sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2nvc | ITA | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 1.000 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.649 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.636 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.615 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.614 | |
| 4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.613 | |
| 2pdy | FID | Aldose reductase | 1.1.1.21 | 0.607 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.605 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.598 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.597 | |
| 1pwm | FID | Aldose reductase | 1.1.1.21 | 0.589 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.584 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.580 | |
| 1ah0 | SBI | Aldose reductase | 1.1.1.21 | 0.577 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.577 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.562 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.555 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.548 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.539 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.532 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.521 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.518 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.511 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.507 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.498 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.497 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.494 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.492 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.492 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.490 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.487 | |
| 1u70 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.487 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.485 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.482 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.481 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.479 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.479 | |
| 1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.478 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.478 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.478 | |
| 4paa | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.478 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.478 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.477 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.476 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.476 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.476 | |
| 3ojw | FMN | NADPH--cytochrome P450 reductase | / | 0.476 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.476 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.475 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.473 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.473 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.472 | |
| 4e2y | JHZ | Methyltransferase | / | 0.472 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.471 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.470 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.470 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.470 | |
| 1az1 | ALR | Aldose reductase | 1.1.1.21 | 0.469 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.469 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.469 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.468 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.468 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.467 | |
| 1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.466 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.466 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.465 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.465 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.465 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.465 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.465 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.465 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.465 | |
| 2e94 | 364 | Geranylgeranyl pyrophosphate synthase | / | 0.464 | |
| 2gl0 | ADN | Uncharacterized protein | / | 0.464 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.464 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.464 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.463 | |
| 2vrj | NCW | Beta-glucosidase A | 3.2.1.21 | 0.463 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.463 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.463 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.463 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.463 | |
| 3qfr | FAD | NADPH--cytochrome P450 reductase | / | 0.463 | |
| 4kmz | FOL | Folate receptor beta | / | 0.463 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.462 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.462 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.462 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.461 | |
| 4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.460 | |
| 2y1x | 845 | Histone-arginine methyltransferase CARM1 | / | 0.460 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.460 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.459 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.459 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.459 | |
| 4hx5 | 19V | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 4nwi | CTN | 7-methylguanosine phosphate-specific 5'-nucleotidase | / | 0.459 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.459 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.458 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.458 | |
| 2vqq | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.458 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.458 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.458 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.458 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.457 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 4kn1 | 04J | Folate receptor beta | / | 0.457 | |
| 2ycx | P32 | Beta-1 adrenergic receptor | / | 0.457 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.457 | |
| 2y03 | 5FW | Beta-1 adrenergic receptor | / | 0.456 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.456 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.456 | |
| 1sqi | 869 | 4-hydroxyphenylpyruvate dioxygenase | / | 0.455 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.455 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.455 | |
| 2y1w | 849 | Histone-arginine methyltransferase CARM1 | / | 0.455 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.455 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 4mqt | 2CU | Muscarinic acetylcholine receptor M2 | / | 0.455 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.454 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.454 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.454 | |
| 1sg0 | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.453 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 2obx | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | 2.5.1.78 | 0.453 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.453 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.453 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
| 5jqh | CAU | Beta-2 adrenergic receptor | / | 0.453 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.452 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.452 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.452 | |
| 3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 3irh | DTP | HD domain protein | / | 0.452 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.452 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.452 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.451 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 2r04 | W71 | Genome polyprotein | / | 0.451 | |
| 3cas | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.451 | |
| 4i5x | FLF | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.451 | |
| 5ds3 | 09L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.451 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.450 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.450 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.450 | |
| 2hzq | STR | Apolipoprotein D | / | 0.450 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.450 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.450 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.450 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.450 | |
| 4wbd | ADP | Putative cysteine ligase BshC | / | 0.450 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.449 | |
| 1qvt | PRL | HTH-type transcriptional regulator QacR | / | 0.449 | |
| 1uk1 | FRQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.449 | |
| 1w76 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.449 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.449 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.448 | |
| 1wkg | POI | [LysW]-aminoadipate semialdehyde transaminase | / | 0.448 | |
| 2b8j | ADN | Class B acid phosphatase | 3.1.3.2 | 0.448 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.448 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.447 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.447 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.447 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.447 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.447 | |
| 1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.446 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.446 | |
| 3f90 | FMN | Flavodoxin | / | 0.446 | |
| 3owx | XRA | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.446 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.446 | |
| 5d5a | CAU | Beta-2 adrenergic receptor | / | 0.446 | |
| 1sa5 | BMV | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.445 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2ohh | FMN | Type A flavoprotein FprA | 1 | 0.445 | |
| 2rcw | AAI | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.445 | |
| 3dr4 | G4M | GDP-perosamine synthase | / | 0.445 | |
| 4dyb | 0MH | Nucleoprotein | / | 0.445 | |
| 4j7g | TRH | PCZA361.3 | / | 0.445 | |
| 4kn0 | MTX | Folate receptor beta | / | 0.445 | |
| 4phl | PIL | Phosphodiesterase | / | 0.445 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.444 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.444 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.444 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.444 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.444 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 4g2w | NI0 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.444 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.444 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.444 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.444 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.443 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.443 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 2r7n | ADP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase | / | 0.443 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.443 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.443 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 4jqa | ID8 | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 4kn2 | LYA | Folate receptor beta | / | 0.443 | |
| 4lrh | FOL | Folate receptor alpha | / | 0.443 | |
| 5agk | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.443 | |
| 4ldl | XQC | Beta-2 adrenergic receptor | / | 0.443 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.442 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.442 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
| 2j83 | BAT | Ulilysin | 3.4.24 | 0.442 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.442 | |
| 2pk3 | GDD | GDP-6-deoxy-D-mannose reductase | / | 0.442 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.442 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.442 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.441 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2a3b | CFF | Endochitinase B1 | 3.2.1.14 | 0.441 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2jgs | BTN | Avidin | / | 0.441 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.441 | |
| 4amj | CVD | Beta-1 adrenergic receptor | / | 0.441 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.441 | |
| 4dya | 0MF | Nucleoprotein | / | 0.441 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1jqd | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.440 | |
| 1k4m | NAD | Nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.440 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1rpw | DID | HTH-type transcriptional regulator QacR | / | 0.440 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2c97 | JCL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.440 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.440 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 3ou2 | SAH | SAM-dependent methyltransferase | / | 0.440 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 4buu | F38 | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.440 | |
| 4to1 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.440 |