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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3r9nZ68Cyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3r9nZ68Cyclin-dependent kinase 22.7.11.221.000
3rahO1ZCyclin-dependent kinase 22.7.11.220.770
3rpr25ZCyclin-dependent kinase 22.7.11.220.646
3qtsX46Cyclin-dependent kinase 22.7.11.220.643
3r8vZ62Cyclin-dependent kinase 22.7.11.220.579
1h0w207Cyclin-dependent kinase 22.7.11.220.565
3r73X87Cyclin-dependent kinase 22.7.11.220.564
3rm719ZCyclin-dependent kinase 22.7.11.220.559
3r71X86Cyclin-dependent kinase 22.7.11.220.557
2c69CT8Cyclin-dependent kinase 22.7.11.220.552
3iggEFQCyclin-dependent kinase 22.7.11.220.551
3qx2X63Cyclin-dependent kinase 22.7.11.220.549
3r8uZ31Cyclin-dependent kinase 22.7.11.220.547
3raiX85Cyclin-dependent kinase 22.7.11.220.547
1w8cN69Cyclin-dependent kinase 22.7.11.220.546
4kd11QKCyclin-dependent kinase 22.7.11.220.542
3r1sX73Cyclin-dependent kinase 22.7.11.220.541
3r8pZ46Cyclin-dependent kinase 22.7.11.220.540
3qruX19Cyclin-dependent kinase 22.7.11.220.539
2w06FRVCyclin-dependent kinase 22.7.11.220.537
2c6iDT1Cyclin-dependent kinase 22.7.11.220.536
3qqlX03Cyclin-dependent kinase 22.7.11.220.534
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.533
3rni21ZCyclin-dependent kinase 22.7.11.220.533
2r3mSCXCyclin-dependent kinase 22.7.11.220.530
2c6lDT4Cyclin-dependent kinase 22.7.11.220.528
2r3fSC8Cyclin-dependent kinase 22.7.11.220.528
3qzgX67Cyclin-dependent kinase 22.7.11.220.527
1e1xNW1Cyclin-dependent kinase 22.7.11.220.526
2c6mDT5Cyclin-dependent kinase 22.7.11.220.526
2fvdLIACyclin-dependent kinase 22.7.11.220.526
3rpo24ZCyclin-dependent kinase 22.7.11.220.526
3r83Z14Cyclin-dependent kinase 22.7.11.220.522
3qxoX65Cyclin-dependent kinase 22.7.11.220.521
3r8lZ30Cyclin-dependent kinase 22.7.11.220.521
2c6o4SPCyclin-dependent kinase 22.7.11.220.517
3lfnA27Cyclin-dependent kinase 22.7.11.220.515
3s2pPMUCyclin-dependent kinase 22.7.11.220.514
2c6kDT2Cyclin-dependent kinase 22.7.11.220.513
3lfsA07Cyclin-dependent kinase 22.7.11.220.513
3sqq99ZCyclin-dependent kinase 22.7.11.220.513
3qxpX64Cyclin-dependent kinase 22.7.11.220.512
4eor4SPCyclin-dependent kinase 22.7.11.220.512
2r3r6SCCyclin-dependent kinase 22.7.11.220.511
3rak03ZCyclin-dependent kinase 22.7.11.220.511
3wblPDYCyclin-dependent kinase 22.7.11.220.511
4fkr45KCyclin-dependent kinase 22.7.11.220.511
3r7iX9ICyclin-dependent kinase 22.7.11.220.510
1pxmCK5Cyclin-dependent kinase 22.7.11.220.507
2c68CT6Cyclin-dependent kinase 22.7.11.220.507
3r9hZ67Cyclin-dependent kinase 22.7.11.220.507
4ek816KCyclin-dependent kinase 22.7.11.220.507
1oirHDYCyclin-dependent kinase 22.7.11.220.506
3lfqA28Cyclin-dependent kinase 22.7.11.220.506
4qmlANPSerine/threonine-protein kinase 242.7.11.10.506
3s00Z60Cyclin-dependent kinase 22.7.11.220.505
3qzhX69Cyclin-dependent kinase 22.7.11.220.504
3rk507ZCyclin-dependent kinase 22.7.11.220.502
3rmf20ZCyclin-dependent kinase 22.7.11.220.502
2a0cCK9Cyclin-dependent kinase 22.7.11.220.501
2a4lRRCCyclin-dependent kinase 22.7.11.220.501
2vu3LZECyclin-dependent kinase 22.7.11.220.501
3qwjX6ACyclin-dependent kinase 22.7.11.220.501
3pj8404Cyclin-dependent kinase 22.7.11.220.500
1y8yCT7Cyclin-dependent kinase 22.7.11.220.499
3rk708ZCyclin-dependent kinase 22.7.11.220.499
1oitHDTCyclin-dependent kinase 22.7.11.220.498
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.498
4fklCK2Cyclin-dependent kinase 22.7.11.220.498
4fko20KCyclin-dependent kinase 22.7.11.220.498
2r3p3SCCyclin-dependent kinase 22.7.11.220.497
3r7vZ02Cyclin-dependent kinase 22.7.11.220.497
3rk909ZCyclin-dependent kinase 22.7.11.220.497
2vtsLZCCyclin-dependent kinase 22.7.11.220.496
3my5RFZCyclin-dependent kinase 22.7.11.220.496
3qtuX44Cyclin-dependent kinase 22.7.11.220.496
3s1h56ZCyclin-dependent kinase 22.7.11.220.496
4bgh3I6Cyclin-dependent kinase 22.7.11.220.496
3qqhX0ACyclin-dependent kinase 22.7.11.220.495
3sw719KCyclin-dependent kinase 22.7.11.220.495
2r3o2SCCyclin-dependent kinase 22.7.11.220.494
2uzoC62Cyclin-dependent kinase 22.7.11.220.494
3r1yX76Cyclin-dependent kinase 22.7.11.220.494
4fkq42KCyclin-dependent kinase 22.7.11.220.493
2r3kSCQCyclin-dependent kinase 22.7.11.220.492
2w1hL0FCyclin-dependent kinase 22.7.11.220.491
3ezrEZRCyclin-dependent kinase 22.7.11.220.491
2r3q5SCCyclin-dependent kinase 22.7.11.220.490
3ral04ZCyclin-dependent kinase 22.7.11.220.490
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.488
3r7eX88Cyclin-dependent kinase 22.7.11.220.488
3r9dX6BCyclin-dependent kinase 22.7.11.220.487
1gz8MBPCyclin-dependent kinase 22.7.11.220.486
3rpv26ZCyclin-dependent kinase 22.7.11.220.486
3s0o50ZCyclin-dependent kinase 22.7.11.220.485
4btjATPTau-tubulin kinase 12.7.11.10.485
4fkpLS5Cyclin-dependent kinase 22.7.11.220.485
1ke6LS2Cyclin-dependent kinase 22.7.11.220.484
1ykr628Cyclin-dependent kinase 22.7.11.220.484
3r7yZ04Cyclin-dependent kinase 22.7.11.220.484
4acm7YGCyclin-dependent kinase 22.7.11.220.484
2r3gSC9Cyclin-dependent kinase 22.7.11.220.483
3qtxX43Cyclin-dependent kinase 22.7.11.220.483
3qtzX42Cyclin-dependent kinase 22.7.11.220.482
1oiyN41Cyclin-dependent kinase 22.7.11.220.481
3roy22ZCyclin-dependent kinase 22.7.11.220.481
3rkb12ZCyclin-dependent kinase 22.7.11.220.480
4ek610KCyclin-dependent kinase 22.7.11.220.480
1gih1PUCyclin-dependent kinase 22.7.11.220.479
2b55D31Cyclin-dependent kinase 22.7.11.220.479
3ddqRRCCyclin-dependent kinase 22.7.11.220.479
3ig7EFPCyclin-dependent kinase 22.7.11.220.479
4fkv61KCyclin-dependent kinase 22.7.11.220.477
1p2a5BNCyclin-dependent kinase 22.7.11.220.476
1w0xOLOCyclin-dependent kinase 22.7.11.220.475
2b53D23Cyclin-dependent kinase 22.7.11.220.475
3qqkX02Cyclin-dependent kinase 22.7.11.220.475
1pxpCK8Cyclin-dependent kinase 22.7.11.220.474
3qwkX62Cyclin-dependent kinase 22.7.11.220.474
3r8zZ63Cyclin-dependent kinase 22.7.11.220.474
3r7uX96Cyclin-dependent kinase 22.7.11.220.473
2r3lSCWCyclin-dependent kinase 22.7.11.220.472
3r1qX75Cyclin-dependent kinase 22.7.11.220.472
3rm618ZCyclin-dependent kinase 22.7.11.220.472
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.472
3ql8X01Cyclin-dependent kinase 22.7.11.220.471
4gmy0X5Tyrosine-protein kinase JAK2/0.470
2r3iSCFCyclin-dependent kinase 22.7.11.220.469
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.469
3r6xX84Cyclin-dependent kinase 22.7.11.220.469
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.469
3ddpRC8Cyclin-dependent kinase 22.7.11.220.468
3qtqX35Cyclin-dependent kinase 22.7.11.220.468
2i40BLZCyclin-dependent kinase 22.7.11.220.467
2xmyCDKCyclin-dependent kinase 22.7.11.220.467
1h1s4SPCyclin-dependent kinase 22.7.11.220.466
2duv371Cyclin-dependent kinase 22.7.11.220.466
4fx360KCyclin-dependent kinase 22.7.11.220.466
2vttLZDCyclin-dependent kinase 22.7.11.220.465
2vv9IM9Cyclin-dependent kinase 22.7.11.220.465
3r28XA0Cyclin-dependent kinase 22.7.11.220.465
1bygSTUTyrosine-protein kinase CSK/0.464
1ke7LS3Cyclin-dependent kinase 22.7.11.220.464
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.463
2exmZIPCyclin-dependent kinase 22.7.11.220.463
2r64740Cyclin-dependent kinase 22.7.11.220.463
2uznC96Cyclin-dependent kinase 22.7.11.220.463
3qtwX3ACyclin-dependent kinase 22.7.11.220.463
1gii1PUCyclin-dependent kinase 22.7.11.220.462
5aniES4Cyclin-dependent kinase 22.7.11.220.462
2w05FRTCyclin-dependent kinase 22.7.11.220.461
3qqfX07Cyclin-dependent kinase 22.7.11.220.461
3qrtX14Cyclin-dependent kinase 22.7.11.220.460
4eol1ROCyclin-dependent kinase 22.7.11.220.460
1oguST8Cyclin-dependent kinase 22.7.11.220.459
1pxlCK4Cyclin-dependent kinase 22.7.11.220.459
1urwI1PCyclin-dependent kinase 22.7.11.220.459
3sw418KCyclin-dependent kinase 22.7.11.220.459
2b54D05Cyclin-dependent kinase 22.7.11.220.458
2btrU73Cyclin-dependent kinase 22.7.11.220.458
2btsU32Cyclin-dependent kinase 22.7.11.220.458
2j0lANPFocal adhesion kinase 12.7.10.20.458
1vyzN5BCyclin-dependent kinase 22.7.11.220.457
3qu0X40Cyclin-dependent kinase 22.7.11.220.457
3tiz3TICyclin-dependent kinase 22.7.11.220.457
3unk0BYCyclin-dependent kinase 22.7.11.220.457
4bcmT7ZCyclin-dependent kinase 22.7.11.220.457
1h1r6CPCyclin-dependent kinase 22.7.11.220.456
1v1k3FPCyclin-dependent kinase 22.7.11.220.456
1y91CT9Cyclin-dependent kinase 22.7.11.220.456
2j9mPY8Cyclin-dependent kinase 22.7.11.220.456
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
3dogNNNCyclin-dependent kinase 22.7.11.220.455
1h0vUN4Cyclin-dependent kinase 22.7.11.220.454
4fkw62KCyclin-dependent kinase 22.7.11.220.454
3efwAK8Aurora kinase A2.7.11.10.453
4erwSTUCyclin-dependent kinase 22.7.11.220.453
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.453
5e8ySTUTGF-beta receptor type-22.7.11.300.453
1unlRRCCyclin-dependent-like kinase 52.7.11.10.452
2c5yMTWCyclin-dependent kinase 22.7.11.220.452
4fkg4CKCyclin-dependent kinase 22.7.11.220.452
4fks46KCyclin-dependent kinase 22.7.11.220.452
1oi9N20Cyclin-dependent kinase 22.7.11.220.451
2c5nCK8Cyclin-dependent kinase 22.7.11.220.451
2w17I19Cyclin-dependent kinase 22.7.11.220.451
4jboWPHAurora kinase A2.7.11.10.451
4jbpYPHAurora kinase A2.7.11.10.451
4o0uADNAurora kinase A2.7.11.10.451
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
1g5sI17Cyclin-dependent kinase 22.7.11.220.450
1ke9LS5Cyclin-dependent kinase 22.7.11.220.450
2bhhRYUCyclin-dependent kinase 22.7.11.220.450
2wpa889Cyclin-dependent kinase 22.7.11.220.450
3qtrX36Cyclin-dependent kinase 22.7.11.220.450
3u4uLNHCasein kinase II subunit alpha2.7.11.10.450
2c4g514Cyclin-dependent kinase 22.7.11.220.449
2uzbC75Cyclin-dependent kinase 22.7.11.220.449
1ckpPVBCyclin-dependent kinase 22.7.11.220.448
2aazCB3Thymidylate synthase2.1.1.450.448
2j0m4STFocal adhesion kinase 12.7.10.20.448
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.448
2xngA0HAurora kinase A2.7.11.10.447
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.447
4lyn1YGCyclin-dependent kinase 22.7.11.220.447
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.446
3bqr4RBDeath-associated protein kinase 3/0.446
3rjc06ZCyclin-dependent kinase 22.7.11.220.446
5jlaNADPutative short-chain dehydrogenase/reductase/0.446
1b38ATPCyclin-dependent kinase 22.7.11.220.445
1fvt106Cyclin-dependent kinase 22.7.11.220.445
2qoqANPEphrin type-A receptor 32.7.10.10.445
3ggfGVDSerine/threonine-protein kinase 26/0.445
3qyw6PBMitogen-activated protein kinase 12.7.11.240.445
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
2r3jSCJCyclin-dependent kinase 22.7.11.220.444
3qziX72Cyclin-dependent kinase 22.7.11.220.444
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.444
1aq1STUCyclin-dependent kinase 22.7.11.220.443
3fz1B98Cyclin-dependent kinase 22.7.11.220.443
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.443
4fkt48KCyclin-dependent kinase 22.7.11.220.443
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.443
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.443
1ke5LS1Cyclin-dependent kinase 22.7.11.220.442
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.442
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.442
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.442
4btjADPTau-tubulin kinase 12.7.11.10.442
4fkj11KCyclin-dependent kinase 22.7.11.220.442
1di8DTQCyclin-dependent kinase 22.7.11.220.441
1e9hINRCyclin-dependent kinase 22.7.11.220.441
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.441
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.441
1pkdUCNCyclin-dependent kinase 22.7.11.220.440
2x1nX1NCyclin-dependent kinase 22.7.11.220.440
3ezvEZVCyclin-dependent kinase 22.7.11.220.440
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.440
4aguD15Cyclin-dependent kinase-like 1/0.440
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.440