclin-dependent kinase 22.7.11.220.541
3s0o50ZCyclin-dependent kinase 22.7.11.220.541
3qwkX62Cyclin-dependent kinase 22.7.11.220.540
4fki09KCyclin-dependent kinase 22.7.11.220.540
3sw418KCyclin-dependent kinase 22.7.11.220.539
1gij2PUCyclin-dependent kinase 22.7.11.220.538
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.538
4fkj11KCyclin-dependent kinase 22.7.11.220.536
1di8DTQCyclin-dependent kinase 22.7.11.220.535
1r78FMDCyclin-dependent kinase 22.7.11.220.535
3qzfX66Cyclin-dependent kinase 22.7.11.220.535
3r8lZ30Cyclin-dependent kinase 22.7.11.220.535
4fkq42KCyclin-dependent kinase 22.7.11.220.535
4fkw62KCyclin-dependent kinase 22.7.11.220.535
1w0xOLOCyclin-dependent kinase 22.7.11.220.533
1ykr628Cyclin-dependent kinase 22.7.11.220.533
2uznC96Cyclin-dependent kinase 22.7.11.220.533
3lfqA28Cyclin-dependent kinase 22.7.11.220.533
1fvt106Cyclin-dependent kinase 22.7.11.220.532
1ke8LS4Cyclin-dependent kinase 22.7.11.220.532
1gii1PUCyclin-dependent kinase 22.7.11.220.531
1oitHDTCyclin-dependent kinase 22.7.11.220.531
3rzb02ZCyclin-dependent kinase 22.7.11.220.531
3lfsA07Cyclin-dependent kinase 22.7.11.220.530
3qtxX43Cyclin-dependent kinase 22.7.11.220.529
3qxpX64Cyclin-dependent kinase 22.7.11.220.529
2uzoC62Cyclin-dependent kinase 22.7.11.220.528
3qtrX36Cyclin-dependent kinase 22.7.11.220.528
4fx360KCyclin-dependent kinase 22.7.11.220.528
2w1hL0FCyclin-dependent kinase 22.7.11.220.527
3rk909ZCyclin-dependent kinase 22.7.11.220.527
4fkpLS5Cyclin-dependent kinase 22.7.11.220.527
1oguST8Cyclin-dependent kinase 22.7.11.220.526
3r9hZ67Cyclin-dependent kinase 22.7.11.220.526
1h1s4SPCyclin-dependent kinase 22.7.11.220.524
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.524
3ql8X01Cyclin-dependent kinase 22.7.11.220.524
3qtuX44Cyclin-dependent kinase 22.7.11.220.524
3sw719KCyclin-dependent kinase 22.7.11.220.524
1pxoCK7Cyclin-dependent kinase 22.7.11.220.523
3r7uX96Cyclin-dependent kinase 22.7.11.220.523
3uli1N3Cyclin-dependent kinase 22.7.11.220.523
3fz1B98Cyclin-dependent kinase 22.7.11.220.521
2vttLZDCyclin-dependent kinase 22.7.11.220.520
3r71X86Cyclin-dependent kinase 22.7.11.220.520
3r7yZ04Cyclin-dependent kinase 22.7.11.220.520
2btsU32Cyclin-dependent kinase 22.7.11.220.519
1fvv107Cyclin-dependent kinase 22.7.11.220.518
2r3kSCQCyclin-dependent kinase 22.7.11.220.518
3r73X87Cyclin-dependent kinase 22.7.11.220.518
2btrU73Cyclin-dependent kinase 22.7.11.220.516
3qwjX6ACyclin-dependent kinase 22.7.11.220.516
4eok4SPCyclin-dependent kinase 22.7.11.220.515
2vtsLZCCyclin-dependent kinase 22.7.11.220.514
2fvdLIACyclin-dependent kinase 22.7.11.220.513
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.513
3ddpRC8Cyclin-dependent kinase 22.7.11.220.513
1h0w207Cyclin-dependent kinase 22.7.11.220.511
1oi9N20Cyclin-dependent kinase 22.7.11.220.511
2r3p3SCCyclin-dependent kinase 22.7.11.220.511
4nj32KDCyclin-dependent kinase 22.7.11.220.511
2vv9IM9Cyclin-dependent kinase 22.7.11.220.510
4bcpT3CCyclin-dependent kinase 22.7.11.220.510
1oiyN41Cyclin-dependent kinase 22.7.11.220.509
2bhhRYUCyclin-dependent kinase 22.7.11.220.509
1h1pCMGCyclin-dependent kinase 22.7.11.220.508
3ig7EFPCyclin-dependent kinase 22.7.11.220.508
2iw84SPCyclin-dependent kinase 22.7.11.220.506
1b38ATPCyclin-dependent kinase 22.7.11.220.505
2c6iDT1Cyclin-dependent kinase 22.7.11.220.505
3bhtMFRCyclin-dependent kinase 22.7.11.220.505
3ddqRRCCyclin-dependent kinase 22.7.11.220.505
2b55D31Cyclin-dependent kinase 22.7.11.220.504
3qruX19Cyclin-dependent kinase 22.7.11.220.504
4bcnT9NCyclin-dependent kinase 22.7.11.220.504
2bheBRYCyclin-dependent kinase 22.7.11.220.503
3ezrEZRCyclin-dependent kinase 22.7.11.220.502
3qtqX35Cyclin-dependent kinase 22.7.11.220.502
1b39ATPCyclin-dependent kinase 22.7.11.220.501
2iw94SPCyclin-dependent kinase 22.7.11.220.501
2w17I19Cyclin-dependent kinase 22.7.11.220.501
1pyePM1Cyclin-dependent kinase 22.7.11.220.500
3r7iX9ICyclin-dependent kinase 22.7.11.220.500
2r3gSC9Cyclin-dependent kinase 22.7.11.220.499
2r3iSCFCyclin-dependent kinase 22.7.11.220.499
1oiuN76Cyclin-dependent kinase 22.7.11.220.498
1pkdUCNCyclin-dependent kinase 22.7.11.220.498
1pxpCK8Cyclin-dependent kinase 22.7.11.220.497
2r3jSCJCyclin-dependent kinase 22.7.11.220.497
2uzlC94Cyclin-dependent kinase 22.7.11.220.497
2wxvWXVCyclin-dependent kinase 22.7.11.220.497
4qmpDKISerine/threonine-protein kinase 242.7.11.10.497
4eon1ROCyclin-dependent kinase 22.7.11.220.496
3r8zZ63Cyclin-dependent kinase 22.7.11.220.495
2c5nCK8Cyclin-dependent kinase 22.7.11.220.494
3r7eX88Cyclin-dependent kinase 22.7.11.220.494
3rm618ZCyclin-dependent kinase 22.7.11.220.494
4eop1ROCyclin-dependent kinase 22.7.11.220.494
4eos1ROCyclin-dependent kinase 22.7.11.220.494
1e9hINRCyclin-dependent kinase 22.7.11.220.493
2wpa889Cyclin-dependent kinase 22.7.11.220.493
2r3o2SCCyclin-dependent kinase 22.7.11.220.492
2w05FRTCyclin-dependent kinase 22.7.11.220.492
4au8Z3RCyclin-dependent-like kinase 52.7.11.10.492
4eomATPCyclin-dependent kinase 22.7.11.220.492
4eoi1ROCyclin-dependent kinase 22.7.11.220.491
2wihP48Cyclin-dependent kinase 22.7.11.220.490
3pxyJWSCyclin-dependent kinase 22.7.11.220.490
3rpo24ZCyclin-dependent kinase 22.7.11.220.490
2a4lRRCCyclin-dependent kinase 22.7.11.220.489
3pj8404Cyclin-dependent kinase 22.7.11.220.489
2c5yMTWCyclin-dependent kinase 22.7.11.220.487
2vu3LZECyclin-dependent kinase 22.7.11.220.487
3r1yX76Cyclin-dependent kinase 22.7.11.220.487
3rpr25ZCyclin-dependent kinase 22.7.11.220.487
3wblPDYCyclin-dependent kinase 22.7.11.220.486
4ez30S0Cyclin-dependent kinase 22.7.11.220.486
2uzeC95Cyclin-dependent kinase 22.7.11.220.485
3r83Z14Cyclin-dependent kinase 22.7.11.220.485
1vyw292Cyclin-dependent kinase 22.7.11.220.484
3tnwF18Cyclin-dependent kinase 22.7.11.220.484
2c6tDT5Cyclin-dependent kinase 22.7.11.220.483
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.483
3ggfGVDSerine/threonine-protein kinase 26/0.483
3r7vZ02Cyclin-dependent kinase 22.7.11.220.483
1oirHDYCyclin-dependent kinase 22.7.11.220.482
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.482
2b54D05Cyclin-dependent kinase 22.7.11.220.481
3qx2X63Cyclin-dependent kinase 22.7.11.220.481
1h0vUN4Cyclin-dependent kinase 22.7.11.220.480
2exmZIPCyclin-dependent kinase 22.7.11.220.480
3s00Z60Cyclin-dependent kinase 22.7.11.220.480
2eufLQQCyclin-dependent kinase 62.7.11.220.479
3qtwX3ACyclin-dependent kinase 22.7.11.220.479
1e1xNW1Cyclin-dependent kinase 22.7.11.220.478
4aua4AUCyclin-dependent kinase 62.7.11.220.478
2vtrLZBCyclin-dependent kinase 22.7.11.220.475
2x1nX1NCyclin-dependent kinase 22.7.11.220.475
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.474
2uzdC85Cyclin-dependent kinase 22.7.11.220.473
3qrtX14Cyclin-dependent kinase 22.7.11.220.472
3qziX72Cyclin-dependent kinase 22.7.11.220.472
3r8vZ62Cyclin-dependent kinase 22.7.11.220.472
1finATPCyclin-dependent kinase 22.7.11.220.470
4eor4SPCyclin-dependent kinase 22.7.11.220.470
4ii5ADPCyclin-dependent kinase 22.7.11.220.470
5aniES4Cyclin-dependent kinase 22.7.11.220.470
1h1q2A6Cyclin-dependent kinase 22.7.11.220.469
1w8cN69Cyclin-dependent kinase 22.7.11.220.469
3r1qX75Cyclin-dependent kinase 22.7.11.220.469
4eol1ROCyclin-dependent kinase 22.7.11.220.469
3r28XA0Cyclin-dependent kinase 22.7.11.220.467
3tiz3TICyclin-dependent kinase 22.7.11.220.466
4kd11QKCyclin-dependent kinase 22.7.11.220.464
2i40BLZCyclin-dependent kinase 22.7.11.220.463
2r3mSCXCyclin-dependent kinase 22.7.11.220.463
3qx4X4BCyclin-dependent kinase 22.7.11.220.463
2cchATPCyclin-dependent kinase 22.7.11.220.462
2r3r6SCCyclin-dependent kinase 22.7.11.220.462
2uzbC75Cyclin-dependent kinase 22.7.11.220.462
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.461
2b53D23Cyclin-dependent kinase 22.7.11.220.460
3dogNNNCyclin-dependent kinase 22.7.11.220.460
2xnbY8LCyclin-dependent kinase 22.7.11.220.459
4bcoT6QCyclin-dependent kinase 22.7.11.220.459
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.457
2c69CT8Cyclin-dependent kinase 22.7.11.220.454
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.453
2wotZZGTGF-beta receptor type-12.7.11.300.452
2xikJ60Serine/threonine-protein kinase 252.7.11.10.452
3qqlX03Cyclin-dependent kinase 22.7.11.220.452
1qmzATPCyclin-dependent kinase 22.7.11.220.451
2c6lDT4Cyclin-dependent kinase 22.7.11.220.451
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.451
1sduMK1Gag-Pol polyprotein3.4.23.160.450
1e1vCMGCyclin-dependent kinase 22.7.11.220.449
2c6mDT5Cyclin-dependent kinase 22.7.11.220.449
3le62BZCyclin-dependent kinase 22.7.11.220.449
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.449
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.448
4eooATPCyclin-dependent kinase 22.7.11.220.446
2c4g514Cyclin-dependent kinase 22.7.11.220.445
3rahO1ZCyclin-dependent kinase 22.7.11.220.445
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.444
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/0.444
1v0oINRCell division control protein 2 homolog2.7.11.220.442
1y8yCT7Cyclin-dependent kinase 22.7.11.220.442
4cfnJYMCyclin-dependent kinase 22.7.11.220.442
3r8pZ46Cyclin-dependent kinase 22.7.11.220.440