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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2v7a627Tyrosine-protein kinase ABL12.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2v7a627Tyrosine-protein kinase ABL12.7.10.21.000
2j0lANPFocal adhesion kinase 12.7.10.20.512
4jia1K3Tyrosine-protein kinase JAK2/0.501
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.501
2ijmATPFocal adhesion kinase 12.7.10.20.493
4e4m0NHTyrosine-protein kinase JAK2/0.493
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.492
1yvj4STTyrosine-protein kinase JAK32.7.10.20.491
4btjADPTau-tubulin kinase 12.7.11.10.491
1i44ACPInsulin receptor2.7.10.10.490
4j99ACPFibroblast growth factor receptor 2/0.490
2pwlACPFibroblast growth factor receptor 2/0.489
3lpbNVBTyrosine-protein kinase JAK2/0.487
4aqc88ATyrosine-protein kinase JAK2/0.487
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.486
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.486
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.485
3zewSTUEphrin type-B receptor 42.7.10.10.485
5dt3ATPAurora kinase A2.7.11.10.485
3t8oATPRhodopsin kinase/0.484
4j95ACPFibroblast growth factor receptor 2/0.482
4k33ACPFibroblast growth factor receptor 32.7.10.10.482
4hvi19STyrosine-protein kinase JAK32.7.10.20.479
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.479
4bbe3O4Tyrosine-protein kinase JAK2/0.478
2w1fL0FAurora kinase A2.7.11.10.476
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.476
4nka2K7Fibroblast growth factor receptor 1/0.476
2qo7ANPEphrin type-A receptor 32.7.10.10.475
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.475
4gmy0X5Tyrosine-protein kinase JAK2/0.475
3bu5ATPInsulin receptor2.7.10.10.474
3js2VM1Fibroblast growth factor receptor 1/0.474
4gu94GUFocal adhesion kinase 12.7.10.20.474
4nks2M2Fibroblast growth factor receptor 1/0.474
5drdATPAurora kinase A2.7.11.10.474
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.473
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.473
4bgg844Activin receptor type-12.7.11.300.473
4j98ACPFibroblast growth factor receptor 2/0.473
2x6dX6DAurora kinase A2.7.11.10.472
5dr9SKEAurora kinase A2.7.11.10.472
2qoqANPEphrin type-A receptor 32.7.10.10.471
4j97ACPFibroblast growth factor receptor 2/0.470
5dnrATPAurora kinase A2.7.11.10.470
2c6eHPMAurora kinase A2.7.11.10.469
2xngA0HAurora kinase A2.7.11.10.469
5dr6SKEAurora kinase A2.7.11.10.469
1dawANPCasein kinase II subunit alpha2.7.11.10.468
1ol5ADPAurora kinase A2.7.11.10.468
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.468
2henADPEphrin type-B receptor 22.7.10.10.467
2wqeADPAurora kinase A2.7.11.10.467
4y93746Tyrosine-protein kinase/0.467
1pmn984Mitogen-activated protein kinase 102.7.11.240.466
2vwx7X4Ephrin type-B receptor 42.7.10.10.466
4hvh19RTyrosine-protein kinase JAK32.7.10.20.466
4qmlANPSerine/threonine-protein kinase 242.7.11.10.466
1ol7ADPAurora kinase A2.7.11.10.465
2qo9ANPEphrin type-A receptor 32.7.10.10.465
2vx07X7Ephrin type-B receptor 42.7.10.10.465
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.465
4jr7GNPCasein kinase II subunit alpha2.7.11.10.465
1u4dDBQActivated CDC42 kinase 1/0.464
3c4zADPRhodopsin kinase/0.464
3pxkPXKFocal adhesion kinase 12.7.10.20.464
5e8wSTUTGF-beta receptor type-12.7.11.300.464
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.463
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.463
4nk92K5Fibroblast growth factor receptor 1/0.463
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.462
1bygSTUTyrosine-protein kinase CSK/0.462
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.462
1u54ACPActivated CDC42 kinase 1/0.461
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.461
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.461
4f650S9Fibroblast growth factor receptor 1/0.461
5cvhADPCasein kinase II subunit alpha2.7.11.10.461
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.460
3at4CCKCasein kinase II subunit alpha2.7.11.10.460
3oriAGSSerine/threonine protein kinase/0.460
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.460
4btjATPTau-tubulin kinase 12.7.11.10.460
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.459
3gxlQIGTGF-beta receptor type-12.7.11.300.459
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.459
5l8lADPAurora kinase A2.7.11.10.459
2ijmADPFocal adhesion kinase 12.7.10.20.458
2j0m4STFocal adhesion kinase 12.7.10.20.458
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.458
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.458
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.458
4o0uADNAurora kinase A2.7.11.10.458
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.457
2etm7PYFocal adhesion kinase 12.7.10.20.457
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.457
4c3pACPAurora kinase A2.7.11.10.457
4hge15VTyrosine-protein kinase JAK2/0.457
5dn3ATPAurora kinase A2.7.11.10.457
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.456
4ic7ANPMitogen-activated protein kinase 72.7.11.240.456
4lfiGNPCasein kinase II subunit alpha2.7.11.10.456
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.456
5e8ySTUTGF-beta receptor type-22.7.11.300.456
3be9P04Casein kinase II subunit alpha2.7.11.10.455
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.455
3ggfGVDSerine/threonine-protein kinase 26/0.455
4deeADPAurora kinase A2.7.11.10.455
4gk4L90Ephrin type-A receptor 32.7.10.10.455
4hvg19QTyrosine-protein kinase JAK32.7.10.20.455
5aabVGHALK tyrosine kinase receptor2.7.10.10.455
2vwz7X6Ephrin type-B receptor 42.7.10.10.454
3zep1NXTyrosine-protein kinase JAK32.7.10.20.454
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.453
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.453
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.453
3c4wATPRhodopsin kinase/0.453
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.453
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.453
4c61LMMTyrosine-protein kinase JAK2/0.453
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.452
5aaaVGHALK tyrosine kinase receptor2.7.10.10.452
5dosATPAurora kinase A2.7.11.10.452
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.451
4iva1J5Tyrosine-protein kinase JAK2/0.451
4jbqVX6Aurora kinase A2.7.11.10.451
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.451
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4iwd1JCHepatocyte growth factor receptor2.7.10.10.450
1vyw292Cyclin-dependent kinase 22.7.11.220.449
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.449
4bbfO19Tyrosine-protein kinase JAK2/0.449
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.449
1eupASD6-deoxyerythronolide B hydroxylase/0.448
1mqbANPEphrin type-A receptor 22.7.10.10.448
2bfyH1NAurora kinase B-A2.7.11.10.448
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.448
3icrCOACoenzyme A disulfide reductase/0.448
3k5uPFQAurora kinase A2.7.11.10.448
3ttjJBIMitogen-activated protein kinase 102.7.11.240.448
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.448
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.448
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.448
2pvnP63Casein kinase II subunit alpha2.7.11.10.447
2x1nX1NCyclin-dependent kinase 22.7.11.220.447
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.447
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.447
5e8xSTUTGF-beta receptor type-12.7.11.300.447
2vgoAD5Aurora kinase B-A2.7.11.10.446
4b8lA0PAurora kinase B-A2.7.11.10.446
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.446
4i4e1BQFocal adhesion kinase 12.7.10.20.446
4jqeANPCasein kinase II subunit alpha2.7.11.10.446
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
2izsBRQCasein kinase I isoform gamma-32.7.11.10.445
2xa4AZ5Tyrosine-protein kinase JAK2/0.445
3hmm855TGF-beta receptor type-12.7.11.300.445
3lxkMI1Tyrosine-protein kinase JAK32.7.10.20.445
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1xjdSTUProtein kinase C theta type2.7.11.130.444
2dwbANPAurora kinase A2.7.11.10.444
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.444
2w1gL0GAurora kinase A2.7.11.10.444
3bc3OPTCathepsin L13.4.22.150.444
4b0gVEKAurora kinase A2.7.11.10.444
4f630S7Fibroblast growth factor receptor 1/0.444
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.444
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
4o0wADNAurora kinase A2.7.11.10.444
2hog710Serine/threonine-protein kinase Chk12.7.11.10.443
3nszANPCasein kinase II subunit alpha2.7.11.10.443
3oroAGSSerine/threonine protein kinase/0.443
3sheI85MAP kinase-activated protein kinase 32.7.11.10.443
3w16P9JAurora kinase A2.7.11.10.443
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.443
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.443
5g3tFDAFlavin-dependent L-tryptophan oxidase VioA/0.443
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.442
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.442
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.442
2np8CC3Aurora kinase A2.7.11.10.442
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.442
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.442
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.442
4o1pANPRibonuclease L/0.442
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.442
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.442
1fvv107Cyclin-dependent kinase 22.7.11.220.441
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1mq4ADPAurora kinase A2.7.11.10.441
1oiyN41Cyclin-dependent kinase 22.7.11.220.441
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.441
2x9fX9FEphrin type-B receptor 42.7.10.10.441
3i60E86Mitogen-activated protein kinase 12.7.11.240.441
4jboWPHAurora kinase A2.7.11.10.441
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.440
1lp4ANPCasein kinase II subunit alpha2.7.11.10.440
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.440
2itqITQEpidermal growth factor receptor2.7.10.10.440
2py3ACPFibroblast growth factor receptor 2/0.440
2zdt46CMitogen-activated protein kinase 102.7.11.240.440
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.440
3l8p0CEAngiopoietin-1 receptor2.7.10.10.440
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.440
4c62XWWTyrosine-protein kinase JAK2/0.440
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.440
4ji91M3Tyrosine-protein kinase JAK2/0.440
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.440
4o0sADNAurora kinase A2.7.11.10.440
5dpvSKEAurora kinase A2.7.11.10.440