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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2r3q5SCCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2r3q5SCCyclin-dependent kinase 22.7.11.221.000
2r3iSCFCyclin-dependent kinase 22.7.11.220.738
2r3fSC8Cyclin-dependent kinase 22.7.11.220.711
2c6iDT1Cyclin-dependent kinase 22.7.11.220.691
2r3p3SCCyclin-dependent kinase 22.7.11.220.683
2r3r6SCCyclin-dependent kinase 22.7.11.220.640
2r3o2SCCyclin-dependent kinase 22.7.11.220.633
2r3mSCXCyclin-dependent kinase 22.7.11.220.624
4ek816KCyclin-dependent kinase 22.7.11.220.606
4fkt48KCyclin-dependent kinase 22.7.11.220.604
2r3gSC9Cyclin-dependent kinase 22.7.11.220.600
2r3jSCJCyclin-dependent kinase 22.7.11.220.586
2r3kSCQCyclin-dependent kinase 22.7.11.220.580
2r3lSCWCyclin-dependent kinase 22.7.11.220.568
2btrU73Cyclin-dependent kinase 22.7.11.220.564
3pj8404Cyclin-dependent kinase 22.7.11.220.562
2w05FRTCyclin-dependent kinase 22.7.11.220.559
4fks46KCyclin-dependent kinase 22.7.11.220.557
2uzoC62Cyclin-dependent kinase 22.7.11.220.546
3sw719KCyclin-dependent kinase 22.7.11.220.544
3qxpX64Cyclin-dependent kinase 22.7.11.220.542
3rpv26ZCyclin-dependent kinase 22.7.11.220.541
1gih1PUCyclin-dependent kinase 22.7.11.220.537
2uznC96Cyclin-dependent kinase 22.7.11.220.537
1y8yCT7Cyclin-dependent kinase 22.7.11.220.536
1p2a5BNCyclin-dependent kinase 22.7.11.220.533
2c6lDT4Cyclin-dependent kinase 22.7.11.220.533
3r73X87Cyclin-dependent kinase 22.7.11.220.533
3r8uZ31Cyclin-dependent kinase 22.7.11.220.533
4fkr45KCyclin-dependent kinase 22.7.11.220.533
3r7iX9ICyclin-dependent kinase 22.7.11.220.531
3r1yX76Cyclin-dependent kinase 22.7.11.220.530
2c6mDT5Cyclin-dependent kinase 22.7.11.220.528
3r71X86Cyclin-dependent kinase 22.7.11.220.527
3rm719ZCyclin-dependent kinase 22.7.11.220.527
1oitHDTCyclin-dependent kinase 22.7.11.220.526
3r8lZ30Cyclin-dependent kinase 22.7.11.220.526
4fkq42KCyclin-dependent kinase 22.7.11.220.525
1ykr628Cyclin-dependent kinase 22.7.11.220.524
2c69CT8Cyclin-dependent kinase 22.7.11.220.524
3r1sX73Cyclin-dependent kinase 22.7.11.220.523
3rni21ZCyclin-dependent kinase 22.7.11.220.523
2vtsLZCCyclin-dependent kinase 22.7.11.220.522
3lfqA28Cyclin-dependent kinase 22.7.11.220.519
3r7uX96Cyclin-dependent kinase 22.7.11.220.519
3s00Z60Cyclin-dependent kinase 22.7.11.220.519
3s2pPMUCyclin-dependent kinase 22.7.11.220.519
4bgh3I6Cyclin-dependent kinase 22.7.11.220.519
3qzhX69Cyclin-dependent kinase 22.7.11.220.518
3r8vZ62Cyclin-dependent kinase 22.7.11.220.518
4kd11QKCyclin-dependent kinase 22.7.11.220.518
2w17I19Cyclin-dependent kinase 22.7.11.220.517
3qzfX66Cyclin-dependent kinase 22.7.11.220.515
1vyzN5BCyclin-dependent kinase 22.7.11.220.514
3qqfX07Cyclin-dependent kinase 22.7.11.220.511
1pxmCK5Cyclin-dependent kinase 22.7.11.220.510
3ezvEZVCyclin-dependent kinase 22.7.11.220.510
1h0w207Cyclin-dependent kinase 22.7.11.220.509
1w0xOLOCyclin-dependent kinase 22.7.11.220.509
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.509
3r7yZ04Cyclin-dependent kinase 22.7.11.220.509
3r9nZ68Cyclin-dependent kinase 22.7.11.220.509
3ezrEZRCyclin-dependent kinase 22.7.11.220.508
2fvdLIACyclin-dependent kinase 22.7.11.220.507
2vv9IM9Cyclin-dependent kinase 22.7.11.220.507
3r8zZ63Cyclin-dependent kinase 22.7.11.220.507
3roy22ZCyclin-dependent kinase 22.7.11.220.507
2xmyCDKCyclin-dependent kinase 22.7.11.220.506
3iggEFQCyclin-dependent kinase 22.7.11.220.506
3rahO1ZCyclin-dependent kinase 22.7.11.220.506
1g5sI17Cyclin-dependent kinase 22.7.11.220.505
2j9mPY8Cyclin-dependent kinase 22.7.11.220.505
3rjc06ZCyclin-dependent kinase 22.7.11.220.505
3qtsX46Cyclin-dependent kinase 22.7.11.220.504
3qxoX65Cyclin-dependent kinase 22.7.11.220.504
3raiX85Cyclin-dependent kinase 22.7.11.220.503
2a0cCK9Cyclin-dependent kinase 22.7.11.220.502
3lfnA27Cyclin-dependent kinase 22.7.11.220.502
3qwjX6ACyclin-dependent kinase 22.7.11.220.502
1h0vUN4Cyclin-dependent kinase 22.7.11.220.501
4fkv61KCyclin-dependent kinase 22.7.11.220.501
1w8cN69Cyclin-dependent kinase 22.7.11.220.500
3qwkX62Cyclin-dependent kinase 22.7.11.220.500
3sqq99ZCyclin-dependent kinase 22.7.11.220.500
2w1hL0FCyclin-dependent kinase 22.7.11.220.499
2wpa889Cyclin-dependent kinase 22.7.11.220.499
3qtqX35Cyclin-dependent kinase 22.7.11.220.499
4fko20KCyclin-dependent kinase 22.7.11.220.499
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.497
3r8pZ46Cyclin-dependent kinase 22.7.11.220.497
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.496
3wblPDYCyclin-dependent kinase 22.7.11.220.496
2wxvWXVCyclin-dependent kinase 22.7.11.220.495
4acm7YGCyclin-dependent kinase 22.7.11.220.495
3lfsA07Cyclin-dependent kinase 22.7.11.220.494
3qqhX0ACyclin-dependent kinase 22.7.11.220.494
3qtxX43Cyclin-dependent kinase 22.7.11.220.494
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.493
4ek610KCyclin-dependent kinase 22.7.11.220.493
3rak03ZCyclin-dependent kinase 22.7.11.220.492
4fkpLS5Cyclin-dependent kinase 22.7.11.220.492
3r7vZ02Cyclin-dependent kinase 22.7.11.220.491
1ke5LS1Cyclin-dependent kinase 22.7.11.220.490
1h1s4SPCyclin-dependent kinase 22.7.11.220.489
2b52D42Cyclin-dependent kinase 22.7.11.220.489
3rmf20ZCyclin-dependent kinase 22.7.11.220.489
3sw418KCyclin-dependent kinase 22.7.11.220.489
4fkw62KCyclin-dependent kinase 22.7.11.220.489
3ig7EFPCyclin-dependent kinase 22.7.11.220.488
3qx2X63Cyclin-dependent kinase 22.7.11.220.488
4fx360KCyclin-dependent kinase 22.7.11.220.488
1fvt106Cyclin-dependent kinase 22.7.11.220.487
3qqkX02Cyclin-dependent kinase 22.7.11.220.487
1oguST8Cyclin-dependent kinase 22.7.11.220.485
1urwI1PCyclin-dependent kinase 22.7.11.220.485
2c6o4SPCyclin-dependent kinase 22.7.11.220.485
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.485
2vttLZDCyclin-dependent kinase 22.7.11.220.485
1ke7LS3Cyclin-dependent kinase 22.7.11.220.484
1oiyN41Cyclin-dependent kinase 22.7.11.220.484
2b54D05Cyclin-dependent kinase 22.7.11.220.484
3rpo24ZCyclin-dependent kinase 22.7.11.220.484
1ke6LS2Cyclin-dependent kinase 22.7.11.220.483
2r64740Cyclin-dependent kinase 22.7.11.220.482
3rm618ZCyclin-dependent kinase 22.7.11.220.482
4eor4SPCyclin-dependent kinase 22.7.11.220.482
3fz1B98Cyclin-dependent kinase 22.7.11.220.481
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.480
3qruX19Cyclin-dependent kinase 22.7.11.220.480
3qtzX42Cyclin-dependent kinase 22.7.11.220.479
3unk0BYCyclin-dependent kinase 22.7.11.220.479
2uzlC94Cyclin-dependent kinase 22.7.11.220.478
4fkg4CKCyclin-dependent kinase 22.7.11.220.478
2x1nX1NCyclin-dependent kinase 22.7.11.220.477
3rk507ZCyclin-dependent kinase 22.7.11.220.477
2b55D31Cyclin-dependent kinase 22.7.11.220.476
2bheBRYCyclin-dependent kinase 22.7.11.220.476
3rk909ZCyclin-dependent kinase 22.7.11.220.476
3r9dX6BCyclin-dependent kinase 22.7.11.220.475
1oiqHDUCyclin-dependent kinase 22.7.11.220.474
1pxpCK8Cyclin-dependent kinase 22.7.11.220.474
2wihP48Cyclin-dependent kinase 22.7.11.220.474
3py0SU9Cyclin-dependent kinase 22.7.11.220.474
3qtrX36Cyclin-dependent kinase 22.7.11.220.474
1gii1PUCyclin-dependent kinase 22.7.11.220.473
3r28XA0Cyclin-dependent kinase 22.7.11.220.473
4eomATPCyclin-dependent kinase 22.7.11.220.473
2i40BLZCyclin-dependent kinase 22.7.11.220.472
3le62BZCyclin-dependent kinase 22.7.11.220.471
4bcmT7ZCyclin-dependent kinase 22.7.11.220.471
2b53D23Cyclin-dependent kinase 22.7.11.220.470
1v1k3FPCyclin-dependent kinase 22.7.11.220.469
3qqlX03Cyclin-dependent kinase 22.7.11.220.469
1fvv107Cyclin-dependent kinase 22.7.11.220.468
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.468
1pyePM1Cyclin-dependent kinase 22.7.11.220.468
1unlRRCCyclin-dependent-like kinase 52.7.11.10.468
3r83Z14Cyclin-dependent kinase 22.7.11.220.468
4ez30S0Cyclin-dependent kinase 22.7.11.220.468
1ke9LS5Cyclin-dependent kinase 22.7.11.220.467
3qtuX44Cyclin-dependent kinase 22.7.11.220.467
3rzb02ZCyclin-dependent kinase 22.7.11.220.467
1vyw292Cyclin-dependent kinase 22.7.11.220.466
4erwSTUCyclin-dependent kinase 22.7.11.220.466
3r6xX84Cyclin-dependent kinase 22.7.11.220.465
2a4lRRCCyclin-dependent kinase 22.7.11.220.464
3pxyJWSCyclin-dependent kinase 22.7.11.220.463
3qu0X40Cyclin-dependent kinase 22.7.11.220.463
3ral04ZCyclin-dependent kinase 22.7.11.220.463
3s1h56ZCyclin-dependent kinase 22.7.11.220.463
1e1xNW1Cyclin-dependent kinase 22.7.11.220.462
1pxkCK3Cyclin-dependent kinase 22.7.11.220.462
3qrtX14Cyclin-dependent kinase 22.7.11.220.462
3r1qX75Cyclin-dependent kinase 22.7.11.220.462
3r9hZ67Cyclin-dependent kinase 22.7.11.220.462
3sheI85MAP kinase-activated protein kinase 32.7.11.10.462
2c68CT6Cyclin-dependent kinase 22.7.11.220.461
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.459
3ddqRRCCyclin-dependent kinase 22.7.11.220.459
3qziX72Cyclin-dependent kinase 22.7.11.220.459
1pxlCK4Cyclin-dependent kinase 22.7.11.220.458
2exmZIPCyclin-dependent kinase 22.7.11.220.458
2vu3LZECyclin-dependent kinase 22.7.11.220.458
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.458
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.457
1aq1STUCyclin-dependent kinase 22.7.11.220.456
1ckpPVBCyclin-dependent kinase 22.7.11.220.456
1pkdUCNCyclin-dependent kinase 22.7.11.220.456
1y91CT9Cyclin-dependent kinase 22.7.11.220.456
2c4g514Cyclin-dependent kinase 22.7.11.220.456
3r7eX88Cyclin-dependent kinase 22.7.11.220.456
1di8DTQCyclin-dependent kinase 22.7.11.220.455
1oi9N20Cyclin-dependent kinase 22.7.11.220.455
2c6tDT5Cyclin-dependent kinase 22.7.11.220.455
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.454
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.454
3rkb12ZCyclin-dependent kinase 22.7.11.220.454
4btjADPTau-tubulin kinase 12.7.11.10.454
3my5RFZCyclin-dependent kinase 22.7.11.220.453
3rk708ZCyclin-dependent kinase 22.7.11.220.453
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.453
4qmlANPSerine/threonine-protein kinase 242.7.11.10.453
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.452
3ql8X01Cyclin-dependent kinase 22.7.11.220.452
3ti1B49Cyclin-dependent kinase 22.7.11.220.452
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.452
2iw84SPCyclin-dependent kinase 22.7.11.220.451
1v0pPVBCell division control protein 2 homolog2.7.11.220.450
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.449
2uzbC75Cyclin-dependent kinase 22.7.11.220.449
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.449
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.449
1e9hINRCyclin-dependent kinase 22.7.11.220.448
2btsU32Cyclin-dependent kinase 22.7.11.220.448
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
1h1r6CPCyclin-dependent kinase 22.7.11.220.446
2c5nCK8Cyclin-dependent kinase 22.7.11.220.446
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.446
3tnwF18Cyclin-dependent kinase 22.7.11.220.446
4eok4SPCyclin-dependent kinase 22.7.11.220.446
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
3dogNNNCyclin-dependent kinase 22.7.11.220.445
3qzgX67Cyclin-dependent kinase 22.7.11.220.445
3ggfGVDSerine/threonine-protein kinase 26/0.444
3t8oATPRhodopsin kinase/0.444
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.444
1b39ATPCyclin-dependent kinase 22.7.11.220.443
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.443
1gij2PUCyclin-dependent kinase 22.7.11.220.442
1ke8LS4Cyclin-dependent kinase 22.7.11.220.442
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.442
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.442
2uzdC85Cyclin-dependent kinase 22.7.11.220.442
4fki09KCyclin-dependent kinase 22.7.11.220.442
4nbwNADShort-chain dehydrogenase/reductase SDR/0.442
2bhhRYUCyclin-dependent kinase 22.7.11.220.441
2c5yMTWCyclin-dependent kinase 22.7.11.220.441
2hog710Serine/threonine-protein kinase Chk12.7.11.10.440
2w06FRVCyclin-dependent kinase 22.7.11.220.440
2xnbY8LCyclin-dependent kinase 22.7.11.220.440
3ddpRC8Cyclin-dependent kinase 22.7.11.220.440
4btjATPTau-tubulin kinase 12.7.11.10.440