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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.11.000
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.721
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.688
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.688
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.680
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.639
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.632
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.607
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.600
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.595
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.591
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.587
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.587
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.583
2hog710Serine/threonine-protein kinase Chk12.7.11.10.580
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.574
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.573
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.568
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.563
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.561
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.559
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.559
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.553
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.552
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.551
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.550
1zys199Serine/threonine-protein kinase Chk12.7.11.10.544
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.544
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.543
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.542
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.542
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.541
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.540
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.539
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.538
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.538
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.537
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.537
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.537
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.536
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.535
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.535
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.534
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.534
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.533
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.533
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.533
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.532
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.529
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.529
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.528
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.525
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.524
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.522
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.522
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.520
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.519
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.519
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.519
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.518
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.515
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.515
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.515
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.514
3a62STURibosomal protein S6 kinase beta-12.7.11.10.514
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.514
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.512
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.510
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.509
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.509
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.507
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.506
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.506
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.506
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.505
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.504
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.504
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.503
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.502
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.502
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.502
3gubGUBDeath-associated protein kinase 12.7.11.10.501
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.501
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.500
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.495
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.493
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.493
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.493
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.493
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.492
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.492
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.492
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.492
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.491
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.489
2ydkYDKSerine/threonine-protein kinase Chk12.7.11.10.488
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.487
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.487
4fto3HKSerine/threonine-protein kinase Chk12.7.11.10.487
2yn8STUEphrin type-B receptor 42.7.10.10.486
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.485
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.485
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.484
3zh8C58Protein kinase C iota type2.7.11.130.484
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.483
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.483
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.483
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.483
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.482
2wxvWXVCyclin-dependent kinase 22.7.11.220.482
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.481
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.480
4bgg844Activin receptor type-12.7.11.300.480
4gmy0X5Tyrosine-protein kinase JAK2/0.480
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.479
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.478
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.478
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.478
3ztxZTXAurora kinase B-A2.7.11.10.477
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.476
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.476
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.475
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.475
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.474
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.474
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
1zrzBI1Protein kinase C iota type2.7.11.130.473
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.473
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.472
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.472
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.472
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.471
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.471
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.471
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.471
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.470
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.470
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.470
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.469
4qmpDKISerine/threonine-protein kinase 242.7.11.10.469
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.468
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.468
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.468
3zep1NXTyrosine-protein kinase JAK32.7.10.20.468
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.467
4qnaX11Serine/threonine-protein kinase 242.7.11.10.467
1oiyN41Cyclin-dependent kinase 22.7.11.220.464
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.464
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.464
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.464
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.464
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.463
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.463
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
4hvh19RTyrosine-protein kinase JAK32.7.10.20.463
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.463
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.462
3eb0DRKUncharacterized protein/0.462
3gu6ADPDeath-associated protein kinase 12.7.11.10.462
3t8oATPRhodopsin kinase/0.462
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.462
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.461
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.461
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.461
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.461
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.460
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.460
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.460
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.460
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.460
1pkdUCNCyclin-dependent kinase 22.7.11.220.459
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.459
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.459
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.459
4a9uA9USerine/threonine-protein kinase Chk22.7.11.10.458
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.457
2x1nX1NCyclin-dependent kinase 22.7.11.220.457
4a9tA9TSerine/threonine-protein kinase Chk22.7.11.10.457
4fv6E57Mitogen-activated protein kinase 12.7.11.240.457
5e8xSTUTGF-beta receptor type-12.7.11.300.457
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.457
2itqITQEpidermal growth factor receptor2.7.10.10.456
2wtjWTJSerine/threonine-protein kinase Chk22.7.11.10.456
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.456
3c4xATPRhodopsin kinase/0.456
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.456
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.456
5auwQUEDeath-associated protein kinase 12.7.11.10.456
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.455
2bfyH1NAurora kinase B-A2.7.11.10.455
2i40BLZCyclin-dependent kinase 22.7.11.220.455
3zmmF9JTyrosine-protein kinase JAK2/0.455
4fob0USALK tyrosine kinase receptor2.7.10.10.455
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.454
2bkzSBCCyclin-dependent kinase 22.7.11.220.454
2wihP48Cyclin-dependent kinase 22.7.11.220.454
3krwBA1Beta-adrenergic receptor kinase 12.7.11.150.454
3r9dX6BCyclin-dependent kinase 22.7.11.220.454
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.454
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.454
2uzlC94Cyclin-dependent kinase 22.7.11.220.453
2vd5BI8Myotonin-protein kinase2.7.11.10.453
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.453
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.453
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.453
3qxpX64Cyclin-dependent kinase 22.7.11.220.453
4gk3L87Ephrin type-A receptor 32.7.10.10.453
2cchATPCyclin-dependent kinase 22.7.11.220.452
2in6839Wee1-like protein kinase2.7.10.20.452
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.452
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.452
2xikJ60Serine/threonine-protein kinase 252.7.11.10.451
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
5dr9SKEAurora kinase A2.7.11.10.451
2vgoAD5Aurora kinase B-A2.7.11.10.450
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.450
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.450
3zewSTUEphrin type-B receptor 42.7.10.10.450
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.449
3biz61EWee1-like protein kinase2.7.10.20.449
3dogNNNCyclin-dependent kinase 22.7.11.220.449
3vf80JETyrosine-protein kinase SYK2.7.10.20.449
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.448
2wpa889Cyclin-dependent kinase 22.7.11.220.448
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.448
3zdu38RCyclin-dependent kinase-like 32.7.11.220.448
1pxpCK8Cyclin-dependent kinase 22.7.11.220.447
2uzbC75Cyclin-dependent kinase 22.7.11.220.447
4gk2L66Ephrin type-A receptor 32.7.10.10.447
4jqeANPCasein kinase II subunit alpha2.7.11.10.447
1bxoPP7Penicillopepsin-13.4.23.200.446
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
4qmySTUSerine/threonine-protein kinase 242.7.11.10.446
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.445
3sheI85MAP kinase-activated protein kinase 32.7.11.10.445
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.445
1e9hINRCyclin-dependent kinase 22.7.11.220.444
2b7aIZATyrosine-protein kinase JAK2/0.444
2c5nCK8Cyclin-dependent kinase 22.7.11.220.444
2ckeIQUDeath-associated protein kinase 2/0.444
3rk507ZCyclin-dependent kinase 22.7.11.220.444
1fvv107Cyclin-dependent kinase 22.7.11.220.443
3i60E86Mitogen-activated protein kinase 12.7.11.240.443
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.443
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.443
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.443
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.442
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
3tnwF18Cyclin-dependent kinase 22.7.11.220.442
4bgh3I6Cyclin-dependent kinase 22.7.11.220.442
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.442
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.442
1xjdSTUProtein kinase C theta type2.7.11.130.441
2eufLQQCyclin-dependent kinase 62.7.11.220.441
2j0lANPFocal adhesion kinase 12.7.10.20.441
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.441
3cr0809Wee1-like protein kinase2.7.10.20.441
3flwFLWMitogen-activated protein kinase 14/0.441
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.441
4j97ACPFibroblast growth factor receptor 2/0.441
4jia1K3Tyrosine-protein kinase JAK2/0.441
4wboANWRhodopsin kinase/0.441
3ral04ZCyclin-dependent kinase 22.7.11.220.440
4acm7YGCyclin-dependent kinase 22.7.11.220.440
4c62XWWTyrosine-protein kinase JAK2/0.440
5e8wSTUTGF-beta receptor type-12.7.11.300.440