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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ckeIQUDeath-associated protein kinase 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ckeIQUDeath-associated protein kinase 2/1.000
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.525
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.499
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.497
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.496
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.495
1wvxBD4Death-associated protein kinase 12.7.11.10.492
3a62STURibosomal protein S6 kinase beta-12.7.11.10.489
4ic7ANPMitogen-activated protein kinase 72.7.11.240.489
3igoANPCalmodulin-domain protein kinase 1, putative/0.488
4hvi19STyrosine-protein kinase JAK32.7.10.20.487
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.486
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.486
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.485
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.485
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.483
3t8oATPRhodopsin kinase/0.483
5av2KMPDeath-associated protein kinase 12.7.11.10.483
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.482
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.481
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.481
2w05FRTCyclin-dependent kinase 22.7.11.220.480
1jklANPDeath-associated protein kinase 12.7.11.10.478
4bbe3O4Tyrosine-protein kinase JAK2/0.477
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.477
1rfvADPPyridoxal kinase2.7.1.350.476
3nynSGVG protein-coupled receptor kinase 62.7.11.160.475
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.474
3bhy7CPDeath-associated protein kinase 3/0.474
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.474
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.473
5av3KMPDeath-associated protein kinase 12.7.11.10.473
2vu3LZECyclin-dependent kinase 22.7.11.220.472
2yaaATPDeath-associated protein kinase 2/0.472
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.472
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.471
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.471
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.470
3bqr4RBDeath-associated protein kinase 3/0.470
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.469
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.468
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.468
4ez50RSCyclin-dependent kinase 62.7.11.220.468
1e9hINRCyclin-dependent kinase 22.7.11.220.467
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.467
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.466
1yvj4STTyrosine-protein kinase JAK32.7.10.20.465
4dgnLU2Casein kinase II subunit alpha2.7.11.10.465
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.464
3q9xEMOCasein kinase II subunit alpha2.7.11.10.464
3zh8C58Protein kinase C iota type2.7.11.130.464
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.464
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.464
5av4GENDeath-associated protein kinase 12.7.11.10.464
3be9P04Casein kinase II subunit alpha2.7.11.10.463
3nux3NVCyclin-dependent kinase 62.7.11.220.463
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.463
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.463
2ijmADPFocal adhesion kinase 12.7.10.20.462
4o0wADNAurora kinase A2.7.11.10.462
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.462
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.461
3pe2E1BCasein kinase II subunit alpha2.7.11.10.461
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.461
3sheI85MAP kinase-activated protein kinase 32.7.11.10.461
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.460
1aq1STUCyclin-dependent kinase 22.7.11.220.459
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.459
2pvnP63Casein kinase II subunit alpha2.7.11.10.459
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.458
2cchATPCyclin-dependent kinase 22.7.11.220.458
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
3at4CCKCasein kinase II subunit alpha2.7.11.10.457
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.457
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.457
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.456
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.456
2j0lANPFocal adhesion kinase 12.7.10.20.456
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.456
3gu6ADPDeath-associated protein kinase 12.7.11.10.456
4ysjADPCalmodulin-like domain protein kinase/0.456
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.455
5auvAGIDeath-associated protein kinase 12.7.11.10.455
1fvv107Cyclin-dependent kinase 22.7.11.220.454
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.454
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.454
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.454
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.454
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.454
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.454
1oiyN41Cyclin-dependent kinase 22.7.11.220.453
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.453
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2zjwREFCasein kinase II subunit alpha2.7.11.10.453
4bbfO19Tyrosine-protein kinase JAK2/0.453
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.453
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4jia1K3Tyrosine-protein kinase JAK2/0.453
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.452
2hog710Serine/threonine-protein kinase Chk12.7.11.10.452
2i40BLZCyclin-dependent kinase 22.7.11.220.452
2uzbC75Cyclin-dependent kinase 22.7.11.220.452
3gubGUBDeath-associated protein kinase 12.7.11.10.452
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.452
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.452
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
1finATPCyclin-dependent kinase 22.7.11.220.451
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.451
1pkdUCNCyclin-dependent kinase 22.7.11.220.451
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.451
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.451
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2w17I19Cyclin-dependent kinase 22.7.11.220.450
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.450
4bcmT7ZCyclin-dependent kinase 22.7.11.220.450
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.450
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4grb0XGCasein kinase II subunit alpha2.7.11.10.449
5auzGENDeath-associated protein kinase 12.7.11.10.449
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.448
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.448
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.448
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.447
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.447
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.447
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
2pvhP19Casein kinase II subunit alpha2.7.11.10.446
3c50ADPRhodopsin kinase/0.446
3lfqA28Cyclin-dependent kinase 22.7.11.220.446
4b7dQLECytochrome P450 monooxygenase PikC/0.446
4wsqKSAAP2-associated protein kinase 12.7.11.10.446
1m2pHNACasein kinase II subunit alpha2.7.11.10.445
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.445
2izuP01Casein kinase I isoform gamma-32.7.11.10.445
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.445
3lltANPProtein serine/threonine kinase-1/0.445
3my5RFZCyclin-dependent kinase 22.7.11.220.445
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.445
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.445
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.445
4gmy0X5Tyrosine-protein kinase JAK2/0.445
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
1p4fDRGDeath-associated protein kinase 12.7.11.10.444
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.444
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.444
3bu5ATPInsulin receptor2.7.10.10.444
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.444
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.444
4hnf16WCasein kinase I isoform delta2.7.11.10.444
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.443
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.443
3ormAGSSerine/threonine protein kinase/0.443
4ix6ADPUncharacterized protein/0.443
5cvfATPCasein kinase II subunit alpha2.7.11.10.443
5e8ySTUTGF-beta receptor type-22.7.11.300.443
1e8wQUEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.442
1u54ACPActivated CDC42 kinase 1/0.442
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.442
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
3juhANPCasein kinase II subunit alpha2.7.11.10.442
4bcqTJFCyclin-dependent kinase 22.7.11.220.442
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.442
4hni16WCasein kinase I isoform epsilon2.7.11.10.442
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.442
4j99ACPFibroblast growth factor receptor 2/0.442
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
4xlvACPInsulin receptor2.7.10.10.442
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.441
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.441
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.441
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.441
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.441
1u4dDBQActivated CDC42 kinase 1/0.440
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.440
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.440
2x1nX1NCyclin-dependent kinase 22.7.11.220.440
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.440
3u4uLNHCasein kinase II subunit alpha2.7.11.10.440
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.440
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.440
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.440
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.440
5auwQUEDeath-associated protein kinase 12.7.11.10.440