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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2etrY27Rho-associated protein kinase 12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2etrY27Rho-associated protein kinase 12.7.11.11.000
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.552
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.546
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.537
3ncz3NCRho-associated protein kinase 12.7.11.10.537
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.536
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.534
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.533
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.531
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.529
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.529
2f2uM77Rho-associated protein kinase 22.7.11.10.527
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.523
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.522
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.522
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.522
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.519
4otiMI1Serine/threonine-protein kinase N1/0.519
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.515
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.508
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.507
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.507
4j99ACPFibroblast growth factor receptor 2/0.506
3juhANPCasein kinase II subunit alpha2.7.11.10.505
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.503
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.503
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.503
1qmzATPCyclin-dependent kinase 22.7.11.220.502
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
4j95ACPFibroblast growth factor receptor 2/0.502
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.499
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.498
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.498
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.495
4eooATPCyclin-dependent kinase 22.7.11.220.495
4ii5ADPCyclin-dependent kinase 22.7.11.220.495
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.494
3gu7ADPDeath-associated protein kinase 12.7.11.10.493
3mvhWFERAC-alpha serine/threonine-protein kinase2.7.11.10.493
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.493
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.492
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.492
4bcmT7ZCyclin-dependent kinase 22.7.11.220.491
4ic7ANPMitogen-activated protein kinase 72.7.11.240.491
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.490
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.490
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.489
3i60E86Mitogen-activated protein kinase 12.7.11.240.489
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.489
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
4crsAGSSerine/threonine-protein kinase N22.7.11.130.488
4btjATPTau-tubulin kinase 12.7.11.10.486
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.485
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.483
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.482
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.482
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.481
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
2vv9IM9Cyclin-dependent kinase 22.7.11.220.480
3s1h56ZCyclin-dependent kinase 22.7.11.220.480
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
2vu3LZECyclin-dependent kinase 22.7.11.220.479
3a8wATPProtein kinase C iota type2.7.11.130.478
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
2fvdLIACyclin-dependent kinase 22.7.11.220.477
4l9i8PRRhodopsin kinase/0.477
5dosATPAurora kinase A2.7.11.10.477
3lpbNVBTyrosine-protein kinase JAK2/0.476
3rak03ZCyclin-dependent kinase 22.7.11.220.476
5cvfATPCasein kinase II subunit alpha2.7.11.10.476
2cjmATPCyclin-dependent kinase 22.7.11.220.475
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.475
4xlvACPInsulin receptor2.7.10.10.475
3ml9ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.474
4c3pACPAurora kinase A2.7.11.10.474
4ez50RSCyclin-dependent kinase 62.7.11.220.474
5av2KMPDeath-associated protein kinase 12.7.11.10.474
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.471
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
2ojj82AMitogen-activated protein kinase 12.7.11.240.471
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
2uzbC75Cyclin-dependent kinase 22.7.11.220.470
2ijmADPFocal adhesion kinase 12.7.10.20.469
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.469
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.469
1jklANPDeath-associated protein kinase 12.7.11.10.468
2cciATPCyclin-dependent kinase 22.7.11.220.468
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.468
2yaaATPDeath-associated protein kinase 2/0.468
3lltANPProtein serine/threonine kinase-1/0.468
2ckeIQUDeath-associated protein kinase 2/0.467
4anmWULCasein kinase II subunit alpha2.7.11.10.467
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.467
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.467
3w2sW2REpidermal growth factor receptor2.7.10.10.466
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.466
4f9b0SYCell division cycle 7-related protein kinase2.7.11.10.466
4btjADPTau-tubulin kinase 12.7.11.10.465
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.464
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.464
5ap7SVEDual specificity protein kinase TTK2.7.12.10.464
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.463
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.463
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.463
4qnyANPMitogen activated protein kinase, putative/0.463
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.462
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.462
4hvi19STyrosine-protein kinase JAK32.7.10.20.462
5aut2ANDeath-associated protein kinase 12.7.11.10.462
5e8ySTUTGF-beta receptor type-22.7.11.300.460
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.459
2pvmP29Casein kinase II subunit alpha2.7.11.10.458
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
5av3KMPDeath-associated protein kinase 12.7.11.10.458
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.457
2uvzGVJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4fv6E57Mitogen-activated protein kinase 12.7.11.240.457
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.456
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.455
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.455
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
2w05FRTCyclin-dependent kinase 22.7.11.220.454
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.454
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.453
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.453
2j0m4STFocal adhesion kinase 12.7.10.20.452
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.452
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.451
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.450
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.450
3bqr4RBDeath-associated protein kinase 3/0.450
4j98ACPFibroblast growth factor receptor 2/0.450
2vtqLZACyclin-dependent kinase 22.7.11.220.449
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.449
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
1finATPCyclin-dependent kinase 22.7.11.220.448
1pjkANPCasein kinase II subunit alpha2.7.11.10.448
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.448
2izuP01Casein kinase I isoform gamma-32.7.11.10.447
3dfcANPDeath-associated protein kinase 12.7.11.10.447
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4jia1K3Tyrosine-protein kinase JAK2/0.447
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.447
5dnrATPAurora kinase A2.7.11.10.447
1e8wQUEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
1w8cN69Cyclin-dependent kinase 22.7.11.220.446
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.446
4o0wADNAurora kinase A2.7.11.10.446
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.445
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
1yvj4STTyrosine-protein kinase JAK32.7.10.20.445
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2x6dX6DAurora kinase A2.7.11.10.444
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.444
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.443
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.443
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.443
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3bu5ATPInsulin receptor2.7.10.10.442
3w32W32Epidermal growth factor receptor2.7.10.10.442
4aqc88ATyrosine-protein kinase JAK2/0.442
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.442
1tqmANPRIO-type serine/threonine-protein kinase Rio22.7.11.10.441
2ijmATPFocal adhesion kinase 12.7.10.20.441
2w1fL0FAurora kinase A2.7.11.10.441
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.441
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.441
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.441
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.441
4ockANPN-acetylhexosamine 1-kinase2.7.1.1620.441
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.440
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.440
4jhz1KVBeta-glucuronidase3.2.1.310.440
4ocvANPAminoglycoside phosphotransferase/0.440
4q5hANPProtein kinase OspG2.70.440