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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ug5H4BNitric oxide synthase oxygenase1.14.13.165

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ug5H4BNitric oxide synthase oxygenase1.14.13.1651.000
4fvzH4BNitric oxide synthase, brain1.14.13.390.616
5aglH4BNitric oxide synthase, brain1.14.13.390.611
3jt6H4BNitric oxide synthase, brain1.14.13.390.593
3pngH4BNitric oxide synthase, brain1.14.13.390.589
1zzrH4BNitric oxide synthase, brain1.14.13.390.588
5agkH4BNitric oxide synthase, brain1.14.13.390.588
4cx5H4BNitric oxide synthase, brain1.14.13.390.585
3q9aH4BNitric oxide synthase, brain1.14.13.390.584
1mmvH4BNitric oxide synthase, brain1.14.13.390.583
4ug7H4BNitric oxide synthase oxygenase1.14.13.1650.579
3ufvH4BNitric oxide synthase, brain1.14.13.390.575
4js9H4BNitric oxide synthase, inducible1.14.13.390.574
4jsfH4BNitric oxide synthase, brain1.14.13.390.574
3jtaH4BNitric oxide synthase, brain1.14.13.390.572
3nljH4BNitric oxide synthase, brain1.14.13.390.572
3nnzH4BNitric oxide synthase, brain1.14.13.390.568
3jt4H4BNitric oxide synthase, brain1.14.13.390.564
4cx4H4BNitric oxide synthase, brain1.14.13.390.563
3tymH4BNitric oxide synthase, brain1.14.13.390.561
3jt3H4BNitric oxide synthase, brain1.14.13.390.560
1dwxH4BNitric oxide synthase, inducible1.14.13.390.558
1qomH4BNitric oxide synthase, inducible1.14.13.390.558
3nlvH4BNitric oxide synthase, brain1.14.13.390.558
4luxH4BNitric oxide synthase, brain1.14.13.390.556
1zzuH4BNitric oxide synthase, brain1.14.13.390.554
3e6tH4BNitric oxide synthase, inducible1.14.13.390.552
3rqjH4BNitric oxide synthase, brain1.14.13.390.552
2hx4H4BNitric oxide synthase, brain1.14.13.390.551
3dwjH4BNitric oxide synthase, inducible1.14.13.390.551
3e67H4BNitric oxide synthase, inducible1.14.13.390.551
4jsgH4BNitric oxide synthase, brain1.14.13.390.549
4k5dH4BNitric oxide synthase, brain1.14.13.390.549
5agpH4BNitric oxide synthase, brain1.14.13.390.549
3e7iH4BNitric oxide synthase, inducible1.14.13.390.547
1vafH4BNitric oxide synthase, inducible1.14.13.390.545
3ej8H4BNitric oxide synthase, inducible1.14.13.390.545
1qw5H4BNitric oxide synthase, inducible1.14.13.390.544
4fvyH4BNitric oxide synthase, brain1.14.13.390.543
3tylH4BNitric oxide synthase, brain1.14.13.390.541
1mjtNADNitric oxide synthase oxygenase/0.540
3jt9H4BNitric oxide synthase, brain1.14.13.390.539
2nodH4BNitric oxide synthase, inducible1.14.13.390.538
3ufrH4BNitric oxide synthase, brain1.14.13.390.538
3dqrH4BNitric oxide synthase, brain1.14.13.390.537
4k5fH4BNitric oxide synthase, brain1.14.13.390.537
3nlqH4BNitric oxide synthase, brain1.14.13.390.536
2g6j7APNitric oxide synthase, brain1.14.13.390.535
2hx3H4BNitric oxide synthase, brain1.14.13.390.535
3e6oH4BNitric oxide synthase, inducible1.14.13.390.535
4d1oH4BNitric oxide synthase, endothelial1.14.13.390.535
1r35H4BNitric oxide synthase, inducible1.14.13.390.534
3ufpH4BNitric oxide synthase, brain1.14.13.390.533
4cx3H4BNitric oxide synthase, brain1.14.13.390.533
3nodH4BNitric oxide synthase, inducible1.14.13.390.532
3jx4H4BNitric oxide synthase, brain1.14.13.390.530
3n5zH4BNitric oxide synthase, brain1.14.13.390.530
3pneH4BNitric oxide synthase, brain1.14.13.390.530
1k2tH4BNitric oxide synthase, brain1.14.13.390.529
1p6kH4BNitric oxide synthase, brain1.14.13.390.528
3jt5H4BNitric oxide synthase, brain1.14.13.390.528
3jwtH4BNitric oxide synthase, brain1.14.13.390.527
3jt7H4BNitric oxide synthase, brain1.14.13.390.526
3nosH4BNitric oxide synthase, endothelial1.14.13.390.526
3rqmH4BNitric oxide synthase, brain1.14.13.390.526
4jshH4BNitric oxide synthase, brain1.14.13.390.526
1zzqH4BNitric oxide synthase, brain1.14.13.390.525
3b3pH4BNitric oxide synthase, brain1.14.13.390.525
3nlyH4BNitric oxide synthase, brain1.14.13.390.525
3svpH4BNitric oxide synthase, brain1.14.13.390.525
4ug91EWNitric oxide synthase oxygenase1.14.13.1650.525
4ugaH4BNitric oxide synthase oxygenase1.14.13.1650.525
3svqH4BNitric oxide synthase, brain1.14.13.390.524
3b3oH4BNitric oxide synthase, brain1.14.13.390.523
1k2uH4BNitric oxide synthase, brain1.14.13.390.522
3jx3H4BNitric oxide synthase, brain1.14.13.390.522
4k5eH4BNitric oxide synthase, brain1.14.13.390.522
2g6iHBINitric oxide synthase, brain1.14.13.390.521
3nloH4BNitric oxide synthase, brain1.14.13.390.521
3nnyH4BNitric oxide synthase, brain1.14.13.390.521
3pnfH4BNitric oxide synthase, brain1.14.13.390.521
1k2sH4BNitric oxide synthase, brain1.14.13.390.520
3e7gH4BNitric oxide synthase, inducible1.14.13.390.520
3nlzH4BNitric oxide synthase, brain1.14.13.390.520
3b3mH4BNitric oxide synthase, brain1.14.13.390.519
1zvlH4BNitric oxide synthase, brain1.14.13.390.518
3nlrH4BNitric oxide synthase, brain1.14.13.390.518
3ufqH4BNitric oxide synthase, brain1.14.13.390.518
4imtH4BNitric oxide synthase, brain1.14.13.390.518
1p6jH4BNitric oxide synthase, brain1.14.13.390.517
3fc5H4BNitric oxide synthase, brain1.14.13.390.517
3jwuH4BNitric oxide synthase, brain1.14.13.390.517
3nlwH4BNitric oxide synthase, brain1.14.13.390.517
1rs6H4BNitric oxide synthase, brain1.14.13.390.515
3jt8H4BNitric oxide synthase, brain1.14.13.390.515
3ufwH4BNitric oxide synthase, brain1.14.13.390.515
3jx6H4BNitric oxide synthase, brain1.14.13.390.514
3nlkH4BNitric oxide synthase, brain1.14.13.390.514
1m00H4BNitric oxide synthase, brain1.14.13.390.513
2geuCOKPantothenate kinase2.7.1.330.513
3jwvH4BNitric oxide synthase, brain1.14.13.390.512
4euxH4BNitric oxide synthase, brain1.14.13.390.512
3n5yH4BNitric oxide synthase, brain1.14.13.390.511
3nlpH4BNitric oxide synthase, brain1.14.13.390.511
3q99H4BNitric oxide synthase, brain1.14.13.390.511
4k5gH4BNitric oxide synthase, brain1.14.13.390.511
3hsnH4BNitric oxide synthase, brain1.14.13.390.510
3ufuH4BNitric oxide synthase, brain1.14.13.390.510
4fw0H4BNitric oxide synthase, brain1.14.13.390.510
3ufoH4BNitric oxide synthase, brain1.14.13.390.509
4imwH4BNitric oxide synthase, brain1.14.13.390.508
4fvxH4BNitric oxide synthase, brain1.14.13.390.507
4gqeH4BNitric oxide synthase, brain1.14.13.390.507
3nlnH4BNitric oxide synthase, brain1.14.13.390.505
1rs7H4BNitric oxide synthase, brain1.14.13.390.503
4lwaQ13Nitric oxide synthase oxygenase1.14.13.1650.503
3b3nH4BNitric oxide synthase, brain1.14.13.390.501
3nw2H4BNitric oxide synthase, inducible1.14.13.390.501
3rqlH4BNitric oxide synthase, brain1.14.13.390.500
3n5vH4BNitric oxide synthase, brain1.14.13.390.499
1esmCOAPantothenate kinase2.7.1.330.497
3jx2H4BNitric oxide synthase, brain1.14.13.390.496
3jx5H4BNitric oxide synthase, brain1.14.13.390.492
2vaxCSCAcetyl-CoA--deacetylcephalosporin C acetyltransferase2.3.1.1750.489
1m8dH4BNitric oxide synthase, inducible1.14.13.390.488
2lbaCHOFatty acid binding protein 6/0.486
4jsiH4BNitric oxide synthase, brain1.14.13.390.486
2gesCOKPantothenate kinase2.7.1.330.484
3rqkH4BNitric oxide synthase, brain1.14.13.390.480
1m8iH4BNitric oxide synthase, inducible1.14.13.390.478
2vrjNCWBeta-glucosidase A3.2.1.210.476
1lb9DNQGlutamate receptor 2/0.473
3juqAJDPhenazine biosynthesis protein A/B/0.473
2j7cIDEBeta-glucosidase A3.2.1.210.472
2zsbADPPantothenate kinase2.7.1.330.472
3gc4AAQQueuine tRNA-ribosyltransferase2.4.2.290.472
4ux6H4BNitric oxide synthase, inducible1.14.13.390.472
1m8eH4BNitric oxide synthase, inducible1.14.13.390.470
1m9tH4BNitric oxide synthase, inducible1.14.13.390.468
4hmvWUBPhenazine biosynthesis protein PhzG1.40.467
5ah5LSSLeucine--tRNA ligase/0.466
3ufsH4BNitric oxide synthase, brain1.14.13.390.463
1jedADPSulfate adenylyltransferase/0.462
3ckqUPGGlucosyl-3-phosphoglycerate synthase2.4.1.2660.462
2ptfFMNUncharacterized protein MTH_863/0.461
3ed1GA3Gibberellin receptor GID1/0.461
3junAJDPhenazine biosynthesis protein A/B/0.461
4z17PEPEnolase/0.461
3kozZ97D-ornithine 4,5-aminomutase subunit beta/0.460
3q9bB3NAcetylpolyamine amidohydrolase/0.460
2vn1FK5Peptidylprolyl isomerase/0.459
4dvq1CACytochrome P450 11B2, mitochondrial1.14.15.40.459
1m8hH4BNitric oxide synthase, inducible1.14.13.390.458
2hctNMNADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.456
2y37H4BNitric oxide synthase, inducible1.14.13.390.456
4becATPType I restriction enzyme EcoR124II R protein3.1.21.30.456
3fufBESLeukotriene A-4 hydrolase3.3.2.60.455
1om5H4BNitric oxide synthase, brain1.14.13.390.454
3n62XFJNitric oxide synthase, brain1.14.13.390.454
3af2ACPPantothenate kinase2.7.1.330.453
3ge7AFQQueuine tRNA-ribosyltransferase2.4.2.290.453
4isuIKMGlutamate receptor 2/0.453
5choFADFlavin reductase/0.453
1g9bBABBotulinum neurotoxin type B3.4.24.690.452
2zsdCOAPantothenate kinase2.7.1.330.452
4e2yJHZMethyltransferase/0.452
5c3aURMHisto-blood group ABO system transferase/0.452
1t13INI6,7-dimethyl-8-ribityllumazine synthase 2/0.451
1v93FADMethylenetetrahydrofolate reductase/0.451
2j7dGI1Beta-glucosidase A3.2.1.210.451
2o7oDXTTetracycline repressor protein class D/0.451
2rl1UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.451
3rl35GPMetallophosphoesterase MPPED23.10.451
4lrrCF9Thymidylate synthase/0.451
1qltFADVanillyl-alcohol oxidase1.1.3.380.450
2getCOKPantothenate kinase2.7.1.330.450
2wvmGDDMannosyl-3-phosphogylcerate synthase/0.450
2vatCOAAcetyl-CoA--deacetylcephalosporin C acetyltransferase2.3.1.1750.449
2vkuDBELanosterol 14-alpha demethylase1.14.13.700.449
3n61H4BNitric oxide synthase, brain1.14.13.390.449
3n66XFNNitric oxide synthase, brain1.14.13.390.449
4u0oMTALipoyl synthase 2/0.449
1r6uTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.448
2ohm8APBeta-secretase 13.4.23.460.448
3iewCTP2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase/0.448
3kt3TYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.448
3n63XFNNitric oxide synthase, brain1.14.13.390.448
3w3zGTPGTP-binding nuclear protein Ran/0.448
4jseH4BNitric oxide synthase, brain1.14.13.390.448
4ug5XFKNitric oxide synthase oxygenase1.14.13.1650.448
4yaw2AMNADPH--cytochrome P450 reductase/0.448
1eyyNAPNADP-dependent fatty aldehyde dehydrogenase1.2.1.40.447
1fwmCB3Thymidylate synthase/0.447
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.447
2r2nKYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.447
2zseACPPantothenate kinase2.7.1.330.447
3af4GCPPantothenate kinase2.7.1.330.447
3fvlBHKCarboxypeptidase A13.4.17.10.447
4a6nT1CTetX family tetracycline inactivation enzyme/0.447
4bfyZVYPantothenate kinase2.7.1.330.447
4dsbA8SAbscisic acid receptor PYL3/0.447
4giu636Anthranilate phosphoribosyltransferase/0.447
1blzACVIsopenicillin N synthase1.21.3.10.446
1g9cBABBotulinum neurotoxin type B3.4.24.690.446
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.446
1v3q2DIPurine nucleoside phosphorylase2.4.2.10.446
2rcwAAIPoly [ADP-ribose] polymerase 12.4.2.300.446
3fr5I4AFatty acid-binding protein, adipocyte/0.446
3h03UBPGlutamate receptor 2/0.446
3rykTYDdTDP-4-dehydrorhamnose 3,5-epimerase/0.446
4h6pFMNChromate reductase/0.446
5c48URMHisto-blood group ABO system transferase/0.446
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.445
3ccc7ACDipeptidyl peptidase 4/0.445
4dyp0MSNucleoprotein/0.445
1g9aBABBotulinum neurotoxin type B3.4.24.690.444
1njjORXOrnithine decarboxylase/0.444
2aj8SC3Dipeptidyl peptidase 4/0.443
3cinNADMyo-inositol-1-phosphate synthase-related protein/0.443
5bt9NAP3-oxoacyl-(Acyl-carrier-protein) reductase/0.443
3opmLUIDipeptidyl peptidase 4/0.442
3q7fED2Uncharacterized protein/0.442
3swqEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.442
4koyCSCUncharacterized protein/0.442
4mzuTYDWxcM-like protein/0.442
4nv0MG77-methylguanosine phosphate-specific 5'-nucleotidase/0.442
1clqGDPDNA-directed DNA polymerase/0.441
2h63NAPBiliverdin reductase A1.3.1.240.441
2j4lUTPUridylate kinase2.7.4.220.441
2r86ATP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase/0.441
2tplHPPTyrosine phenol-lyase4.1.99.20.441
4ac0MIYTetracycline repressor protein class B from transposon Tn10/0.441
4hmz18TdTDP-4-dehydro-6-deoxyglucose 3-epimerase5.1.3.270.441
1fw0KAIGlutamate receptor 2/0.440
1n0sFLUBilin-binding protein/0.440
3af1GDPPantothenate kinase2.7.1.330.440
3ldwIPEFarnesyl pyrophosphate synthase, putative/0.440
4gtv7TRGeranylgeranyl transferase type-2 subunit beta2.5.1.600.440
4qak2AMRNA 2',3'-cyclic phosphodiesterase/0.440
5a05NDPGlucose-fructose oxidoreductase/0.440