sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3ref | GDP | Rho family GTPase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3ref | GDP | Rho family GTPase | / | 1.000 | |
| 1cul | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.529 | |
| 1cs4 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.523 | |
| 1mh1 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.521 | |
| 3vhx | GTP | ADP-ribosylation factor 6 | / | 0.518 | |
| 3c14 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.516 | |
| 4a4v | YFD | Peroxisome proliferator-activated receptor gamma | / | 0.514 | |
| 4e03 | ADP | Plasmid partitioning protein ParF | / | 0.512 | |
| 2gvd | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.507 | |
| 2p2l | GDP | Ras-related C3 botulinum toxin substrate 1 | / | 0.506 | |
| 3pcr | GTP | ADP-ribosylation factor 6 | / | 0.506 | |
| 4fid | GDP | G protein alpha subunit, putative | / | 0.506 | |
| 4pan | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.505 | |
| 3ums | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.504 | |
| 1wdt | GTP | Elongation factor G (EF-G-2) | / | 0.503 | |
| 2xtz | GSP | Guanine nucleotide-binding protein alpha-1 subunit | / | 0.503 | |
| 2q3f | GNP | Ras-related GTP-binding protein D | / | 0.502 | |
| 1azt | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.501 | |
| 1gia | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.501 | |
| 4hdq | GNP | Ras-related protein Rap-1b | / | 0.501 | |
| 1gil | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.499 | |
| 5di3 | GNP | ADP-ribosylation factor-like protein 3 | / | 0.499 | |
| 4eut | BX7 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.498 | |
| 1e79 | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.497 | |
| 1e79 | ATP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.497 | |
| 2ic5 | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.497 | |
| 3mjh | GTP | Ras-related protein Rab-5A | / | 0.496 | |
| 3r7w | GNP | GTP-binding protein GTR2 | / | 0.496 | |
| 4dvg | GSP | Rho family GTPase | / | 0.495 | |
| 1z0a | GDP | Ras-related protein Rab-2A | / | 0.494 | |
| 2yfe | YFE | Peroxisome proliferator-activated receptor gamma | / | 0.492 | |
| 3c16 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.491 | |
| 1y3a | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.490 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 4oh4 | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.490 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.487 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.487 | |
| 2g0n | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.486 | |
| 4gzm | GSP | Ras-related C3 botulinum toxin substrate 1 | / | 0.486 | |
| 1equ | EQI | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.485 | |
| 4btj | ATP | Tau-tubulin kinase 1 | 2.7.11.1 | 0.485 | |
| 4dzz | ADP | Plasmid partitioning protein ParF | / | 0.485 | |
| 1ky2 | GNP | GTP-binding protein YPT7 | / | 0.484 | |
| 2ic5 | GNP | Ras-related C3 botulinum toxin substrate 3 | / | 0.484 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.484 | |
| 4fvq | ATP | Tyrosine-protein kinase JAK2 | / | 0.484 | |
| 2pd8 | FAD | Vivid PAS protein VVD | / | 0.483 | |
| 3cph | GDP | Ras-related protein SEC4 | / | 0.483 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.483 | |
| 2fe4 | GDP | Ras-related protein Rab-6B | / | 0.482 | |
| 3keu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.482 | |
| 3qe0 | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.482 | |
| 4ech | FAD | Polyamine oxidase FMS1 | / | 0.482 | |
| 2nu9 | COA | Succinate--CoA ligase [ADP-forming] subunit alpha | 6.2.1.5 | 0.481 | |
| 1u0h | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.480 | |
| 3jvv | ACP | Twitching mobility protein | / | 0.480 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.480 | |
| 2q5p | 241 | Peroxisome proliferator-activated receptor gamma | / | 0.479 | |
| 3hji | FAD | Vivid PAS protein VVD | / | 0.479 | |
| 3tgp | GNP | GTPase HRas | / | 0.479 | |
| 5ftc | ADP | TPR domain protein | / | 0.478 | |
| 3c15 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.477 | |
| 3qd0 | 3Q4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.477 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.476 | |
| 1ybm | NAP | Uncharacterized protein At5g02240 | / | 0.475 | |
| 3qbt | GNP | Ras-related protein Rab-8A | / | 0.475 | |
| 3uhm | RFN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.475 | |
| 2fg5 | GNP | Ras-related protein Rab-31 | / | 0.474 | |
| 2j0v | GDP | Rac-like GTP-binding protein ARAC7 | / | 0.474 | |
| 3sbd | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.474 | |
| 1z2a | GDP | Ras-related protein Rab-23 | / | 0.473 | |
| 2oo7 | AP5 | Adenylate kinase | / | 0.473 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.472 | |
| 5k5z | ANP | Uncharacterized protein | / | 0.472 | |
| 6cts | CIC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.472 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.471 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.471 | |
| 3ea4 | FAB | Acetolactate synthase, chloroplastic | 2.2.1.6 | 0.471 | |
| 3q0g | BCO | Probable enoyl-CoA hydratase echA8 | 4.2.1.17 | 0.471 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.470 | |
| 1glf | ADP | Glycerol kinase | / | 0.470 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.470 | |
| 4goj | GNP | ADP-ribosylation factor-like protein 3 | / | 0.470 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.469 | |
| 3kz1 | GSP | Transforming protein RhoA | / | 0.469 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.469 | |
| 4pl4 | ADP | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.469 | |
| 4y0v | GDP | ADP-ribosylation factor 1, putative | / | 0.469 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.469 | |
| 5doz | NDP | JamJ | / | 0.469 | |
| 5e92 | ANP | TGF-beta receptor type-2 | 2.7.11.30 | 0.469 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.468 | |
| 3a20 | FMN | FMN-binding protein | / | 0.468 | |
| 3is2 | FAD | Vivid PAS protein VVD | / | 0.468 | |
| 3r9x | GNP | GTPase Era | / | 0.468 | |
| 3tqa | NDP | Dihydrofolate reductase | / | 0.468 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.468 | |
| 4xvr | GNP | GTPase HRas | / | 0.468 | |
| 5l3r | GCP | Cell division protein FtsY homolog, chloroplastic | / | 0.468 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.467 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 4pao | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.467 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.467 | |
| 1aj8 | COA | Citrate synthase | / | 0.466 | |
| 1rj9 | GCP | Signal recognition particle receptor FtsY | / | 0.466 | |
| 2w4j | ADP | Death-associated protein kinase 1 | 2.7.11.1 | 0.466 | |
| 3tso | GNP | Ras-related protein Rab-25 | / | 0.466 | |
| 4dpm | COA | Malonyl-CoA reductase | 1.2.1.75 | 0.466 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.465 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.464 | |
| 2v1x | ADP | ATP-dependent DNA helicase Q1 | 3.6.4.12 | 0.464 | |
| 3lbh | GNP | GTPase HRas | / | 0.464 | |
| 4aw1 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.464 | |
| 5iqi | GNP | Bifunctional AAC/APH | 2.3.1 | 0.464 | |
| 1dj3 | GDP | Adenylosuccinate synthetase, chloroplastic | / | 0.463 | |
| 1zd9 | GDP | ADP-ribosylation factor-like protein 8A | / | 0.463 | |
| 2qme | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.463 | |
| 2z4s | ADP | Chromosomal replication initiator protein DnaA | / | 0.463 | |
| 4e6q | 0NV | Tyrosine-protein kinase JAK2 | / | 0.463 | |
| 4fv6 | E57 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.463 | |
| 4l2i | FAD | Electron transfer flavoprotein alpha/beta-subunit | / | 0.463 | |
| 4l9s | GDP | GTPase HRas | / | 0.463 | |
| 4v02 | ATP | Site-determining protein | / | 0.463 | |
| 5kcz | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.463 | |
| 1j1c | ADP | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.462 | |
| 1kmq | GNP | Transforming protein RhoA | / | 0.462 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.462 | |
| 2rc6 | NAP | Ferredoxin--NADP reductase | / | 0.462 | |
| 2z6d | FMN | Phototropin-2 | 2.7.11.1 | 0.462 | |
| 3k9l | GNP | GTPase HRas | / | 0.462 | |
| 3kkq | GDP | Ras-related protein M-Ras | / | 0.462 | |
| 4fkv | 61K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.462 | |
| 4lj9 | ACP | Chaperone protein ClpB | / | 0.462 | |
| 2bhi | SFT | Cytotoxin 3 | / | 0.461 | |
| 2pd7 | FAD | Vivid PAS protein VVD | / | 0.461 | |
| 2rc3 | NAD | CBS domain | / | 0.461 | |
| 3hjk | FAD | Vivid PAS protein VVD | / | 0.461 | |
| 3jzd | NAD | Maleylacetate reductase | / | 0.461 | |
| 4bwx | AGS | PAB-dependent poly(A)-specific ribonuclease subunit pan3 | / | 0.461 | |
| 4luc | GDP | GTPase KRas | / | 0.461 | |
| 4wa7 | GDP | GTPase KRas | / | 0.461 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.460 | |
| 1kev | NDP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.460 | |
| 2b9f | ADP | Mitogen-activated protein kinase FUS3 | 2.7.11.24 | 0.460 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.460 | |
| 3zxt | ACP | Death-associated protein kinase 1 | 2.7.11.1 | 0.460 | |
| 5iqd | GNP | Bifunctional AAC/APH | 2.3.1 | 0.460 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.459 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.459 | |
| 4fv5 | EK9 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.459 | |
| 1tu3 | GNP | Ras-related protein Rab-5A | / | 0.458 | |
| 2gcp | GSP | Rho-related GTP-binding protein RhoC | / | 0.458 | |
| 2hf8 | GSP | Probable hydrogenase nickel incorporation protein HypB | / | 0.458 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.458 | |
| 2zrj | AGS | Protein RecA | / | 0.458 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.458 | |
| 3cnd | FAD | Polyamine oxidase FMS1 | / | 0.458 | |
| 3dvl | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.458 | |
| 3rus | ADP | Chaperonin | / | 0.458 | |
| 3uoy | NAP | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.458 | |
| 4h4w | NAP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.458 | |
| 4jr7 | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.458 | |
| 4nxv | GDP | Mitochondrial dynamics protein MID51 | / | 0.458 | |
| 4tq9 | GDP | GTPase KRas | / | 0.458 | |
| 2b9i | ADP | Mitogen-activated protein kinase FUS3 | 2.7.11.24 | 0.457 | |
| 2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.457 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3ruv | ANP | Chaperonin | / | 0.457 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 4cta | ATP | CinA-like protein | / | 0.457 | |
| 4nif | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.457 | |
| 5kjf | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.457 | |
| 1bmf | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.456 | |
| 1bmf | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.456 | |
| 1bwf | ATF | Glycerol kinase | / | 0.456 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.456 | |
| 3cn8 | FAD | Polyamine oxidase FMS1 | / | 0.456 | |
| 4i3z | ADP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 4z26 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.456 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.455 | |
| 1jsc | FAD | Acetolactate synthase catalytic subunit, mitochondrial | 2.2.1.6 | 0.455 | |
| 1m2o | GNP | Small COPII coat GTPase SAR1 | 3.6.5 | 0.455 | |
| 1yu9 | GNP | Ras-related protein Rab-4A | / | 0.455 | |
| 2b9j | ADP | Mitogen-activated protein kinase FUS3 | 2.7.11.24 | 0.455 | |
| 2ce2 | GDP | GTPase HRas | / | 0.455 | |
| 4h3q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.455 | |
| 1got | GDP | Guanine nucleotide-binding protein G(t) subunit alpha-1 | / | 0.454 | |
| 1gp2 | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.454 | |
| 1i44 | ACP | Insulin receptor | 2.7.10.1 | 0.454 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.454 | |
| 2eu8 | AP5 | Adenylate kinase | / | 0.454 | |
| 2gtm | LID | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.454 | |
| 2w2x | GSP | Ras-related C3 botulinum toxin substrate 2 | / | 0.454 | |
| 3lu6 | IMX | Serum albumin | / | 0.454 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.454 | |
| 4h4u | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.454 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.453 | |
| 1p7c | T5A | Thymidine kinase | / | 0.453 | |
| 2fgk | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.453 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.453 | |
| 4ylg | GDP | ADP-ribosylation factor 1, putative | / | 0.453 | |
| 5a3c | NAD | SIR2 family protein | / | 0.453 | |
| 5dt0 | SKE | Aurora kinase A | 2.7.11.1 | 0.453 | |
| 1wvg | APR | CDP-glucose 4,6-dehydratase | 4.2.1.45 | 0.452 | |
| 1y91 | CT9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.452 | |
| 3cx6 | GDP | Guanine nucleotide-binding protein subunit alpha-13 | / | 0.452 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.452 | |
| 3kko | GNP | Ras-related protein M-Ras | / | 0.452 | |
| 4fg9 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.452 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1pn3 | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.451 | |
| 1zbd | GTP | Ras-related protein Rab-3A | / | 0.451 | |
| 1zgd | NAP | Chalcone reductase | / | 0.451 | |
| 2v7q | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.451 | |
| 2v7q | ATP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.451 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.451 | |
| 3lki | ATP | Fructokinase | / | 0.451 | |
| 3nie | ANP | Mitogen-activated protein kinase | / | 0.451 | |
| 4e6d | 0NU | Tyrosine-protein kinase JAK2 | / | 0.451 | |
| 4e8y | IHA | D-beta-D-heptose 7-phosphate kinase | / | 0.451 | |
| 4lpk | GDP | GTPase KRas | / | 0.451 | |
| 4nxx | GDP | Mitochondrial dynamics protein MID51 | / | 0.451 | |
| 4u2t | FAD | Cholesterol oxidase | 1.1.3.6 | 0.451 | |
| 4xd2 | NAI | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.451 | |
| 5fl3 | ADP | Pili retraction protein PilT | / | 0.451 | |
| 1eh4 | IC1 | Casein kinase I homolog 1 | 2.7.11.1 | 0.450 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.450 | |
| 1oix | GDP | Ras-related protein Rab-11A | / | 0.450 | |
| 1u2o | NEC | Endoplasmin | / | 0.450 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.450 | |
| 2gil | GTP | Ras-related protein Rab-6A | / | 0.450 | |
| 2ov2 | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.450 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.450 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.450 | |
| 3cgf | JNF | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.450 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.450 | |
| 3i60 | E86 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.450 | |
| 3oom | 507 | Activin receptor type-1 | 2.7.11.30 | 0.450 | |
| 4c0b | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.450 | |
| 4c4g | 7RO | Dual specificity protein kinase TTK | 2.7.12.1 | 0.450 | |
| 4lrj | ANP | Uncharacterized protein | / | 0.450 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.450 | |
| 5a3b | APR | SIR2 family protein | / | 0.450 | |
| 5dha | GNP | GTP-binding nuclear protein Ran | / | 0.450 | |
| 5ios | FAD | Flavin-dependent thymidylate synthase | 2.1.1.148 | 0.450 | |
| 1g16 | GDP | Ras-related protein SEC4 | / | 0.449 | |
| 1ict | T44 | Transthyretin | / | 0.449 | |
| 1mru | AGS | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.449 | |
| 1t3r | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3ddc | GNP | GTPase HRas | / | 0.449 | |
| 3dh7 | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.449 | |
| 3hja | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.449 | |
| 3ruq | ADP | Chaperonin | / | 0.449 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.449 | |
| 4a4w | YFB | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.449 | |
| 4oa9 | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.449 | |
| 4oi2 | ADP | Protein clpf-1 | / | 0.449 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.449 | |
| 1a7k | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.448 | |
| 1m2g | APR | NAD-dependent protein deacylase 1 | / | 0.448 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.448 | |
| 2j7p | GNP | Signal recognition particle protein | / | 0.448 | |
| 2j7p | GNP | Signal recognition particle receptor FtsY | / | 0.448 | |
| 3em6 | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 3ntd | COA | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.448 | |
| 4lv6 | GDP | GTPase KRas | / | 0.448 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.448 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 5br7 | FAD | UDP-galactopyranose mutase | / | 0.448 | |
| 1gqt | ACP | Ribokinase | / | 0.447 | |
| 1okk | GCP | Signal recognition particle protein | / | 0.447 | |
| 1okk | GCP | Signal recognition particle receptor FtsY | / | 0.447 | |
| 2gtk | 208 | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 2iut | AGS | DNA translocase FtsK | / | 0.447 | |
| 2rge | GNP | GTPase HRas | / | 0.447 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.447 | |
| 3da2 | 4MD | Carbonic anhydrase 13 | 4.2.1.1 | 0.447 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.447 | |
| 3o9a | K14 | Pol polyprotein | / | 0.447 | |
| 3oee | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.447 | |
| 3oee | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.447 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.447 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.447 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.447 | |
| 3v0t | ATR | Perakine reductase | 1.1.1.317 | 0.447 | |
| 4hge | 15V | Tyrosine-protein kinase JAK2 | / | 0.447 | |
| 4w9w | YDJ | BMP-2-inducible protein kinase | 2.7.11.1 | 0.447 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 5c88 | COA | N-alpha-acetyltransferase | / | 0.447 | |
| 5dac | AGS | Uncharacterized protein | / | 0.447 | |
| 1e4y | AP5 | Adenylate kinase | / | 0.446 | |
| 1v8k | ANP | Kinesin-like protein KIF2C | / | 0.446 | |
| 1vcf | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.446 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2vyn | NAD | Glyceraldehyde-3-phosphate dehydrogenase A | / | 0.446 | |
| 3cnt | FAD | Polyamine oxidase FMS1 | / | 0.446 | |
| 3hrf | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.446 | |
| 3i4b | Z48 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.446 | |
| 3nbv | ANP | Ketohexokinase | / | 0.446 | |
| 3p7n | FMN | Light-activated DNA-binding protein EL222 | / | 0.446 | |
| 3wfj | NAD | 2-dehydropantoate 2-reductase | / | 0.446 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 4fry | NAD | Putative signal-transduction protein with CBS domains | / | 0.446 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.446 | |
| 4jnq | FDA | Thioredoxin reductase | / | 0.446 | |
| 4k9d | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.446 | |
| 4ktc | 1X3 | Genome polyprotein | 3.4.21.98 | 0.446 | |
| 4mcv | 29K | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.446 | |
| 4nxw | ADP | Mitochondrial dynamics protein MID51 | / | 0.446 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.446 | |
| 4wuj | FMN | Glycoside hydrolase family 15, cellulose signaling associated protein envoy | / | 0.446 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1e96 | GTP | Ras-related C3 botulinum toxin substrate 1 | / | 0.445 | |
| 1fnn | ADP | ORC1-type DNA replication protein | / | 0.445 | |
| 1ppj | ANY | Cytochrome b | / | 0.445 | |
| 1unh | IXM | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.445 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.445 | |
| 3g51 | ANP | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.445 | |
| 3ge6 | FMN | Nitroreductase | / | 0.445 | |
| 3h0s | B38 | Acetyl-CoA carboxylase | / | 0.445 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.445 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4h4z | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.445 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.445 | |
| 4lhw | GNP | Ras-related protein Rab-8A | / | 0.445 | |
| 4otw | DB8 | Receptor tyrosine-protein kinase erbB-3 | 2.7.10.1 | 0.445 | |
| 5cdg | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.445 | |
| 1cbr | REA | Cellular retinoic acid-binding protein 1 | / | 0.444 | |
| 1glb | ADP | Glycerol kinase | / | 0.444 | |
| 1sn5 | T3 | Transthyretin | / | 0.444 | |
| 1z5m | LI8 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 1zdw | FLV | Prenyltransferase | / | 0.444 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.444 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.444 | |
| 2c5l | GTP | GTPase HRas | / | 0.444 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.444 | |
| 2ijm | ATP | Focal adhesion kinase 1 | 2.7.10.2 | 0.444 | |
| 2ozo | ANP | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.444 | |
| 2q4w | FAD | Cytokinin dehydrogenase 7 | 1.5.99.12 | 0.444 | |
| 3cbl | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.444 | |
| 3dl0 | AP5 | Adenylate kinase | / | 0.444 | |
| 3ews | ADP | ATP-dependent RNA helicase DDX19B | 3.6.4.13 | 0.444 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 3kmw | ATP | Integrin-linked protein kinase | 2.7.11.1 | 0.444 | |
| 3nfa | CBJ | Gag-Pol polyprotein | / | 0.444 | |
| 4btj | ADP | Tau-tubulin kinase 1 | 2.7.11.1 | 0.444 | |
| 4eoo | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 4q1y | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.444 | |
| 1tll | NAP | Nitric oxide synthase, brain | 1.14.13.39 | 0.443 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.443 | |
| 2gqw | FAD | Ferredoxin reductase | / | 0.443 | |
| 2r5t | ANP | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.443 | |
| 3lf0 | ATP | Nitrogen regulatory protein P-II | / | 0.443 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.443 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3ump | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.443 | |
| 4agu | D15 | Cyclin-dependent kinase-like 1 | / | 0.443 | |
| 4g01 | GDP | Ras-related protein RABF2b | / | 0.443 | |
| 4h4q | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.443 | |
| 4njs | G08 | Protease | / | 0.443 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 5hpy | GDP | Transforming protein RhoA | / | 0.443 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1n6l | GTP | Ras-related protein Rab-5A | / | 0.442 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.442 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.442 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.442 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 2k5t | COA | PanD regulatory factor | / | 0.442 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.442 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.442 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.442 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.442 | |
| 3bi5 | FAD | Polyamine oxidase FMS1 | / | 0.442 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.442 | |
| 3dm5 | GDP | Signal recognition particle 54 kDa protein | / | 0.442 | |
| 3f3s | NAD | Lambda-crystallin homolog | / | 0.442 | |
| 3nwx | KVS | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3r4b | 74T | Gag-Pol polyprotein | / | 0.442 | |
| 3u33 | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.442 | |
| 4n9i | PCG | Catabolite expression activator | / | 0.442 | |
| 5kcp | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 1efv | FAD | Electron transfer flavoprotein subunit alpha, mitochondrial | / | 0.441 | |
| 1f8s | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.441 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.441 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.441 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.441 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.441 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.441 | |
| 2z6c | FMN | Phototropin-1 | 2.7.11.1 | 0.441 | |
| 3d72 | FAD | Vivid PAS protein VVD | / | 0.441 | |
| 3h0a | D30 | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 3lli | FAD | Sulfhydryl oxidase 1 | 1.8.3.2 | 0.441 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3of4 | FMN | Nitroreductase | / | 0.441 | |
| 3sdk | P3N | Proteasome subunit beta type-5 | 3.4.25.1 | 0.441 | |
| 3sdk | P3N | Proteasome subunit beta type-6 | 3.4.25.1 | 0.441 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.441 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 4e07 | ACP | Plasmid partitioning protein ParF | / | 0.441 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.441 | |
| 4fr4 | STU | Serine/threonine-protein kinase 32A | 2.7.11.1 | 0.441 | |
| 4uj3 | GNP | Ras-related protein Rab-11A | / | 0.441 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.441 | |
| 5cdt | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 1l3i | SAH | Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) | / | 0.440 | |
| 1m2k | APR | NAD-dependent protein deacylase 1 | / | 0.440 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.440 | |
| 2bme | GNP | Ras-related protein Rab-4A | / | 0.440 | |
| 2fon | FAD | Acyl-coenzyme A oxidase | / | 0.440 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 3a58 | GNP | GTP-binding protein RHO1 | / | 0.440 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.440 | |
| 3oy4 | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.440 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.440 | |
| 3v4t | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.440 | |
| 3vy5 | FMN | FMN-binding protein | / | 0.440 | |
| 3wd7 | COA | Acridone synthase | / | 0.440 | |
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.440 | |
| 4fv1 | EK4 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.440 | |
| 4o1p | ANP | Ribonuclease L | / | 0.440 | |
| 4u03 | GTP | Cyclic GMP-AMP synthase | / | 0.440 | |
| 4w6z | 8ID | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.440 |