sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3wd7 | COA | Acridone synthase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3wd7 | COA | Acridone synthase | / | 1.000 | |
| 3wxy | COA | Uncharacterized protein | / | 0.586 | |
| 1ee0 | CAA | 2-pyrone synthase | / | 0.564 | |
| 3wy0 | COA | Uncharacterized protein | / | 0.546 | |
| 2d3m | COA | 5,7-dihydroxy-2-methylchromone synthase | 2.3.1.216 | 0.537 | |
| 4jaq | COA | Alpha-pyrone synthesis polyketide synthase-like Pks11 | 2.3.1 | 0.537 | |
| 4jd3 | COA | Alpha-pyrone synthesis polyketide synthase-like Pks11 | 2.3.1 | 0.522 | |
| 2d52 | COA | 5,7-dihydroxy-2-methylchromone synthase | 2.3.1.216 | 0.520 | |
| 1bq6 | COA | Chalcone synthase 2 | 2.3.1.74 | 0.516 | |
| 1chw | HXC | Chalcone synthase 2 | 2.3.1.74 | 0.514 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.513 | |
| 4aw3 | MYV | Mycinamicin IV hydroxylase/epoxidase | / | 0.505 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.504 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.503 | |
| 3h0a | D30 | Peroxisome proliferator-activated receptor gamma | / | 0.499 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.499 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.497 | |
| 4jap | COA | Alpha-pyrone synthesis polyketide synthase-like Pks11 | 2.3.1 | 0.497 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.496 | |
| 2hfp | NSI | Peroxisome proliferator-activated receptor gamma | / | 0.496 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.496 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.495 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.494 | |
| 3vso | EK1 | Peroxisome proliferator-activated receptor gamma | / | 0.494 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.493 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.493 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.491 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.491 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.490 | |
| 3gub | GUB | Death-associated protein kinase 1 | 2.7.11.1 | 0.490 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.490 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.489 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.489 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.488 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.488 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.487 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.486 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.486 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.485 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.485 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.485 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.484 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.483 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.482 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.481 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.480 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.480 | |
| 1fm9 | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.479 | |
| 3m7r | VDX | Vitamin D3 receptor | / | 0.479 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.479 | |
| 1ict | T44 | Transthyretin | / | 0.478 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.478 | |
| 1sn5 | T3 | Transthyretin | / | 0.478 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.477 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.477 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.477 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.477 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.476 | |
| 2zno | S44 | Peroxisome proliferator-activated receptor gamma | / | 0.476 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.476 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.476 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.476 | |
| 1ie4 | T44 | Transthyretin | / | 0.475 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.474 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.474 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.474 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.474 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.474 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.473 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.472 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.471 | |
| 2hbh | XE4 | Vitamin D3 receptor A | / | 0.471 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.471 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.471 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.471 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.470 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.470 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.469 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.469 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.469 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.469 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.469 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.469 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.469 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.469 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.469 | |
| 1cbr | REA | Cellular retinoic acid-binding protein 1 | / | 0.468 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.468 | |
| 3nwy | GTP | Uridylate kinase | / | 0.468 | |
| 3r3b | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.468 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.468 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.468 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.468 | |
| 4gue | QCT | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.468 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.468 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.467 | |
| 4b7x | NAP | Probable oxidoreductase | / | 0.467 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.467 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.467 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.466 | |
| 2gtk | 208 | Peroxisome proliferator-activated receptor gamma | / | 0.466 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.466 | |
| 4hee | 14R | Peroxisome proliferator-activated receptor gamma | / | 0.466 | |
| 4inb | 1F6 | Gag protein | / | 0.466 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.466 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.466 | |
| 3vjh | J35 | Peroxisome proliferator-activated receptor gamma | / | 0.465 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.465 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.465 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.465 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.465 | |
| 4k1b | 1OC | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.465 | |
| 1eh4 | IC1 | Casein kinase I homolog 1 | 2.7.11.1 | 0.464 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.464 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.464 | |
| 2y00 | Y01 | Beta-1 adrenergic receptor | / | 0.464 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.464 | |
| 4b10 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.464 | |
| 1jvs | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.463 | |
| 2c6h | PXI | Cytochrome P450 monooxygenase PikC | / | 0.463 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.463 | |
| 3cx5 | SMA | Cytochrome b | / | 0.463 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.463 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.463 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.463 | |
| 4fkv | 61K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 4h3c | 0YZ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.463 | |
| 4h4u | NDP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.463 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.462 | |
| 3vsp | EK8 | Peroxisome proliferator-activated receptor gamma | / | 0.462 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.462 | |
| 1pp9 | SMA | Cytochrome b | / | 0.461 | |
| 2xp2 | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.461 | |
| 2y30 | SM8 | Putative repressor SimReg2 | / | 0.461 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.461 | |
| 2yek | EAM | Bromodomain-containing protein 2 | / | 0.461 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.461 | |
| 3n7u | NAD | Formate dehydrogenase, chloroplastic/mitochondrial | / | 0.461 | |
| 4ubs | DIF | Pentalenic acid synthase | 1.14.15.11 | 0.461 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.460 | |
| 2h8h | H8H | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.460 | |
| 4ez5 | 0RS | Cyclin-dependent kinase 6 | 2.7.11.22 | 0.460 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.460 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.460 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.460 | |
| 5eyp | LOC | Tubulin beta chain | / | 0.460 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 1ppj | SMA | Cytochrome b | / | 0.459 | |
| 1zgy | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 2e9c | B75 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.459 | |
| 2q5p | 241 | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.459 | |
| 2y01 | Y01 | Beta-1 adrenergic receptor | / | 0.459 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.459 | |
| 3cge | NDP | Coenzyme A disulfide reductase | / | 0.459 | |
| 3qai | XNN | Ketohexokinase | / | 0.459 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.459 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.459 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.459 | |
| 4l3l | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.459 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.459 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.458 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.458 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.458 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.458 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.458 | |
| 3icr | COA | Coenzyme A disulfide reductase | / | 0.458 | |
| 3poz | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.458 | |
| 3stx | BKA | Methylketone synthase I | / | 0.458 | |
| 4jbq | VX6 | Aurora kinase A | 2.7.11.1 | 0.458 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.458 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.457 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.457 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.457 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.457 | |
| 2jkq | VG8 | Focal adhesion kinase 1 | 2.7.10.2 | 0.457 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta | / | 0.457 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta' | / | 0.457 | |
| 3gc8 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.457 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.457 | |
| 4feq | 0T8 | Tyrosine-protein kinase receptor TYRO3 | 2.7.10.1 | 0.457 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 1e6e | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.456 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.456 | |
| 2fgk | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.456 | |
| 2hk5 | 1BM | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.456 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.456 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.456 | |
| 3zcw | 4A2 | Kinesin-like protein KIF11 | / | 0.456 | |
| 3zux | TCH | Transporter | / | 0.456 | |
| 4a95 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
| 4l9q | 9TP | Serum albumin | / | 0.456 | |
| 1s9j | BBM | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.455 | |
| 3d8b | ADP | Fidgetin-like protein 1 | 3.6.4 | 0.455 | |
| 4g2h | 0VQ | Vitamin D3 receptor A | / | 0.455 | |
| 4gmy | 0X5 | Tyrosine-protein kinase JAK2 | / | 0.455 | |
| 4jay | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.455 | |
| 4nka | 2K7 | Fibroblast growth factor receptor 1 | / | 0.455 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.454 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.454 | |
| 1w2x | RCP | Acetyl-CoA carboxylase | / | 0.454 | |
| 3anl | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.454 | |
| 3crz | FAD | Ferredoxin--NADP+ reductase | / | 0.454 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.454 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.454 | |
| 1rbm | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.453 | |
| 1rdt | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.453 | |
| 1ysx | 4EB | Serum albumin | / | 0.453 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.453 | |
| 2wmq | ZYQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.453 | |
| 3cs8 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 3h0s | B38 | Acetyl-CoA carboxylase | / | 0.453 | |
| 4hgs | 15G | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.453 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.452 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.452 | |
| 1sn0 | T44 | Transthyretin | / | 0.452 | |
| 1wvg | APR | CDP-glucose 4,6-dehydratase | 4.2.1.45 | 0.452 | |
| 2dqs | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.452 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.452 | |
| 2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.452 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.452 | |
| 3klj | FAD | NADH-rubredoxin oxidoreductase | 1.18.1.1 | 0.452 | |
| 3s3r | 0IW | Cathepsin B-like peptidase (C01 family) | / | 0.452 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.452 | |
| 3w1f | 1O5 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.452 | |
| 3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.452 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.452 | |
| 4l3j | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.452 | |
| 5ag6 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.452 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.451 | |
| 1k74 | 544 | Peroxisome proliferator-activated receptor gamma | / | 0.451 | |
| 1kb9 | SMA | Cytochrome b | / | 0.451 | |
| 1zhw | HC2 | Oxysterol-binding protein homolog 4 | / | 0.451 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.451 | |
| 3aba | FLI | Cytochrome P450 | / | 0.451 | |
| 3kdu | NKS | Peroxisome proliferator-activated receptor alpha | / | 0.451 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.451 | |
| 3lu8 | IQX | Serum albumin | / | 0.451 | |
| 3p9t | TCL | Repressor | / | 0.451 | |
| 3syi | FAD | Sulfide-quinone reductase | / | 0.451 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.451 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.451 | |
| 3zok | NAD | 3-dehydroquinate synthase, chloroplastic | 4.2.3.4 | 0.451 | |
| 4b14 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.451 | |
| 4fsu | HK5 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.451 | |
| 4kln | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.451 | |
| 4mcv | 29K | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.451 | |
| 1yon | A2R | 2-dehydropantoate 2-reductase | 1.1.1.169 | 0.450 | |
| 3iqz | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.450 | |
| 3vev | 0H4 | Glucokinase | 2.7.1.2 | 0.450 | |
| 3we4 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.450 | |
| 3zep | 1NX | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.450 | |
| 4a30 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4dhy | S41 | Glucokinase | 2.7.1.2 | 0.450 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.450 | |
| 4mxy | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.450 | |
| 4mxz | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.450 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.450 | |
| 5a27 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 1d6h | COA | Chalcone synthase 2 | 2.3.1.74 | 0.449 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.449 | |
| 1yol | S03 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.449 | |
| 2y02 | Y01 | Beta-1 adrenergic receptor | / | 0.449 | |
| 3jsk | AHZ | Thiamine thiazole synthase | / | 0.449 | |
| 3lfn | A27 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.449 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.449 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.449 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.449 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.449 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.449 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 5eox | ADP | Type 4 fimbrial biogenesis protein PilM | / | 0.449 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.449 | |
| 1fm6 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 1gqt | ACP | Ribokinase | / | 0.448 | |
| 1kk4 | ACO | Streptogramin A acetyltransferase | 2.3.1 | 0.448 | |
| 2w4i | VGA | Glutamate racemase | / | 0.448 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.448 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 3hl7 | I47 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3ogq | AB1 | Pol polyprotein | / | 0.448 | |
| 3v9v | 21L | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 4bwx | AGS | PAB-dependent poly(A)-specific ribonuclease subunit pan3 | / | 0.448 | |
| 4hfm | NAP | 2-alkenal reductase (NADP(+)-dependent) | / | 0.448 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.448 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.448 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.447 | |
| 1pmn | 984 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.447 | |
| 2vd5 | BI8 | Myotonin-protein kinase | 2.7.11.1 | 0.447 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.447 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4k11 | 0J9 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.447 | |
| 5e8y | STU | TGF-beta receptor type-2 | 2.7.11.30 | 0.447 | |
| 1i7i | AZ2 | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 1qpd | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.446 | |
| 1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.446 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.446 | |
| 2q8s | L92 | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.446 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.446 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.446 | |
| 3oom | 507 | Activin receptor type-1 | 2.7.11.30 | 0.446 | |
| 3tkh | 07S | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.446 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.446 | |
| 1tz8 | DES | Transthyretin | / | 0.445 | |
| 1uum | AFI | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.445 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 2oax | SNL | Mineralocorticoid receptor | / | 0.445 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.445 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.445 | |
| 3dmt | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.445 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.445 | |
| 4fz6 | 0VG | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.445 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.445 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.445 | |
| 4wsq | KSA | AP2-associated protein kinase 1 | 2.7.11.1 | 0.445 | |
| 5ag7 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.444 | |
| 1xl2 | 189 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 2ghm | LIC | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 2y03 | Y01 | Beta-1 adrenergic receptor | / | 0.444 | |
| 2ydi | YDI | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.444 | |
| 3et7 | 349 | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.444 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.444 | |
| 3t11 | 3T1 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.444 | |
| 3w2o | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.444 | |
| 4bbh | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4grb | 0XG | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 4k33 | ACP | Fibroblast growth factor receptor 3 | 2.7.10.1 | 0.444 | |
| 1ezv | SMA | Cytochrome b | / | 0.443 | |
| 1g5s | I17 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.443 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2j0d | ERY | Cytochrome P450 3A4 | / | 0.443 | |
| 3cwk | REA | Cellular retinoic acid-binding protein 2 | / | 0.443 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.443 | |
| 3zbn | COA | 3-ketoacyl-CoA thiolase-like protein | / | 0.443 | |
| 4bqp | VMY | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 4hgl | 0YO | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.443 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.443 | |
| 4loq | SB4 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 4neu | Q1A | Receptor-interacting serine/threonine-protein kinase 1 | 2.7.11.1 | 0.443 | |
| 1h1s | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 1o8c | NDP | Probable acrylyl-CoA reductase AcuI | 1.3.1.84 | 0.442 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.442 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.442 | |
| 3qlf | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.442 | |
| 3r9d | X6B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3tvu | B37 | Acetyl-CoA carboxylase | / | 0.442 | |
| 3uyt | 0CK | Casein kinase I isoform delta | 2.7.11.1 | 0.442 | |
| 3v5l | 0G1 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.442 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.442 | |
| 4i0r | 1B4 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.442 | |
| 4kbk | 1QG | Casein kinase I isoform delta | 2.7.11.1 | 0.442 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.442 | |
| 4ww0 | ADP | ATP-dependent zinc metalloprotease FtsH | / | 0.442 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.441 | |
| 1npa | 3NH | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1npw | LGZ | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.441 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.441 | |
| 2fgj | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.441 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.441 | |
| 2ibz | SMA | Cytochrome b | / | 0.441 | |
| 2pmd | GNP | Translation initiation factor 2 subunit gamma | / | 0.441 | |
| 2vnh | FAD | NADPH:ferredoxin reductase | / | 0.441 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.441 | |
| 3a0i | AJI | Glucokinase | 2.7.1.2 | 0.441 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.441 | |
| 3cjg | KIM | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.441 | |
| 3eel | 53T | Uncharacterized protein | / | 0.441 | |
| 3hu1 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.441 | |
| 3i59 | N6S | CRP-like cAMP-activated global transcriptional regulator | / | 0.441 | |
| 3ma3 | 01I | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.441 | |
| 4bid | IE8 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.441 | |
| 4c57 | FEF | Cyclin-G-associated kinase | 2.7.11.1 | 0.441 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.441 | |
| 4lch | 1WN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.441 | |
| 4o2b | LOC | Tubulin beta-2B chain | / | 0.441 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.441 | |
| 6cox | S58 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.441 | |
| 1eio | GCH | Gastrotropin | / | 0.440 | |
| 1nde | MON | Estrogen receptor beta | / | 0.440 | |
| 1yre | COA | Uncharacterized protein | / | 0.440 | |
| 2b52 | D42 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2gdo | 12C | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2j3k | NAP | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.440 | |
| 2j4z | 626 | Aurora kinase A | 2.7.11.1 | 0.440 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.440 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.440 | |
| 3be9 | P04 | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 3bhe | BZN | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3mfr | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.440 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3s0o | 50Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3s1h | 56Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3sgt | P09 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | / | 0.440 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.440 | |
| 4b11 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4b13 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4f9m | FCM | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 4fti | H7K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4l2i | FAD | Electron transfer flavoprotein alpha/beta-subunit | / | 0.440 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.440 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.440 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.440 | |
| 5cms | APR | O-acetyl-ADP-ribose deacetylase | / | 0.440 |