Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4xiwAZMCarbonic anhydrase, alpha type

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4xiwAZMCarbonic anhydrase, alpha type/1.000
1m13HYFNuclear receptor subfamily 1 group I member 2/0.506
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.497
1i9nIOACarbonic anhydrase 24.2.1.10.495
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.493
2uxoTACHTH-type transcriptional regulator TtgR/0.492
1g4jFFBCarbonic anhydrase 24.2.1.10.491
4v2gITCTetracycline repressor protein class D/0.491
3lqfNADGalactitol dehydrogenase/0.489
1bwsNDPGDP-L-fucose synthase/0.486
4g7gVFVLanosterol 14-alpha-demethylase/0.486
4uymVOR14-alpha sterol demethylase Cyp51B/0.486
1fxsNAPGDP-L-fucose synthase/0.485
1jioDEB6-deoxyerythronolide B hydroxylase/0.484
4enhFVXCholesterol 24-hydroxylase/0.484
2e9cB75Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.483
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.481
3gw9VNILanosterol 14-alpha-demethylase/0.481
4ipw1G7Mycocyclosin synthase1.14.21.90.481
1rj6AZMCarbonic anhydrase 144.2.1.10.480
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.480
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.480
2cy0NAPShikimate dehydrogenase (NADP(+))/0.479
1nzdUPGDNA beta-glucosyltransferase/0.477
3zuyTCHTransporter/0.477
3gfbNADL-threonine 3-dehydrogenase/0.476
4g3jVNTLanosterol 14-alpha-demethylase/0.476
4ht2V50Carbonic anhydrase 124.2.1.10.476
3gobHXXDdmC/0.475
2zbaZBATrichothecene 3-O-acetyltransferase/0.474
3f7bAG5Carbonic anhydrase 44.2.1.10.474
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.473
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.473
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.472
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.472
4k0zMZMCarbonic anhydrase 24.2.1.10.471
4ktoFADPutative isovaleryl-CoA dehydrogenase protein/0.471
4nxvGDPMitochondrial dynamics protein MID51/0.471
1bn1AL5Carbonic anhydrase 24.2.1.10.470
1i9pIOECarbonic anhydrase 24.2.1.10.470
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.470
3gstGPRGlutathione S-transferase Mu 12.5.1.180.470
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.470
1a42BZUCarbonic anhydrase 24.2.1.10.469
3vt7VDXVitamin D3 receptor/0.469
1nvtNAPShikimate dehydrogenase (NADP(+))/0.468
3gwfFADCyclohexanone monooxygenase/0.468
3vt8YI3Vitamin D3 receptor/0.468
4q71FADBifunctional protein PutA/0.468
1eupASD6-deoxyerythronolide B hydroxylase/0.467
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.467
2nnhREACytochrome P450 2C8/0.467
4i6gFADCryptochrome-2/0.466
1jipKTN6-deoxyerythronolide B hydroxylase/0.464
2ie0ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.463
2w2lNADD-mandelate dehydrogenase/0.463
4r20AERCytochrome P450 family 17 polypeptide 2/0.463
2vn0TDZCytochrome P450 2C8/0.462
4cd2FOLDihydrofolate reductase1.5.1.30.462
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.462
1bnnAL1Carbonic anhydrase 24.2.1.10.461
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
2ev9NAPShikimate dehydrogenase (NADP(+))/0.461
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.461
4kp8E1GCarbonic anhydrase 124.2.1.10.461
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
1jd0AZMCarbonic anhydrase 124.2.1.10.460
1zeoC01Peroxisome proliferator-activated receptor gamma/0.460
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
4cukNAID-lactate dehydrogenase/0.460
5itzLOCTubulin beta-2B chain/0.460
1tdrMTXDihydrofolate reductase1.5.1.30.459
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.459
4ambDUDPutative glycosyl transferase/0.459
1g4oBSBCarbonic anhydrase 24.2.1.10.458
2e9dB76Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.458
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.458
1aj8COACitrate synthase/0.457
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.457
1zmdNAIDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.457
2d29FADAcyl-CoA dehydrogenase/0.457
3a1nNADNDP-sugar epimerase/0.457
3cgdNADCoenzyme A disulfide reductase/0.457
3vt65YIVitamin D3 receptor/0.457
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.457
1i9qIOFCarbonic anhydrase 24.2.1.10.456
1j49NADD-lactate dehydrogenase1.1.1.280.456
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.456
2vkeTACTetracycline repressor protein class D/0.456
3b2eADPATPase GET3/0.456
4q73FADBifunctional protein PutA/0.456
2dteNAIGlucose 1-dehydrogenase related protein/0.455
2gstGPSGlutathione S-transferase Mu 12.5.1.180.455
2hcdBIVVitamin D3 receptor A/0.455
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.455
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.455
4a83DXCMajor pollen allergen Bet v 1-A/0.455
4kp5E1FCarbonic anhydrase 124.2.1.10.455
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.454
4g1z0VPVitamin D3 receptor A/0.454
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
5a9sNAPPutative dehydrogenase/0.454
1eioGCHGastrotropin/0.453
1fm4DXCMajor pollen allergen Bet v 1-L/0.453
1g45FSBCarbonic anhydrase 24.2.1.10.453
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
1nzfUPGDNA beta-glucosyltransferase/0.453
1xddAAYIntegrin alpha-L/0.453
2ft9CHDFatty acid-binding protein 2, liver/0.453
2oapANPType II secretion system protein (GspE-2)/0.453
3otxAP5Adenosine kinase, putative/0.453
3p62FMNPentaerythritol tetranitrate reductase/0.453
4g6hNAIRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.453
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.452
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.452
1fmlRTLRetinol dehydratase/0.451
1h51FMNPentaerythritol tetranitrate reductase/0.451
1rb3MTXDihydrofolate reductase1.5.1.30.451
1uymPU3Heat shock protein HSP 90-beta/0.451
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.451
2qblCAMCamphor 5-monooxygenase1.14.15.10.451
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.451
3d4pNADL-lactate dehydrogenase 11.1.1.270.451
3slkNDPPolyketide synthase extender module 2/0.451
4e2bFMNDehydrogenase/0.451
1bsvNDPGDP-L-fucose synthase/0.450
1qiqACCIsopenicillin N synthase1.21.3.10.450
1rf7DHFDihydrofolate reductase1.5.1.30.450
2po7CHDFerrochelatase, mitochondrial4.99.1.10.450
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.450
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
4k0tD9ZCarbonic anhydrase 24.2.1.10.450
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.450
4nh82LCHeat shock protein HSP 90-alpha/0.450
4xwtU5PRibonuclease J/0.450
1p0hACOMycothiol acetyltransferase2.3.1.1890.449
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
3vtdTKDVitamin D3 receptor/0.449
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.449
4ryvZEAProtein LlR18A/0.449
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.449
1adfTADAlcohol dehydrogenase E chain1.1.1.10.448
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1kkq471Peroxisome proliferator-activated receptor alpha/0.448
1oyaFMNNADPH dehydrogenase 11.6.99.10.448
1tezFADDeoxyribodipyrimidine photo-lyase4.1.99.30.448
2ejvNADL-threonine 3-dehydrogenase/0.448
2f1kNAPPrephenate dehydrogenase/0.448
2lbaCHOFatty acid binding protein 6/0.448
2y3sTIRTamL/0.448
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.448
5ag6MYAGlycylpeptide N-tetradecanoyltransferase/0.448
1rv1IMZE3 ubiquitin-protein ligase Mdm26.3.20.447
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
2jn3JN3Fatty acid-binding protein, liver/0.447
2y3rTRKTamL/0.447
3vt9YI4Vitamin D3 receptor/0.447
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.447
4du82P0Mevalonate diphosphate decarboxylase/0.447
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.447
5hs1VORLanosterol 14-alpha demethylase/0.447
1dhiMTXDihydrofolate reductase1.5.1.30.446
1h50FMNPentaerythritol tetranitrate reductase/0.446
1yrdCAMCamphor 5-monooxygenase1.14.15.10.446
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.446
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.446
2o7oDXTTetracycline repressor protein class D/0.446
3fwgCAMCamphor 5-monooxygenase1.14.15.10.446
3ibqATPPyridoxal kinase/0.446
3u9eCOALmo1369 protein/0.446
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4q72FADBifunctional protein PutA/0.446
4rnuFMNNADPH dehydrogenase 11.6.99.10.446
4v12POGMaoC like domain protein/0.446
5cwa0GAAnthranilate synthase component 14.1.3.270.446
1drbMTXDihydrofolate reductase1.5.1.30.445
1h74AGSHomoserine kinase2.7.1.390.445
1lluNADAlcohol dehydrogenase/0.445
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.445
1x1aSAMC-20 methyltransferase/0.445
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.445
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.445
2q66ATPPoly(A) polymerase2.7.7.190.445
2z1mNDPGDP-mannose 4,6-dehydratase/0.445
3cgeNDPCoenzyme A disulfide reductase/0.445
3hyoADPPyridoxal kinase/0.445
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
3vt5YI2Vitamin D3 receptor/0.445
4h9814QUncharacterized protein/0.445
4lt63ATPoly(A) polymerase gamma2.7.7.190.445
5fl49FKCarbonic anhydrase 94.2.1.10.445
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1e3eNAIAlcohol dehydrogenase 41.1.1.10.444
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.444
1t2bCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.444
3bc3OPTCathepsin L13.4.22.150.444
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.444
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.444
3fwiCAMCamphor 5-monooxygenase1.14.15.10.444
3gwfNAPCyclohexanone monooxygenase/0.444
3s1dZIRCytokinin dehydrogenase 11.5.99.120.444
3t2kFADSulfide-quinone reductase/0.444
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4l8u9AZSerum albumin/0.444
4ruoBIVVitamin D3 receptor A/0.444
1bwfATFGlycerol kinase/0.443
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.443
1k6tXN1Gag-Pol polyprotein3.4.23.160.443
1nytNAPShikimate dehydrogenase (NADP(+))/0.443
1orkATCTetracycline repressor protein class D/0.443
2hw2RFPRifampin ADP-ribosyl transferase/0.443
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.443
3l63CAMCamphor 5-monooxygenase1.14.15.10.443
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
1nooCAHCamphor 5-monooxygenase1.14.15.10.442
1q20PLOSulfotransferase family cytosolic 2B member 12.8.2.20.442
1t86CAMCamphor 5-monooxygenase1.14.15.10.442
1y0s331Peroxisome proliferator-activated receptor delta/0.442
2hk9NAPShikimate dehydrogenase (NADP(+))/0.442
2pobGW4Peroxisome proliferator-activated receptor gamma/0.442
2y4gTIRTamL/0.442
3b70NAPEnoyl reductase LovC10.442
3h3t16HCollagen type IV alpha-3-binding protein/0.442
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.442
3r324CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.442
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.442
3tjzGNPADP-ribosylation factor 1/0.442
4a862ANMajor pollen allergen Bet v 1-A/0.442
4l9kEHFSerum albumin/0.442
1dhjMTXDihydrofolate reductase1.5.1.30.441
1oc1ASVIsopenicillin N synthase1.21.3.10.441
1u3dFADCryptochrome-1/0.441
2q59240Peroxisome proliferator-activated receptor gamma/0.441
2znnS44Peroxisome proliferator-activated receptor alpha/0.441
3f03FMNPentaerythritol tetranitrate reductase/0.441
3mdmFJZCholesterol 24-hydroxylase/0.441
3nr4PYVAbscisic acid receptor PYL2/0.441
3vrwYS5Vitamin D3 receptor/0.441
4b13NHWGlycylpeptide N-tetradecanoyltransferase/0.441
1bwlFMNNADPH dehydrogenase 11.6.99.10.440
1hb1OCVIsopenicillin N synthase1.21.3.10.440
2h15B19Carbonic anhydrase 24.2.1.10.440
2p33J07Mitogen-activated protein kinase 102.7.11.240.440
2znq401Peroxisome proliferator-activated receptor delta/0.440
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.440
3abaFLICytochrome P450/0.440
3ixp834Ecdysone receptor/0.440
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.440
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3ut5LOCTubulin beta chain/0.440
3zkyWT4Isopenicillin N synthase1.21.3.10.440
4a6nFADTetX family tetracycline inactivation enzyme/0.440
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4r21STRCytochrome P450 family 17 polypeptide 2/0.440