Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3ztxZTXAurora kinase B-A2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3ztxZTXAurora kinase B-A2.7.11.11.000
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.551
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.543
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.533
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.531
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.528
2vrx447Aurora kinase B-A2.7.11.10.528
2vgoAD5Aurora kinase B-A2.7.11.10.526
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.522
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.520
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.518
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.515
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.515
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.514
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.512
4anqVGHALK tyrosine kinase receptor2.7.10.10.508
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.507
2vgpAD6Aurora kinase B-A2.7.11.10.507
3k5uPFQAurora kinase A2.7.11.10.507
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.506
2hog710Serine/threonine-protein kinase Chk12.7.11.10.504
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.503
4i4e1BQFocal adhesion kinase 12.7.10.20.503
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.502
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.502
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.502
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.501
2yfxVGHALK tyrosine kinase receptor2.7.10.10.500
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.497
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.497
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.497
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.496
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.495
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.495
4f640S8Fibroblast growth factor receptor 1/0.495
2bfyH1NAurora kinase B-A2.7.11.10.494
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.493
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.493
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.492
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.491
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.490
2ijmATPFocal adhesion kinase 12.7.10.20.490
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.490
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.489
4ansVGHALK tyrosine kinase receptor2.7.10.10.489
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.489
5aaaVGHALK tyrosine kinase receptor2.7.10.10.489
5aacVGHALK tyrosine kinase receptor2.7.10.10.489
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.488
2j0lANPFocal adhesion kinase 12.7.10.20.488
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.486
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.486
2qo9ANPEphrin type-A receptor 32.7.10.10.483
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.483
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.483
2pwlACPFibroblast growth factor receptor 2/0.482
2w1fL0FAurora kinase A2.7.11.10.482
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.482
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.482
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.482
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.481
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.481
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.481
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.479
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.479
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.479
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.478
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.477
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.477
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.477
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.476
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.476
2wqeADPAurora kinase A2.7.11.10.476
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.476
4a9uA9USerine/threonine-protein kinase Chk22.7.11.10.476
3a7hATPSerine/threonine-protein kinase 242.7.11.10.475
3w18N13Aurora kinase A2.7.11.10.475
4c3pACPAurora kinase A2.7.11.10.475
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.474
2w1eL0EAurora kinase A2.7.11.10.474
5auwQUEDeath-associated protein kinase 12.7.11.10.474
2c6eHPMAurora kinase A2.7.11.10.473
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.473
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.473
4utdACPAurora kinase A2.7.11.10.473
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.472
2qoqANPEphrin type-A receptor 32.7.10.10.472
5l8lADPAurora kinase A2.7.11.10.472
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.471
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.470
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.470
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.470
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.470
4j97ACPFibroblast growth factor receptor 2/0.470
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.469
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.469
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
4jbqVX6Aurora kinase A2.7.11.10.469
4o0uADNAurora kinase A2.7.11.10.469
1zys199Serine/threonine-protein kinase Chk12.7.11.10.468
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.468
5dr9SKEAurora kinase A2.7.11.10.468
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.467
1pmn984Mitogen-activated protein kinase 102.7.11.240.467
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.467
2x6dX6DAurora kinase A2.7.11.10.467
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.466
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.466
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.465
3t8oATPRhodopsin kinase/0.465
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.465
4d58BI9Focal adhesion kinase 12.7.10.20.465
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.465
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.465
2xp2VGHALK tyrosine kinase receptor2.7.10.10.464
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.464
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.464
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.464
4b8lA0PAurora kinase B-A2.7.11.10.464
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.463
4jia1K3Tyrosine-protein kinase JAK2/0.463
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
4gk3L87Ephrin type-A receptor 32.7.10.10.462
1bygSTUTyrosine-protein kinase CSK/0.461
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.460
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.460
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.459
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.459
4b8mVX6Aurora kinase B-A2.7.11.10.459
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.458
2vwu7X1Ephrin type-B receptor 42.7.10.10.458
2wtjWTJSerine/threonine-protein kinase Chk22.7.11.10.458
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.458
4a9tA9TSerine/threonine-protein kinase Chk22.7.11.10.458
4cd0AWJALK tyrosine kinase receptor2.7.10.10.458
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.458
1finATPCyclin-dependent kinase 22.7.11.220.457
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.457
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.457
4j99ACPFibroblast growth factor receptor 2/0.457
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.456
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.456
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.456
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.455
3my5RFZCyclin-dependent kinase 22.7.11.220.455
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.455
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.454
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.454
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.453
2henADPEphrin type-B receptor 22.7.10.10.453
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.453
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.453
3efwAK8Aurora kinase A2.7.11.10.453
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.453
4d4sBI9Focal adhesion kinase 12.7.10.20.453
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.453
4hvh19RTyrosine-protein kinase JAK32.7.10.20.453
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.452
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.452
3c4xATPRhodopsin kinase/0.452
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.452
4j95ACPFibroblast growth factor receptor 2/0.452
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.452
5ap7SVEDual specificity protein kinase TTK2.7.12.10.452
3bu5ATPInsulin receptor2.7.10.10.451
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.451
4fob0USALK tyrosine kinase receptor2.7.10.10.451
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.451
1i44ACPInsulin receptor2.7.10.10.450
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.450
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.450
2xru400Aurora kinase A2.7.11.10.450
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.450
3bqr4RBDeath-associated protein kinase 3/0.450
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.450
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.450
1mp8ADPFocal adhesion kinase 12.7.10.20.449
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.449
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.449
2r5tANPSerine/threonine-protein kinase Sgk12.7.11.10.449
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.449
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.449
5aabVGHALK tyrosine kinase receptor2.7.10.10.449
2ckeIQUDeath-associated protein kinase 2/0.448
2ydkYDKSerine/threonine-protein kinase Chk12.7.11.10.448
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.448
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.448
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.447
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.447
4dtaADNAPH(2'')-Id/0.447
4gmy0X5Tyrosine-protein kinase JAK2/0.447
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.447
4l9i8PRRhodopsin kinase/0.447
2etm7PYFocal adhesion kinase 12.7.10.20.446
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.446
2xngA0HAurora kinase A2.7.11.10.446
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.446
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
5dt0SKEAurora kinase A2.7.11.10.446
1fvv107Cyclin-dependent kinase 22.7.11.220.445
2ijmADPFocal adhesion kinase 12.7.10.20.445
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.445
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.445
4b99R4LMitogen-activated protein kinase 72.7.11.240.445
4jboWPHAurora kinase A2.7.11.10.445
4jbpYPHAurora kinase A2.7.11.10.445
1ol6ATPAurora kinase A2.7.11.10.444
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.444
3gu6ADPDeath-associated protein kinase 12.7.11.10.444
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.444
4s34ANPMitogen-activated protein kinase 12.7.11.240.444
2fgiPD1Fibroblast growth factor receptor 1/0.443
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.443
3eb0DRKUncharacterized protein/0.443
3emg685Tyrosine-protein kinase SYK2.7.10.20.443
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.443
3js2VM1Fibroblast growth factor receptor 1/0.443
3kvxFMYMitogen-activated protein kinase 102.7.11.240.443
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.443
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.443
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.443
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.443
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.443
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.443
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.442
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.442
1ol5ADPAurora kinase A2.7.11.10.442
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3s4qNK0Mitogen-activated protein kinase 14/0.442
4o0wADNAurora kinase A2.7.11.10.442
5e8ySTUTGF-beta receptor type-22.7.11.300.442
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.441
2itnANPEpidermal growth factor receptor2.7.10.10.441
4c4f7CEDual specificity protein kinase TTK2.7.12.10.441
4k33ACPFibroblast growth factor receptor 32.7.10.10.441
4s33ANPMitogen-activated protein kinase 12.7.11.240.441
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.441
2c4g514Cyclin-dependent kinase 22.7.11.220.440
2j0k4STFocal adhesion kinase 12.7.10.20.440
2j0m4STFocal adhesion kinase 12.7.10.20.440
2qo7ANPEphrin type-A receptor 32.7.10.10.440