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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1a8rGTPGTP cyclohydrolase 13.5.4.16

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1a8rGTPGTP cyclohydrolase 13.5.4.161.000
1n3rGTPGTP cyclohydrolase 13.5.4.160.607
1a9cGTPGTP cyclohydrolase 13.5.4.160.524
4du6GTPGTP cyclohydrolase 1/0.511
1l8qADPChromosomal replication initiator protein DnaA/0.500
4dptAGSMevalonate diphosphate decarboxylase/0.500
1c9k5GPBifunctional adenosylcobalamin biosynthesis protein CobU/0.484
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.484
3qt62P0Mevalonate diphosphate decarboxylase/0.482
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.482
5irnADPNucleotide binding oligomerization domain containing 2/0.481
1h62ANBPentaerythritol tetranitrate reductase/0.480
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.476
4bfxZVXPantothenate kinase2.7.1.330.476
1ipeNDPTropinone reductase 21.1.1.2360.475
4bb3KKAIsopenicillin N synthase1.21.3.10.474
2cv2GSUGlutamate--tRNA ligase6.1.1.170.473
3uovFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.473
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.472
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.472
3c1y2BADNA integrity scanning protein DisA/0.472
4bfzZVZPantothenate kinase2.7.1.330.472
4lcg1WMUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.472
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.471
2w6zL21Biotin carboxylase6.3.4.140.469
3bl7DD1m7GpppX diphosphatase3.6.1.590.469
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.468
1rneC60Renin3.4.23.150.467
2fgjATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.466
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.466
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.466
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.465
1eyyNAPNADP-dependent fatty aldehyde dehydrogenase1.2.1.40.464
2x06NADL-sulfolactate dehydrogenase/0.464
3lqfNADGalactitol dehydrogenase/0.464
5d3qGDPDynamin-13.6.5.50.464
3vt7VDXVitamin D3 receptor/0.463
4jayNAPUDP-N-acetylenolpyruvoylglucosamine reductase/0.463
4wfr2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.463
5dp2NAPCurF/0.463
1uxyEPUUDP-N-acetylenolpyruvoylglucosamine reductase1.3.1.980.462
1x1aSAMC-20 methyltransferase/0.462
2i4qUA4Renin3.4.23.150.462
2oapANPType II secretion system protein (GspE-2)/0.462
2x3jATPAcsD/0.462
2zbaZBATrichothecene 3-O-acetyltransferase/0.462
3a3gDLZLumazine protein/0.462
3ukoNADAlcohol dehydrogenase class-3/0.462
4g6gFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.462
4k6fNAPPutative Acetoacetyl-CoA reductase/0.462
3jzdNADMaleylacetate reductase/0.461
3uoxFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.461
4du82P0Mevalonate diphosphate decarboxylase/0.461
4ho6UTPGlucose-1-phosphate thymidylyltransferase/0.461
4m83ERYOleandomycin glycosyltransferase2.4.10.461
5ftcADPTPR domain protein/0.461
1bwsNDPGDP-L-fucose synthase/0.460
3a0tADPSensor histidine kinase/0.460
3lutNAPVoltage-gated potassium channel subunit beta-2/0.460
1cqp803Integrin alpha-L/0.459
1f8fNADBenzyl alcohol dehydrogenase/0.459
1gv4FADApoptosis-inducing factor 1, mitochondrial1.1.10.459
3h06VBPGlutamate receptor 2/0.459
4jicFMNGTN Reductase/0.459
4ke11R6Beta-secretase 13.4.23.460.459
4wrkDUPDUTPase/0.459
1kh3ANPArgininosuccinate synthase/0.458
2a94AP0L-lactate dehydrogenase1.1.1.270.458
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.458
3vt9YI4Vitamin D3 receptor/0.458
4dfg0JVGag-Pol polyprotein3.4.23.160.458
4wdfA2P2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.458
1xs7MMIBeta-secretase 13.4.23.460.457
4g74FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.457
4u0mGTPCyclic GMP-AMP synthase/0.457
1kevNDPNADP-dependent isopropanol dehydrogenase1.1.1.800.456
1obbNADAlpha-glucosidase3.2.1.200.456
1xddAAYIntegrin alpha-L/0.456
2ft9CHDFatty acid-binding protein 2, liver/0.456
2g8yNADHydroxycarboxylate dehydrogenase B/0.456
2iqgF2IBeta-secretase 13.4.23.460.456
3qe2FMNNADPH--cytochrome P450 reductase/0.456
3qw4U5POrotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative/0.456
4wriOKAOkadaic acid binding protein 2-alpha/0.456
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.456
2b4qNAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.455
3bk2U5PRibonuclease J/0.455
3f03FMNPentaerythritol tetranitrate reductase/0.455
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.455
4bftZVTPantothenate kinase2.7.1.330.455
4mkhAP5Adenylate kinase/0.455
5c1mCLRMu-type opioid receptor/0.455
1adfTADAlcohol dehydrogenase E chain1.1.1.10.454
1dvrATFAdenylate kinase/0.454
1xp8AGSProtein RecA/0.454
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.454
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
2w6qOA5Biotin carboxylase6.3.4.140.454
2y882ERPhosphoribosyl isomerase A5.3.1.160.454
3ge6FMNNitroreductase/0.454
3nbvANPKetohexokinase/0.454
3sx2NADUncharacterized protein/0.454
3uoyFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.454
4prvADPDNA gyrase subunit B/0.454
4rquNADAlcohol dehydrogenase class-P/0.454
4y8vADPAcyl-CoA synthetase (NDP forming)/0.454
4s0vSUVOrexin receptor type 2/0.454
1xkdNAPIsocitrate dehydrogenase [NADP]/0.453
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.453
3ox4NADAlcohol dehydrogenase 21.1.1.10.453
4bfvZVVPantothenate kinase2.7.1.330.453
4f9fGDPPutative glycosyltransferase/0.453
1kqcFMNOxygen-insensitive NAD(P)H nitroreductase/0.452
1tehNADAlcohol dehydrogenase class-31.1.1.10.452
3gegNADShort-chain dehydrogenase/reductase SDR/0.452
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.452
1r58AO5Methionine aminopeptidase 2/0.451
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.451
2cvzNDP3-hydroxyisobutyrate dehydrogenase/0.451
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.451
2vtbFADCryptochrome DASH, chloroplastic/mitochondrial/0.451
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
4b68FADL-ornithine N(5)-monooxygenase/0.451
4cpdNADAlcohol dehydrogenase/0.451
4e2dFMNDehydrogenase/0.451
4l3q926Glucokinase2.7.1.20.451
4mlp2CXCryptochrome-2/0.451
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.451
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.451
5fklTDCTetracycline repressor protein class D/0.451
1aa6MGDFormate dehydrogenase H1.1.99.330.450
1u3dFADCryptochrome-1/0.450
2dv4SAHDiphthine synthase/0.450
4jzr4JREgl nine homolog 1/0.450
4nfsNAJAlcohol dehydrogenase E chain1.1.1.10.450
4xd2NAIAlcohol dehydrogenase E chain1.1.1.10.450
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.450
1kolNADGlutathione-independent formaldehyde dehydrogenase/0.449
1lnmDTXBilin-binding protein/0.449
1mjaCOAHistone acetyltransferase ESA1/0.449
1x1cSAHC-20 methyltransferase/0.449
2d3aADPGlutamine synthetase root isozyme 36.3.1.20.449
2d4vNADIsocitrate dehydrogenase [NADP]/0.449
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.449
2o12FMNChorismate synthase/0.449
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.449
3d4pNADL-lactate dehydrogenase 11.1.1.270.449
3gwfNAPCyclohexanone monooxygenase/0.449
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.449
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.449
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4dxhNAJAlcohol dehydrogenase E chain1.1.1.10.449
1ppjANYCytochrome b/0.448
2v58LZJBiotin carboxylase6.3.4.140.448
3docNADGlyceraldehyde-3-phosphate dehydrogenase/0.448
3keuATPPyridoxal kinase2.7.1.350.448
3lzwNAPFerredoxin--NADP reductase 21.18.1.20.448
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.448
1og4NAIT-cell ecto-ADP-ribosyltransferase 2/0.447
2bn4FMNNADPH--cytochrome P450 reductase/0.447
2d1cNAPIsocitrate dehydrogenase [NADP]1.1.1.420.447
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.447
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3tneRITCandidapepsin-13.4.23.240.447
4ba5PXGProbable aminotransferase/0.447
4blrUTPNTPase P4/0.447
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.447
4gxs0YSGlutamate receptor 2/0.447
4i1iNADMalate dehydrogenase/0.447
4ji91M3Tyrosine-protein kinase JAK2/0.447
1g1aNADdTDP-glucose 4,6-dehydratase/0.446
1tqf32PBeta-secretase 13.4.23.460.446
2cf8ESHProthrombin3.4.21.50.446
2ql6ADPNicotinamide riboside kinase 1/0.446
2qs4LY5Glutamate receptor ionotropic, kainate 1/0.446
2yj5ATPCopper-transporting ATPase/0.446
2ylzFADPhenylacetone monooxygenase1.14.13.920.446
3qiyQI1Botulinum neurotoxin type A3.4.24.690.446
4dqwATPInosine-5'-monophosphate dehydrogenase/0.446
4oztP1AEcdysone receptor, putative/0.446
4p9dTMPDeoxycytidylate deaminase/0.446
4y9qC2EUncharacterized protein/0.446
1ay0TPPTransketolase 12.2.1.10.445
1b5eDCMDeoxycytidylate 5-hydroxymethyltransferase2.1.2.80.445
1mjbACOHistone acetyltransferase ESA1/0.445
1n75ATPGlutamate--tRNA ligase6.1.1.170.445
1qjfACSIsopenicillin N synthase1.21.3.10.445
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.445
1udbUFGUDP-glucose 4-epimerase5.1.3.20.445
1vceSAHDiphthine synthase/0.445
2geuCOKPantothenate kinase2.7.1.330.445
2r8oT5XTransketolase 1/0.445
2vouFAD2,6-dihydroxypyridine 3-monooxygenase1.14.13.100.445
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.445
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.445
3vqsJT1Genome polyprotein/0.445
4brdANPEctonucleoside triphosphate diphosphohydrolase I/0.445
4dpuAGSMevalonate diphosphate decarboxylase/0.445
4fxy0W2Neurolysin, mitochondrial3.4.24.160.445
4loi1YCStimulator of interferon genes protein/0.445
4r81FMNPredicted NADH dehydrogenase/0.445
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.445
1drhNAPDihydrofolate reductase1.5.1.30.444
1ky2GNPGTP-binding protein YPT7/0.444
1x2hLPALipoate-protein ligase A6.3.1.200.444
1ypeUIPProthrombin3.4.21.50.444
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.444
2rlcCHDCholoylglycine hydrolase3.5.1.240.444
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.444
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3hyoADPPyridoxal kinase/0.444
3own3OWRenin3.4.23.150.444
4bis8HQLysine-specific demethylase 4A1.14.110.444
4d9eLCSD-cysteine desulfhydrase/0.444
4e03ADPPlasmid partitioning protein ParF/0.444
4xbjIN5Alanine racemase, biosynthetic/0.444
4xsvCTPEthanolamine-phosphate cytidylyltransferase2.7.7.140.444
1kt8ILPBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.443
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.443
2c29NAPDihydroflavonol 4-reductase/0.443
2g226IGRenin3.4.23.150.443
2wezZYEBeta-secretase 13.4.23.460.443
2xiq5ADMethylmalonyl-CoA mutase, mitochondrial/0.443
2z6dFMNPhototropin-22.7.11.10.443
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.443
3rqqBA3ADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.443
3t58FADSulfhydryl oxidase 11.8.3.20.443
4dwvNAJAlcohol dehydrogenase E chain1.1.1.10.443
4jx1CAHCamphor 5-monooxygenase1.14.15.10.443
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.443
1g6oADPCag alpha/0.442
1rdwLARActin, alpha skeletal muscle/0.442
1rfvADPPyridoxal kinase2.7.1.350.442
1xefATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.442
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.442
2g1o2IGRenin3.4.23.150.442
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.442
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.442
2yozOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.442
3ai3NDPNADPH-sorbose reductase/0.442
3fstFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.442
3h3qH13Collagen type IV alpha-3-binding protein/0.442
3vp6HLDGlutamate decarboxylase 14.1.1.150.442
4m4922YL-lactate dehydrogenase A chain1.1.1.270.442
4xf6ADPCarbohydrate/pyrimidine kinase, PfkB family/0.442
5cdgNAJAlcohol dehydrogenase E chain1.1.1.10.442
5dn1AMZPhosphoribosyl isomerase A5.3.1.160.442
1b2lNDCAlcohol dehydrogenase1.1.1.10.441
1kquBR4Phospholipase A2, membrane associated/0.441
1psa0ZLPepsin A3.4.23.10.441
1x1dSAHC-20 methyltransferase/0.441
2anmCDOProthrombin3.4.21.50.441
2ay95PVAromatic-amino-acid aminotransferase2.6.1.570.441
2gjnFMNNitronate monooxygenase1.13.12.160.441
2webPP4Penicillopepsin-13.4.23.200.441
3e8xNAPBH1520 protein/0.441
3h3t16HCollagen type IV alpha-3-binding protein/0.441
3ibqATPPyridoxal kinase/0.441
3v2uATPProtein GAL3/0.441
4bfwZVWPantothenate kinase2.7.1.330.441
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.441
4j7uNAPSepiapterin reductase1.1.1.1530.441
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.441
4jjiNADAlcohol dehydrogenase class-3/0.441
4lj9ACPChaperone protein ClpB/0.441
4nbwNADShort-chain dehydrogenase/reductase SDR/0.441
4nhyPD2Prolyl 3-hydroxylase OGFOD11.14.110.441
5af7FADAcyl-CoA dehydrogenase/0.441
5kj1NAJAlcohol dehydrogenase E chain1.1.1.10.441
1ae1NAPTropinone reductase 1/0.440
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.440
1qrrUPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.440
1v4sMRKGlucokinase2.7.1.20.440
1wuaAP8Actin, alpha skeletal muscle/0.440
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.440
2b53D23Cyclin-dependent kinase 22.7.11.220.440
2gv8NDPThiol-specific monooxygenase1.14.130.440
3atzFMNProstaglandin F2a synthase/0.440
3cgdCOACoenzyme A disulfide reductase/0.440
3tjlFMNNADPH dehydrogenase/0.440
3uayADNPurine nucleoside phosphorylase DeoD-type/0.440
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.440
3wagTYDGlycosyltransferase/0.440
4dbzNDPPutative ketoacyl reductase1.3.10.440
4j7xNAPSepiapterin reductase1.1.1.1530.440
4kbyC2EStimulator of interferon genes protein/0.440
4yqfGDPSeptin-9/0.440