sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3kvu | ACO | Fluoroacetyl-CoA thioesterase | 3.1.2.29 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3kvu | ACO | Fluoroacetyl-CoA thioesterase | 3.1.2.29 | 1.000 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.511 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.495 | |
| 2fvd | LIA | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.487 | |
| 1kt7 | RTL | Retinol-binding protein 4 | / | 0.485 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.485 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.484 | |
| 4rpg | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.483 | |
| 3up0 | D7S | aceDAF-12 | / | 0.481 | |
| 4o7u | THF | Thymidylate synthase | / | 0.481 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.480 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.478 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.478 | |
| 2ix5 | CAA | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.475 | |
| 3r32 | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.475 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 4jln | 18V | Deoxycytidine kinase | 2.7.1.74 | 0.475 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.475 | |
| 4ug2 | NGI | Adenosine receptor A2a | / | 0.475 | |
| 1h0w | 207 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.474 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 2v3a | FAD | Rubredoxin-NAD(+) reductase | 1.18.1.1 | 0.474 | |
| 3mb7 | 14I | Casein kinase II subunit alpha | 2.7.11.1 | 0.474 | |
| 3os3 | 3OS | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.474 | |
| 5aaj | HSC | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.474 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.473 | |
| 3bej | MUF | Bile acid receptor | / | 0.473 | |
| 1buc | CAA | Acyl-CoA dehydrogenase, short-chain specific | 1.3.8.1 | 0.472 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.471 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.470 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.470 | |
| 3thr | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.470 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.470 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.469 | |
| 1q4u | 4CA | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.469 | |
| 2imk | GTX | AGAP009194-PA | / | 0.469 | |
| 4plp | NAD | Homospermidine synthase | 2.5.1.44 | 0.469 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.469 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.468 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.468 | |
| 4kko | 1RE | Gag-Pol polyprotein | 2.7.7.49 | 0.468 | |
| 5c3a | URM | Histo-blood group ABO system transferase | / | 0.468 | |
| 2a5u | QYT | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.467 | |
| 4dgg | I76 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.467 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.466 | |
| 1mj3 | HXC | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.466 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 1ztq | 033 | Collagenase 3 | 3.4.24 | 0.466 | |
| 2zb1 | GK4 | Mitogen-activated protein kinase 14 | / | 0.466 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.466 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.466 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1iiu | RTL | Retinol-binding protein 4 | / | 0.465 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.465 | |
| 3ruv | ANP | Chaperonin | / | 0.465 | |
| 4fv3 | EK6 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.465 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.465 | |
| 4n4w | SNT | Smoothened homolog | / | 0.465 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.464 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.464 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.464 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.464 | |
| 4dxh | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.464 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.463 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.463 | |
| 3iph | G11 | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 3r35 | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.463 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.463 | |
| 4ivb | 1J5 | Tyrosine-protein kinase JAK1 | / | 0.463 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.462 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.462 | |
| 1tsx | UMP | Thymidylate synthase | / | 0.462 | |
| 1xqc | AEJ | Estrogen receptor | / | 0.462 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.462 | |
| 2avi | BTN | Avidin | / | 0.462 | |
| 2gnh | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.462 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.462 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 3fmz | 2T1 | Retinol-binding protein 4 | / | 0.462 | |
| 3ruq | ADP | Chaperonin | / | 0.462 | |
| 4i4b | 1CV | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.462 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.462 | |
| 3vpc | ADP | Glutamate--LysW ligase ArgX | 6.3.2 | 0.461 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.461 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.460 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 3nww | 3NW | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 3sdk | P3N | Proteasome subunit beta type-5 | 3.4.25.1 | 0.460 | |
| 3sdk | P3N | Proteasome subunit beta type-6 | 3.4.25.1 | 0.460 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.460 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.460 | |
| 4hgt | 15G | Casein kinase I isoform delta | 2.7.11.1 | 0.460 | |
| 4yjd | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.460 | |
| 1aiq | CB3 | Thymidylate synthase | / | 0.459 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.459 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.459 | |
| 2uzw | SS4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.459 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.459 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.459 | |
| 3nrc | TCL | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.459 | |
| 3q0j | CAA | Probable enoyl-CoA hydratase echA8 | 4.2.1.17 | 0.459 | |
| 3r3d | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.459 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.459 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.459 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.459 | |
| 4z35 | ON9 | Lysophosphatidic acid receptor 1 | / | 0.459 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.458 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.458 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.458 | |
| 3qgd | 26S | Genome polyprotein | 2.7.7.48 | 0.458 | |
| 3vqh | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.458 | |
| 4hzp | COA | Conserved hypthetical protein | / | 0.458 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.458 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.458 | |
| 1rm5 | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.457 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.457 | |
| 2woa | 576 | Macrophage metalloelastase | 3.4.24.65 | 0.457 | |
| 3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.457 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.457 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.457 | |
| 1kt4 | RTL | Retinol-binding protein 4 | / | 0.456 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.456 | |
| 2jdt | I5S | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.456 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.456 | |
| 3bhr | THG | Thymidylate synthase | / | 0.456 | |
| 3fnh | JPJ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.456 | |
| 3juh | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.456 | |
| 3ts4 | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.456 | |
| 3ums | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.456 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.456 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.456 | |
| 1e1m | NAP | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.455 | |
| 1eqh | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.455 | |
| 1you | PFD | Collagenase 3 | 3.4.24 | 0.455 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.455 | |
| 3uwl | FOZ | Thymidylate synthase | / | 0.455 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.455 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.455 | |
| 3wtk | TH4 | Acetylcholine-binding protein | / | 0.455 | |
| 3x2w | ATP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.455 | |
| 3zxs | DLZ | Deoxyribodipyrimidine photolyase-related protein | / | 0.455 | |
| 4d86 | ADP | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.455 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.455 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.455 | |
| 4o59 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.455 | |
| 1egc | CO8 | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.454 | |
| 1llu | NAD | Alcohol dehydrogenase | / | 0.454 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.454 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 2qa2 | FAD | Polyketide oxygenase CabE | / | 0.454 | |
| 2rtr | IMI | Streptavidin | / | 0.454 | |
| 2vo6 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.454 | |
| 2yph | QQY | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.454 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.454 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.454 | |
| 3hng | 8ST | Vascular endothelial growth factor receptor 1 | 2.7.10.1 | 0.454 | |
| 3tea | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.454 | |
| 3ukr | CKH | Actin-related protein 3 | / | 0.454 | |
| 3ukr | CKH | Actin-related protein 2 | / | 0.454 | |
| 4xrg | NAD | Homospermidine synthase | 2.5.1.44 | 0.454 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.454 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 1fel | FEN | Retinol-binding protein 4 | / | 0.453 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.453 | |
| 1j3k | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 1jqi | CAA | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.453 | |
| 2gfs | PQB | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.453 | |
| 3lil | EEA | Macrophage metalloelastase | 3.4.24.65 | 0.453 | |
| 3rv4 | ADP | Biotin carboxylase | 6.3.4.14 | 0.453 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.453 | |
| 4oh4 | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.453 | |
| 4uck | SAM | Large structural protein | / | 0.453 | |
| 1dd6 | MCI | Metallo-beta-lactamase type 2 | / | 0.452 | |
| 1qvn | FRI | Interleukin-2 | / | 0.452 | |
| 1s9j | BBM | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.452 | |
| 1xur | PB5 | Collagenase 3 | 3.4.24 | 0.452 | |
| 2b35 | TCL | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 2nsd | 4PI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 2ojj | 82A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.452 | |
| 2rki | TT1 | Gag-Pol polyprotein | 2.7.7.49 | 0.452 | |
| 2vu3 | LZE | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 3lf0 | ATP | Nitrogen regulatory protein P-II | / | 0.452 | |
| 3lsm | SFD | Pyranose 2-oxidase | / | 0.452 | |
| 3r3b | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.452 | |
| 4btj | ADP | Tau-tubulin kinase 1 | 2.7.11.1 | 0.452 | |
| 4na4 | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.452 | |
| 4xq9 | NAD | Homospermidine synthase | 2.5.1.44 | 0.452 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.452 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.451 | |
| 1q4t | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.451 | |
| 1std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.451 | |
| 1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.451 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.451 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.451 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.451 | |
| 4gv1 | 0XZ | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.451 | |
| 1fml | RTL | Retinol dehydratase | / | 0.450 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.450 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.450 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1qnf | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.450 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.450 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 2cnd | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.450 | |
| 2fjd | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.450 | |
| 2yig | 5EL | Collagenase 3 | 3.4.24 | 0.450 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.450 | |
| 3ey4 | 352 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.450 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.450 | |
| 3up3 | XCA | aceDAF-12 | / | 0.450 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.450 | |
| 4xqc | NAD | Homospermidine synthase | 2.5.1.44 | 0.450 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.450 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.450 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1eio | GCH | Gastrotropin | / | 0.449 | |
| 1ivh | COS | Isovaleryl-CoA dehydrogenase, mitochondrial | 1.3.8.4 | 0.449 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.449 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.449 | |
| 1nlm | UD1 | UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | / | 0.449 | |
| 2a4z | BYM | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.449 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.449 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2wmq | ZYQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 3dol | GWI | Pol protein | / | 0.449 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.449 | |
| 3vs1 | VSA | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.449 | |
| 4b0j | 3MQ | 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase | 4.2.1.59 | 0.449 | |
| 4bcq | TJF | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 4dsg | FAD | Uncharacterized protein | / | 0.449 | |
| 4h3q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.449 | |
| 4otw | DB8 | Receptor tyrosine-protein kinase erbB-3 | 2.7.10.1 | 0.449 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.449 | |
| 5cdg | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2ahv | COA | Acetate CoA-transferase YdiF | 2.8.3.8 | 0.448 | |
| 2pvn | P63 | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.448 | |
| 3e01 | PZ2 | Gag-Pol polyprotein | 2.7.7.49 | 0.448 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3owu | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.448 | |
| 3vfq | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.448 | |
| 4hfm | NAP | 2-alkenal reductase (NADP(+)-dependent) | / | 0.448 | |
| 4zzj | CNA | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.448 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 1a27 | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.447 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.447 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.447 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.447 | |
| 2a8x | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.447 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.447 | |
| 2j8z | NAP | Quinone oxidoreductase PIG3 | 1 | 0.447 | |
| 2rc4 | ACO | Histone acetyltransferase KAT6A | / | 0.447 | |
| 2uzt | SS3 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.447 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.447 | |
| 3q7d | NPX | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.447 | |
| 3v76 | FDA | Uncharacterized protein | / | 0.447 | |
| 4bqu | CLR | Japanin | / | 0.447 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.447 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.447 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 5env | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.447 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.447 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 1ikw | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.446 | |
| 1mzs | 669 | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | / | 0.446 | |
| 1rx0 | 2MC | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.446 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.446 | |
| 1zmd | NAI | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.446 | |
| 2a3i | C0R | Mineralocorticoid receptor | / | 0.446 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.446 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.446 | |
| 2uyw | BTN | Avd protein | / | 0.446 | |
| 2vf0 | F89 | Thymidylate synthase | / | 0.446 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.446 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.446 | |
| 3ggf | GVD | Serine/threonine-protein kinase 26 | / | 0.446 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.446 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 3stu | DK3 | Methylketone synthase I | / | 0.446 | |
| 3tvu | B37 | Acetyl-CoA carboxylase | / | 0.446 | |
| 4fmq | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.446 | |
| 4iaf | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.446 | |
| 5dbv | COA | Aldehyde Dehydrogenase | / | 0.446 | |
| 5kj6 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 1brp | RTL | Retinol-binding protein 4 | / | 0.445 | |
| 1ckp | PVB | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1tys | DHF | Thymidylate synthase | / | 0.445 | |
| 1vyz | N5B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 2b01 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.445 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.445 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.445 | |
| 2vce | U2F | UDP-glycosyltransferase 72B1 | / | 0.445 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.445 | |
| 3cwk | REA | Cellular retinoic acid-binding protein 2 | / | 0.445 | |
| 3e8n | VRA | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.445 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.445 | |
| 3jzf | JZK | Biotin carboxylase | 6.3.4.14 | 0.445 | |
| 3kdu | NKS | Peroxisome proliferator-activated receptor alpha | / | 0.445 | |
| 3zhv | TDW | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.445 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.445 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.445 | |
| 4fyh | TR5 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | / | 0.445 | |
| 4ho8 | THM | Glucose-1-phosphate thymidylyltransferase | / | 0.445 | |
| 4i03 | L88 | Macrophage metalloelastase | 3.4.24.65 | 0.445 | |
| 4k4f | K4F | Tankyrase-1 | 2.4.2.30 | 0.445 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.445 | |
| 4q5j | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.445 | |
| 1osv | CHC | Bile acid receptor | / | 0.444 | |
| 1rc1 | KT3 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.444 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.444 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2iw8 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 2uup | LK4 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.444 | |
| 3ang | DCC | Transcriptional repressor, TetR family | / | 0.444 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.444 | |
| 3b8r | 887 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.444 | |
| 3di6 | PDZ | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.444 | |
| 3fsk | RO6 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 4fki | 09K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 4fkp | LS5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 4imp | NDP | Polyketide synthase extender modules 3-4 | / | 0.444 | |
| 4jl6 | ADP | Adenylate kinase | / | 0.444 | |
| 4rd2 | GNP | Translation initiation factor 2 subunit gamma | / | 0.444 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.444 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.444 | |
| 5l7d | CLR | Smoothened homolog | / | 0.444 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.443 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.443 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1kmy | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.443 | |
| 1o1v | TCH | Gastrotropin | / | 0.443 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1tl1 | H18 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 1u8f | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.443 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.443 | |
| 2eeq | SAH | Diphthine synthase | / | 0.443 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.443 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.443 | |
| 2vg7 | NNI | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 2zzc | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.443 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.443 | |
| 3lad | FAD | Dihydrolipoyl dehydrogenase | / | 0.443 | |
| 3pp1 | IZG | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.443 | |
| 3r9h | Z67 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3stw | 2TD | Methylketone synthase I | / | 0.443 | |
| 3zdu | 38R | Cyclin-dependent kinase-like 3 | 2.7.11.22 | 0.443 | |
| 4dit | 0KD | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.443 | |
| 4mo2 | FAD | UDP-galactopyranose mutase | / | 0.443 | |
| 1hpz | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 1lqu | NDP | NADPH-ferredoxin reductase FprA | 1.18.1.2 | 0.442 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.442 | |
| 2gu8 | 796 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2vo7 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 3cbl | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.442 | |
| 3g51 | ANP | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.442 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.442 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.442 | |
| 3sgx | 0FW | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.442 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4a7b | 3W4 | Collagenase 3 | 3.4.24 | 0.442 | |
| 4a9o | A9O | Bromodomain-containing protein 2 | / | 0.442 | |
| 4an2 | EUI | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.442 | |
| 4b1f | KRH | Glutamate racemase | / | 0.442 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.442 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.442 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.442 | |
| 4fi1 | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.442 | |
| 4i7f | NVE | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 4iac | ACP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 4l2g | 1V4 | Tankyrase-2 | 2.4.2.30 | 0.442 | |
| 4xwr | FAD | Cholesterol oxidase | 1.1.3.6 | 0.442 | |
| 5cdt | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1ey3 | DAK | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.441 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.441 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.441 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.441 | |
| 2ibz | UQ6 | Cytochrome b | / | 0.441 | |
| 2yaa | ATP | Death-associated protein kinase 2 | / | 0.441 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3mfu | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.441 | |
| 3mpt | 1GK | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3py0 | SU9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3r37 | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.441 | |
| 3r3f | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.441 | |
| 3r8l | Z30 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.441 | |
| 3suf | SUE | Polyprotein | / | 0.441 | |
| 3v04 | V04 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.441 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.441 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.441 | |
| 3zdn | FAD | Monoamine oxidase N | 1.4.3.4 | 0.441 | |
| 4abk | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.441 | |
| 4an9 | 2P7 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.441 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.441 | |
| 4lsl | 1YQ | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 4mle | VO1 | Glucokinase | 2.7.1.2 | 0.441 | |
| 4mzu | COA | WxcM-like protein | / | 0.441 | |
| 4xiv | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.441 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.440 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.440 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 3dya | PZL | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3ffi | 3OB | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3iif | APR | Core histone macro-H2A.1 | / | 0.440 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 3q71 | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.440 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4a9u | A9U | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.440 | |
| 4bcm | T7Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.440 | |
| 4fln | UNK_UNK_TRP_UNK | Protease Do-like 2, chloroplastic | 3.4.21 | 0.440 | |
| 4g17 | 0VN | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.440 | |
| 4gkv | NAD | Alcohol dehydrogenase, propanol-preferring | 1.1.1.1 | 0.440 | |
| 4h4m | 494 | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.440 | |
| 4kvz | SAH | PtnL protein | / | 0.440 | |
| 4lcg | 1WM | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.440 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.440 | |
| 4xwz | FAD | Fructosyl amine:oxygen oxidoreductase | / | 0.440 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.440 |