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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3pxyJWSCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3pxyJWSCyclin-dependent kinase 22.7.11.221.000
3qqhX0ACyclin-dependent kinase 22.7.11.220.608
4fki09KCyclin-dependent kinase 22.7.11.220.601
3sw719KCyclin-dependent kinase 22.7.11.220.589
4fkt48KCyclin-dependent kinase 22.7.11.220.572
4acm7YGCyclin-dependent kinase 22.7.11.220.569
3fz1B98Cyclin-dependent kinase 22.7.11.220.562
3qzgX67Cyclin-dependent kinase 22.7.11.220.558
1oitHDTCyclin-dependent kinase 22.7.11.220.557
2r3iSCFCyclin-dependent kinase 22.7.11.220.557
3unk0BYCyclin-dependent kinase 22.7.11.220.557
4fko20KCyclin-dependent kinase 22.7.11.220.553
4ek610KCyclin-dependent kinase 22.7.11.220.550
2r3jSCJCyclin-dependent kinase 22.7.11.220.549
4fkq42KCyclin-dependent kinase 22.7.11.220.549
2c5yMTWCyclin-dependent kinase 22.7.11.220.548
3lfsA07Cyclin-dependent kinase 22.7.11.220.546
1pxmCK5Cyclin-dependent kinase 22.7.11.220.545
3r8lZ30Cyclin-dependent kinase 22.7.11.220.545
4ek816KCyclin-dependent kinase 22.7.11.220.545
2w1hL0FCyclin-dependent kinase 22.7.11.220.542
3sw418KCyclin-dependent kinase 22.7.11.220.541
3r1yX76Cyclin-dependent kinase 22.7.11.220.538
2r3lSCWCyclin-dependent kinase 22.7.11.220.536
2btrU73Cyclin-dependent kinase 22.7.11.220.535
2xmyCDKCyclin-dependent kinase 22.7.11.220.535
3rpv26ZCyclin-dependent kinase 22.7.11.220.534
2a0cCK9Cyclin-dependent kinase 22.7.11.220.531
1di8DTQCyclin-dependent kinase 22.7.11.220.530
1pxpCK8Cyclin-dependent kinase 22.7.11.220.530
3r9dX6BCyclin-dependent kinase 22.7.11.220.530
4fkpLS5Cyclin-dependent kinase 22.7.11.220.529
3s1h56ZCyclin-dependent kinase 22.7.11.220.528
1pxoCK7Cyclin-dependent kinase 22.7.11.220.524
2uzoC62Cyclin-dependent kinase 22.7.11.220.523
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.523
3r7uX96Cyclin-dependent kinase 22.7.11.220.522
2vttLZDCyclin-dependent kinase 22.7.11.220.521
1w0xOLOCyclin-dependent kinase 22.7.11.220.519
3rm618ZCyclin-dependent kinase 22.7.11.220.519
2btsU32Cyclin-dependent kinase 22.7.11.220.518
3r7vZ02Cyclin-dependent kinase 22.7.11.220.518
3rak03ZCyclin-dependent kinase 22.7.11.220.518
3qxoX65Cyclin-dependent kinase 22.7.11.220.517
3py0SU9Cyclin-dependent kinase 22.7.11.220.516
4fks46KCyclin-dependent kinase 22.7.11.220.516
4fklCK2Cyclin-dependent kinase 22.7.11.220.515
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.512
3ral04ZCyclin-dependent kinase 22.7.11.220.512
2c6o4SPCyclin-dependent kinase 22.7.11.220.510
2r3p3SCCyclin-dependent kinase 22.7.11.220.510
1fvt106Cyclin-dependent kinase 22.7.11.220.509
3rjc06ZCyclin-dependent kinase 22.7.11.220.509
3rni21ZCyclin-dependent kinase 22.7.11.220.509
3unj0BXCyclin-dependent kinase 22.7.11.220.509
3lfnA27Cyclin-dependent kinase 22.7.11.220.508
3qtxX43Cyclin-dependent kinase 22.7.11.220.508
3qwjX6ACyclin-dependent kinase 22.7.11.220.508
4ez30S0Cyclin-dependent kinase 22.7.11.220.508
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.507
3qqgX06Cyclin-dependent kinase 22.7.11.220.507
3r1sX73Cyclin-dependent kinase 22.7.11.220.507
3s2pPMUCyclin-dependent kinase 22.7.11.220.507
2b52D42Cyclin-dependent kinase 22.7.11.220.506
3qtsX46Cyclin-dependent kinase 22.7.11.220.506
3rmf20ZCyclin-dependent kinase 22.7.11.220.506
3qtrX36Cyclin-dependent kinase 22.7.11.220.503
3sqq99ZCyclin-dependent kinase 22.7.11.220.503
2c6iDT1Cyclin-dependent kinase 22.7.11.220.502
2vthLZ2Cyclin-dependent kinase 22.7.11.220.501
4fkr45KCyclin-dependent kinase 22.7.11.220.500
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.499
3r7yZ04Cyclin-dependent kinase 22.7.11.220.499
1h0vUN4Cyclin-dependent kinase 22.7.11.220.497
3qrtX14Cyclin-dependent kinase 22.7.11.220.497
4nj32KDCyclin-dependent kinase 22.7.11.220.497
2w06FRVCyclin-dependent kinase 22.7.11.220.495
3lfqA28Cyclin-dependent kinase 22.7.11.220.495
3qtuX44Cyclin-dependent kinase 22.7.11.220.495
3qtzX42Cyclin-dependent kinase 22.7.11.220.495
1b39ATPCyclin-dependent kinase 22.7.11.220.494
3r7iX9ICyclin-dependent kinase 22.7.11.220.494
3rm719ZCyclin-dependent kinase 22.7.11.220.494
4fkj11KCyclin-dependent kinase 22.7.11.220.492
2a4lRRCCyclin-dependent kinase 22.7.11.220.491
1h1r6CPCyclin-dependent kinase 22.7.11.220.490
1urwI1PCyclin-dependent kinase 22.7.11.220.490
2exmZIPCyclin-dependent kinase 22.7.11.220.490
2r3kSCQCyclin-dependent kinase 22.7.11.220.489
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.488
3r8vZ62Cyclin-dependent kinase 22.7.11.220.488
3s0o50ZCyclin-dependent kinase 22.7.11.220.488
1ykr628Cyclin-dependent kinase 22.7.11.220.487
3rk507ZCyclin-dependent kinase 22.7.11.220.487
1gii1PUCyclin-dependent kinase 22.7.11.220.483
1h0w207Cyclin-dependent kinase 22.7.11.220.483
3iggEFQCyclin-dependent kinase 22.7.11.220.483
1w8cN69Cyclin-dependent kinase 22.7.11.220.481
2r3mSCXCyclin-dependent kinase 22.7.11.220.481
2w05FRTCyclin-dependent kinase 22.7.11.220.481
3le62BZCyclin-dependent kinase 22.7.11.220.481
3r9oZ71Cyclin-dependent kinase 22.7.11.220.481
4bgh3I6Cyclin-dependent kinase 22.7.11.220.481
1e1xNW1Cyclin-dependent kinase 22.7.11.220.480
1ke6LS2Cyclin-dependent kinase 22.7.11.220.480
1g5sI17Cyclin-dependent kinase 22.7.11.220.477
3r6xX84Cyclin-dependent kinase 22.7.11.220.477
3rk909ZCyclin-dependent kinase 22.7.11.220.477
4eon1ROCyclin-dependent kinase 22.7.11.220.477
3tiz3TICyclin-dependent kinase 22.7.11.220.476
1ke5LS1Cyclin-dependent kinase 22.7.11.220.475
3pj8404Cyclin-dependent kinase 22.7.11.220.475
1pxlCK4Cyclin-dependent kinase 22.7.11.220.474
4fkg4CKCyclin-dependent kinase 22.7.11.220.474
3qqlX03Cyclin-dependent kinase 22.7.11.220.473
1gih1PUCyclin-dependent kinase 22.7.11.220.472
1pxkCK3Cyclin-dependent kinase 22.7.11.220.472
3qu0X40Cyclin-dependent kinase 22.7.11.220.472
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.472
1hckATPCyclin-dependent kinase 22.7.11.220.471
2r3fSC8Cyclin-dependent kinase 22.7.11.220.471
2vv9IM9Cyclin-dependent kinase 22.7.11.220.471
3rk708ZCyclin-dependent kinase 22.7.11.220.471
4erwSTUCyclin-dependent kinase 22.7.11.220.471
4fkv61KCyclin-dependent kinase 22.7.11.220.471
1v1k3FPCyclin-dependent kinase 22.7.11.220.470
2b55D31Cyclin-dependent kinase 22.7.11.220.470
2uznC96Cyclin-dependent kinase 22.7.11.220.469
3rpo24ZCyclin-dependent kinase 22.7.11.220.468
1y91CT9Cyclin-dependent kinase 22.7.11.220.467
3qqkX02Cyclin-dependent kinase 22.7.11.220.467
4lyn1YGCyclin-dependent kinase 22.7.11.220.467
1ke7LS3Cyclin-dependent kinase 22.7.11.220.466
2fvdLIACyclin-dependent kinase 22.7.11.220.466
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.466
2r3r6SCCyclin-dependent kinase 22.7.11.220.466
2w17I19Cyclin-dependent kinase 22.7.11.220.466
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
3nynSGVG protein-coupled receptor kinase 62.7.11.160.465
3qzhX69Cyclin-dependent kinase 22.7.11.220.464
3raiX85Cyclin-dependent kinase 22.7.11.220.464
3ti1B49Cyclin-dependent kinase 22.7.11.220.464
1p2a5BNCyclin-dependent kinase 22.7.11.220.463
3qziX72Cyclin-dependent kinase 22.7.11.220.463
3r7eX88Cyclin-dependent kinase 22.7.11.220.463
3r83Z14Cyclin-dependent kinase 22.7.11.220.463
4dgo0JWCasein kinase II subunit alpha2.7.11.10.463
3qruX19Cyclin-dependent kinase 22.7.11.220.462
3r28XA0Cyclin-dependent kinase 22.7.11.220.462
1vyzN5BCyclin-dependent kinase 22.7.11.220.461
4dgnLU2Casein kinase II subunit alpha2.7.11.10.461
4eok4SPCyclin-dependent kinase 22.7.11.220.461
1ke8LS4Cyclin-dependent kinase 22.7.11.220.460
1ke9LS5Cyclin-dependent kinase 22.7.11.220.460
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.459
2r64740Cyclin-dependent kinase 22.7.11.220.458
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.458
3ezrEZRCyclin-dependent kinase 22.7.11.220.458
3ezvEZVCyclin-dependent kinase 22.7.11.220.458
3qx2X63Cyclin-dependent kinase 22.7.11.220.458
3rkb12ZCyclin-dependent kinase 22.7.11.220.458
4kd11QKCyclin-dependent kinase 22.7.11.220.458
1me6IVSPlasmepsin-23.4.23.390.457
2iw94SPCyclin-dependent kinase 22.7.11.220.457
4fkw62KCyclin-dependent kinase 22.7.11.220.457
3ddqRRCCyclin-dependent kinase 22.7.11.220.456
1h1pCMGCyclin-dependent kinase 22.7.11.220.455
1h1s4SPCyclin-dependent kinase 22.7.11.220.455
3rpy27ZCyclin-dependent kinase 22.7.11.220.455
3ddpRC8Cyclin-dependent kinase 22.7.11.220.454
3r1qX75Cyclin-dependent kinase 22.7.11.220.454
1oi9N20Cyclin-dependent kinase 22.7.11.220.453
2b53D23Cyclin-dependent kinase 22.7.11.220.453
2bheBRYCyclin-dependent kinase 22.7.11.220.453
2bhhRYUCyclin-dependent kinase 22.7.11.220.453
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.453
3r9hZ67Cyclin-dependent kinase 22.7.11.220.453
2c6lDT4Cyclin-dependent kinase 22.7.11.220.452
1ckpPVBCyclin-dependent kinase 22.7.11.220.451
2iw84SPCyclin-dependent kinase 22.7.11.220.451
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.451
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
2r3q5SCCyclin-dependent kinase 22.7.11.220.450
1y8yCT7Cyclin-dependent kinase 22.7.11.220.449
2cchATPCyclin-dependent kinase 22.7.11.220.449
2x1nX1NCyclin-dependent kinase 22.7.11.220.449
3r8pZ46Cyclin-dependent kinase 22.7.11.220.449
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.449
2cppCAMCamphor 5-monooxygenase1.14.15.10.448
2duv371Cyclin-dependent kinase 22.7.11.220.448
3roy22ZCyclin-dependent kinase 22.7.11.220.448
1b38ATPCyclin-dependent kinase 22.7.11.220.447
2pvlP55Casein kinase II subunit alpha2.7.11.10.447
2pvnP63Casein kinase II subunit alpha2.7.11.10.447
2xnbY8LCyclin-dependent kinase 22.7.11.220.447
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
2om9AJAPeroxisome proliferator-activated receptor gamma/0.446
2r3gSC9Cyclin-dependent kinase 22.7.11.220.446
3qtqX35Cyclin-dependent kinase 22.7.11.220.446
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.445
2b7aIZATyrosine-protein kinase JAK2/0.444
2c6tDT5Cyclin-dependent kinase 22.7.11.220.444
3my5RFZCyclin-dependent kinase 22.7.11.220.444
4aqc88ATyrosine-protein kinase JAK2/0.444
4eos1ROCyclin-dependent kinase 22.7.11.220.444
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.443
1aq1STUCyclin-dependent kinase 22.7.11.220.442
2pvhP19Casein kinase II subunit alpha2.7.11.10.442
2vtrLZBCyclin-dependent kinase 22.7.11.220.442
3bhtMFRCyclin-dependent kinase 22.7.11.220.442
3iok1P6Tyrosine-protein kinase JAK2/0.442
3mtfA3FActivin receptor type-12.7.11.300.442
4eueNAITrans-2-enoyl-CoA reductase [NADH]/0.442
4fv6E57Mitogen-activated protein kinase 12.7.11.240.442
1e9hINRCyclin-dependent kinase 22.7.11.220.441
2i40BLZCyclin-dependent kinase 22.7.11.220.441
2xa4AZ5Tyrosine-protein kinase JAK2/0.441
1h1q2A6Cyclin-dependent kinase 22.7.11.220.440
2r3o2SCCyclin-dependent kinase 22.7.11.220.440
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.440
3gggNADPrephenate dehydrogenase/0.440
3qxpX64Cyclin-dependent kinase 22.7.11.220.440
5aniES4Cyclin-dependent kinase 22.7.11.220.440